Gene

KWMTBOMO14756  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003817

Annotation

UDP-glycosyltransferase_UGT41A1_precursor_[Bombyx_mori]

Location

Bomo_Chr24(-):14453668-14476566      View in EpiBrowser

Full name

UDP-glucuronosyltransferase      

Location in the cell

PlasmaMembrane   Reliability : 3.181

CDS

ATGAGGTGTCTCGGACTGCTTTTCTTCTTGGTGTGCGTGGTGACGTCGGCGCGTGCGTACCACGTGCTCTGCGTGTTCCCGATACCTTCGCGCAGCCACAACTCCCTCGGCAAAGGGATAGTCGACGCGTTGCTTGAGGCTGGTCACGAGGTGACCTGGGTGACTCCGTATCCTCCGAGCGAACTGGCCAAAGGTCTGAAGATAGTCGACGTCAGCGCTACAGTATCTATAAGTAAAACGGTGGACATGCATGAGCAGAGAAACTCGAATACTGGTGTATCTTTCGTGAAGGCTTTGGCCGAGAACATCACCAGGGTTTCCCTGGCAACGCCGGCTCTACAGCAGGCGATCGTCCAGGGGAAATACGACGCGGTCATCACGGAAACGTTCTTCAACGATGCCGAAGCTGGTTACGGGGCAGTACTTCAAGTGCCCTGGATCTTGATGTCCAGCATCGCAATGATGCCTCAGTTGGAAGCCATCGTCGATGAGGTGCGGTCGGTCACCACCATACCGCTGCTGTTCAACAACGCCCCAACCCCCATGGGTTTCTGGGACAGACTGAAGAATGTCTTTCTCCACAGCGTCATGGTGATATCTGATTGGCTAGACCGCCCCAAGACGGTGGCATTCTACGAGTCCCTATTCGCGCCGCTGGCCACCGCCCGGGGGGTCGCGCTGCCCCCCTTCGAGGAAGCCCTGTACAACGTGTCGGTGCTGCTTGTGAACTCCCACCCGGCCTTCGCTCCGCCCCTGAGCTTGCCCCCGAACGTCGTCGAGATCGCGGGCTACCATATCGACCCAAAAACACCCCCCTTGCCGAAGGACCTGCAGAGCATCCTGGACTCGTCGCCGCAGGGCGTGGTGTACTTCAGCATGGGCTCGGTGCTCAAGTCGTCCAAACTCTCCGAACAAACTAGACGAGAGTTATTGGATGTGTTTGGGTCTATACCGCAGACTGTCCTTTGGAAGTTCGAAGAGGATCTCCAAGATCTACCGAAGAACGTTCACATTAGATCGTGGATGCCTCAGTCCAGTATACTAGCTCATCCGAACATGAAGGTCTTCATCACGCACGGCGGCTTACTCAGCATCCTCGAGACCTTGCATTACGGAGTACCGATCCTCGCTGTGCCGGTGTTCGGGGACCAGCCCTCAAACGCCAATAGCGCTGTCCGTAACGGATTTGCGAAAAGTATAGAGTACAAGCCTGATATGGCTAAGGACATGAAGGTGGCCCTGAATGAAATGCTGAGCGACGACAGTTACTACAAACGTGCGAGATATCTGTCGAAGATCTTCGGCGATAAGTTGGTGCCGCCGGCCAAGGTGATATCGCATTATGTGAAGGTCGCCATCGAAACTAATGGAGCCTACCATCTGCGCTCTAAGAGCCTGCTGTATCCGTGGTACCAGCGTTGGCTCGTGGACATCATAGCGGCACTACTTCTGGCGTGCCTCGCGGTGTACGTAGTGGCCAGGAGGGTCTTGTGTTACCTCTACACCTCCGTGACCGGTGGGGGCTGTAACAGGAGTGTTAAAGTCAAGAAAAACTAA

Protein

MRCLGLLFFLVCVVTSARAYHVLCVFPIPSRSHNSLGKGIVDALLEAGHEVTWVTPYPPSELAKGLKIVDVSATVSISKTVDMHEQRNSNTGVSFVKALAENITRVSLATPALQQAIVQGKYDAVITETFFNDAEAGYGAVLQVPWILMSSIAMMPQLEAIVDEVRSVTTIPLLFNNAPTPMGFWDRLKNVFLHSVMVISDWLDRPKTVAFYESLFAPLATARGVALPPFEEALYNVSVLLVNSHPAFAPPLSLPPNVVEIAGYHIDPKTPPLPKDLQSILDSSPQGVVYFSMGSVLKSSKLSEQTRRELLDVFGSIPQTVLWKFEEDLQDLPKNVHIRSWMPQSSILAHPNMKVFITHGGLLSILETLHYGVPILAVPVFGDQPSNANSAVRNGFAKSIEYKPDMAKDMKVALNEMLSDDSYYKRARYLSKIFGDKLVPPAKVISHYVKVAIETNGAYHLRSKSLLYPWYQRWLVDIIAALLLACLAVYVVARRVLCYLYTSVTGGGCNRSVKVKKN

Catalytic Activity

glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP

Similarity

Belongs to the UDP-glycosyltransferase family.

Feature

chain  UDP-glucuronosyltransferase

Uniprot

G9LPV2   G9LPV3   G9LPV4   H9J2T0   H9IVQ7   H9J2U8   + More
G9LPR1   A0A2W1BAL9   A0A024AGL8   A0A2A4JV21   A0A2W1BD64   A0A0N0PBY8   A0A2A4JD43   A0A140EA38   A0A1L8D6F2   G9LPQ8   A0A2H1VNG6   A0A286MXP3   A0A2H4WB50   G9LPR0   A0A2W1BBU4   A0A140EA39   A0A212EW66   A0A2A4JUA9   A0A2A4JVG7   G9LPQ9   A0A2W1BEH1   A0A2H4WB58   A0A2H4WB67   A0A2A4J0B4   A0A191T1M8   A0A191T1M6   A0A2A4J6T0   G9LPQ4   A0A3S2NJP8   A0A2W1BQJ6   A0A194RDA8   A0A194Q0G5   A0A2H4WB53   G9LPQ6   A0A2H1VVH6   A0A140EA37   G9LPU4   A0A191T2G6   Q8WPG4   A0A024AGG4   G9LPU0   A0A024AG04   G9LPQ3   G9LPQ0   G9LPU3   A0A2H1WNF9   A0A191T2K0   D6RUU7   A0A1L8D6H0   A0A024AH17   A0A2W1BXG7   A0A191T2K2   A0A2W1BQJ5   A0A2A4J325   A0A191T2J8   A0A1L8D6E4   D6RUU6   G9LPQ5   A0A2W1BVZ0   G9LPU8   A0A2A4K2B6   A0A2H1V1W5   G9LPU6   A0A2A4J419   A0A2W1BX32   A0A140EA36   A0A212FKT5   A0A212FD09   D6RUV0   A0A024AHN0   G9LPU7   A0A2H4WB78   G9LPQ1   A0A194RKA9   A0A191T1P1   A0A2W1BQS6   I4DN89   A0A194RKU4   A0A0N1IN21   A0A2A4K0I8   D6RUV1   G9LPQ7   A0A2H1X1Y8   A0A3S2LTQ3   A0A3S2LD93   H9JL88   A0A194R8C7   A0A191T1N5   A0A1L8D6R9   I4DR17  

EC Number

2.4.1.17

Pubmed

22155036    19121390    28756777    24698447    26354079    26873292    + More
19954531    25299618    29027758    22118469    11846783    20534444    22651552   

EMBL

JQ070259    AEW43175.1    JQ070260    AEW43176.1    JQ070261    AEW43177.1    + More
BABH01036935    BABH01036936    BABH01036937    BABH01042490    BABH01036929    BABH01036930    JQ070218    AEW43134.1    KZ150343    PZC71295.1    KF777117    AHY99688.1    NWSH01000566    PCG75616.1    KZ150120    PZC73179.1    KQ460735    KPJ12633.1    NWSH01001859    PCG69891.1    KU214509    AMK97475.1    GEYN01000097    JAV02032.1    JQ070215    AEW43131.1    ODYU01003485    SOQ42346.1    MF684361    ASX93995.1    KY202927    AUC64271.1    JQ070217    AEW43133.1    PZC71294.1    KU214510    AMK97476.1    AGBW02012074    OWR45723.1    PCG75617.1    PCG75614.1    JQ070216    AEW43132.1    PZC71296.1    KY202932    AUC64276.1    KY202937    AUC64281.1    NWSH01003979    PCG65597.1    KU680303    ANI22009.1    KU680302    ANI22008.1    NWSH01002698    PCG67661.1    JQ070211    AEW43127.1    RSAL01000067    RVE49308.1    KZ149930    PZC77372.1    KQ460597    KPJ13896.1    KQ459582    KPI98793.1    KY202925    AUC64269.1    JQ070213    AEW43129.1    ODYU01004685    SOQ44830.1    KU214508    AMK97474.1    JQ070251    AEW43167.1    KU680295    ANI22001.1    AF324465    AAL55994.1    KF777115    AHY99686.1    JQ070247    AEW43163.1    KF777114    AHY99685.1    JQ070210    AEW43126.1    JQ070207    AEW43123.1    JQ070250    AEW43166.1    ODYU01009829    SOQ54516.1    KU680299    ANI22005.1    JQ070252    AB539964    AEW43168.1    BAJ08154.1    GEYN01000076    JAV02053.1    KF777116    AHY99687.1    PZC77366.1    KU680304    ANI22010.1    PZC77369.1    NWSH01003818    PCG65793.1    KU680294    ANI22000.1    GEYN01000100    JAV02029.1    AB539963    BAJ08153.1    JQ070212    AEW43128.1    PZC77367.1    JQ070255    AEW43171.1    NWSH01000282    PCG77782.1    ODYU01000116    SOQ34342.1    JQ070253    AEW43169.1    NWSH01003535    PCG66153.1    PZC77370.1    KU214507    AMK97473.1    AGBW02007992    OWR54346.1    AGBW02009118    OWR51610.1    AB539967    BAJ08157.1    KF777113    AHY99684.1    JQ070254    AEW43170.1    KY202946    AUC64290.1    JQ070208    AEW43124.1    KQ460075    KPJ17977.1    KU680301    ANI22007.1    PZC77368.1    AK402777    BAM19379.1    KPJ17950.1    KQ459356    KPJ01283.1    PCG77781.1    JQ070258    AB539968    AEW43174.1    BAJ08158.1    JQ070214    AEW43130.1    ODYU01012744    SOQ59206.1    RSAL01000210    RVE44215.1    RVE44216.1    BABH01011785    BABH01011786    BABH01011787    KPJ13897.1    KU680296    ANI22002.1    GEYN01000085    JAV02044.1    AK404892    BAM20357.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000007151    UP000283053    UP000053268    + More

PRIDE

G9LPV2    G9LPV3    G9LPV4    H9J2T0    H9IVQ7    H9J2U8    + More
G9LPU4    Q8WPG4    G9LPU0    G9LPU3    D6RUU7    D6RUU6    G9LPU8    G9LPU6    D6RUV0    G9LPU7    D6RUV1    H9JL88   

Pfam

PF00201   UDPGT

Interpro

IPR035595   UDP_glycos_trans_CS        + More
IPR002213   UDP_glucos_trans       

ProteinModelPortal

G9LPV2   G9LPV3   G9LPV4   H9J2T0   H9IVQ7   H9J2U8   + More
G9LPR1   A0A2W1BAL9   A0A024AGL8   A0A2A4JV21   A0A2W1BD64   A0A0N0PBY8   A0A2A4JD43   A0A140EA38   A0A1L8D6F2   G9LPQ8   A0A2H1VNG6   A0A286MXP3   A0A2H4WB50   G9LPR0   A0A2W1BBU4   A0A140EA39   A0A212EW66   A0A2A4JUA9   A0A2A4JVG7   G9LPQ9   A0A2W1BEH1   A0A2H4WB58   A0A2H4WB67   A0A2A4J0B4   A0A191T1M8   A0A191T1M6   A0A2A4J6T0   G9LPQ4   A0A3S2NJP8   A0A2W1BQJ6   A0A194RDA8   A0A194Q0G5   A0A2H4WB53   G9LPQ6   A0A2H1VVH6   A0A140EA37   G9LPU4   A0A191T2G6   Q8WPG4   A0A024AGG4   G9LPU0   A0A024AG04   G9LPQ3   G9LPQ0   G9LPU3   A0A2H1WNF9   A0A191T2K0   D6RUU7   A0A1L8D6H0   A0A024AH17   A0A2W1BXG7   A0A191T2K2   A0A2W1BQJ5   A0A2A4J325   A0A191T2J8   A0A1L8D6E4   D6RUU6   G9LPQ5   A0A2W1BVZ0   G9LPU8   A0A2A4K2B6   A0A2H1V1W5   G9LPU6   A0A2A4J419   A0A2W1BX32   A0A140EA36   A0A212FKT5   A0A212FD09   D6RUV0   A0A024AHN0   G9LPU7   A0A2H4WB78   G9LPQ1   A0A194RKA9   A0A191T1P1   A0A2W1BQS6   I4DN89   A0A194RKU4   A0A0N1IN21   A0A2A4K0I8   D6RUV1   G9LPQ7   A0A2H1X1Y8   A0A3S2LTQ3   A0A3S2LD93   H9JL88   A0A194R8C7   A0A191T1N5   A0A1L8D6R9   I4DR17  

PDB

2O6L     E-value=4.95824e-25,     Score=285

KEGG

100862843    K00699 glucuronosyltransferase [EC:2.4.1.17] | (RefSeq) UGT41A1; UDP-glycosyltransferase UGT41A1

PATHWAY

00040    Pentose and glucuronate interconversions - Bombyx mori (domestic silkworm)
00053    Ascorbate and aldarate metabolism - Bombyx mori (domestic silkworm)
00830    Retinol metabolism - Bombyx mori (domestic silkworm)
00860    Porphyrin and chlorophyll metabolism - Bombyx mori (domestic silkworm)
00980    Metabolism of xenobiotics by cytochrome P450 - Bombyx mori (domestic silkworm)
00982    Drug metabolism - cytochrome P450 - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0015020   GO:0016021   GO:0016758   GO:0016740   GO:0008152   GO:0050482   GO:0009451   GO:0009982   GO:0006355   GO:0003824   GO:0016491   GO:0015930  

Subcellular location

Membrane  

SignalP

Position:   1 - 19,         Likelihood:  0.997984

 

 

Length:

518

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

28.5335

Exp number, first 60 AAs:

6.53421999999999

Total prob of N-in:

0.29319

outside

1  -  469

TMhelix

470  -  492

inside

493  -  518

 

 

Pi

208.642853

Theta

170.601519

Tajima's D

0.512248

CLR

1.432403

CSRT

0.517774111294435

Interpretation

Uncertain