Gene

KWMTBOMO14752  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003833

Annotation

PREDICTED:_H/ACA_ribonucleoprotein_complex_subunit_4_[Amyelois_transitella]

Location

Bomo_Chr24(+):14238897-14240401      View in EpiBrowser

Full name

H/ACA ribonucleoprotein complex subunit 4      

Alternative Name

Nucleolar protein AT band 60B
Protein minifly

Location in the cell

Mitochondrial   Reliability : 1.636 Nuclear   Reliability : 1.86

CDS

ATGACGGAGGTACTGCAGCCCGGTAACGAGACACTTTCTGAGAAGAAAAAGAAAAAAAACAAGGATGGTGTTTCGTTGGGAGCTTTTCAGACGATTGGCGACTTCAAAATCGAACCTTCGGAGAGCGTGAAGAAGCTGGACACCGCTTACTGGCCTTTATTGTTGAAAAACTTCGATCGCTTAAATGTGCGCACTAACCATTACACGCCGCTACCATTCGGCAACTCGCCTTTAAAACGCCCCATCTCTGATTACGTCAAATCTGGCTTCATCAACGTCGACAAACCGAGCAACCCCAGCTCCCACGAAGTAGTTTCATGGATAAAACGTATTTTAAAAGTCGAAAAGACTGGTCATTCGGGCACGCTCGATCCGAAAGTTACGGGTTGCCTTATCGTTTGCATAGACCGCGCCACGAGACTCGTCAAATCACAACAGAACGCCGGCAAAGAGTACGTAGCCGTTTTCAACTTGCATTCAGCCGTAGAGAATATTCAAAAAGTCACACAGGGCTTGGAGAAGCTGCGTGGAGCTCTATTCCAGAGGCCCCCGCTTATATCGGCCGTGAAGCGACAACTTCGTGTCAGGACGGTGTACGACAGTAAACTCCTGGATTTCGACCAGGACAAGAATATTGGGGTGTTCTGGGTTAGTTGCGAGGCTGGATCGTATATCCGGACGATGTGTGTGCATTTAGGTCTGATGCTTGGCGTGGGAGGTCAGATGATCGAACTCAGACGAGTACGGTCCGGCATTCAGGGCGAGAAGGAAGGCATGGTCACGATGCACGACATCCTAGACGCACAATGGTCATATGAAAACCACAAAGACGAGACTTACCTTCGTCGAGTAATCAAACCTCTGGAAGGCCTCCTGATTGCTCACAAAAGGATATTTATCAAAGATAGCGCCGTTAATGCTGTTTGCTACGGTGCTAAAGTGCTGTTACCAGGTATTTTAAGATACGAAGACGGCATCGAAGTTGACCAAGAAATCGTAATAGTCACCACTAAAGGTGAGGCAGTAGCGTTGGCCGTTGCTCTGATGACCACGTCTACGATGGCCTCATGCGATCATGGTGTAGCCGCGAAACTGAAGCGTGTCATAATGGAACGAGACACGTACCCCAGAAAATGGGGTCTCGGACCGAAAGCTTCACAGAAAAAAATCCTCATACAACAAGGGAAACTTGACAAATATGGCAAACCAAATGAGAACACACCAAAAGAATGGTTAAACAGTTACGTCAACTATAATGTTAAGAAAGAACCGGAGAACGGTGACGGTGTCGAGGAAGGCAGCAGAAAGCGAACGGCAAGCACAGCTAACGCGGAAGATCCCGATGTCTCCATAGAGGTGAAGCAGGAAAAGAAGAAGAAGAAGAAAAAGAGAGATAGTGAAGCCCCGTAA

Protein

MTEVLQPGNETLSEKKKKKNKDGVSLGAFQTIGDFKIEPSESVKKLDTAYWPLLLKNFDRLNVRTNHYTPLPFGNSPLKRPISDYVKSGFINVDKPSNPSSHEVVSWIKRILKVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQNAGKEYVAVFNLHSAVENIQKVTQGLEKLRGALFQRPPLISAVKRQLRVRTVYDSKLLDFDQDKNIGVFWVSCEAGSYIRTMCVHLGLMLGVGGQMIELRRVRSGIQGEKEGMVTMHDILDAQWSYENHKDETYLRRVIKPLEGLLIAHKRIFIKDSAVNAVCYGAKVLLPGILRYEDGIEVDQEIVIVTTKGEAVALAVALMTTSTMASCDHGVAAKLKRVIMERDTYPRKWGLGPKASQKKILIQQGKLDKYGKPNENTPKEWLNSYVNYNVKKEPENGDGVEEGSRKRTASTANAEDPDVSIEVKQEKKKKKKKRDSEAP

Description

Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. Required for maintenance of the germline stem cell lineage during spermatogenesis.

Catalytic Activity

a uridine in RNA = a psi-uridine in RNA

Subunit

Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs).

Similarity

Belongs to the pseudouridine synthase TruB family.
Belongs to the type-B carboxylesterase/lipase family.

Keywords

Alternative splicing   Complete proteome   Isomerase   Nucleus   Phosphoprotein   Reference proteome   Ribonucleoprotein   Ribosome biogenesis   RNA-binding   rRNA processing  

Feature

chain  H/ACA ribonucleoprotein complex subunit 4
splice variant  In isoform C.

Uniprot

H9J2U6   A0A212EMT1   A0A0N1PGC5   A0A0L7LV79   A0A2H1VJ55   A0A2A4K2B0   + More
A0A194Q729   A0A2W1BIJ1   A0A182J790   U5EZN4   A0A182MIS3   A0A182R2S0   A0A182WAR9   A0A182SM12   A0A084WIA0   A0A182WZW6   A0A182QMF4   A0A182VIW2   A0A182JVE8   Q7PMU4   A0A182P609   A0A182NNA7   B0W1L7   B0WI05   A0A1S4F520   W8CCM1   Q0IG45   A0A2M4A8W0   A0A182FTX0   A0A2M4A8U3   A0A2M4A8S4   A0A2M3Z206   A0A2M4BK78   A0A2M4BK29   A0A2M4BKR6   A0A2M3ZGF4   W5JHW9   A0A034VRL9   T1DQ85   A0A1Q3EWE0   A0A1Q3EWB2   A0A182GN81   A0A0A1WIC1   B4PAW0   B3NQG5   A0A023EWJ2   A0A0K8UWZ2   H5V894   B4QBJ6   C0P8M5   E1JGV6   O44081   B4I2E9   A0A1L8DSB9   A0A1W4UMH6   A0A1J1IQ89   B4J4S2   A0A3B0IYW7   A0A1I8PCY8   A0A1A9UES3   A0A1B0CIC5   A0A0L0C603   T1PDS7   A0A1A9Y4U5   D2CFW9   B3MDN0   A0A336LNS5   D3TP71   A0A1I8MBT6   A0A0Q9WPI8   B4H6A4   A0A336LIQ0   A0A1Y1LPL5   B4KM31   B4LK39   A0A0M4EVY8   A0A1A9ZQU3   B5DZ83   A0A1B0G7F7   N6T638   U4U617   E9HCX8   A0A0P4WPK2   A0A0P5PGT8   A0A0P5GBW8   A0A0P5KSS2   A0A0P5FKC1   A0A0P5ED15   A0A0P5B0W9   A0A0P5ZNN2   A0A0P4WPN5   A0A0P6I206   A0A0P5FML6   A0A0P5FTI3   A0A0P6FCW9   A0A0P5K1J9   A0A0P5W8B6   A0A0P4ZXP1   A0A0P5A4Y4   A0A0P5MHG3  

EC Number

5.4.99.-

Pubmed

19121390    22118469    26354079    26227816    28756777    24438588    + More
12364791    14747013    17210077    24495485    17510324    20920257    23761445    25348373    26483478    25830018    17994087    17550304    24945155    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    9829824    10087258    17328797    12537569    12645924    18327897    26108605    18362917    19820115    20353571    25315136    28004739    15632085    23537049    21292972   

EMBL

BABH01036910    AGBW02013797    OWR42805.1    KQ460735    KPJ12619.1    JTDY01000027    + More
KOB79335.1    ODYU01002860    SOQ40865.1    NWSH01000242    PCG78068.1    KQ459580    KPI99200.1    KZ150307    PZC71493.1    GANO01000464    JAB59407.1    AXCM01000074    ATLV01023923    KE525347    KFB49944.1    AXCN02001904    AAAB01008968    EAA13199.5    DS231822    EDS25815.1    DS231941    EDS28087.1    GAMC01003457    GAMC01003456    JAC03100.1    CH477274    EAT45166.1    GGFK01003888    MBW37209.1    GGFK01003868    MBW37189.1    GGFK01003883    MBW37204.1    GGFM01001799    MBW22550.1    GGFJ01004242    MBW53383.1    GGFJ01004241    MBW53382.1    GGFJ01004247    MBW53388.1    GGFM01006820    MBW27571.1    ADMH02001457    ETN62500.1    GAKP01012995    GAKP01012991    JAC45961.1    GAMD01001305    JAB00286.1    GFDL01015459    JAV19586.1    GFDL01015455    JAV19590.1    JXUM01014594    JXUM01014595    KQ560407    KXJ82572.1    GBXI01015886    JAC98405.1    CM000158    EDW92500.1    CH954179    EDV56968.1    GAPW01000719    JAC12879.1    GDHF01021454    JAI30860.1    BT133195    AFA28436.1    CM000362    CM002911    EDX08514.1    KMY96287.1    BT064644    ACN29341.1    AE013599    ACZ94558.1    ACZ94561.1    AF017230    AF089837    AF097634    DQ841550    DQ857345    DQ857346    AY089408    BT030987    CH480820    EDW53944.1    GFDF01004869    JAV09215.1    CVRI01000057    CRL02405.1    CH916367    EDW00618.1    OUUW01000001    SPP73404.1    AJWK01013184    AJWK01013185    JRES01000857    KNC27710.1    KA646849    AFP61478.1    DS497670    EFA13038.1    CH902619    EDV37493.1    UFQT01000092    SSX19580.1    EZ423223    ADD19499.1    CH963850    KRF98116.1    CH479213    EDW33328.1    UFQS01002236    UFQT01002236    SSX13562.1    SSX32989.1    GEZM01050460    JAV75583.1    CH933808    EDW10820.1    CH940648    EDW60628.1    CP012524    ALC41870.1    CM000071    EDY69554.2    CCAG010019065    APGK01050961    APGK01050962    KB741180    ENN73118.1    KB631687    ERL85380.1    GL732621    EFX70431.1    GDIP01253467    JAI69934.1    GDIQ01128641    JAL23085.1    GDIQ01250590    JAK01135.1    GDIQ01181258    JAK70467.1    GDIQ01253294    JAJ98430.1    GDIP01144646    JAJ78756.1    GDIP01191595    JAJ31807.1    GDIP01041404    JAM62311.1    GDIP01253421    JAI69980.1    GDIQ01018381    JAN76356.1    GDIQ01253295    JAJ98429.1    GDIQ01250591    JAK01134.1    GDIQ01050666    JAN44071.1    GDIQ01196047    JAK55678.1    GDIP01089809    JAM13906.1    GDIP01210975    JAJ12427.1    GDIP01207534    JAJ15868.1    GDIQ01159173    JAK92552.1   

Proteomes

UP000005204    UP000007151    UP000053240    UP000037510    UP000218220    UP000053268    + More
UP000075880    UP000075883    UP000075900    UP000075920    UP000075901    UP000030765    UP000076407    UP000075886    UP000075903    UP000075881    UP000007062    UP000075885    UP000075884    UP000002320    UP000008820    UP000069272    UP000000673    UP000069940    UP000249989    UP000002282    UP000008711    UP000000304    UP000000803    UP000001292    UP000192221    UP000183832    UP000001070    UP000268350    UP000095300    UP000078200    UP000092461    UP000037069    UP000092443    UP000007266    UP000007801    UP000095301    UP000007798    UP000008744    UP000009192    UP000008792    UP000092553    UP000092445    UP000001819    UP000092444    UP000019118    UP000030742    UP000000305   

PRIDE

H9J2U6    H5V894    C0P8M5    E1JGV6    O44081   

Pfam

PF08068   DKCLD        + More
PF01472   PUA
PF01509   TruB_N
PF16198   TruB_C_2
PF00135   COesterase

Interpro

IPR004521   Uncharacterised_CHP00451        + More
IPR032819   TruB_C       
IPR002501   PsdUridine_synth_N       
IPR002478   PUA       
IPR004802   tRNA_PsdUridine_synth_B_fam       
IPR015947   PUA-like_sf       
IPR020103   PsdUridine_synth_cat_dom_sf       
IPR012960   Dyskerin-like       
IPR019819   Carboxylesterase_B_CS       
IPR029058   AB_hydrolase       
IPR002018   CarbesteraseB       
IPR019826   Carboxylesterase_B_AS       

SUPFAM

SSF55120   SSF55120        + More
SSF88697   SSF88697       
SSF53474   SSF53474       

Gene 3D

3.40.50.1820    

ProteinModelPortal

H9J2U6   A0A212EMT1   A0A0N1PGC5   A0A0L7LV79   A0A2H1VJ55   A0A2A4K2B0   + More
A0A194Q729   A0A2W1BIJ1   A0A182J790   U5EZN4   A0A182MIS3   A0A182R2S0   A0A182WAR9   A0A182SM12   A0A084WIA0   A0A182WZW6   A0A182QMF4   A0A182VIW2   A0A182JVE8   Q7PMU4   A0A182P609   A0A182NNA7   B0W1L7   B0WI05   A0A1S4F520   W8CCM1   Q0IG45   A0A2M4A8W0   A0A182FTX0   A0A2M4A8U3   A0A2M4A8S4   A0A2M3Z206   A0A2M4BK78   A0A2M4BK29   A0A2M4BKR6   A0A2M3ZGF4   W5JHW9   A0A034VRL9   T1DQ85   A0A1Q3EWE0   A0A1Q3EWB2   A0A182GN81   A0A0A1WIC1   B4PAW0   B3NQG5   A0A023EWJ2   A0A0K8UWZ2   H5V894   B4QBJ6   C0P8M5   E1JGV6   O44081   B4I2E9   A0A1L8DSB9   A0A1W4UMH6   A0A1J1IQ89   B4J4S2   A0A3B0IYW7   A0A1I8PCY8   A0A1A9UES3   A0A1B0CIC5   A0A0L0C603   T1PDS7   A0A1A9Y4U5   D2CFW9   B3MDN0   A0A336LNS5   D3TP71   A0A1I8MBT6   A0A0Q9WPI8   B4H6A4   A0A336LIQ0   A0A1Y1LPL5   B4KM31   B4LK39   A0A0M4EVY8   A0A1A9ZQU3   B5DZ83   A0A1B0G7F7   N6T638   U4U617   E9HCX8   A0A0P4WPK2   A0A0P5PGT8   A0A0P5GBW8   A0A0P5KSS2   A0A0P5FKC1   A0A0P5ED15   A0A0P5B0W9   A0A0P5ZNN2   A0A0P4WPN5   A0A0P6I206   A0A0P5FML6   A0A0P5FTI3   A0A0P6FCW9   A0A0P5K1J9   A0A0P5W8B6   A0A0P4ZXP1   A0A0P5A4Y4   A0A0P5MHG3  

PDB

3UAI     E-value=2.01393e-161,     Score=1461

KEGG

101744752    K11131 H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-] | (RefSeq) H/ACA ribonucleoprotein co

PATHWAY

03008    Ribosome biogenesis in eukaryotes - Bombyx mori (domestic silkworm)

GO

GO:0003723   GO:0001522   GO:0009982   GO:0006396   GO:0000495   GO:0031118   GO:0031429   GO:1990481   GO:0031120   GO:0006364   GO:0007281   GO:0005730   GO:0106029   GO:0035220   GO:0042254   GO:0016787   GO:0009451   GO:0006355   GO:0003824   GO:0008152   GO:0016491   GO:0015930  

PANTHER

PTHR23127  

Subcellular location

  

Length:

469

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.13896

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00329

outside

1  -  469

 

 

Pi

330.514046

Theta

210.769896

Tajima's D

1.439667

CLR

0

CSRT

0.774461276936153

Interpretation

Uncertain