Gene

KWMTBOMO14750

Pre Gene Modal

BGIBMGA003821

Annotation

PREDICTED:_single-minded_homolog_1_[Bombyx_mori]

Location

Bomo_Chr24(-):14152404-14164201      View in EpiBrowser

Full name

Protein single-minded      

Transcription factor

bHLH

Location in the cell

Mitochondrial   Reliability : 2.361

CDS

ATGGCCGACGCAGGCCGCAAGGAGCTGCGGCAGCTGTCGCAGGTCGCGGCAAACATCATGAAGGAGAAAAGCAAAAACGCGGCACGATCCAGGAGGGAAAAAGAGAACACAGAATTCTTGGAGCTGGCGAAGCTGCTGCCTCTGCCTTCTGCGATCACCTCGCAGCTGGACAAGGCCTCCGTTATAAGACTAACGACCAGCTACCTGAAGATGCGCCAGGTTTTTCCTGATGGCTTGGGGGACGCGTGGGGAGCGGCGCCACCACCACCGCAACCCCGCGAATTGTCGATACGAGAGCTCGGGTCGCATTTGCTCCAAACTTTGGACGGTTTTATATTCGTAGTGGCTCCCGATGGCAAAATTATGTACATCAGCGAAACTGCGTCAGTACATCTTGGCTTGAGTCAGGTGGAACTGACCGGCAACTCTATATACGAGTACATCCACCAAGCAGACCACGAGGAGATGAATGCAGTACTGAGTCTCCACCACCCTCATTCATACCACGGCCACCAGTATCCTTCAGTTGGGTATCCGGTGGGAGGGACATGGGGTCCGACAGTCGATGCGGAGTGTGAAAGAGCGTTCTTCATCAGAATGAAATGTGTGCTGGCGAAGAGGAACGCCGGCTTAACCACCTCAGGATACAAGGTGATCCACTGCTCCGGCTACCTAAGAGTTCGGCGGTTTGGTGAGGGCTCCGCCCCCCTCGGGCTGGTCGCGGTGGGTCACTCCCTCCCGCCCTCCGCCGTCACAGAACTCAAGCTGCACTCCAACATGTTCATGTTCCGAGCGTCGTTGGACATGCGGCTGATCTTCCTGGATGCAAGACTTCGTAGTGCCTCAATCGATAAATAA

Protein

MADAGRKELRQLSQVAANIMKEKSKNAARSRREKENTEFLELAKLLPLPSAITSQLDKASVIRLTTSYLKMRQVFPDGLGDAWGAAPPPPQPRELSIRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHQADHEEMNAVLSLHHPHSYHGHQYPSVGYPVGGTWGPTVDAECERAFFIRMKCVLAKRNAGLTTSGYKVIHCSGYLRVRRFGEGSAPLGLVAVGHSLPPSAVTELKLHSNMFMFRASLDMRLIFLDARLRSASIDK

Description

Transcription factor that functions as a master developmental regulator controlling midline development of the ventral nerve cord. Required to correctly specify the formation of the central brain complex, which controls walking behavior. Also required for correct patterning of the embryonic genital disk and anal pad anlage. Plays a role in synapse development.

Subunit

Efficient DNA binding requires dimerization with another bHLH protein.

Miscellaneous

Mutations result in the loss of the precursor cells that give rise to midline cells of the embryonic central nervous system.

Keywords

Alternative splicing   Complete proteome   Developmental protein   Differentiation   DNA-binding   Neurogenesis   Nucleus   Polymorphism   Reference proteome   Repeat   Transcription   Transcription regulation  

Feature

chain  Protein single-minded
splice variant  In isoform B.

Uniprot

A0A194Q1J7   A0A3S2NEK8   A0A2H1VVZ3   A0A2A4K220   A0A212F8X1   A0A0N1IFA4   + More
H9J2T4   A0A2J7QQL4   A0A2J7QQN0   A0A067QLY0   A0A2P8ZFK6   A0A1Y1JWW2   A0A2R7WII5   A0A023F2C6   A0A0F7II89   A0A146MAW1   A0A146KRX5   A0A0P5V8R1   A0A1B6K0I5   A0A1B6IIL4   T1HC33   A0A1B6LAG7   A0A0P6BZK7   A0A0P6CLA7   A0A0B6VJJ6   E9FY44   T1IKN0   E0VC62   A0A3L8SZW5   A0A226PUL3   Q25C45   A0A2U3X830   A0A3L7I4L7   A0A1B6CUM8   V3ZDU5   L5JM98   A0A1B6CA85   A0A060XJA4   H3B852   B4NG65   B4G5M2   A0A0M5J5E5   B5DXT9   A0A1S3JVS7   A0A3Q7XWA1   C3XTH0   B3LX41   A0A3B0KMU7   A0A067Y793   A0A0L0C053   B4M6L5   A0A0B4KH05   A0A1S3JVT4   P05709-2   P05709   A0A3B0KRN7   A0A3B0KVA8   B3P185   A0A1S3JV10   A0A0B4KFY1   B4R1W3   A0A1A9V500   A0A1A9W571   B4K8H0   B4JEV3   Q1PHQ4   Q5R8E1   A0A2C9KA40   A0A1W4UKT6   A0A1B0FK96   A0A1A9X5X0   A0A1B0AWL8   A0A0B6ZMK6   A0A3B3W0U5   A0A3B0KHJ5   B4PPW7   A0A0R1E2U3   G1KJZ0   F7GDY6   A0A1I8NLQ3   A0A0Q3MJN7   A0A2S2P376   A0A1L8G9C3   A0A3B4ZHA9   A0A0R1E2V5   A0A1B0AKC2   A0A0R1E3F6   A0A0R1E6T5   A0A338P771   A0A3B5KJW1   F6U9K2   A0A0R1E2S5   R0LKM3   A0A151NTB9   A0A3Q1F0W8   A0A1U7RM06   A0A0R1E495   A0A226E3G3   A0A091GA89   H0ZPV8  

Pubmed

26354079    22118469    19121390    24845553    29403074    28004739    + More
25474469    26823975    25447925    21292972    20566863    30282656    24621616    16720876    29704459    23254933    23258410    24755649    9215903    17994087    15632085    18563158    24959341    26108605    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    9840810    12221007    12537569    1760843    3345560    23644463    16933975    15562597    17550304    18464734    27762356    19468303    21551351    20431018    22293439    20360741   

EMBL

KQ459580    KPI99198.1    RSAL01000072    RVE49077.1    ODYU01004781    SOQ45021.1    + More
NWSH01000242    PCG78066.1    AGBW02009662    OWR50177.1    KQ460735    KPJ12617.1    BABH01036902    BABH01036903    BABH01036904    NEVH01012087    PNF30878.1    PNF30877.1    KK853270    KDR09145.1    PYGN01000072    PSN55283.1    GEZM01098957    JAV53613.1    KK854838    PTY19151.1    GBBI01002945    JAC15767.1    KP147936    AKG92773.1    GDHC01002447    JAQ16182.1    GDHC01020642    JAP97986.1    GDIP01105491    JAL98223.1    GECU01002752    JAT04955.1    GECU01020951    JAS86755.1    ACPB03006262    GEBQ01019265    JAT20712.1    GDIP01181764    GDIP01007128    JAM96587.1    GDIQ01090729    JAN04008.1    AB981593    BAQ21977.1    GL732527    EFX87839.1    JH430577    DS235047    EEB10968.1    QUSF01000002    RLW12415.1    AWGT02000016    OXB83170.1    AB236150    BAE87099.1    RAZU01000101    RLQ72890.1    GEDC01020263    JAS17035.1    KB202619    ESO89288.1    KB031158    ELK00052.1    GEDC01026937    JAS10361.1    FR905472    CDQ79551.1    AFYH01063801    AFYH01063802    CH964251    EDW83282.2    CH479179    EDW24888.1    CP012526    ALC47531.1    CM000070    EDY67905.2    GG666463    EEN68596.1    CH902617    EDV41641.2    OUUW01000013    SPP87909.1    KC305631    AGX25236.1    JRES01001168    KNC24839.1    CH940652    EDW59291.2    AE014297    AGB95909.1    AF071934    AY129457    M19020    SPP87911.1    SPP87908.1    CH954181    EDV49274.1    AGB95910.1    CM000364    EDX13115.1    CH933806    EDW14369.2    CH916369    EDV93234.1    DQ431043    ABD97275.1    CR859812    CAH91969.1    CCAG010014365    JXJN01004815    HACG01022898    CEK69763.1    SPP87910.1    CM000160    EDW97194.1    KRK03579.1    LMAW01001780    KQK82664.1    GGMR01011183    MBY23802.1    CM004474    OCT80433.1    KRK03580.1    KRK03581.1    KRK03583.1    KRK03585.1    AC165961    CU207273    AAMC01009000    AAMC01009001    KRK03584.1    KB742627    EOB06249.1    AKHW03002098    KYO40028.1    KRK03582.1    LNIX01000008    OXA51036.1    KL447928    KFO78838.1    ABQF01000555   

Proteomes

UP000053268    UP000283053    UP000218220    UP000007151    UP000053240    UP000005204    + More
UP000235965    UP000027135    UP000245037    UP000015103    UP000000305    UP000009046    UP000276834    UP000198419    UP000245341    UP000273346    UP000030746    UP000010552    UP000193380    UP000008672    UP000007798    UP000008744    UP000092553    UP000001819    UP000085678    UP000286642    UP000001554    UP000007801    UP000268350    UP000037069    UP000008792    UP000000803    UP000008711    UP000000304    UP000078200    UP000091820    UP000009192    UP000001070    UP000076420    UP000192221    UP000092444    UP000092443    UP000092460    UP000261500    UP000002282    UP000001646    UP000002279    UP000095300    UP000051836    UP000186698    UP000261400    UP000092445    UP000000589    UP000005226    UP000008143    UP000050525    UP000257200    UP000189705    UP000198287    UP000053760    UP000007754   

PRIDE

H9J2T4    P05709   

Pfam

PF00989   PAS        + More
PF00010   HLH
PF08447   PAS_3
PF06621   SIM_C

Interpro

IPR001067   Nuc_translocat        + More
IPR000014   PAS       
IPR011598   bHLH_dom       
IPR013767   PAS_fold       
IPR036638   HLH_DNA-bd_sf       
IPR035965   PAS-like_dom_sf       
IPR001610   PAC       
IPR013655   PAS_fold_3       
IPR010578   SIM_C       

SUPFAM

SSF55785   SSF55785        + More
SSF47459   SSF47459       

Gene 3D

4.10.280.10    

CDD

cd00130  PAS
cd00083  HLH

ProteinModelPortal

A0A194Q1J7   A0A3S2NEK8   A0A2H1VVZ3   A0A2A4K220   A0A212F8X1   A0A0N1IFA4   + More
H9J2T4   A0A2J7QQL4   A0A2J7QQN0   A0A067QLY0   A0A2P8ZFK6   A0A1Y1JWW2   A0A2R7WII5   A0A023F2C6   A0A0F7II89   A0A146MAW1   A0A146KRX5   A0A0P5V8R1   A0A1B6K0I5   A0A1B6IIL4   T1HC33   A0A1B6LAG7   A0A0P6BZK7   A0A0P6CLA7   A0A0B6VJJ6   E9FY44   T1IKN0   E0VC62   A0A3L8SZW5   A0A226PUL3   Q25C45   A0A2U3X830   A0A3L7I4L7   A0A1B6CUM8   V3ZDU5   L5JM98   A0A1B6CA85   A0A060XJA4   H3B852   B4NG65   B4G5M2   A0A0M5J5E5   B5DXT9   A0A1S3JVS7   A0A3Q7XWA1   C3XTH0   B3LX41   A0A3B0KMU7   A0A067Y793   A0A0L0C053   B4M6L5   A0A0B4KH05   A0A1S3JVT4   P05709-2   P05709   A0A3B0KRN7   A0A3B0KVA8   B3P185   A0A1S3JV10   A0A0B4KFY1   B4R1W3   A0A1A9V500   A0A1A9W571   B4K8H0   B4JEV3   Q1PHQ4   Q5R8E1   A0A2C9KA40   A0A1W4UKT6   A0A1B0FK96   A0A1A9X5X0   A0A1B0AWL8   A0A0B6ZMK6   A0A3B3W0U5   A0A3B0KHJ5   B4PPW7   A0A0R1E2U3   G1KJZ0   F7GDY6   A0A1I8NLQ3   A0A0Q3MJN7   A0A2S2P376   A0A1L8G9C3   A0A3B4ZHA9   A0A0R1E2V5   A0A1B0AKC2   A0A0R1E3F6   A0A0R1E6T5   A0A338P771   A0A3B5KJW1   F6U9K2   A0A0R1E2S5   R0LKM3   A0A151NTB9   A0A3Q1F0W8   A0A1U7RM06   A0A0R1E495   A0A226E3G3   A0A091GA89   H0ZPV8  

PDB

5SY7     E-value=6.02641e-59,     Score=575

KEGG

101735872    K09100 single-minded | (RefSeq) single-minded homolog 1

GO

GO:0005667   GO:0005737   GO:0003700   GO:0005634   GO:0046983   GO:0003677   GO:0006355   GO:0006357   GO:0000981   GO:0016021   GO:0035225   GO:0045944   GO:0046982   GO:0007419   GO:0007411   GO:0040011   GO:0007409   GO:0007418   GO:0000978   GO:0043565   GO:0007398   GO:0007420   GO:0007628   GO:0001657   GO:0003824   GO:0008152   GO:0016491   GO:0015930  

Subcellular location

Nucleus  

Length:

285

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.06044

Exp number, first 60 AAs:

0.00126

Total prob of N-in:

0.07814

outside

1  -  285

 

 

Pi

212.300422

Theta

149.168889

Tajima's D

1.60155

CLR

0.083394

CSRT

0.813359332033398

Interpretation

Uncertain