Gene

KWMTBOMO14680  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009613

Annotation

PREDICTED:_probable_proline--tRNA_ligase?_mitochondrial_[Bombyx_mori]

Location

Bomo_Chr24(+):12589117-12597547      View in EpiBrowser

Full name

Probable proline--tRNA ligase, mitochondrial      

Alternative Name

Prolyl-tRNA synthetase

Location in the cell

Cytoplasmic   Reliability : 1.761

CDS

ATGGGCGGAAGCTTCTCGCACGAGTGGCAGCTCGCGGCGACCTCGGGCGAAGACCAGATAAAAGTCTGCCCGTCCTGCTCGCACGCGGCGCTCTTGAACGATGAGGGAACGAGATGCCAGAGCTGTGGGAAAGACGCGGAAATCTTGCAAAGTATAGAGGTTGGCCACACGTTCATCCTGGGCACGAAGTACAGTGAGGCTCTGGAGGCGACGTACTGCCCCCCCTCGGGGCCCCCCCTGCCCATCATCATGTCGTGTTACGGCATCGGCATCACAAGGTTATTGGCGGCGAGCTTAGAAGCTTTATCAACCGAGAAAGCTCTGCGTTGGCCGAAAGCTATAGCCCCGTACTCGGCAATCATCATTGGGCCCAAGGAAGGCTCCAAAGAATGGAATGATCACGGCATGGACCAGGTTAAGTTGGTCTACGATGCTTTGAATAGTGTACCGGCTCTGAGGTCCGATGTGCTGGTCGACGACCGCCACGGCCTCACCATCGGAAAGAGACTGCTCATGGCTGATAAAATGGGATATCCGATAGTAATAGCGTGCGGTAAAGAATCAAGCAGTAATCCCCCGAGATACGAAGTGACCATCGACGGCGCCACGCAGCTGTGCACTGCACAGGAGCTGGTGCAGATCCTGTCTGATAAATATGCGCACTTGGAATATTGTACATAA

Protein

MGGSFSHEWQLAATSGEDQIKVCPSCSHAALLNDEGTRCQSCGKDAEILQSIEVGHTFILGTKYSEALEATYCPPSGPPLPIIMSCYGIGITRLLAASLEALSTEKALRWPKAIAPYSAIIIGPKEGSKEWNDHGMDQVKLVYDALNSVPALRSDVLVDDRHGLTIGKRLLMADKMGYPIVIACGKESSSNPPRYEVTIDGATQLCTAQELVQILSDKYAHLEYCT

Catalytic Activity

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)

Similarity

Belongs to the class-II aminoacyl-tRNA synthetase family.

Keywords

Aminoacyl-tRNA synthetase   ATP-binding   Complete proteome   Ligase   Mitochondrion   Nucleotide-binding   Protein biosynthesis   Reference proteome   Transit peptide   Polymorphism  

Feature

chain  Probable proline--tRNA ligase, mitochondrial
sequence variant  In dbSNP:rs11577368.

Uniprot

H9JJB2   A0A3S2NS35   A0A2H1WFD1   A0A212EIR1   A0A194Q9P0   A0A194QUG2   + More
A0A1B0DGL6   A0A091G277   A0A093GEI3   A0A093QD60   A0A1L8DHL5   A0A1L8DHM3   A0A091J295   A0A2R7WAR1   A0A091MLW6   A0A1V4JXU3   A0A091UTM1   A0A1B0C8D2   A0A1V4JXU8   A0A093I1D1   A0A2I0MBX6   A0A1W4WLN3   V9KV88   A0A0A0AHJ2   V9KV10   A0A3M0K6C8   A0A0N7Z978   A0A087RHU8   A0A1B6C380   A0A1S3FPD2   A0A0Q3UQY0   A0A034VE38   A0A2P4SGW7   S9X8D1   A0A034VBT6   M7B8X5   G1NFW8   A0A383YP11   U3KCB6   A0A3L8SQE4   A0A218UXP9   A0A2I0T4F4   Q3U4M2   A0A226M805   A0A2Y9FCM8   A0A383YNM3   D6WC57   A0A0K8UCF6   A0A3Q7SLJ5   H3A726   A0A3Q7VY19   A0A1B6C484   A0A1I8MRT3   A0A1D1V1T1   A0A226PPV4   A0A2D4FWL5   S4RXW2   A0A091EL36   A0A2D4N9N8   V8NQG1   A0A091I9N8   S7NE33   Q8CFI5   A0A2D4JLI6   E1BZP0   M3WXQ3   A8Y5T6   A0A340YBY3   A0A1Y1LL22   A0A182M4Y8   D2H2H1   L5LKI0   A0A182U533   A0A2F0BI34   H0ZGQ9   G1Q3P4   L5K3A0   A0A0A1XAV5   A0A3Q3EQ91   F7A6N2   T1IBH4   U6D6E1   G1QRW1   A0A0A9YV78   A0A2Y9N9J4   G3QRP9   V4A4J6   H2PZ38   Q7L3T8   A0A0P4W8D1   A0A1U7QEJ3   A0A341AZN3   A0A2R8Z6L0   F1S781   A0A1S3R5K4   A0A182V1E4   A0A1S2ZEB9   A0A2C9H8K8   A0A2Y9GLF7   A0A2U4BXP3  

EC Number

6.1.1.15

Pubmed

19121390    22118469    26354079    23371554    24402279    27129103    + More
25348373    23149746    23624526    20838655    30282656    10349636    11042159    11076861    11217851    12466851    16141073    18362917    19820115    9215903    25315136    27649274    24621616    24297900    19468303    15489334    21183079    15592404    17975172    28004739    20010809    20360741    21993624    23258410    25830018    17495919    25401762    26823975    22398555    23254933    16136131    14702039    16710414    17974005    24275569    22722832   

EMBL

BABH01036404    BABH01036405    RSAL01000277    RVE43088.1    ODYU01008302    SOQ51773.1    + More
AGBW02014604    OWR41350.1    KQ459249    KPJ02223.1    KQ461108    KPJ08964.1    AJVK01060067    KL447657    KFO76008.1    KL216271    KFV68645.1    KL671386    KFW82047.1    GFDF01008125    JAV05959.1    GFDF01008126    JAV05958.1    KK501293    KFP13825.1    KK854531    PTY16629.1    KK829937    KFP75747.1    LSYS01005497    OPJ77040.1    KL410116    KFQ94061.1    AJWK01000428    OPJ77039.1    KL206787    KFV85630.1    AKCR02000021    PKK27181.1    JW869664    AFP02182.1    KL871737    KGL92913.1    JW869816    AFP02334.1    QRBI01000117    RMC08719.1    GDKW01001307    JAI55288.1    KL226373    KFM13052.1    GEDC01029332    GEDC01021029    JAS07966.1    JAS16269.1    LMAW01002834    KQK76602.1    GAKP01018208    JAC40744.1    PPHD01049625    POI23364.1    KB016750    EPY84593.1    GAKP01018211    GAKP01018206    GAKP01018203    JAC40741.1    KB535465    EMP33599.1    AGTO01000977    QUSF01000010    RLW05691.1    MUZQ01000109    OWK58082.1    KZ519645    PKU28670.1    AK154150    BAE32409.1    MCFN01015524    OXB51380.1    KQ971316    EEZ98764.2    GDHF01027990    GDHF01019235    GDHF01005964    JAI24324.1    JAI33079.1    JAI46350.1    AFYH01161970    GEDC01028995    JAS08303.1    BDGG01000003    GAU94800.1    AWGT02000029    OXB82115.1    IACJ01093488    LAA51848.1    KK718817    KFO58633.1    IACM01154129    LAB42394.1    AZIM01002357    ETE64201.1    KL217543    KFO96460.1    KE164147    EPQ15421.1    AL929585    BC027073    BC038817    IACK01215540    LAA97274.1    AADN05000647    AANG04003279    GEZM01057514    GEZM01057513    JAV72286.1    AXCM01001019    ACTA01042127    GL192442    EFB29169.1    KB110890    ELK26757.1    NTJE010214322    MBW02663.1    ABQF01030873    AAPE02039894    KB031032    ELK06189.1    GBXI01006442    JAD07850.1    ACPB03000224    HAAF01006357    CCP78181.1    ADFV01074719    GBHO01008601    GBHO01002625    GBRD01009873    GDHC01014726    GDHC01002541    JAG35003.1    JAG40979.1    JAG55951.1    JAQ03903.1    JAQ16088.1    CABD030003367    KB202752    ESO88186.1    AACZ04058269    AK025585    AK289679    AL139244    CH471059    BC007956    BC011758    AL117473    GDRN01082238    JAI61873.1    AJFE02049418    AEMK02000048   

Proteomes

UP000005204    UP000283053    UP000007151    UP000053268    UP000053240    UP000092462    + More
UP000053760    UP000053875    UP000053258    UP000053119    UP000190648    UP000053283    UP000092461    UP000053584    UP000053872    UP000192223    UP000053858    UP000269221    UP000053286    UP000081671    UP000051836    UP000031443    UP000001645    UP000261681    UP000016665    UP000276834    UP000197619    UP000198323    UP000248484    UP000007266    UP000286640    UP000008672    UP000286642    UP000095301    UP000186922    UP000198419    UP000245300    UP000052976    UP000054308    UP000000589    UP000000539    UP000011712    UP000265300    UP000075883    UP000008912    UP000075902    UP000007754    UP000001074    UP000010552    UP000261660    UP000002280    UP000015103    UP000001073    UP000248483    UP000001519    UP000030746    UP000002277    UP000005640    UP000189706    UP000252040    UP000240080    UP000008227    UP000087266    UP000075903    UP000079721    UP000076407    UP000248481    UP000245320   

PRIDE

H9JJB2    Q3U4M2    Q8CFI5    A8Y5T6    Q7L3T8    F1S781    + More

Pfam

PF00587   tRNA-synt_2b        + More
PF03129   HGTP_anticodon

Interpro

IPR036621   Anticodon-bd_dom_sf        + More
IPR002314   aa-tRNA-synt_IIb       
IPR004154   Anticodon-bd       
IPR006195   aa-tRNA-synth_II       
IPR033730   ProRS_core_prok       
IPR002316   Pro-tRNA-ligase_IIa       
IPR002315   tRNA-synt_gly       
IPR019734   TPR_repeat       
IPR011990   TPR-like_helical_dom_sf       
IPR013026   TPR-contain_dom       

SUPFAM

SSF48452   SSF48452       

Gene 3D

3.40.50.800     1.25.40.10    

CDD

cd00779  ProRS_core_prok

ProteinModelPortal

H9JJB2   A0A3S2NS35   A0A2H1WFD1   A0A212EIR1   A0A194Q9P0   A0A194QUG2   + More
A0A1B0DGL6   A0A091G277   A0A093GEI3   A0A093QD60   A0A1L8DHL5   A0A1L8DHM3   A0A091J295   A0A2R7WAR1   A0A091MLW6   A0A1V4JXU3   A0A091UTM1   A0A1B0C8D2   A0A1V4JXU8   A0A093I1D1   A0A2I0MBX6   A0A1W4WLN3   V9KV88   A0A0A0AHJ2   V9KV10   A0A3M0K6C8   A0A0N7Z978   A0A087RHU8   A0A1B6C380   A0A1S3FPD2   A0A0Q3UQY0   A0A034VE38   A0A2P4SGW7   S9X8D1   A0A034VBT6   M7B8X5   G1NFW8   A0A383YP11   U3KCB6   A0A3L8SQE4   A0A218UXP9   A0A2I0T4F4   Q3U4M2   A0A226M805   A0A2Y9FCM8   A0A383YNM3   D6WC57   A0A0K8UCF6   A0A3Q7SLJ5   H3A726   A0A3Q7VY19   A0A1B6C484   A0A1I8MRT3   A0A1D1V1T1   A0A226PPV4   A0A2D4FWL5   S4RXW2   A0A091EL36   A0A2D4N9N8   V8NQG1   A0A091I9N8   S7NE33   Q8CFI5   A0A2D4JLI6   E1BZP0   M3WXQ3   A8Y5T6   A0A340YBY3   A0A1Y1LL22   A0A182M4Y8   D2H2H1   L5LKI0   A0A182U533   A0A2F0BI34   H0ZGQ9   G1Q3P4   L5K3A0   A0A0A1XAV5   A0A3Q3EQ91   F7A6N2   T1IBH4   U6D6E1   G1QRW1   A0A0A9YV78   A0A2Y9N9J4   G3QRP9   V4A4J6   H2PZ38   Q7L3T8   A0A0P4W8D1   A0A1U7QEJ3   A0A341AZN3   A0A2R8Z6L0   F1S781   A0A1S3R5K4   A0A182V1E4   A0A1S2ZEB9   A0A2C9H8K8   A0A2Y9GLF7   A0A2U4BXP3  

PDB

5ZNK     E-value=5.00655e-19,     Score=229

KEGG

101736571    K01881 prolyl-tRNA synthetase [EC:6.1.1.15] | (RefSeq) probable proline--tRNA ligase, mitochondrial

PATHWAY

00970    Aminoacyl-tRNA biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0006433   GO:0004827   GO:0005737   GO:0005524   GO:0006426   GO:0004820   GO:0004812   GO:0006418   GO:0005739   GO:0016874   GO:0005759   GO:0000166   GO:0005634   GO:0006303   GO:0003824   GO:0008152   GO:0016491   GO:0015930  

Subcellular location

Mitochondrion matrix  

Length:

226

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.32568

Exp number, first 60 AAs:

0

Total prob of N-in:

0.02454

outside

1  -  226

 

 

Pi

163.026622

Theta

121.790263

Tajima's D

1.979757

CLR

0.42537

CSRT

0.879106044697765

Interpretation

Uncertain