Gene

KWMTBOMO14678

Pre Gene Modal

BGIBMGA009611

Annotation

PREDICTED:_protein_slit_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr24(+):12555057-12574401      View in EpiBrowser

Full name

Protein slit      

Location in the cell

Extracellular   Reliability : 3.761

CDS

ATGTCGTGGCTGGCACAGTGGCTGCGATCGCGGCGTTTGTCGACGACAGCCACGTGTGGCTACCCGGCTGCGCTCAGAGACGCCAGCATCCACCACCTCGAGCCGGCTGACTTTAAATGCACCCCCGAGGACAAAGGTTGTCTGTCGCCTGAGTATTGCCCGGCTCAGTGCTCGTGCACCGGGACCGTGGTCCGGTGTTCCCGGGCGAAGCTCACCTCTCTGCCAGCCAACATCCCCAAGCAAACAACCGAGCTATACCTAGAGTCGAACGAGCTTACGTCGATCCCGCCGGATCAAATCCGCCACCTCACGCAGCTGACCCGGCTGGACCTGTCCAACAATAAGATCAGCGTTCTCGGCAACAACACCTTCGAGGGCCTCACCAAGCTGTCCACGCTCATCGTCAGCTACAACAGGCTGAGATGTGTCCAGAGGGACGCCCTGAAGGGTCTGAGTCAGCTGCGGGTGTTGTCCCTTCACGGCAACAACATATCGCTGCTCGCGGACGGCGTCTTCAGGGACCTGGAGTCCATATCGCATGTAGCGCTGGGCTCCAACCCCCTGTACTGCGACTGCCACTCCCGCTGGCTGTCAGAGTGGGTGCAGAGCGCGGGGGAGTTCGTGGAGGCCGGCATAGCGAGGTGCGCTGAGCCTCCCGCCATGAAGGACAAACTGCTTCTAAGCACTGCCTCTTCTGCTTTTGTATGCACAGGCAACCCGCCGGCGGAGATCATATCGAAATGCGACCGCTGCTACAGCAACCCCTGCCTGAACGGGGGGAAGTGCCTCCCCGGCGCCGGGGGAGGGTTCGAGTGCGTCTGCGCCCGCGGTTACCATGGCAACGCGTGTCAATTCCAAATAGACGCCTGCTACGGGTCGCCGTGCGCCAACGGACAATGCCAAGTCTTGGAAGAGGGCAGGTTCCACTGCTCCTGCCAGCCGGGCTACACGGGGCTGCGGTGCGAGGTCAACGTGGACGACTGCCTTGGGAACCGGTGCCAGAATAACGCGACCTGCGTGGACCTCCTCGAGGGGTACATCTGCAAGTGCTCTCCAGGGTTCATGGGAGAATTCTGCGAGACGAAGATACCGTTCTGCACGGCGGAGTTCAACCCGTGCGCCAACGGGGCCGCGTGCACCGACCACCGCAGCCACTACACCTGCAGCTGCCCCAAGGGCTACTCCGGACAGAACTGCACCGTCAACGCGGACGACTGCATCAACCACATGTGCCAGAACGGCGCGACGTGCGTGGACGGGCTGGAGGAGTATCGGTGCGCATGCGCGGCGGGGTACGCCGGGCGGTACTGCGAAGCGGCGCCCCACGCCGCGCTCGGCACCTCGCCCTGCGCCCACCACGACTGCCTGCATGGGGTCTGCTACCTGCCGCCACCGCGACCCTTGCAGGACGACATCATCATGGAGGAGCATCCGCTGATCTCGCAACCTAACGATTACCTCTGCAAGTGCGCTCCGGGATACTCGGGCCGGCTCTGCGAATATCTCACATCCCTGACCTTCAACCACAACGATTCCCTGGTGGAGTTGGAGCCGTTAAGGACAATGCCGCAAGCCAACGTCACGTTGGTCTTCAGCACCAAGCAGCATCACGGCGTGCTCATGTACTTCGGTGAGAACGAGCATCTGGCTGTGGAGTTGTTCAATGGGAGGATCAGAGTCAGCTACGACGTCGGCAACCATCCCACCTCTACCATGTACAGCTTTGAAATGGTGTCAGACGGAAGTTACCACAAAGCGGAGCTTTTGGCGATCAAGAAAAACTTTACCCTCAAAGTCGACGACGGACCCGCCAGATCCATCATCAACGAAGGCAGCAAGGAATTCTTGAGACTAGAGAGACCGATGTACCTCGGAGGAGTGCCGCAGGAGGTCGCCAAGGAGGCTTTCTCGAAATGGCATCTGCGGAACATAACCAGCTTTAAAGGTTGTTTGAAAGAGGCCTGGATCAACCACAAGCGAGTGGACTTCGTGAACGCTGTCCGGGTACAGCGCACAACCCCGGGATGCGGAGACGACGACGCGCCAGCCCCCTCCGTCATCAGCGGCGTCCAGGACGACACCACCCACGAGGAGGACCCGTGCGTGCCGAACCCGTGCGCGCGGGGGGGGCGGTGCGTGCAGCGGGCCCGCGGACACTACTCCTGCCGCTGCCCCCCGGGGACCGCCGGCCCCCAGTGCGAGCTCCGCGCCAGCATCCGTGGCGCCCCAGTGATAACGCAAGCCAAGCTCCCCGCCAGGAGGACCGGGTTCAGCAACGTCCAGGCTTCTCCAGCTGCACCTCCTCATAAGCAAGAGGTCCCGGCGGAGCCCTCGGCACCGAGCGCTACCCCACCGCCGTGCAAGAAGGAGCCAACCCGGGAGTTCGTGACGGAGGGCGCGTGTCGCAGCCGCCGCGCCGTACGGGGGGCGAGGTGTGTCGCCAGGACGGACCGGTGA

Protein

MSWLAQWLRSRRLSTTATCGYPAALRDASIHHLEPADFKCTPEDKGCLSPEYCPAQCSCTGTVVRCSRAKLTSLPANIPKQTTELYLESNELTSIPPDQIRHLTQLTRLDLSNNKISVLGNNTFEGLTKLSTLIVSYNRLRCVQRDALKGLSQLRVLSLHGNNISLLADGVFRDLESISHVALGSNPLYCDCHSRWLSEWVQSAGEFVEAGIARCAEPPAMKDKLLLSTASSAFVCTGNPPAEIISKCDRCYSNPCLNGGKCLPGAGGGFECVCARGYHGNACQFQIDACYGSPCANGQCQVLEEGRFHCSCQPGYTGLRCEVNVDDCLGNRCQNNATCVDLLEGYICKCSPGFMGEFCETKIPFCTAEFNPCANGAACTDHRSHYTCSCPKGYSGQNCTVNADDCINHMCQNGATCVDGLEEYRCACAAGYAGRYCEAAPHAALGTSPCAHHDCLHGVCYLPPPRPLQDDIIMEEHPLISQPNDYLCKCAPGYSGRLCEYLTSLTFNHNDSLVELEPLRTMPQANVTLVFSTKQHHGVLMYFGENEHLAVELFNGRIRVSYDVGNHPTSTMYSFEMVSDGSYHKAELLAIKKNFTLKVDDGPARSIINEGSKEFLRLERPMYLGGVPQEVAKEAFSKWHLRNITSFKGCLKEAWINHKRVDFVNAVRVQRTTPGCGDDDAPAPSVISGVQDDTTHEEDPCVPNPCARGGRCVQRARGHYSCRCPPGTAGPQCELRASIRGAPVITQAKLPARRTGFSNVQASPAAPPHKQEVPAEPSAPSATPPPCKKEPTREFVTEGACRSRRAVRGARCVARTDR

Description

A short-range repellent, controlling axon crossing of the midline and a long-range chemorepellent, controlling mesoderm migration and patterning away from the midline. May interact with extracellular matrix molecules. Repulsive ligand for the guidance receptor roundabout (robo) and prevents inappropriate midline crossing by Robo-expressing axons.

Subunit

Interacts with robo.

Keywords

3D-structure   Alternative splicing   Complete proteome   Developmental protein   Differentiation   Disulfide bond   EGF-like domain   Glycoprotein   Leucine-rich repeat   Neurogenesis   Reference proteome   Repeat   Secreted   Signal  

Feature

chain  Protein slit
splice variant  In isoform A and isoform B.

Uniprot

H9JJB0   A0A096ZEC0   A0A2A4JQN3   A0A194QFI1   A0A139WM17   A0A139WM31   + More
A0A139WMC0   A0A2P8Y8J6   A0A1B0CM21   A0A1W5LU06   A0A1J1HFQ7   A0A1B6GPI2   Q16WM1   A0A1Y1MIY6   A0A1Y1MHN4   A0A2J7QL17   B0WB86   T1ID82   A0A2J7QL39   W5JBC8   A0A182YR84   A0A1I8NNR6   A0A182XHS7   A0A182LGL3   A0A182F736   A0A0J9REU2   A0A182T8E9   A0A0B4KES0   Q7QCT2   N6WCZ8   B3NQ10   A0A195CE52   A0A182W0N9   A0A182HTL0   B4KM13   A0A182RIF3   A0A3B0IZ80   A0A1W4UZ69   B4QGZ8   A0A182V3E2   E3CTP8   B4P6U8   P24014   E1NZA8   E1NZD6   A0A0M9ACF8   B4LQ27   F0JAL2   E1NZD5   A0A182KBF6   P24014-3   P24014-2   A0A0L7R2L4   A0A088AS83   B3MC19   B4HSG3   A0A182Q2Z8   A0A182MDH5   A0A151JLV6   A0A158NCN5   A0A182N797   A0A026WGR8   A0A0L0CU11   A0A2S2R2P7   K7INA9   W8BHF3   A0A0M4EA23   A0A1B0FKZ4   W8AUW0   A0A154PLC6   B4MNM8   W8B2B3   F4W9S8   E2BPP0   A0A1A9ZRB4   A0A1A9YJM8   A0A1I8MJQ3   A0A0K8UZ73   A0A0K8TXL8   A0A0K8UWZ3   A0A182TWV5   A0A1A9WAF0   A0A034V560   A0A034V1X2   B4J4Q8   X1WIF9   A0A0A1X6C6   A0A0A1X7M8   E2B242   E0VSI9   A0A151WKI6   A0A232FEP7   B4HBE5   A0A1A9VA99   A0A182IKD9   N6TNE5   A0A1D2NK21   A0A0P5U8J6   A0A0P5WQ00   A0A0P6HUB3  

Pubmed

19121390    25285792    26354079    18362917    19820115    29403074    + More
17510324    28004739    20920257    23761445    25244985    20966253    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    12364791    15632085    17994087    17550304    2176636    10102267    3144436    10102268    15496984    21347285    24508170    26108605    20075255    24495485    21719571    20798317    25315136    25348373    25830018    20566863    28648823    23537049    27289101   

EMBL

BABH01036403    BABH01036404    KF739412    AIP87150.1    NWSH01000762    PCG74365.1    + More
KQ459249    KPJ02226.1    KQ971316    KYB28990.1    KYB28992.1    KYB28991.1    PYGN01000805    PSN40578.1    AJWK01018062    AJWK01018063    AJWK01018064    AJWK01018065    AJWK01018066    AJWK01018067    AJWK01018068    AJWK01018069    AJWK01018070    KX034172    ANO54002.1    CVRI01000002    CRK86807.1    GECZ01005434    JAS64335.1    CH477561    EAT38989.1    GEZM01034259    JAV83846.1    GEZM01034260    JAV83845.1    NEVH01013254    PNF29279.1    DS231877    EDS42151.1    ACPB03002829    PNF29278.1    ADMH02001876    ETN60703.1    CM002911    KMY94099.1    AE013599    AGB93549.1    AAAB01008859    EAA07783.5    CM000071    ENO01959.1    CH954179    EDV55857.2    KQ977876    KYM99087.1    APCN01000566    APCN01000567    CH933808    EDW10802.2    OUUW01000001    SPP73287.1    CM000362    EDX07261.1    BT125714    ADO51076.1    CM000158    EDW92025.2    X53959    AF126540    M23543    BT125657    ADN39445.1    BT125685    ADO16251.1    KQ435693    KOX81006.1    CH940648    EDW60350.2    BT126054    ADY17753.1    BT125684    ADO14992.1    KQ414666    KOC65117.1    CH902619    EDV37206.2    CH480816    EDW48041.1    AXCN02001179    AXCM01003787    KQ978967    KYN26878.1    ADTU01000786    ADTU01000787    ADTU01000788    ADTU01000789    ADTU01000790    KK107226    EZA55118.1    JRES01000018    KNC34864.1    GGMS01015063    MBY84266.1    GAMC01013889    JAB92666.1    CP012524    ALC41858.1    CCAG010020342    GAMC01013890    JAB92665.1    KQ434938    KZC12030.1    CH963848    EDW73717.2    GAMC01013888    JAB92667.1    GL888033    EGI69064.1    GL449639    EFN82339.1    GDHF01021411    GDHF01020476    GDHF01008854    GDHF01000960    JAI30903.1    JAI31838.1    JAI43460.1    JAI51354.1    GDHF01033283    GDHF01030424    GDHF01002259    JAI19031.1    JAI21890.1    JAI50055.1    GDHF01032461    GDHF01027435    GDHF01021208    GDHF01019939    GDHF01001960    JAI19853.1    JAI24879.1    JAI31106.1    JAI32375.1    JAI50354.1    GAKP01021700    JAC37252.1    GAKP01021711    JAC37241.1    CH916367    EDW00604.1    ABLF02034397    ABLF02034398    ABLF02034400    GBXI01007851    JAD06441.1    GBXI01007604    JAD06688.1    GL445052    EFN60246.1    DS235751    EEB16345.1    KQ983012    KYQ48330.1    NNAY01000318    OXU29264.1    CH479252    EDW38687.1    APGK01016975    APGK01016976    APGK01016977    APGK01016978    KB739995    ENN82014.1    LJIJ01000019    ODN05623.1    GDIP01120321    JAL83393.1    GDIP01083232    JAM20483.1    GDIQ01029750    JAN64987.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007266    UP000245037    UP000092461    + More
UP000183832    UP000008820    UP000235965    UP000002320    UP000015103    UP000000673    UP000076408    UP000095300    UP000076407    UP000075882    UP000069272    UP000075901    UP000000803    UP000007062    UP000001819    UP000008711    UP000078542    UP000075920    UP000075840    UP000009192    UP000075900    UP000268350    UP000192221    UP000000304    UP000075903    UP000002282    UP000053105    UP000008792    UP000075881    UP000053825    UP000005203    UP000007801    UP000001292    UP000075886    UP000075883    UP000078492    UP000005205    UP000075884    UP000053097    UP000037069    UP000002358    UP000092553    UP000092444    UP000076502    UP000007798    UP000007755    UP000008237    UP000092445    UP000092443    UP000095301    UP000075902    UP000091820    UP000001070    UP000007819    UP000000311    UP000009046    UP000075809    UP000215335    UP000008744    UP000078200    UP000075880    UP000019118    UP000094527   

PRIDE

H9JJB0    P24014    F0JAL2   

Pfam

PF01463   LRRCT        + More
PF12661   hEGF
PF00008   EGF
PF01462   LRRNT
PF00054   Laminin_G_1
PF13855   LRR_8
PF00560   LRR_1
PF13306   LRR_5

Interpro

IPR000372   LRRNT        + More
IPR000742   EGF-like_dom       
IPR001791   Laminin_G       
IPR013032   EGF-like_CS       
IPR018097   EGF_Ca-bd_CS       
IPR003591   Leu-rich_rpt_typical-subtyp       
IPR001611   Leu-rich_rpt       
IPR000152   EGF-type_Asp/Asn_hydroxyl_site       
IPR013320   ConA-like_dom_sf       
IPR001881   EGF-like_Ca-bd_dom       
IPR032675   LRR_dom_sf       
IPR000483   Cys-rich_flank_reg_C       
IPR006207   Cys_knot_C       
IPR009030   Growth_fac_rcpt_cys_sf       
IPR026906   LRR_5       
IPR036047   F-box-like_dom_sf       

SUPFAM

SSF49899   SSF49899        + More
SSF57184   SSF57184       
SSF81383   SSF81383       

Gene 3D

3.80.10.10    

ProteinModelPortal

H9JJB0   A0A096ZEC0   A0A2A4JQN3   A0A194QFI1   A0A139WM17   A0A139WM31   + More
A0A139WMC0   A0A2P8Y8J6   A0A1B0CM21   A0A1W5LU06   A0A1J1HFQ7   A0A1B6GPI2   Q16WM1   A0A1Y1MIY6   A0A1Y1MHN4   A0A2J7QL17   B0WB86   T1ID82   A0A2J7QL39   W5JBC8   A0A182YR84   A0A1I8NNR6   A0A182XHS7   A0A182LGL3   A0A182F736   A0A0J9REU2   A0A182T8E9   A0A0B4KES0   Q7QCT2   N6WCZ8   B3NQ10   A0A195CE52   A0A182W0N9   A0A182HTL0   B4KM13   A0A182RIF3   A0A3B0IZ80   A0A1W4UZ69   B4QGZ8   A0A182V3E2   E3CTP8   B4P6U8   P24014   E1NZA8   E1NZD6   A0A0M9ACF8   B4LQ27   F0JAL2   E1NZD5   A0A182KBF6   P24014-3   P24014-2   A0A0L7R2L4   A0A088AS83   B3MC19   B4HSG3   A0A182Q2Z8   A0A182MDH5   A0A151JLV6   A0A158NCN5   A0A182N797   A0A026WGR8   A0A0L0CU11   A0A2S2R2P7   K7INA9   W8BHF3   A0A0M4EA23   A0A1B0FKZ4   W8AUW0   A0A154PLC6   B4MNM8   W8B2B3   F4W9S8   E2BPP0   A0A1A9ZRB4   A0A1A9YJM8   A0A1I8MJQ3   A0A0K8UZ73   A0A0K8TXL8   A0A0K8UWZ3   A0A182TWV5   A0A1A9WAF0   A0A034V560   A0A034V1X2   B4J4Q8   X1WIF9   A0A0A1X6C6   A0A0A1X7M8   E2B242   E0VSI9   A0A151WKI6   A0A232FEP7   B4HBE5   A0A1A9VA99   A0A182IKD9   N6TNE5   A0A1D2NK21   A0A0P5U8J6   A0A0P5WQ00   A0A0P6HUB3  

PDB

2WFH     E-value=2.55107e-52,     Score=522

KEGG

101736444    K06839 slit 2 | (RefSeq) slit; protein slit

GO

GO:0005509   GO:0005576   GO:0016021   GO:0048495   GO:0008201   GO:0071666   GO:0030182   GO:0050929   GO:0007432   GO:0008347   GO:0035385   GO:2000274   GO:0016199   GO:0001764   GO:0048813   GO:0010632   GO:0008406   GO:0008078   GO:0007502   GO:0030335   GO:0005886   GO:0007427   GO:0035050   GO:0003151   GO:0022409   GO:0007509   GO:0007411   GO:0016201   GO:0004714   GO:0005515   GO:0004677   GO:0005524   GO:0005634   GO:0006303   GO:0003824   GO:0008152   GO:0016491   GO:0015930  

Subcellular location

Secreted  

Length:

818

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00323

Exp number, first 60 AAs:

0.00181

Total prob of N-in:

0.00022

outside

1  -  818

 

 

Pi

224.661651

Theta

158.24913

Tajima's D

1.831679

CLR

0.144569

CSRT

0.854407279636018

Interpretation

Uncertain