Gene

KWMTBOMO14677

Pre Gene Modal

BGIBMGA009611

Annotation

slit?_partial_[Bombyx_mori]

Location

Bomo_Chr24(+):12550217-12553881      View in EpiBrowser

Full name

Protein slit      

Location in the cell

Extracellular   Reliability : 1.459 Mitochondrial   Reliability : 1.095

CDS

ATGATGTCGGACAATAATTTGGGACAGATAAAGTCTGACGGACTCTTCGGGAGGCTGCCGGACCTCACCAAACTGGACTTCAGGAACAACGGCATATCGGTCATTGAGGACAACGCGTTTGACGGCGCCGCCAACATCCAGGAGATGCTGCTGGATGGGAATCTGCTGCAGACCGTCACCGACAAAATGTTCTTCGGACTCCACAGTCTTAATGTCCTATCATTAACGCATAACAAGATTAAATGCATCACACCGGGCGCATTTGACCATCTCACCACGCTCTCAACACTGTAA

Protein

MMSDNNLGQIKSDGLFGRLPDLTKLDFRNNGISVIEDNAFDGAANIQEMLLDGNLLQTVTDKMFFGLHSLNVLSLTHNKIKCITPGAFDHLTTLSTL

Description

A short-range repellent, controlling axon crossing of the midline and a long-range chemorepellent, controlling mesoderm migration and patterning away from the midline. May interact with extracellular matrix molecules. Repulsive ligand for the guidance receptor roundabout (robo) and prevents inappropriate midline crossing by Robo-expressing axons.

Subunit

Interacts with robo.

Keywords

3D-structure   Alternative splicing   Complete proteome   Developmental protein   Differentiation   Disulfide bond   EGF-like domain   Glycoprotein   Leucine-rich repeat   Neurogenesis   Reference proteome   Repeat   Secreted   Signal  

Feature

chain  Protein slit
splice variant  In isoform A and isoform B.

Uniprot

A0A096ZEC0   H9JJB0   A0A2H1V322   A0A2A4JQN3   A0A2W1BK68   A0A0N0PF71   + More
A0A194QFI1   A0A0N1IQX4   A0A1Y1MIY6   A0A1Y1MHN4   A0A139WMC0   A0A139WM31   A0A139WM17   A0A3Q0IWG0   A0A0T6B2W9   A0A182TWV5   A0A182V3E2   N6TNE5   A0A2P8Y8J6   A0A182HTL0   A0A182Q2Z8   A0A182MDH5   A0A182LGL3   A0A182RIF3   A0A182XHS7   Q7QCT2   A0A182T8E9   A0A182KBF6   A0A1W5LU06   A0A182PQM3   A0A182W0N9   A0A182IKD9   A0A034V560   A0A034V1X2   A0A0K8TXL8   A0A1J1HFQ7   A0A182YR84   A0A182N797   A0A0K8UZ73   W8AUW0   A0A0K8UWZ3   A0A1B0CM21   A0A0A1X6C6   A0A0A1X7M8   W8BHF3   W8B2B3   W5JBC8   A0A182F736   A0A0A9ZHF7   A0A0L0CU11   U4TY49   E1NZA8   E1NZD6   E1NZD5   F0JAL2   P24014-3   E3CTP8   P24014-2   P24014   B4QGZ8   B4HSG3   A0A1B6GPI2   A0A1W4UZ69   B3MC19   A0A0B4KES0   A0A0J9REU2   B4P6U8   B3NQ10   B0WB86   A0A3B0IZ80   B4HBE5   B4J4Q8   A0A0M4EA23   N6WCZ8   A0A1I8MJQ3   Q16WM1   B4KM13   E0VSI9   B4LQ27   A0A1I8NNR6   A0A1B6IAM4   B4MNM8   A0A1A9VA99   A0A2H8TPR9   A0A2J7QL17   T1ID82   X1WIF9   A0A1A9YJM8   A0A1B0FKZ4   A0A1A9ZRB4   A0A1A9WAF0   A0A1B6DDC0   A0A1B6MA00   A0A1B6KZT4   A0A2S2R2P7   A0A0P5J8I2   A0A0N7ZNI4   A0A0P5RT15   E9GML1   A0A0P5B8Z2  

Pubmed

25285792    19121390    28756777    26354079    28004739    18362917    + More
19820115    23537049    29403074    20966253    12364791    25348373    25244985    24495485    25830018    20920257    23761445    25401762    26108605    2176636    10102267    10731132    12537572    3144436    10102268    15496984    17994087    12537568    12537573    12537574    16110336    17569856    17569867    22936249    17550304    15632085    25315136    17510324    20566863    21292972   

EMBL

KF739412    AIP87150.1    BABH01036403    BABH01036404    ODYU01000445    SOQ35227.1    + More
NWSH01000762    PCG74365.1    KZ150125    PZC73120.1    KQ459628    KPJ20532.1    KQ459249    KPJ02226.1    LADJ01059812    KPJ21600.1    GEZM01034259    JAV83846.1    GEZM01034260    JAV83845.1    KQ971316    KYB28991.1    KYB28992.1    KYB28990.1    LJIG01016128    KRT81531.1    APGK01016975    APGK01016976    APGK01016977    APGK01016978    KB739995    ENN82014.1    PYGN01000805    PSN40578.1    APCN01000566    APCN01000567    AXCN02001179    AXCM01003787    AAAB01008859    EAA07783.5    KX034172    ANO54002.1    GAKP01021700    JAC37252.1    GAKP01021711    JAC37241.1    GDHF01033283    GDHF01030424    GDHF01002259    JAI19031.1    JAI21890.1    JAI50055.1    CVRI01000002    CRK86807.1    GDHF01021411    GDHF01020476    GDHF01008854    GDHF01000960    JAI30903.1    JAI31838.1    JAI43460.1    JAI51354.1    GAMC01013890    JAB92665.1    GDHF01032461    GDHF01027435    GDHF01021208    GDHF01019939    GDHF01001960    JAI19853.1    JAI24879.1    JAI31106.1    JAI32375.1    JAI50354.1    AJWK01018062    AJWK01018063    AJWK01018064    AJWK01018065    AJWK01018066    AJWK01018067    AJWK01018068    AJWK01018069    AJWK01018070    GBXI01007851    JAD06441.1    GBXI01007604    JAD06688.1    GAMC01013889    JAB92666.1    GAMC01013888    JAB92667.1    ADMH02001876    ETN60703.1    GBHO01000376    JAG43228.1    JRES01000018    KNC34864.1    KB631748    ERL85742.1    BT125657    ADN39445.1    BT125685    ADO16251.1    BT125684    ADO14992.1    BT126054    ADY17753.1    X53959    AF126540    AE013599    M23543    BT125714    ADO51076.1    CM000362    EDX07261.1    CH480816    EDW48041.1    GECZ01005434    JAS64335.1    CH902619    EDV37206.2    AGB93549.1    CM002911    KMY94099.1    CM000158    EDW92025.2    CH954179    EDV55857.2    DS231877    EDS42151.1    OUUW01000001    SPP73287.1    CH479252    EDW38687.1    CH916367    EDW00604.1    CP012524    ALC41858.1    CM000071    ENO01959.1    CH477561    EAT38989.1    CH933808    EDW10802.2    DS235751    EEB16345.1    CH940648    EDW60350.2    GECU01023737    JAS83969.1    CH963848    EDW73717.2    GFXV01004351    MBW16156.1    NEVH01013254    PNF29279.1    ACPB03002829    ABLF02034397    ABLF02034398    ABLF02034400    CCAG010020342    GEDC01013713    JAS23585.1    GEBQ01007303    JAT32674.1    GEBQ01023010    JAT16967.1    GGMS01015063    MBY84266.1    GDIQ01209578    JAK42147.1    GDIP01228065    JAI95336.1    GDIQ01105818    JAL45908.1    GL732553    EFX79275.1    GDIP01187765    JAJ35637.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007266    UP000079169    + More
UP000075902    UP000075903    UP000019118    UP000245037    UP000075840    UP000075886    UP000075883    UP000075882    UP000075900    UP000076407    UP000007062    UP000075901    UP000075881    UP000075885    UP000075920    UP000075880    UP000183832    UP000076408    UP000075884    UP000092461    UP000000673    UP000069272    UP000037069    UP000030742    UP000000803    UP000000304    UP000001292    UP000192221    UP000007801    UP000002282    UP000008711    UP000002320    UP000268350    UP000008744    UP000001070    UP000092553    UP000001819    UP000095301    UP000008820    UP000009192    UP000009046    UP000008792    UP000095300    UP000007798    UP000078200    UP000235965    UP000015103    UP000007819    UP000092443    UP000092444    UP000092445    UP000091820    UP000000305   

PRIDE

H9JJB0    F0JAL2    P24014   

Pfam

PF00054   Laminin_G_1        + More
PF01462   LRRNT
PF00008   EGF
PF01463   LRRCT
PF13855   LRR_8
PF12661   hEGF
PF13306   LRR_5
PF00560   LRR_1

Interpro

IPR000483   Cys-rich_flank_reg_C        + More
IPR032675   LRR_dom_sf       
IPR001881   EGF-like_Ca-bd_dom       
IPR013320   ConA-like_dom_sf       
IPR001611   Leu-rich_rpt       
IPR000152   EGF-type_Asp/Asn_hydroxyl_site       
IPR003591   Leu-rich_rpt_typical-subtyp       
IPR013032   EGF-like_CS       
IPR018097   EGF_Ca-bd_CS       
IPR001791   Laminin_G       
IPR000742   EGF-like_dom       
IPR000372   LRRNT       
IPR006207   Cys_knot_C       
IPR026906   LRR_5       
IPR009030   Growth_fac_rcpt_cys_sf       
IPR011009   Kinase-like_dom_sf       

SUPFAM

SSF49899   SSF49899        + More
SSF57184   SSF57184       
SSF56112   SSF56112       

Gene 3D

3.80.10.10    

ProteinModelPortal

A0A096ZEC0   H9JJB0   A0A2H1V322   A0A2A4JQN3   A0A2W1BK68   A0A0N0PF71   + More
A0A194QFI1   A0A0N1IQX4   A0A1Y1MIY6   A0A1Y1MHN4   A0A139WMC0   A0A139WM31   A0A139WM17   A0A3Q0IWG0   A0A0T6B2W9   A0A182TWV5   A0A182V3E2   N6TNE5   A0A2P8Y8J6   A0A182HTL0   A0A182Q2Z8   A0A182MDH5   A0A182LGL3   A0A182RIF3   A0A182XHS7   Q7QCT2   A0A182T8E9   A0A182KBF6   A0A1W5LU06   A0A182PQM3   A0A182W0N9   A0A182IKD9   A0A034V560   A0A034V1X2   A0A0K8TXL8   A0A1J1HFQ7   A0A182YR84   A0A182N797   A0A0K8UZ73   W8AUW0   A0A0K8UWZ3   A0A1B0CM21   A0A0A1X6C6   A0A0A1X7M8   W8BHF3   W8B2B3   W5JBC8   A0A182F736   A0A0A9ZHF7   A0A0L0CU11   U4TY49   E1NZA8   E1NZD6   E1NZD5   F0JAL2   P24014-3   E3CTP8   P24014-2   P24014   B4QGZ8   B4HSG3   A0A1B6GPI2   A0A1W4UZ69   B3MC19   A0A0B4KES0   A0A0J9REU2   B4P6U8   B3NQ10   B0WB86   A0A3B0IZ80   B4HBE5   B4J4Q8   A0A0M4EA23   N6WCZ8   A0A1I8MJQ3   Q16WM1   B4KM13   E0VSI9   B4LQ27   A0A1I8NNR6   A0A1B6IAM4   B4MNM8   A0A1A9VA99   A0A2H8TPR9   A0A2J7QL17   T1ID82   X1WIF9   A0A1A9YJM8   A0A1B0FKZ4   A0A1A9ZRB4   A0A1A9WAF0   A0A1B6DDC0   A0A1B6MA00   A0A1B6KZT4   A0A2S2R2P7   A0A0P5J8I2   A0A0N7ZNI4   A0A0P5RT15   E9GML1   A0A0P5B8Z2  

PDB

1W8A     E-value=4.91132e-25,     Score=277

KEGG

101736444    K06839 slit 2 | (RefSeq) slit; protein slit

GO

GO:0005509   GO:0005576   GO:0016021   GO:0048495   GO:0008201   GO:0007502   GO:0008078   GO:0035050   GO:0005886   GO:0007427   GO:0030335   GO:0007509   GO:0022409   GO:0003151   GO:0016201   GO:0007411   GO:0050929   GO:0007432   GO:0030182   GO:0071666   GO:0008347   GO:0035385   GO:0001764   GO:0016199   GO:2000274   GO:0008406   GO:0010632   GO:0048813   GO:0004714   GO:0005515   GO:0003677   GO:0004677   GO:0005524   GO:0005634   GO:0006303   GO:0003824   GO:0008152   GO:0016491   GO:0015930  

Subcellular location

Secreted  

Length:

97

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02056

Exp number, first 60 AAs:

0.00431

Total prob of N-in:

0.22952

outside

1  -  97

 

 

Pi

210.417791

Theta

142.032475

Tajima's D

2.358887

CLR

0

CSRT

0.929403529823509

Interpretation

Uncertain