Gene

KWMTBOMO14676

Pre Gene Modal

BGIBMGA009611

Annotation

PREDICTED:_protein_slit_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr24(+):12497307-12549001      View in EpiBrowser

Full name

Protein slit       + More
Slit homolog 1 protein      

Alternative Name

Multiple epidermal growth factor-like domains protein 4

Location in the cell

Extracellular   Reliability : 2.28

CDS

ATGAAGGTCCTACTCCTCTTGGCTCTGAGCTGGGCGACCGCCGCGGCCACCTGCCCATGGGCTTGCTCCTGCAGACCACCGGCGGCTGACTGCGCGCACAGAGGACTCCTGCATGTACCGAAGCGCTTGCCTCCGGATTCGCATAGACTAGACCTTCAGGGTAACAATATCAGCATAGTCTTTCAGAGCGACTTCCAGAACATCAAGGAGCTTAAAGTTTTACAGCTGTCGGAGAACCAGATTCACACGATTGAGAGAGACGCCTTCCTCGAGCTGACGTCACTTGAACGATTAGATCTGAGCCGAAACGAGTTGACAGCGATCAGTCGCCGCACGTTCCGAGGATTGACCGCTCTGAAGAGTCTACACCTCGACGGGAACCAGCTGAAATGCATCGACGAGAAAGCTCTGGAGAACTTGAAAAGCCTGGAAGTTCTGACTTTAAATAACAACAACCTAACGTATTTGTCGTTGGAGCCGGTCACCGTCTCGCGACTGAGCACGCTGCGGCTGAGCGACAATCCGGTTGTCTGCGACTGTCGCGTCGCAAGACTGTCCACAGCTGTCCGGTCTGCTGGGATCATGGGCGTCGGCGCGAGGTGTCAAGCTCCTGCAGCTCTACGTGGCTCGTTGCTGACCGACTTAGAGCCTCACGAACTCATCTGCAGTGGACCTACAACAGCTTCGTCTGGTGAATGCTCAGCGGAGCCCCGCTGCCCGCCACCCTGTCGCTGCACTCCTGAGGGTATAGTGGACTGCAGGGAGAAGATGCTCTCAGAGCTGCCACCTACTATACCTCACAGAGCTACGGAGATTCGCTTGGAACAGAATGAGATAACCGAAGTCGGCAGCGGCGCCTTCTCATCCATAAAGAGGGTGACCAGGATCGACCTGTCCAACAACAAGATCGCCAAAATCTCAGCGGACACATTCCAAGGACTCGTACATTTAACCTCACTAGTCTTGTACGGAAATAAAATAAAGGATTTGCCGTCGGGAGTATTCCACGGGCTGGGATCGCTCCAATTATTACTGCTGAACTCGAATGAGATTACGTGCGTCAAAAAGGACACGTTCCGTGATTTAGAGAATCTAAAATTACTGTCTTTATACGACAACAATATACGATCACTGCCGAATGGTACCTTCGATGCTTTGACGGGAATCCAGACCTTGCATTTAGGTCGGAATCCGTTCGTATGCGACTGTTCCCTCCGCTGGCTGGCTGCCTACTTGCGCAAGAATCCCATCGAGACGTCTGGTGCCAAGTGTGACTCTCCGAAGCGCATGAACAAAAAGCGAATCGACGCTCTCAGGGAAGAGAACTTCAAATGCAAGCGTGAGTTGCCATCGTAG

Protein

MKVLLLLALSWATAAATCPWACSCRPPAADCAHRGLLHVPKRLPPDSHRLDLQGNNISIVFQSDFQNIKELKVLQLSENQIHTIERDAFLELTSLERLDLSRNELTAISRRTFRGLTALKSLHLDGNQLKCIDEKALENLKSLEVLTLNNNNLTYLSLEPVTVSRLSTLRLSDNPVVCDCRVARLSTAVRSAGIMGVGARCQAPAALRGSLLTDLEPHELICSGPTTASSGECSAEPRCPPPCRCTPEGIVDCREKMLSELPPTIPHRATEIRLEQNEITEVGSGAFSSIKRVTRIDLSNNKIAKISADTFQGLVHLTSLVLYGNKIKDLPSGVFHGLGSLQLLLLNSNEITCVKKDTFRDLENLKLLSLYDNNIRSLPNGTFDALTGIQTLHLGRNPFVCDCSLRWLAAYLRKNPIETSGAKCDSPKRMNKKRIDALREENFKCKRELPS

Description

A short-range repellent, controlling axon crossing of the midline and a long-range chemorepellent, controlling mesoderm migration and patterning away from the midline. May interact with extracellular matrix molecules. Repulsive ligand for the guidance receptor roundabout (robo) and prevents inappropriate midline crossing by Robo-expressing axons.
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb (By similarity).
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.

Subunit

Interacts with robo.
Interacts with ROBO1 (By similarity) and GREM1.
Interacts with ROBO1 and GREM1.

Keywords

3D-structure   Alternative splicing   Complete proteome   Developmental protein   Differentiation   Disulfide bond   EGF-like domain   Glycoprotein   Leucine-rich repeat   Neurogenesis   Reference proteome   Repeat   Secreted   Signal   Polymorphism  

Feature

chain  Protein slit
splice variant  In isoform A and isoform B.
sequence variant  In dbSNP:rs2817673.

Uniprot

H9JJB0   A0A2H1V322   A0A2W1BK68   A0A194QFI1   A0A034V431   A0A1B6KZT4   + More
A0A1B6IAM4   A0A1W5LU06   W8AUW0   A0A1B6MA00   A0A1Y1MIY6   A0A1Y1MHN4   A0A034V6T1   W8BHF3   W8B2B3   A0A034V560   A0A034V1X2   E1NZD5   P24014-3   P24014-2   A0A139WM17   A0A0K8TXL8   E0VSI9   A0A0A1X6C6   A0A0A1X7M8   E3CTP8   F0JAL2   P24014   B4QGZ8   B4HSG3   A0A3B0IZ80   A0A0K8UZ73   A0A0M4EA23   A0A0K8UWZ3   A0A1I8NNR6   A0A0L0CU11   B4P6U8   E1NZD6   N6WCZ8   B3MC19   B4J4Q8   A0A0B4KES0   B3NQ10   A0A0J9REU2   A0A182Q2Z8   A0A1I8MJQ3   B4KM13   A0A1W4UZ69   B0WB86   B4LQ27   B4MNM8   A0A182N797   Q16WM1   A0A2H8TPR9   Q7QCT2   A0A1J1HFQ7   A0A232FEP7   K7INA9   A0A0P5QAF6   A0A0N8BJW4   A0A0P5QV25   A0A0P5LP38   A0A182F736   A0A0P5G8Z9   A0A0P5HSP1   A0A0P6GCF6   A0A0P5HM86   A0A0D6A818   A0A0P5ELL6   A0A0P6HUB3   A0A0P5WQ00   A0A0P6CY20   A0A0P5U8J6   A0A0P5V3A4   A0A0P5BKL2   A0A0P4YJ18   A0A0P5UWX4   A0A0P5B090   A0A0P5Z6T7   E9GML1   A0A0P5WVB3   A6YB93   A0A0P6BYS5   A0A0P5VTL1   X1WIF9   A0A2S2R2P7   A0A2J8PDR7   A0A2I2MJP8   A0A1A9YJM8   O88279-4   A0A0P5RH75   A0A182YR84   A0A182XHS7   A0A088AS83   Q5T0V4   A0A2J8PDS4   O75093-2   A0A146WBZ8   A0A147BKB3   A1A5F4  

Pubmed

19121390    28756777    26354079    25348373    24495485    28004739    + More
2176636    10102267    10731132    12537572    3144436    10102268    15496984    18362917    19820115    20566863    25830018    17994087    26108605    17550304    15632085    12537568    12537573    12537574    16110336    17569856    17569867    22936249    25315136    17510324    12364791    28648823    20075255    21292972    17448990    9693030    9813312    10864956    11754167    15528323    25244985    15164054    12168954    15489334    12141424    12200164    29652888    20431018   

EMBL

BABH01036403    BABH01036404    ODYU01000445    SOQ35227.1    KZ150125    PZC73120.1    + More
KQ459249    KPJ02226.1    GAKP01021703    JAC37249.1    GEBQ01023010    JAT16967.1    GECU01023737    JAS83969.1    KX034172    ANO54002.1    GAMC01013890    JAB92665.1    GEBQ01007303    JAT32674.1    GEZM01034259    JAV83846.1    GEZM01034260    JAV83845.1    GAKP01021709    JAC37243.1    GAMC01013889    JAB92666.1    GAMC01013888    JAB92667.1    GAKP01021700    JAC37252.1    GAKP01021711    JAC37241.1    BT125684    ADO14992.1    X53959    AF126540    AE013599    M23543    KQ971316    KYB28990.1    GDHF01033283    GDHF01030424    GDHF01002259    JAI19031.1    JAI21890.1    JAI50055.1    DS235751    EEB16345.1    GBXI01007851    JAD06441.1    GBXI01007604    JAD06688.1    BT125714    ADO51076.1    BT126054    ADY17753.1    CM000362    EDX07261.1    CH480816    EDW48041.1    OUUW01000001    SPP73287.1    GDHF01021411    GDHF01020476    GDHF01008854    GDHF01000960    JAI30903.1    JAI31838.1    JAI43460.1    JAI51354.1    CP012524    ALC41858.1    GDHF01032461    GDHF01027435    GDHF01021208    GDHF01019939    GDHF01001960    JAI19853.1    JAI24879.1    JAI31106.1    JAI32375.1    JAI50354.1    JRES01000018    KNC34864.1    CM000158    EDW92025.2    BT125685    ADO16251.1    CM000071    ENO01959.1    CH902619    EDV37206.2    CH916367    EDW00604.1    AGB93549.1    CH954179    EDV55857.2    CM002911    KMY94099.1    AXCN02001179    CH933808    EDW10802.2    DS231877    EDS42151.1    CH940648    EDW60350.2    CH963848    EDW73717.2    CH477561    EAT38989.1    GFXV01004351    MBW16156.1    AAAB01008859    EAA07783.5    CVRI01000002    CRK86807.1    NNAY01000318    OXU29264.1    GDIQ01117370    JAL34356.1    GDIQ01170547    JAK81178.1    GDIQ01116073    JAL35653.1    GDIQ01170548    JAK81177.1    GDIQ01251925    JAJ99799.1    GDIQ01223277    JAK28448.1    GDIQ01035346    JAN59391.1    GDIQ01231381    JAK20344.1    AB981662    BAQ58829.1    GDIP01157966    JAJ65436.1    GDIQ01029750    JAN64987.1    GDIP01083232    JAM20483.1    GDIQ01085977    GDIQ01009364    JAN08760.1    GDIP01120321    JAL83393.1    GDIP01107667    JAL96047.1    GDIP01198213    JAJ25189.1    GDIP01228066    JAI95335.1    GDIP01107668    JAL96046.1    GDIP01191860    JAJ31542.1    GDIP01050330    JAM53385.1    GL732553    EFX79275.1    GDIP01081276    JAM22439.1    EF384216    ABO93215.1    GDIP01008518    JAM95197.1    GDIP01095530    JAM08185.1    ABLF02034397    ABLF02034398    ABLF02034400    GGMS01015063    MBY84266.1    NBAG03000216    PNI82166.1    LT968152    SOU94110.1    AB011530    AF133730    AB073213    AB073214    AB073215    AB017170    GDIQ01120016    JAL31710.1    AL442123    AL512424    PNI82169.1    AB017167    AB011537    CH471066    BC146851    AY029183    GCES01059767    JAR26556.1    GEGO01004177    JAR91227.1    AAMC01095566    AAMC01095567    AAMC01095568    AAMC01095569    AAMC01095570    AAMC01095571    AAMC01095572    AAMC01095573    AAMC01095574    AAMC01095575    BC128626    BC135997    AAI28627.1   

Proteomes

UP000005204    UP000053268    UP000000803    UP000007266    UP000009046    UP000000304    + More
UP000001292    UP000268350    UP000092553    UP000095300    UP000037069    UP000002282    UP000001819    UP000007801    UP000001070    UP000008711    UP000075886    UP000095301    UP000009192    UP000192221    UP000002320    UP000008792    UP000007798    UP000075884    UP000008820    UP000007062    UP000183832    UP000215335    UP000002358    UP000069272    UP000000305    UP000007819    UP000092443    UP000002494    UP000076408    UP000076407    UP000005203    UP000005640    UP000008143   

PRIDE

H9JJB0    P24014    F0JAL2    O88279    Q5T0V4    O75093    + More

Pfam

PF01463   LRRCT        + More
PF12661   hEGF
PF00008   EGF
PF01462   LRRNT
PF00054   Laminin_G_1
PF13855   LRR_8
PF00560   LRR_1
PF13306   LRR_5
PF02210   Laminin_G_2

Interpro

IPR000372   LRRNT        + More
IPR000742   EGF-like_dom       
IPR001791   Laminin_G       
IPR013032   EGF-like_CS       
IPR018097   EGF_Ca-bd_CS       
IPR003591   Leu-rich_rpt_typical-subtyp       
IPR001611   Leu-rich_rpt       
IPR000152   EGF-type_Asp/Asn_hydroxyl_site       
IPR013320   ConA-like_dom_sf       
IPR001881   EGF-like_Ca-bd_dom       
IPR032675   LRR_dom_sf       
IPR000483   Cys-rich_flank_reg_C       
IPR006207   Cys_knot_C       
IPR026906   LRR_5       
IPR009030   Growth_fac_rcpt_cys_sf       
IPR036047   F-box-like_dom_sf       
IPR003645   Fol_N       

SUPFAM

SSF49899   SSF49899        + More
SSF57184   SSF57184       
SSF81383   SSF81383       

Gene 3D

3.80.10.10    

ProteinModelPortal

H9JJB0   A0A2H1V322   A0A2W1BK68   A0A194QFI1   A0A034V431   A0A1B6KZT4   + More
A0A1B6IAM4   A0A1W5LU06   W8AUW0   A0A1B6MA00   A0A1Y1MIY6   A0A1Y1MHN4   A0A034V6T1   W8BHF3   W8B2B3   A0A034V560   A0A034V1X2   E1NZD5   P24014-3   P24014-2   A0A139WM17   A0A0K8TXL8   E0VSI9   A0A0A1X6C6   A0A0A1X7M8   E3CTP8   F0JAL2   P24014   B4QGZ8   B4HSG3   A0A3B0IZ80   A0A0K8UZ73   A0A0M4EA23   A0A0K8UWZ3   A0A1I8NNR6   A0A0L0CU11   B4P6U8   E1NZD6   N6WCZ8   B3MC19   B4J4Q8   A0A0B4KES0   B3NQ10   A0A0J9REU2   A0A182Q2Z8   A0A1I8MJQ3   B4KM13   A0A1W4UZ69   B0WB86   B4LQ27   B4MNM8   A0A182N797   Q16WM1   A0A2H8TPR9   Q7QCT2   A0A1J1HFQ7   A0A232FEP7   K7INA9   A0A0P5QAF6   A0A0N8BJW4   A0A0P5QV25   A0A0P5LP38   A0A182F736   A0A0P5G8Z9   A0A0P5HSP1   A0A0P6GCF6   A0A0P5HM86   A0A0D6A818   A0A0P5ELL6   A0A0P6HUB3   A0A0P5WQ00   A0A0P6CY20   A0A0P5U8J6   A0A0P5V3A4   A0A0P5BKL2   A0A0P4YJ18   A0A0P5UWX4   A0A0P5B090   A0A0P5Z6T7   E9GML1   A0A0P5WVB3   A6YB93   A0A0P6BYS5   A0A0P5VTL1   X1WIF9   A0A2S2R2P7   A0A2J8PDR7   A0A2I2MJP8   A0A1A9YJM8   O88279-4   A0A0P5RH75   A0A182YR84   A0A182XHS7   A0A088AS83   Q5T0V4   A0A2J8PDS4   O75093-2   A0A146WBZ8   A0A147BKB3   A1A5F4  

PDB

2V9T     E-value=9.94909e-56,     Score=549

KEGG

101736444    K06839 slit 2 | (RefSeq) slit; protein slit

GO

GO:0005509   GO:0016021   GO:0005576   GO:0048495   GO:0007502   GO:0008078   GO:0035050   GO:0005886   GO:0007427   GO:0030335   GO:0007509   GO:0022409   GO:0003151   GO:0016201   GO:0007411   GO:0050929   GO:0007432   GO:0030182   GO:0071666   GO:0008347   GO:0035385   GO:0001764   GO:0016199   GO:2000274   GO:0008201   GO:0008406   GO:0010632   GO:0048813   GO:0004714   GO:0007420   GO:0050919   GO:0051964   GO:0043395   GO:0048843   GO:0021510   GO:0005615   GO:0033563   GO:0008045   GO:0022028   GO:0048846   GO:0048853   GO:0031290   GO:0007097   GO:0005623   GO:0045773   GO:0021602   GO:0005515   GO:0003677   GO:0004677   GO:0005524   GO:0005634   GO:0006303   GO:0003824   GO:0008152   GO:0016491   GO:0015930  

Subcellular location

Secreted  

SignalP

Position:   1 - 16,         Likelihood:  0.997945

 

 

Length:

451

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0915199999999999

Exp number, first 60 AAs:

0.08155

Total prob of N-in:

0.00411

outside

1  -  451

 

 

Pi

244.265883

Theta

156.643071

Tajima's D

1.672801

CLR

0.075635

CSRT

0.822308884555772

Interpretation

Uncertain