Silkworm Genome Informatics Database

Gene

KWMTBOMO14656

Pre Gene Modal

BGIBMGA009604

Annotation

1-phosphatidylinositol-4?5-bisphosphate_phosphodiesterase_epsilon-1_[Papilio_machaon]

Location

Bomo_Chr24(+):12078702-12098146 View in EpiBrowser

Full name

Phosphoinositide phospholipase C

Location in the cell

Nuclear Reliability : 4.215

CDS

ATGGAAGATAAGAGCGGTAGGACGTCTCTCTCGTTCTACCAGGGCTTCCGTAGGAGCGAGGGGGACGGAGAATCTTCAAGCGTCAAACATTCGACCAGGAAGAGAAGCAATCAGATCGCCCGGGAACTTAGTGATATGGTCATCTACGTTCAGGCGATCAAGTTCCGTGGCTTGAATCCTCTATCACCGAAGAGTTCCATCAGACAGCCCAAGTCCAAGGAGACGGCTCCAAGCAGCTTCGAGTCATCCGAAAGCAGCGACAGCACCAGCGCGCAAATAGCTCAAGGCACGAGGCCTCGCTGCCTCAACGCTCCGGCTGTCCACCACCCTTGCTATCGATGCTCCTCAGTCAACGAAGCCATCGGGAAGAAGATATGCAGGAAGCACCCGGTAGCGCTAATCGCTCATACGGAAACGCAACTCGTGCGGACCTATCCAGCCGGCATACGAATAGACTCGTCCAACTTCGACCCGGTCACGTTCTGGGCTTGCGGCGTGCAGATGGTCGCTCTCAACTACCAAACCGAGGACGCCGCGATGGCCATCAACGCCGCAATGTACGAGAGCAACGGGTGTCTGGGCTACGTCAGGAAACCCATAGTCATGTGGGACCCTTCGCACATAGCCTACAGAAGATTCAATCCAATGGATAAAGAGTTCGATGGTATCCACGCGTCTCACCTGACCCTGGCGGTCATATCCGGGCAGTACGTGGCCGAAAACGTGTACTCCTTCTACAACGCCTTCGTGGAGGTGGAAATACTTGGAGTCCCAGCCGACTGCAGGAAGATCAGGACCAAAGTGGCCAGGAGGAACGCTCTGAACCCCGTCTGGAATGAAACCTTTAATTTCAAGATAAACTTTCCCGAGCTGGCTTTCGTTCGCTTCGAGATATACGACGCGGATACCAACTACATGTTGTCGCAACGGGTCATCCCACTGCACTGCCTCAGACCAGGGTACCGGCACGTCCGGCTGAGGTCCCCGACAAACCAGCCGCTAAACATGGCGTCTCTGTTCATCTTCTCCCGCTGCTCTGAGGAGCTGGCTGGAGAGAGTTGCCGGAACGATCTGGACTCCAATTCCCCCCACGAAAGACTGAAGATACACTTCATCGTGGTCTACGCGGTCTCAAGGAACGAACCTTATTCTATTCTGAAGGTGACGCAAGATACCACGGCTAATGAGGCAATAGCGCAGTGCTTAGCCAAGGGTGGTCTTTGCGGGTCGTCCCGGGGCAGCTACGTGCTAGTGGAGGAGTGCAGAGGAAACGCTCGCCAGCGGGTCCTGGCTCCTCACGAGAGGGTGCTGAGGGCTGGCAACTCTAGGTTACTCCTGAAACGAGTCGGTGACGACCCTAGCAGCAGGGCTTGGCTTACTAGCATACGGTCGACGTCCTCGGACCGCAACAAGGATCGCTCGGTGCCTTCGGACGAGGAGTCCGCTCAGGATGACGAGCCTCGGCGCGCAGATAGCTACCTGGTCTGCGTTCACAACGTCTCGCACGAGATCCCGTACGCAATACTCAAGGTACCTCTGGGAGCGACAGCGTCGTTTGTCGTCCACCAAGCGCTGACGAAGGCCAGATGTCAAGAGGATCCCAAAAGATTCGTGCTAGTTGAGGAATTGGAGTGGGGCGGGAGAGCTGGTGGTGGACCTCAGCAAAGGGCGTTAGCTGATGATGAAGTGGTATACGCAGCTCAGGCCAGCTGGAAGACCTTAGGTAGATTTGTTCTGCAGGAGAAAGGATCGTCGGCTCCTTTGCCGAGACACCGCGCGGCCATCGCTAGAATCCAAAGAGGACTTAGCATTACTAAAGGCGCTTTTACTGGTAATGCTGGCTTCCCGATCGGCAGCTTCGGGTCCTCGGAGACACCCGAAGGCAAAACTCCAGTTCAAACGGCCTATAGCGACCCCACGCACTGCAGGAGATTATCAACAGCTCCTCTGGGGAAAGGGATAGAGCGAGCCAAGGGGCACTCGGATAAGGACTTCAGGACCTACATGCAAAGAAGGCAGGGCTGCAGAGAGGTGCACTCCGAAGGCGAGACCGTGTGGCAGGTTCTCCGCCGACTAGGGAACAGTCTGGCGAACCATCGTGCGTCCCTTTCATCTGAGCTAGGCTCCTTATGGGATTTCTTCAAGATAGAGCGCGACAGGCGGAGATCCGCGACGACCACAACGTACGAACCGATTCTGACCGAGTCTAAATCACCAGTTAAACTGGCCAGAGATTTGCTCCAAGTCATTCAGGAAACGGTATTCACTAAGAAGGATGATGAACCGAAGCGATGTCCTCTGGTCAAAGAGGAATCAGACCTCAGCTCCGAGGAGGACGAAGGAACCGACAGCAGAATAGCAAACCTAATTGATTTCTTCTTCACGATCGTCAAGAGTCAGAAGGAAGACCGCAAAGGCTCCGGAGGTAGTTGCTTCAAATCCGAAGCCAGTCCGGACGAGGCCAGAGAATTACCCAAGAAAGTCAACAGGGAACTTGAAGAGAAAATGGACACTCTAATGGAATTCCTCGCAACGACCGGCTGTATGAACAAAGAAGACCAGACTCAAAAAGAAGGGAAGAAGATAACTCTGATGGAGTTCCTCTTCGGCGTAGAAGAACGTAAGATGGAGATCGTTGAACCTAAAAGCCTTAGTCTGTCCGAATCAAACGTTAATGTGAAGCTTTGTTACATAGACGAAACTCCGAACGAAGATGGAACGGAATCCTTTGTCGAGATCCTCCTGAAATACATGGAGGACTACAAAAAGGAGGACAACACAAAATCGATGTCCGTCACTCCCTCTCTATCGGAGAAAAGCAAGTCCGACGTGACGATCAGCAAATTGGAGACCTTTAGCGACATCAGCAAGACCAAATCGGATTCAACGCTGACCCACACCCAGGAGACGGTGGTCGATCGCGGAGACGAGAACCCTCAGGGACCTCAAGACAGAAGGCGGATATCCGAAGCTAATATAGACTTGAGCTACGTTAAACAGGATCTGGAAGAGATTATAAATGAAGCTCTTAACAGAGTGGAACAGTTGACGATTAATCATGATGATACGATGTCTGAACAAGAAGACTTCGAGAATTACAACGCTTACACGAAACCGCCGCAGTATTTCCAGTATTTCCCTTACAGCATCGAGCTGTCAGACATACTAGAGGAAGATGAGCTCTCGTATAGAGAACAGGAGTCCGACTCTTTTGTGGCGAGGAGACTAGCGGAAGAACTCCTGAACTACATCGAAGCGAAAGTGGAACGGCATTTCGATGATTCAGAATTCGATTTGAGTCCGGTCAAGCGTTCGTCGAGCCTCATAGACTTGAGGTCGATTCCGGATCTGCCGCCGAGCATGATCATCAAGCCGAGGGTCGCGAGAATGAATCGATCGACTTCGACCACGGAGATTTCCGATTCGAATTCCGATTTGTCCAGGAGGATGGACTCCGGTTGTATGACCGAAGACACCACCCTGAGTTCAAGTTCGGAGAGAAATGAGAGGGCTCTTGATAAATTAGAGTCATTGCACAAGTTCTTCTCCAAATCTAGACTAGAAATCATTGATGAAAGCGATGAACACCTCGATAAAGCCAAGTCTAGGAGGCGTTCTAAGGTTAAAAGCGCAGACCTGAATGTAGACCAATCAAGTTTAGACGACGTGGAAGATTTGCAAGCGGATAATGAATCGAAAGATAAAGACCAAAAGAAAGCCAAAAACATAGACATCGCGGAAGATATCAGAACTGAAAAAGCAATGGAAACGTGCGAAAAATAA

Protein

MEDKSGRTSLSFYQGFRRSEGDGESSSVKHSTRKRSNQIARELSDMVIYVQAIKFRGLNPLSPKSSIRQPKSKETAPSSFESSESSDSTSAQIAQGTRPRCLNAPAVHHPCYRCSSVNEAIGKKICRKHPVALIAHTETQLVRTYPAGIRIDSSNFDPVTFWACGVQMVALNYQTEDAAMAINAAMYESNGCLGYVRKPIVMWDPSHIAYRRFNPMDKEFDGIHASHLTLAVISGQYVAENVYSFYNAFVEVEILGVPADCRKIRTKVARRNALNPVWNETFNFKINFPELAFVRFEIYDADTNYMLSQRVIPLHCLRPGYRHVRLRSPTNQPLNMASLFIFSRCSEELAGESCRNDLDSNSPHERLKIHFIVVYAVSRNEPYSILKVTQDTTANEAIAQCLAKGGLCGSSRGSYVLVEECRGNARQRVLAPHERVLRAGNSRLLLKRVGDDPSSRAWLTSIRSTSSDRNKDRSVPSDEESAQDDEPRRADSYLVCVHNVSHEIPYAILKVPLGATASFVVHQALTKARCQEDPKRFVLVEELEWGGRAGGGPQQRALADDEVVYAAQASWKTLGRFVLQEKGSSAPLPRHRAAIARIQRGLSITKGAFTGNAGFPIGSFGSSETPEGKTPVQTAYSDPTHCRRLSTAPLGKGIERAKGHSDKDFRTYMQRRQGCREVHSEGETVWQVLRRLGNSLANHRASLSSELGSLWDFFKIERDRRRSATTTTYEPILTESKSPVKLARDLLQVIQETVFTKKDDEPKRCPLVKEESDLSSEEDEGTDSRIANLIDFFFTIVKSQKEDRKGSGGSCFKSEASPDEARELPKKVNRELEEKMDTLMEFLATTGCMNKEDQTQKEGKKITLMEFLFGVEERKMEIVEPKSLSLSESNVNVKLCYIDETPNEDGTESFVEILLKYMEDYKKEDNTKSMSVTPSLSEKSKSDVTISKLETFSDISKTKSDSTLTHTQETVVDRGDENPQGPQDRRRISEANIDLSYVKQDLEEIINEALNRVEQLTINHDDTMSEQEDFENYNAYTKPPQYFQYFPYSIELSDILEEDELSYREQESDSFVARRLAEELLNYIEAKVERHFDDSEFDLSPVKRSSSLIDLRSIPDLPPSMIIKPRVARMNRSTSTTEISDSNSDLSRRMDSGCMTEDTTLSSSSERNERALDKLESLHKFFSKSRLEIIDESDEHLDKAKSRRRSKVKSADLNVDQSSLDDVEDLQADNESKDKDQKKAKNIDIAEDIRTEKAMETCEK

Catalytic Activity

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)

Feature

chain Phosphoinositide phospholipase C

Uniprot

H9JJA3 A0A2H1VHU8 A0A0N1PIP4 A0A2A4K3D1 A0A2W1BFX9

EC Number

3.1.4.11

Pubmed

19121390 26354079 28756777

EMBL

BABH01036346 BABH01036347 BABH01036348 BABH01036349 ODYU01002410 SOQ39854.1 + More
KQ460857 KPJ11820.1 NWSH01000206 PCG78428.1 KZ150174 PZC72584.1

Proteomes

UP000005204 UP000053240 UP000218220

PRIDE

H9JJA3

Pfam

PF00788   RA        + More
PF00387   PI-PLC-Y
PF00168   C2
PF00388   PI-PLC-X
PF09279   EF-hand_like

Interpro

IPR017946   PLC-like_Pdiesterase_TIM-brl        + More
IPR029071   Ubiquitin-like_domsf
IPR001192   PI-PLC_fam
IPR001711   PLipase_C_Pinositol-sp_Y
IPR000159   RA_dom
IPR035892   C2_domain_sf
IPR028398   PLC-epsilon1
IPR000008   C2_dom
IPR000909   PLipase_C_PInositol-sp_X_dom
IPR015359   PLC_EF-hand-like
IPR011992   EF-hand-dom_pair

SUPFAM

SSF54236   SSF54236        + More
SSF51695   SSF51695
SSF47473   SSF47473

Gene 3D

2.60.40.150 3.20.20.190

ProteinModelPortal

H9JJA3 A0A2H1VHU8 A0A0N1PIP4 A0A2A4K3D1 A0A2W1BFX9

PDB

4QJ5 E-value=8.4774e-40, Score=416

KEGG

101735646 K05860 phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11] | (RefSeq) 1-phosphatidylinositol

PATHWAY

00562    Inositol phosphate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04070    Phosphatidylinositol signaling system - Bombyx mori (domestic silkworm)
04933    AGE-RAGE signaling pathway in diabetic complications - Bombyx mori (domestic silkworm)

GO

GO:0035556 GO:0004435 GO:0006629 GO:0016042 GO:0005515 GO:0007165 GO:0008081 GO:0005234 GO:0003824 GO:0008152 GO:0016491 GO:0015930

PANTHER

PTHR10336 PTHR10336:SF6

Length:

1260

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00869999999999999

Exp number, first 60 AAs:

0.00083

Total prob of N-in:

0.00045

outside

1 - 1260

Pi

223.118328

Theta

145.748287

Tajima's D

1.617908

CLR

0.181707

CSRT

0.814259287035648

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics