Silkworm Genome Informatics Database

Gene

KWMTBOMO14655

Annotation

PREDICTED:_1-phosphatidylinositol_4?5-bisphosphate_phosphodiesterase_epsilon-1-like_[Bombyx_mori]

Location

Bomo_Chr24(+):12070972-12076206 View in EpiBrowser

Full name

Phosphoinositide phospholipase C

Location in the cell

Nuclear Reliability : 2.91

CDS

ATGCAGGTGCTATTAACGGGATGCCGTTGCGTCGAGCTGGACTGCTGGGACGGCGACGATGGAAACCCTGTCATCTACCACGGCCACACTTTCACGACGAAAATTCAGTTCCGTCGAGTTGTTGAAACTATTGCGAGGAGCGCGTTCGTTGCATCACCGTACCCCCTGATTTTGAGTATTGAGAACCATTGCAGTCTCCCGCAACAACAAGTTATGGCCAGCACATTTGAGGCAGTTTTCGGAGACAAACTGGTCACGTCGTTTTTATTCGAAGTCGACTATACAGACGAACCGAGACTCCCTAGTCCGGAGCGACTAAAATATAAGGTCCTCATCAAGAATAAGAAGCTACTGCCATTCGAATCGAGTCCCACAGTAGGCTTGGGGGCCAGCTCATCCCAGGGCTACGGGGGCGTGCTGACCACCCCCAGCAGTGCGAGGACGAATGAGAAGCCAGCCACCGCGTCGCTACCAGATAGCAACCGGACCAGTTCCGGAGTCTCCCAGCAGTCAGGAAGCTCGCTGACCGAATACTTCTCCGACGAAGACTACGAGGAAGACGACGACGATATCGATGGTAAAATAGAAGCTGCAAAGTTTACGTGA

Protein

MQVLLTGCRCVELDCWDGDDGNPVIYHGHTFTTKIQFRRVVETIARSAFVASPYPLILSIENHCSLPQQQVMASTFEAVFGDKLVTSFLFEVDYTDEPRLPSPERLKYKVLIKNKKLLPFESSPTVGLGASSSQGYGGVLTTPSSARTNEKPATASLPDSNRTSSGVSQQSGSSLTEYFSDEDYEEDDDDIDGKIEAAKFT

Catalytic Activity

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)

Feature

chain Phosphoinositide phospholipase C

Uniprot

A0A2W1BFR6 A0A2W1BFM6 A0A2A4K3D1 A0A0N1PIP4 A0A2H1VHU8 A0A023F1J6 + More
A0A336M8P5 A0A0A9XDT7 J9K7P1 A0A087TCF5 A0A2S2PSY0

EC Number

3.1.4.11

Pubmed

28756777 26354079 25474469 25401762

EMBL

KZ150174 PZC72585.1 KZ150594 PZC70473.1 NWSH01000206 PCG78428.1 + More
KQ460857 KPJ11820.1 ODYU01002410 SOQ39854.1 GBBI01003544 JAC15168.1 UFQS01000490 UFQT01000490 SSX04363.1 SSX24727.1 GBHO01028344 JAG15260.1 ABLF02037697 ABLF02037701 ABLF02051407 KK114576 KFM62794.1 GGMR01019825 MBY32444.1

Proteomes

UP000218220 UP000053240 UP000007819 UP000054359

Pfam

PF00388   PI-PLC-X        + More
PF00168   C2
PF00387   PI-PLC-Y
PF00788   RA
PF09279   EF-hand_like
PF00617   RasGEF
PF00373   FERM_M
PF13606   Ank_3

Interpro

IPR001192   PI-PLC_fam        + More
IPR028398   PLC-epsilon1
IPR017946   PLC-like_Pdiesterase_TIM-brl
IPR000909   PLipase_C_PInositol-sp_X_dom
IPR029071   Ubiquitin-like_domsf
IPR000008   C2_dom
IPR001711   PLipase_C_Pinositol-sp_Y
IPR035892   C2_domain_sf
IPR000159   RA_dom
IPR015359   PLC_EF-hand-like
IPR011992   EF-hand-dom_pair
IPR001895   RASGEF_cat_dom
IPR036964   RASGEF_cat_dom_sf
IPR023578   Ras_GEF_dom_sf
IPR036770   Ankyrin_rpt-contain_sf
IPR016024   ARM-type_fold
IPR020683   Ankyrin_rpt-contain_dom
IPR011989   ARM-like
IPR019748   FERM_central
IPR002110   Ankyrin_rpt
IPR011993   PH-like_dom_sf
IPR019749   Band_41_domain

SUPFAM

SSF51695   SSF51695        + More
SSF54236   SSF54236
SSF47473   SSF47473
SSF48366   SSF48366
SSF48403   SSF48403
SSF48371   SSF48371

Gene 3D

3.20.20.190 2.60.40.150 1.10.840.10 1.25.10.10 1.25.40.20 2.30.29.30

CDD

cd00204 ANK
cd14473 FERM_B-lobe

ProteinModelPortal

A0A2W1BFR6 A0A2W1BFM6 A0A2A4K3D1 A0A0N1PIP4 A0A2H1VHU8 A0A023F1J6 + More
A0A336M8P5 A0A0A9XDT7 J9K7P1 A0A087TCF5 A0A2S2PSY0

PDB

3QR0 E-value=4.64489e-29, Score=315

KEGG

101735646 K05860 phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11] | (RefSeq) 1-phosphatidylinositol

GO

GO:0035556 GO:0004435 GO:0016042 GO:0007264 GO:0005085 GO:0016021 GO:0006629 GO:0008081 GO:0006281 GO:0016020 GO:0004970 GO:0005234 GO:0003824 GO:0008152 GO:0016491 GO:0015930

PANTHER

PTHR10336 PTHR10336:SF6

Length:

201

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02595

Exp number, first 60 AAs:

0.02034

Total prob of N-in:

0.10832

outside

1 - 201

Pi

215.73885

Theta

158.004452

Tajima's D

1.078674

CLR

0.018732

CSRT

0.68011599420029

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics