Gene

KWMTBOMO14652

Pre Gene Modal

BGIBMGA009602

Annotation

PREDICTED:_1-phosphatidylinositol_4?5-bisphosphate_phosphodiesterase_epsilon-1-like_[Bombyx_mori]

Location

Bomo_Chr24(+):12037552-12043766      View in EpiBrowser

Full name

Phosphoinositide phospholipase C      

Location in the cell

Mitochondrial   Reliability : 1.665 Nuclear   Reliability : 1.291

CDS

ATGTGCTTACGAAGACTAGAGAACAGTGAACGTTTTTGGGAGAATCTGAAGCACCTTCGGGCCGGATCCGTCGGCTACGACACTCAGCTGGATTTCATGGGCTTCGTGGCTCTGTTCAGAAGCTTCAGCTTGGCGATGCGTTCTGAACTAAGAGAAGTCTTTGAGCAACTGGCCGTGCCAAGGCTGAACACCCAGCTCCTCGGCGAGAAGAGCAGGAGCTCACCAGAGCTGTTCCGAAACAGAGCTGTCTTTAGGACCGGCCTACTCACAAGGAACGGGTCTTTGGACTTAGAACCGCCCACCGACAAAGCTAGCAGGAAGAAAGCCTTCGATCTTTTGGCCGGTGCGGCCCTGCCAGGTAGTACCAGTCCTGATGTGAGCGGGCGTGTCCTGTCGCTACCCACCCTTGGAAAGTTCTGCGAGGCCAGACAAATGGAACCGAAAACCGAGCAGCAACTGAAGGAAATAATCCAGAGGCACGAACCGGACCCGTTGCTGAGGGCTGACCACTGCCTCTCCTTCGAGGGTTTCGTGAGGTTTCTAACGGACAAGGACAACTATGCCTTCGTCCCTGAGCAGAGAAGGGCTTCTAATTTCAACACGTAA

Protein

MCLRRLENSERFWENLKHLRAGSVGYDTQLDFMGFVALFRSFSLAMRSELREVFEQLAVPRLNTQLLGEKSRSSPELFRNRAVFRTGLLTRNGSLDLEPPTDKASRKKAFDLLAGAALPGSTSPDVSGRVLSLPTLGKFCEARQMEPKTEQQLKEIIQRHEPDPLLRADHCLSFEGFVRFLTDKDNYAFVPEQRRASNFNT

Catalytic Activity

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)

Uniprot

H9JJA1   A0A2W1BHB2   A0A2A4K333   A0A0N1PIP4   A0A1B0EZW8   A0A1L8DL28   + More
A0A1L8DL80   A0A182J671   A0A1B0CFK7   A0A336M8P5   A0A182SJ13   W5J883   A0A182MIL3   A0A182TG27   A0A182P033   A0A182FRJ5   A0A182VWU0   A0A182RS41   A0A182YHP2   A0A0L7KPV3   A0A182HST1   A0A182NRP4   A0A182XAX7   A0A182LEV3   A0A182QPJ9   A0A182VKE3   Q5TTU0   A0A084VXW7   A0A182JUB0   A0A2J7R6W3   B0XGN4   A0A067RBS2   A0A2P8YCC3   U4U4H8   A0A1B6GN38   A0A1B6JTA7   A0A1B6MER0   A0A139WMF0   A0A1B6IR25   A0A1B6I7B9   A0A146LS52   A0A1Y1NIH4   A0A139WM82   A0A1J1HRK1   A0A0T6BI83   A0A0A9XDT7   A0A0C9RDT3   A0A023F1J6   A0A0L7RKT9   K7J244   A0A158P3S7   A0A195BCR6   F4X1Z1   A0A195FJD8   E2AJ85   A0A151J5J9   A0A0J7KMI7   A0A0M9A3B5   A0A026WCL3   A0A2A3EFA3   A0A3L8DQY8   A0A087ZVV1   A0A151WF00   E9IK32   A0A1B6CP49   A0A3Q0IUA8   E2BFR6   T1I3W1   A0A2T7P992   A0A087TCF5   A0A310SS70   T1IQR7   N6TCN0   A0A3R7M0H3   A0A2R7VUI6   A0A210QRR5   V4C9H5   A0A0L8IDP4   W4XB64   T1K4Q4   A0A2A2JLJ2   J9K7P1   A0A3S3PKR4   A0A3S3P291   A0A183C4W4   A0A3P6SAM6   A0A182DWQ3   A0A044TMV5   A0A2S2NPE0   A0A1I7SA92   A0A2S2PXZ0   A0A2S2PWW2   A0A2S2PSY0   F1KPI9   A0A2H8TWL9   A0A132AJM1   A0A1S0U8F5   A0A1I7W479  

EC Number

3.1.4.11

Pubmed

19121390    28756777    26354079    20920257    23761445    25244985    + More
26227816    20966253    12364791    24438588    24845553    29403074    23537049    18362917    19820115    26823975    28004739    25401762    25474469    20075255    21347285    21719571    20798317    24508170    30249741    21282665    28812685    23254933    22919073    21909270    21685128    26555130    25217238   

EMBL

BABH01036342    KZ150174    PZC72587.1    NWSH01000206    PCG78426.1    KQ460857    + More
KPJ11820.1    AJVK01019252    AJVK01019253    AJVK01019254    AJVK01019255    GFDF01006932    JAV07152.1    GFDF01006882    JAV07202.1    AJWK01010146    AJWK01010147    AJWK01010148    AJWK01010149    UFQS01000490    UFQT01000490    SSX04363.1    SSX24727.1    ADMH02002105    ETN58994.1    AXCM01011683    JTDY01007699    KOB65004.1    APCN01000337    APCN01000338    APCN01000339    AXCN02000007    AAAB01008859    EAL40899.4    ATLV01018208    KE525224    KFB42811.1    NEVH01006749    PNF36577.1    DS233046    EDS27728.1    KK852805    KDR16109.1    PYGN01000708    PSN41893.1    KB631924    ERL87253.1    GECZ01005948    JAS63821.1    GECU01005252    JAT02455.1    GEBQ01005573    JAT34404.1    KQ971316    KYB28995.1    GECU01018330    JAS89376.1    GECU01024875    JAS82831.1    GDHC01007986    JAQ10643.1    GEZM01003608    JAV96680.1    KYB28994.1    CVRI01000017    CRK90154.1    LJIG01000065    KRT86875.1    GBHO01028344    JAG15260.1    GBYB01006500    JAG76267.1    GBBI01003544    JAC15168.1    KQ414570    KOC71351.1    ADTU01008417    ADTU01008418    ADTU01008419    ADTU01008420    ADTU01008421    KQ976524    KYM81985.1    GL888558    EGI59527.1    KQ981523    KYN40481.1    GL439967    EFN66525.1    KQ979970    KYN18394.1    LBMM01005498    KMQ91469.1    KQ435775    KOX74989.1    KK107293    EZA53416.1    KZ288262    PBC30398.1    QOIP01000005    RLU22706.1    KQ983227    KYQ46424.1    GL763924    EFZ19046.1    GEDC01022052    JAS15246.1    GL448039    EFN85454.1    ACPB03010600    PZQS01000005    PVD29971.1    KK114576    KFM62794.1    KQ760538    OAD59996.1    JH431313    APGK01035466    APGK01035467    APGK01035468    APGK01035469    KB740925    ENN78054.1    QCYY01002694    ROT68308.1    KK854094    PTY11162.1    NEDP02002268    OWF51423.1    KB201262    ESO98394.1    KQ416011    KOF99130.1    AAGJ04143679    CAEY01001579    LIAE01010359    PAV62554.1    ABLF02037697    ABLF02037701    ABLF02051407    NCKU01006638    RWS03296.1    NCKU01006850    NCKU01004063    RWS03101.1    RWS06500.1    UYRX01000080    VDK72952.1    UYRW01000006    VDK61164.1    CMVM020000149    GGMR01006422    MBY19041.1    GGMS01001173    MBY70376.1    GGMS01000647    MBY69850.1    GGMR01019825    MBY32444.1    JI163817    ADY39793.1    GFXV01005753    MBW17558.1    JXLN01016687    KPM11218.1    JH712538    EFO26855.2   

Proteomes

UP000005204    UP000218220    UP000053240    UP000092462    UP000075880    UP000092461    + More
UP000075901    UP000000673    UP000075883    UP000075902    UP000075885    UP000069272    UP000075920    UP000075900    UP000076408    UP000037510    UP000075840    UP000075884    UP000076407    UP000075882    UP000075886    UP000075903    UP000007062    UP000030765    UP000075881    UP000235965    UP000002320    UP000027135    UP000245037    UP000030742    UP000007266    UP000183832    UP000053825    UP000002358    UP000005205    UP000078540    UP000007755    UP000078541    UP000000311    UP000078492    UP000036403    UP000053105    UP000053097    UP000242457    UP000279307    UP000005203    UP000075809    UP000079169    UP000008237    UP000015103    UP000245119    UP000054359    UP000019118    UP000283509    UP000242188    UP000030746    UP000053454    UP000007110    UP000015104    UP000218231    UP000007819    UP000285301    UP000050741    UP000277928    UP000077448    UP000271087    UP000024404    UP000095284    UP000095285   

PRIDE

H9JJA1   

Pfam

PF09279   EF-hand_like        + More
PF00388   PI-PLC-X
PF00788   RA
PF00168   C2
PF00387   PI-PLC-Y
PF00617   RasGEF
PF00373   FERM_M
PF13606   Ank_3
PF04968   CHORD
PF04969   CS
PF00023   Ank

Interpro

IPR000909   PLipase_C_PInositol-sp_X_dom        + More
IPR015359   PLC_EF-hand-like       
IPR017946   PLC-like_Pdiesterase_TIM-brl       
IPR001192   PI-PLC_fam       
IPR028398   PLC-epsilon1       
IPR011992   EF-hand-dom_pair       
IPR023578   Ras_GEF_dom_sf       
IPR035892   C2_domain_sf       
IPR029071   Ubiquitin-like_domsf       
IPR000008   C2_dom       
IPR001711   PLipase_C_Pinositol-sp_Y       
IPR000159   RA_dom       
IPR036964   RASGEF_cat_dom_sf       
IPR001895   RASGEF_cat_dom       
IPR019748   FERM_central       
IPR008937   Ras-like_GEF       
IPR019749   Band_41_domain       
IPR018247   EF_Hand_1_Ca_BS       
IPR002110   Ankyrin_rpt       
IPR011993   PH-like_dom_sf       
IPR016024   ARM-type_fold       
IPR020683   Ankyrin_rpt-contain_dom       
IPR014352   FERM/acyl-CoA-bd_prot_sf       
IPR036770   Ankyrin_rpt-contain_sf       
IPR011989   ARM-like       
IPR007051   CHORD_dom       
IPR008978   HSP20-like_chaperone       
IPR007052   CS_dom       
IPR035963   FERM_2       

SUPFAM

SSF47473   SSF47473        + More
SSF51695   SSF51695       
SSF48366   SSF48366       
SSF54236   SSF54236       
SSF48371   SSF48371       
SSF48403   SSF48403       
SSF49764   SSF49764       
SSF47031   SSF47031       

Gene 3D

3.20.20.190     2.60.40.150     1.10.840.10     1.20.80.10     2.30.29.30     1.25.10.10     1.25.40.20     2.60.40.790    

CDD

cd14473  FERM_B-lobe
cd00204  ANK

ProteinModelPortal

H9JJA1   A0A2W1BHB2   A0A2A4K333   A0A0N1PIP4   A0A1B0EZW8   A0A1L8DL28   + More
A0A1L8DL80   A0A182J671   A0A1B0CFK7   A0A336M8P5   A0A182SJ13   W5J883   A0A182MIL3   A0A182TG27   A0A182P033   A0A182FRJ5   A0A182VWU0   A0A182RS41   A0A182YHP2   A0A0L7KPV3   A0A182HST1   A0A182NRP4   A0A182XAX7   A0A182LEV3   A0A182QPJ9   A0A182VKE3   Q5TTU0   A0A084VXW7   A0A182JUB0   A0A2J7R6W3   B0XGN4   A0A067RBS2   A0A2P8YCC3   U4U4H8   A0A1B6GN38   A0A1B6JTA7   A0A1B6MER0   A0A139WMF0   A0A1B6IR25   A0A1B6I7B9   A0A146LS52   A0A1Y1NIH4   A0A139WM82   A0A1J1HRK1   A0A0T6BI83   A0A0A9XDT7   A0A0C9RDT3   A0A023F1J6   A0A0L7RKT9   K7J244   A0A158P3S7   A0A195BCR6   F4X1Z1   A0A195FJD8   E2AJ85   A0A151J5J9   A0A0J7KMI7   A0A0M9A3B5   A0A026WCL3   A0A2A3EFA3   A0A3L8DQY8   A0A087ZVV1   A0A151WF00   E9IK32   A0A1B6CP49   A0A3Q0IUA8   E2BFR6   T1I3W1   A0A2T7P992   A0A087TCF5   A0A310SS70   T1IQR7   N6TCN0   A0A3R7M0H3   A0A2R7VUI6   A0A210QRR5   V4C9H5   A0A0L8IDP4   W4XB64   T1K4Q4   A0A2A2JLJ2   J9K7P1   A0A3S3PKR4   A0A3S3P291   A0A183C4W4   A0A3P6SAM6   A0A182DWQ3   A0A044TMV5   A0A2S2NPE0   A0A1I7SA92   A0A2S2PXZ0   A0A2S2PWW2   A0A2S2PSY0   F1KPI9   A0A2H8TWL9   A0A132AJM1   A0A1S0U8F5   A0A1I7W479  

PDB

2ISD     E-value=0.0355463,     Score=83

KEGG

101735646    K05860 phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11] | (RefSeq) 1-phosphatidylinositol

GO

GO:0008081   GO:0035556   GO:0006629   GO:0004435   GO:0016042   GO:0005085   GO:0007264   GO:0003964   GO:0004519   GO:0017016   GO:0007265   GO:0048015   GO:0032959   GO:0051209   GO:0005623   GO:0007165   GO:0016021   GO:0005886   GO:1902634   GO:0050830   GO:0008340   GO:0042307   GO:0005095   GO:0002253   GO:1902477  

PANTHER

PTHR10336:SF6   PTHR10336   PTHR23113  

Length:

201

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.31666

Exp number, first 60 AAs:

0.315

Total prob of N-in:

0.14056

outside

1  -  201

 

 

Pi

255.588161

Theta

148.967239

Tajima's D

2.647815

CLR

0.033681

CSRT

0.95795210239488

Interpretation

Uncertain