Gene

KWMTBOMO14650

Pre Gene Modal

BGIBMGA009601

Annotation

PREDICTED:_1-phosphatidylinositol_4?5-bisphosphate_phosphodiesterase_epsilon-1-like_[Bombyx_mori]

Location

Bomo_Chr24(+):11988012-12033846      View in EpiBrowser

Full name

Phosphoinositide phospholipase C      

Location in the cell

Nuclear   Reliability : 2.302

CDS

ATGCGAGAAGGGTCCAAGCCTGGGCCGAGTGGTGCCTCAACGGGGCTTGGTAACGACAATAATGGCTTATGGAACGAAAGCAGCTTCGAAGAGCTTACGTCTTTAAAAGCTTTGCTACATTTCCCTGAAGAAGTTGCTTTGAGACTGACCGACACAGAATATCAGCTGTTTTACCAGGTATCAGCGTGGGTCACGGAGCTTGTCTTAGCTAGCGGGTCACAGGAGGACCGGAAGGCGGCTCTCGCCTGCGTTCTCCGGGTAGCCCTGACCTGCTGGAACATCGGGAATTTCAACAGCGCCATGGAAATCGTCGCGGGACTGAAATCAACGAAACTTAAAGCCTTCTGGCTGAGCGTGTCTGATGAGCCTCTACCCTCGCTGGACTTCCTCTCGGCGGCCCTGCTCTCGGCAGAATACGAGAGGGCGTTGAGCAGAGCCCTCGCCATGCAAGAGTGCAGATTAATACCATTCTTCGGTGCCTTCCTGAGAGAACTAAGAGAGATTTTGGCTGCAACTCCATCTCTTACCAGCACCCCAACACACAGGAGAGACTTCAAAAGGGACTCGTTGAGAGACGATAGGGGCTCATTAAAGAAAGACCCGAAAAGAGAAAGTGGGAAGCGCGCAGACCAAGGCACCGCGAACAGTTCTCCACGGGAGAGCTGCAAAAGAGATCCCAGGCTTAATGAACAGAATCGACAAGTCTACATTGCGTCGTTCGATGAAGACGGCGACCAGACTCCAGGGTGGAGGCGCGTTGGCCCCGAGGGTCTCGTGAACTTGGAGAAGGTTTACAGGACCCAGGCAGTGATGGACCACATAGCAAGCTTCCACCAGCACCACTACCTGTTGTCCAGAACCCACACGCCCGTCTTCGGAGATTACTTAAGAACAGCTCTAGCATCCTGCGAGGATCCGGTCTTTTCGCAGACAGCTCAGAAGACAAGCGGCTGTGACTTCGAAAACGAGGCCCTCTACGAGCTGGAAGGCGGCGGCTACAGTCCTGTTCAGCCGTTACCGCATGACCACGGAGTCACTATGTTTCCTCTGGCCCCGCAGAATGGAGAAAGAATAGATAGGCATGTATTGCAGATTCTGCATCACGGTACCACGTGCGTGGTAGGAGATTCAGAGTGGAGCGGGAACCTAGCTCATTTGAGGTTAGAGAGAGCCTGCGCTCTACTCTCGTGGACCAGAACAAGTCACAGACCCCATAGCTGTCACGGTGAAACCCCATCAGACAACGTTCAGCAATCTGAAATCAGCTTCTCATACAACCCCGAGGAAGTCATCCCGTTGAAGTACACAGCGAATATACATGAAAACGAAGCGGGGGTGGTCGGAGAAGAGGGGTTCATCGATCTCCAATGCGTGAAGGACATGAGACTGAATGGGAGATTACTAGATTCAAGAGACGCTTCGGAGCTGACCTCCTGCGCTAAGAGACACGGCCTGGACTGCTCCAGCGGACCCAACATAATTTCTCTGGTCTACGGAAGGACGTTGAGTGACAACCGTATTGTGCATTTCGTGCTTCCTACGTATTCATATAAGGTCTGGGCTATTGGACTTCATTCGGTGATCAGGGCCCTCATGAGCCAAGAGAAGCTTGCCGACAGGAGTTTGACGTGGCTGAAAAACAAATACACGGCCTTGTACTATGAAGACGGATGCTGCTGCGAGCCATTGGTATCAGACGCCATTCGGGTCTTCGGAGGAAGAGAGTCGGCATACGGCAGCTCTTCTCACTCGACTCCCGTGAAAGGAACATGCTCCGATTCTCATACTGACTCCTCCAGAAGTTCTGGGATTAAATTCAAGAAGAACAAGTCTACGTCAGAACTGAAGAGTTCTCCAAAGAGCTACGGGTCCCACGCGTCTGGAGCGAGAAGCGAAGACGAGATCCATGGTTCTCCCAGACACAGCATGTATTCTACGATGAGCTACCACCACCACTGCCCCCCACGACACAACAGCTTGACAATGGCTTCTTCCAGCATAGCGACTAGCTCCCCAAACAGGAGTAGGTAA

Protein

MREGSKPGPSGASTGLGNDNNGLWNESSFEELTSLKALLHFPEEVALRLTDTEYQLFYQVSAWVTELVLASGSQEDRKAALACVLRVALTCWNIGNFNSAMEIVAGLKSTKLKAFWLSVSDEPLPSLDFLSAALLSAEYERALSRALAMQECRLIPFFGAFLRELREILAATPSLTSTPTHRRDFKRDSLRDDRGSLKKDPKRESGKRADQGTANSSPRESCKRDPRLNEQNRQVYIASFDEDGDQTPGWRRVGPEGLVNLEKVYRTQAVMDHIASFHQHHYLLSRTHTPVFGDYLRTALASCEDPVFSQTAQKTSGCDFENEALYELEGGGYSPVQPLPHDHGVTMFPLAPQNGERIDRHVLQILHHGTTCVVGDSEWSGNLAHLRLERACALLSWTRTSHRPHSCHGETPSDNVQQSEISFSYNPEEVIPLKYTANIHENEAGVVGEEGFIDLQCVKDMRLNGRLLDSRDASELTSCAKRHGLDCSSGPNIISLVYGRTLSDNRIVHFVLPTYSYKVWAIGLHSVIRALMSQEKLADRSLTWLKNKYTALYYEDGCCCEPLVSDAIRVFGGRESAYGSSSHSTPVKGTCSDSHTDSSRSSGIKFKKNKSTSELKSSPKSYGSHASGARSEDEIHGSPRHSMYSTMSYHHHCPPRHNSLTMASSSIATSSPNRSR

Catalytic Activity

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)

Uniprot

A0A3S2LXU3   H9JJA0   A0A2A4K333   A0A2W1BC88   A0A2P8YCC3   A0A067RBS2   + More
A0A1Y1NIH4   A0A139WM82   A0A2J7R6X2   A0A1B6IR25   A0A1B6JTA7   A0A1B6MER0   A0A1B6I7B9   A0A023F1J6   A0A1B6CP49   A0A0A9XDT7   T1I3W1   A0A3R7M0H3   A0A2J7R6X1   A0A0M9A3B5   A0A0L7RKT9   A0A182LEV3   Q5TTU0   T1IQR7   A0A182P033   A0A182NRP4   A0A182XAX7   A0A087ZVV1   A0A2A3EFA3   A0A182VKE3   A0A084VXW7   E2AJ85   A0A195FJD8   A0A151J5J9   F4X1Z1   B0XGN4   A0A182FRJ5   E2BFR6   B7PYJ2   A0A0C9RDT3   A0A087TCF5   A0A2S2PXZ0   A0A1S3JD61   A0A2S2PWW2   A0A226DIW3   A0A336M8P5   K1PM95   V4C9H5   A0A210QRR5   J9K7P1   A0A2S2NPE0   A0A1B6GN38   A0A2C9KBQ5   A0A2C9KBQ6   A0A2H8TWL9   A0A016TVM0   A0A016TUI5   A0A016TUU9   A0A158P3S7   A0A195BCR6   A0A182YHP2   A0A158Q9V1   A0A3L8DQY8   F1KPI9   A0A1I8CME4   A0A090LM46   A0A0N5BH47   A0A158R571   A0A0K0DZ03   A0A183V5M9   A0A0N4TN26   A0A0N5A3Q4   A0A1I9G546   A0A158PZ74   A0A0K0EXP6   A0A183H1J8   A0A1I7Z066   A0A1I8EC77   A0A1I7Z0P3   A0A1S0U8F5   A0A0P6FXN4   A0A3S3PKR4   A0A0P5LYG8   A0A0P5AH12   A0A158Q7B3   A0A0P5UWN8   A0A0P5WQV4   A0A0N8AEQ3   A0A0P5AVV8   A0A0P5XEW8   A0A0N8CYE7   A0A0P5BWH2  

EC Number

3.1.4.11

Pubmed

19121390    28756777    29403074    24845553    28004739    18362917    + More
19820115    25474469    25401762    20966253    12364791    24438588    20798317    21719571    22992520    23254933    28812685    15562597    25730766    21347285    25244985    30249741    21685128    26829753    17885136    26392177    26850696   

EMBL

RSAL01000128    RVE46490.1    BABH01036339    BABH01036340    NWSH01000206    PCG78426.1    + More
KZ150174    PZC72588.1    PYGN01000708    PSN41893.1    KK852805    KDR16109.1    GEZM01003608    JAV96680.1    KQ971316    KYB28994.1    NEVH01006749    PNF36582.1    GECU01018330    JAS89376.1    GECU01005252    JAT02455.1    GEBQ01005573    JAT34404.1    GECU01024875    JAS82831.1    GBBI01003544    JAC15168.1    GEDC01022052    JAS15246.1    GBHO01028344    JAG15260.1    ACPB03010600    QCYY01002694    ROT68308.1    PNF36581.1    KQ435775    KOX74989.1    KQ414570    KOC71351.1    AAAB01008859    EAL40899.4    JH431313    KZ288262    PBC30398.1    ATLV01018208    KE525224    KFB42811.1    GL439967    EFN66525.1    KQ981523    KYN40481.1    KQ979970    KYN18394.1    GL888558    EGI59527.1    DS233046    EDS27728.1    GL448039    EFN85454.1    ABJB010015881    ABJB010050012    ABJB010216624    ABJB010402176    ABJB010439564    ABJB010459220    ABJB010540979    ABJB010700814    ABJB010965794    ABJB010984630    DS820282    EEC11664.1    GBYB01006500    JAG76267.1    KK114576    KFM62794.1    GGMS01001173    MBY70376.1    GGMS01000647    MBY69850.1    LNIX01000017    OXA45472.1    UFQS01000490    UFQT01000490    SSX04363.1    SSX24727.1    JH816643    EKC20004.1    KB201262    ESO98394.1    NEDP02002268    OWF51423.1    ABLF02037697    ABLF02037701    ABLF02051407    GGMR01006422    MBY19041.1    GECZ01005948    JAS63821.1    GFXV01005753    MBW17558.1    JARK01001412    EYC06423.1    EYC06421.1    EYC06422.1    ADTU01008417    ADTU01008418    ADTU01008419    ADTU01008420    ADTU01008421    KQ976524    KYM81985.1    UXUI01007465    VDD87741.1    QOIP01000005    RLU22706.1    JI163817    ADY39793.1    LN609530    CEF70920.1    UYWY01023291    VDM47370.1    UZAD01013167    VDN91021.1    LN857014    CDQ00688.1    UZAJ01000621    VDO29230.1    JH712538    EFO26855.2    GDIQ01041442    JAN53295.1    NCKU01006638    RWS03296.1    GDIQ01172391    JAK79334.1    GDIP01199258    JAJ24144.1    GDIP01109117    JAL94597.1    GDIP01095469    JAM08246.1    GDIP01154713    JAJ68689.1    GDIP01207557    JAJ15845.1    GDIP01085421    JAM18294.1    GDIP01086671    JAM17044.1    GDIP01183108    JAJ40294.1   

Proteomes

UP000283053    UP000005204    UP000218220    UP000245037    UP000027135    UP000007266    + More
UP000235965    UP000015103    UP000283509    UP000053105    UP000053825    UP000075882    UP000007062    UP000075885    UP000075884    UP000076407    UP000005203    UP000242457    UP000075903    UP000030765    UP000000311    UP000078541    UP000078492    UP000007755    UP000002320    UP000069272    UP000008237    UP000001555    UP000054359    UP000085678    UP000198287    UP000005408    UP000030746    UP000242188    UP000007819    UP000076420    UP000024635    UP000005205    UP000078540    UP000076408    UP000038041    UP000274131    UP000279307    UP000095286    UP000035682    UP000046392    UP000046393    UP000035681    UP000050794    UP000267007    UP000038020    UP000278627    UP000038045    UP000006672    UP000035680    UP000050787    UP000095287    UP000093561    UP000285301    UP000050640   

PRIDE

H9JJA0   

Pfam

PF05485   THAP        + More
PF00617   RasGEF
PF09279   EF-hand_like
PF00388   PI-PLC-X
PF00168   C2
PF00387   PI-PLC-Y
PF00788   RA
PF00373   FERM_M
PF00023   Ank
PF12796   Ank_2
PF13606   Ank_3

Interpro

IPR001895   RASGEF_cat_dom        + More
IPR038441   THAP_Znf_sf       
IPR008937   Ras-like_GEF       
IPR023578   Ras_GEF_dom_sf       
IPR006612   THAP_Znf       
IPR015359   PLC_EF-hand-like       
IPR000909   PLipase_C_PInositol-sp_X_dom       
IPR017946   PLC-like_Pdiesterase_TIM-brl       
IPR011992   EF-hand-dom_pair       
IPR028398   PLC-epsilon1       
IPR001192   PI-PLC_fam       
IPR035892   C2_domain_sf       
IPR000008   C2_dom       
IPR029071   Ubiquitin-like_domsf       
IPR000159   RA_dom       
IPR001711   PLipase_C_Pinositol-sp_Y       
IPR036964   RASGEF_cat_dom_sf       
IPR019748   FERM_central       
IPR018247   EF_Hand_1_Ca_BS       
IPR019749   Band_41_domain       
IPR011989   ARM-like       
IPR002110   Ankyrin_rpt       
IPR036770   Ankyrin_rpt-contain_sf       
IPR016024   ARM-type_fold       
IPR020683   Ankyrin_rpt-contain_dom       
IPR011993   PH-like_dom_sf       
IPR014352   FERM/acyl-CoA-bd_prot_sf       
IPR000299   FERM_domain       
IPR035963   FERM_2       

SUPFAM

SSF48366   SSF48366        + More
SSF47473   SSF47473       
SSF51695   SSF51695       
SSF54236   SSF54236       
SSF48403   SSF48403       
SSF48371   SSF48371       
SSF47031   SSF47031       

Gene 3D

3.30.40.180     3.20.20.190     2.60.40.150     1.10.840.10     1.25.10.10     1.25.40.20     2.30.29.30     1.20.80.10    

CDD

cd14473  FERM_B-lobe
cd00204  ANK

ProteinModelPortal

A0A3S2LXU3   H9JJA0   A0A2A4K333   A0A2W1BC88   A0A2P8YCC3   A0A067RBS2   + More
A0A1Y1NIH4   A0A139WM82   A0A2J7R6X2   A0A1B6IR25   A0A1B6JTA7   A0A1B6MER0   A0A1B6I7B9   A0A023F1J6   A0A1B6CP49   A0A0A9XDT7   T1I3W1   A0A3R7M0H3   A0A2J7R6X1   A0A0M9A3B5   A0A0L7RKT9   A0A182LEV3   Q5TTU0   T1IQR7   A0A182P033   A0A182NRP4   A0A182XAX7   A0A087ZVV1   A0A2A3EFA3   A0A182VKE3   A0A084VXW7   E2AJ85   A0A195FJD8   A0A151J5J9   F4X1Z1   B0XGN4   A0A182FRJ5   E2BFR6   B7PYJ2   A0A0C9RDT3   A0A087TCF5   A0A2S2PXZ0   A0A1S3JD61   A0A2S2PWW2   A0A226DIW3   A0A336M8P5   K1PM95   V4C9H5   A0A210QRR5   J9K7P1   A0A2S2NPE0   A0A1B6GN38   A0A2C9KBQ5   A0A2C9KBQ6   A0A2H8TWL9   A0A016TVM0   A0A016TUI5   A0A016TUU9   A0A158P3S7   A0A195BCR6   A0A182YHP2   A0A158Q9V1   A0A3L8DQY8   F1KPI9   A0A1I8CME4   A0A090LM46   A0A0N5BH47   A0A158R571   A0A0K0DZ03   A0A183V5M9   A0A0N4TN26   A0A0N5A3Q4   A0A1I9G546   A0A158PZ74   A0A0K0EXP6   A0A183H1J8   A0A1I7Z066   A0A1I8EC77   A0A1I7Z0P3   A0A1S0U8F5   A0A0P6FXN4   A0A3S3PKR4   A0A0P5LYG8   A0A0P5AH12   A0A158Q7B3   A0A0P5UWN8   A0A0P5WQV4   A0A0N8AEQ3   A0A0P5AVV8   A0A0P5XEW8   A0A0N8CYE7   A0A0P5BWH2  

KEGG

101735646    K05860 phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11] | (RefSeq) 1-phosphatidylinositol

GO

GO:0005085   GO:0003677   GO:0008081   GO:0035556   GO:0006629   GO:0004435   GO:0016042   GO:0007264   GO:0048015   GO:0005623   GO:0051209   GO:0032959   GO:0017016   GO:0007265   GO:0007165   GO:0016021   GO:0005856   GO:0005095   GO:0042307   GO:1902477   GO:0002253   GO:0050830   GO:1902634   GO:0008340   GO:0006811   GO:0016020   GO:0004970   GO:0005234   GO:0003824   GO:0008152   GO:0016491   GO:0015930  

PANTHER

PTHR23113   PTHR10336:SF6   PTHR10336  

Length:

676

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.14973

Exp number, first 60 AAs:

0.00066

Total prob of N-in:

0.00283

outside

1  -  676

 

 

Pi

211.07737

Theta

168.339708

Tajima's D

1.536661

CLR

0.330783

CSRT

0.794610269486526

Interpretation

Uncertain