Gene

KWMTBOMO14644

Pre Gene Modal

BGIBMGA009568

Annotation

acyl-CoA_Delta(11)_desaturase-like_[Bombyx_mori]

Location

Bomo_Chr24(+):11812919-11817263      View in EpiBrowser

Full name

Acyl-CoA Delta(11) desaturase       + More
(11Z)-hexadec-11-enoyl-CoA conjugase      

Alternative Name

Acyl-CoA Delta-11 desaturase
Acyl-CoA Z/E11 desaturase
SlsZ/E11
Acyl-CoA Delta(11) desaturase
Acyl-CoA Z11/delta10,12 desaturase

Location in the cell

PlasmaMembrane   Reliability : 3.835

CDS

ATGTCACGATTCCAGGCGCCCTCGAATGAAGACCGCGATGACGTTTTCTCTGAAGAGGAGACACGATTGGAGAAGCTGATCGCCCCTCAAGCAGAGCCCAGGGAGTTCAAAGTGGTGTATAGGAATATAATAGTGCTTCTTTACTACCACATGGCCGGAATATACGGCCTATACCTTGGACTGATCGCAGCTAAATGGGCCACAGTAATTTCAGCATTCATTACTTACTGCATTAGTGGTATTGGAGTGACGGCAGGAAGTCACCGACTCTGGTCCCACAAGTCGTATAAAGCAACAAAACCACTGCAGCTATTCCTGATGCTGTGTCAGTCGGTGTCCAACCAACATTCGGTGGCGTATTGGGTCATGGTCCATAGACTACACCATAAATACAGCGATTCCGACGCTGATCCGCACAACGCGACCCGTGGGCTCTTTTACTCCCACATGGGATGGCTGATGGTGAGGAAGCACCCTGAAATAGAAAAAAGGGGGAAGCTGCTGGATTTGTCCGATATTTACGGAAATCCCTACCTCAAATTCCAGGACACGCATTACTATTGGTTCCTTCCGCTAATGTCGTTTTTATTGCCGACGATCATTCCTATGTACTTCTGGGGGGAGACCTGCAGCGTCGCGTGGAACGTCAACATGTGCAGATACGTCATGAACCTTAACGCCATTTTTCTGGTGAACAGCGTGGCCCATATGTGGGGATACAAGCCTTACGACAAGAACATTGCCCCTTCACAGAACCTTTCGGTGTCTGTGCTGAGCCTGGGCGAGGGCTTTCACAACTACCACCACGTCTTCCCTTGGGACTATAAGTGCGATGAATTGAGCTCGTTCAGGACCAACCCTACCACTGTATTTATAGAGCTGTGCGCGAAATTGGGGCTGGCGTATGATCTGAGGAGCGCTTCGGATGACTTGATCGAGGGTAGAGCCAAGCGGACCGGCGATGGAAGTTATCTGACCCTAAAAAAAAGTAGATAG

Protein

MSRFQAPSNEDRDDVFSEEETRLEKLIAPQAEPREFKVVYRNIIVLLYYHMAGIYGLYLGLIAAKWATVISAFITYCISGIGVTAGSHRLWSHKSYKATKPLQLFLMLCQSVSNQHSVAYWVMVHRLHHKYSDSDADPHNATRGLFYSHMGWLMVRKHPEIEKRGKLLDLSDIYGNPYLKFQDTHYYWFLPLMSFLLPTIIPMYFWGETCSVAWNVNMCRYVMNLNAIFLVNSVAHMWGYKPYDKNIAPSQNLSVSVLSLGEGFHNYHHVFPWDYKCDELSSFRTNPTTVFIELCAKLGLAYDLRSASDDLIEGRAKRTGDGSYLTLKKSR

Description

Catalyzes the formation of Delta(11) fatty acyl precursors in the pheromone gland, with a preference for myristic acid.
Catalyzes the formation of delta(11) fatty acyl precursors in the pheromone gland, and has high activity towards palmitic acid and stearic acid.
Catalyzes the formation of Delta(11) fatty acyl precursors in the pheromone gland.
Fatty acid desaturase that catalyzes 2 consecutive steps in the biosynthesis of bombykol, a sex pheromone produced by the moth. First acts as an acyl-CoA Delta(11) desaturase (1) by catalyzing the formation of Delta(11) fatty acyl precursors. Then acts as a (11Z)-hexadec-11-enoyl-CoA conjugase (2) by converting a single cis double bond at position 11 of (11Z)-hexadec-11-enoyl-CoA into conjugated 10 trans and 12 cis double bonds.

Catalytic Activity

2 [Fe(II)-cytochrome b5] + an 11,12-saturated fatty acyl-CoA + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an (11Z)-Delta(11)-fatty acyl-CoA + 2 H2O
(11Z)-hexadecenoyl-CoA + AH2 + O2 = (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O

Cofactor

Fe cation
Fe(2+)

Similarity

Belongs to the fatty acid desaturase type 1 family.

Keywords

Fatty acid biosynthesis   Fatty acid metabolism   Iron   Lipid biosynthesis   Lipid metabolism   Membrane   Metal-binding   Oxidoreductase   Transmembrane   Transmembrane helix   Endoplasmic reticulum   Complete proteome   Reference proteome  

Feature

chain  Acyl-CoA Delta(11) desaturase

Uniprot

T1RTF9   H9JJ67   B7SB73   Q2YHQ4   A0A1L8D6M1   Q8ISS3   + More
Q4A181   G8FQ78   G8FQ79   Q9NB26   G8FQ76   D2SNV3   A0A0U2F3E1   T1RU40   A8QVZ1   A0A076FRH6   A0A0U2F3F2   A0A291P0P5   G8FQ77   A0A2A4JG15   Q8MZZ2   Q6A4M5   A0A0N1PJV1   Q95VE7   A9YRX6   A0A1V0M868   Q6US81   A0A068FKA4   A9ZSZ6   Q95UJ3   M4PTD0   S4WAY4   E3UYX7   Q75PL5   E3UYX8   A0A0K2GV16   U5KFQ4   A0A0L7L2G4   O44390   B7SB74   A0A212FJD3   S4PEM6   Q7K403   Q9NGQ7   A0A212FG51   A0A1L8D6B5   B6CBS5   D8UUT5   A0A0K0N452   E3TMU8   Q2F669   W5QM97   B7SB75   B7SB76   E3TMV0   B7SB77   A0A194R0B7   A0A075BRA0   A0A1L8D6C0   A0A194PHD4   Q75PL7   T1RTD3   T1RTE1   A0A023EPC8   T1RTF5   Q9GU82   I3QPX9   Q75PL6   Q9NB25   A0A0U2F3B9   A0A291P0G3   H9JF74   H9JLG4   A0A1L8D6L2   G8FQ72   A9YRX5   A0A1E1VYJ4   A0A0U2F3B3   Q8MZZ4   G8FQ80   Q6US82   G8FQ74   A0A2H1V8Q0   G8FQ63   A0A1L8D6B6   A9ZSZ7   A0A1L8DYT8   G8FQ64   A0A0M3L9S4   Q4A182   A0A182NRU1   Q9NG28   A0A0K2GVJ8   U5KFT8   G8FQ75   Q8WPC0   Q7KEQ2   Q17G31   G8FQ73   I7B370  

EC Number

1.14.19.5
1.14.19.15

Pubmed

24500170    19121390    20403437    26417103    15455060    17517337    + More
22291612    11483431    20074338    17921252    24817326    28986331    12524345    12770579    15527989    26354079    18405835    25796477    28349297    15544945    26385554    24211206    11805319    24569486    21331247    24053512    26227816    9860961    22118469    23622113    12237399    18831750    20691782    24862548    10767556    15173596    24945155    28756777    12213232    17510324   

EMBL

JX531668    AGO45853.1    BABH01041576    BABH01041577    EU152399    FJ466456    + More
FJ466457    ABX71808.1    ACS69069.1    ACS69070.1    AM158251    CAJ43430.2    GEYN01000135    JAV01994.1    AF545481    FJ999625    AM076339    CAJ27976.2    JN022488    AER29853.1    JN022489    AER29854.1    AF272342    AAF81787.1    JN022486    AER29851.1    EZ407237    ACX53794.1    KP008117    AKU76404.1    JX531654    AGO45839.1    EF150363    ABO43722.1    KF960741    AII21943.1    KP008124    MF687587    AKU76411.1    ATJ44513.1    MF687528    ATJ44454.1    JN022487    AER29852.1    NWSH01001511    PCG71017.1    AF482908    AAM28483.2    AF518014    AAQ12891.1    KQ460301    KPJ16138.1    AF416738    AAL16642.1    EU285580    KM283200    ABX90049.1    AIU96339.1    KU755471    ARD71181.1    AY362879    KJ622051    AID66659.1    AB373030    BAF97041.1    AY049741    AAL11496.1    KC422668    AGH12217.1    JX964774    AGO96562.1    HM636633    ADP21587.1    BABH01040457    AB166853    BAD18124.1    HM636634    ADP21588.1    KP890026    ALA65425.1    JX989153    AGR49312.1    JTDY01003403    KOB69615.1    AF035375    AF297114    AF297113    EU152400    FJ466458    ABX71809.1    ACS69071.1    AGBW02008279    OWR53845.1    GAIX01006995    JAA85565.1    AY057862    AAL27033.1    AF243047    AAF44710.1    AGBW02008720    OWR52703.1    GEYN01000136    JAV01993.1    EU152335    ABX71630.1    GQ225747    GQ225749    ADE58520.1    KM378664    AKJ32408.1    GU952763    ADO85596.1    DQ311203    ABD36148.1    JQ978772    AGD98720.1    EU152401    ABX71810.1    EU152402    ABX71811.1    GU952765    ADO85598.1    EU152403    ABX71812.1    KQ460883    KPJ11142.1    JX679209    AGP26038.1    GEYN01000123    JAV02006.1    KQ459603    KPI92821.1    AF157627    AB166851    BABH01015400    AAF80355.1    BAD18122.1    JX531660    AGO45845.1    JX531667    AGO45852.1    GAPW01002266    JAC11332.1    JX531653    NWSH01001519    AGO45838.1    PCG70996.1    AF182405    AAG16901.1    JQ729998    AFK13830.1    JQ729997    AB166852    AFK13829.1    BAD18123.1    AF272343    AAF81788.1    KP008120    MF687582    AKU76407.1    ATJ44508.1    MF687527    KZ149911    ATJ44453.1    PZC78117.1    BABH01026838    BABH01026839    BABH01026840    BABH01005826    GEYN01000122    JAV02007.1    JN022482    AER29856.1    EU285579    ABX90048.1    GDQN01011259    GDQN01009722    GDQN01007857    JAT79795.1    JAT81332.1    JAT83197.1    KP008113    AKU76400.1    AF482906    AAM28481.2    JN022490    AER29859.1    AY362878    AAQ74258.1    JN022484    AER29858.1    ODYU01001259    SOQ37220.1    JN022473    AER29842.1    GEYN01000137    JAV01992.1    AB373031    BAF97042.1    GFDF01002622    JAV11462.1    JN022474    JN022475    AER29843.1    KM366791    AIM40221.1    AM076338    CAJ27975.1    AF268275    JN022476    AAF73073.1    AER29845.1    KP890029    ALA65428.1    JX989152    AGR49311.1    JN022485    AER29855.1    AF441861    AAL32060.1    AF441221    AAL35331.1    CH477266    EAT45554.1    EAT45555.1    JN022483    AER29857.1    JX126483    AFO38464.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000037510    UP000007151    UP000053268    + More
UP000075884    UP000008820   

PRIDE

T1RTF9    H9JJ67    Q75PL5    Q2F669    Q75PL7    T1RTE1    + More
Q9GU82    Q75PL6    H9JF74    H9JLG4   

Pfam

PF00487   FA_desaturase

Interpro

IPR015876   Acyl-CoA_DS        + More
IPR005804   FA_desaturase_dom       
IPR001522   FADS-1_CS       

CDD

cd03505  Delta9-FADS-like

ProteinModelPortal

T1RTF9   H9JJ67   B7SB73   Q2YHQ4   A0A1L8D6M1   Q8ISS3   + More
Q4A181   G8FQ78   G8FQ79   Q9NB26   G8FQ76   D2SNV3   A0A0U2F3E1   T1RU40   A8QVZ1   A0A076FRH6   A0A0U2F3F2   A0A291P0P5   G8FQ77   A0A2A4JG15   Q8MZZ2   Q6A4M5   A0A0N1PJV1   Q95VE7   A9YRX6   A0A1V0M868   Q6US81   A0A068FKA4   A9ZSZ6   Q95UJ3   M4PTD0   S4WAY4   E3UYX7   Q75PL5   E3UYX8   A0A0K2GV16   U5KFQ4   A0A0L7L2G4   O44390   B7SB74   A0A212FJD3   S4PEM6   Q7K403   Q9NGQ7   A0A212FG51   A0A1L8D6B5   B6CBS5   D8UUT5   A0A0K0N452   E3TMU8   Q2F669   W5QM97   B7SB75   B7SB76   E3TMV0   B7SB77   A0A194R0B7   A0A075BRA0   A0A1L8D6C0   A0A194PHD4   Q75PL7   T1RTD3   T1RTE1   A0A023EPC8   T1RTF5   Q9GU82   I3QPX9   Q75PL6   Q9NB25   A0A0U2F3B9   A0A291P0G3   H9JF74   H9JLG4   A0A1L8D6L2   G8FQ72   A9YRX5   A0A1E1VYJ4   A0A0U2F3B3   Q8MZZ4   G8FQ80   Q6US82   G8FQ74   A0A2H1V8Q0   G8FQ63   A0A1L8D6B6   A9ZSZ7   A0A1L8DYT8   G8FQ64   A0A0M3L9S4   Q4A182   A0A182NRU1   Q9NG28   A0A0K2GVJ8   U5KFT8   G8FQ75   Q8WPC0   Q7KEQ2   Q17G31   G8FQ73   I7B370  

PDB

4ZYO     E-value=1.92477e-76,     Score=726

KEGG

101738534    K00507 stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1] | (RefSeq) BmorAPSQ; acyl-CoA Del

PATHWAY

01040    Biosynthesis of unsaturated fatty acids - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01212    Fatty acid metabolism - Bombyx mori (domestic silkworm)

GO

GO:0006633   GO:0016021   GO:0016717   GO:0006631   GO:0055114   GO:0046872   GO:0017105   GO:0042811   GO:0004768   GO:0005789   GO:0006629   GO:0016020   GO:0004872   GO:0005216   GO:0006811   GO:0003824   GO:0008152   GO:0016491   GO:0015930  

PANTHER

PTHR11351  

Subcellular location

Membrane  
Endoplasmic reticulum membrane  

Length:

331

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

87.57507

Exp number, first 60 AAs:

18.20208

Total prob of N-in:

0.91390

POSSIBLE N-term signal

sequence

inside

1  -  41

TMhelix

42  -  64

outside

65  -  68

TMhelix

69  -  91

inside

92  -  183

TMhelix

184  -  206

outside

207  -  220

TMhelix

221  -  240

inside

241  -  331

 

 

Pi

201.481096

Theta

189.010303

Tajima's D

0.278477

CLR

0.849497

CSRT

0.447727613619319

Interpretation

Uncertain