Gene

KWMTBOMO14623

Pre Gene Modal

BGIBMGA009555

Annotation

Tankyrase-1_[Papilio_xuthus]

Location

Bomo_Chr24(-):11416134-11434263      View in EpiBrowser

Full name

Poly [ADP-ribose] polymerase       + More
Poly [ADP-ribose] polymerase tankyrase      

Alternative Name

Poly [ADP-ribose] polymerase
Protein poly-ADP-ribosyltransferase tankyrase

Location in the cell

Extracellular   Reliability : 1.038 Mitochondrial   Reliability : 1.478

CDS

ATGTCGAGCCGCCGTTCGATGCTCGGTTCGGCGTTAGATGCTCTTCCGGCGCCCACGGATCCCTTAAGGGAATTGTTCGAAGCTTGCAAAATAGGCGATGCAGCCCGTGTAAAAAAACTAGTTACACCACAAACGGTGAATGCAAGGGACACGGCCGGACGTAAATCAACGCCTCTACATTTCGCTGCAGGTTACGGACGCAGGGAAATAGTGGAGATACTCATCGCTGCCGGAGCCGCTCTTCAGGCGAGAGACGATGGCGGGCTGCAGCCGTTACATAACGCGTGCTCGTTCGGTCACGCTGACGTCGTCAGGGCCCTGCTTACAGCTGGAGCTCCACCGGCCGCCAGAGACAACTGGGGGTACACGCCCCTCCACGAAGCGGCTGCGAAAGGGAAAGTCGACGTTTGCATAGCTCTCCTCCAGCACGGCGCCGATCCGAACATCAGGAACACCGAGGGTAAGACGCCCCTCGATCTGGCGGACTCTTCCACCAGGCCCGTGCTGACAGGCGAGCATTGTGCGGCGGAGGTCTTGGAAGCGGCCCGGTCCGGCTCCGAGGACCGGCTGGCGGCCCTGCTGACGCCGCTGAATGTGAACGTACACGCTGGGGACGGGCGCCGCTCGACGCCGCTGCACCTCGCCGCCGGGTACAACCGCGCGCGGGCGCTGCGCCTGCTGCTGCAGCGGGGTGCCGACGTGCACGCCAAGGACAAGGGAGGCCTGGTCCCCCTGCACAACGCGTGCTCGTATGGTCACTACGAGGTCACGGAGCTGCTGGTGGGGGCGGGGGCCGATGTCAACGCCACCGATCTGTGGGCCTTCACGCCCCTGCACGAGGCCGCCAGCAAAGCCAGGCTCGAGGTCTGCTCTTTGTTGCTGAGCGAGGGGGCGGACCCAACCCTGCTCAACTGCCACGGGAAGTCGGCGCTAGACGTCGCGCCCACCAGAGAACTCCAAGACAGACTGGCCTTCGAGTACCGCGGACATTGTCTCCTGGAAGCCTGCAGGCTCGCGGAACCAACGAGGGTCAAGAAGCAGTTGTCTTCCACGGCGATCCAGCATCAGTACCAAAGCACGTCCGCATCGACGACAGAGAGCACGCAGTCGCTACCAGGAGATTGCACCATGGAGGCCCTGGTCAACTTCCAACACCTGACCACAGGAGATCGGCCTCTACACTGCGCAGCCGCCAGCGTCTACCCGAAGAGGAAACAGGTCATGGAAATGCTGATCAGGAAGGGTGCCCGTGTAAATGAGAAGAACAAAGATGGCCAGACTCCACTTCATGTTGCCACGGAGCATTCACATCTGGATGCCATGGATCTCCTATTAAGACACGGTGCTAAGGTGAACGCTTGCGACGGTCGCGGCGAGAGCGCGCTGTGCGTGGCGGCGCGGCGGGACGCGGCGGCGGCGTGTCGCCTGCTGCTGGCGTGCGGCGCCGACGCGAGGACCGATGCCGGACCCGCGCCCGACGGCCACGACAACTTCAAATGGTCTGACTGTTTAGGATATTAG

Protein

MSSRRSMLGSALDALPAPTDPLRELFEACKIGDAARVKKLVTPQTVNARDTAGRKSTPLHFAAGYGRREIVEILIAAGAALQARDDGGLQPLHNACSFGHADVVRALLTAGAPPAARDNWGYTPLHEAAAKGKVDVCIALLQHGADPNIRNTEGKTPLDLADSSTRPVLTGEHCAAEVLEAARSGSEDRLAALLTPLNVNVHAGDGRRSTPLHLAAGYNRARALRLLLQRGADVHAKDKGGLVPLHNACSYGHYEVTELLVGAGADVNATDLWAFTPLHEAASKARLEVCSLLLSEGADPTLLNCHGKSALDVAPTRELQDRLAFEYRGHCLLEACRLAEPTRVKKQLSSTAIQHQYQSTSASTTESTQSLPGDCTMEALVNFQHLTTGDRPLHCAAASVYPKRKQVMEMLIRKGARVNEKNKDGQTPLHVATEHSHLDAMDLLLRHGAKVNACDGRGESALCVAARRDAAAACRLLLACGADARTDAGPAPDGHDNFKWSDCLGY

Description

Stimulates proteasome activity, probably by ADP-ribosylation of PI31 (PubMed:23622245). Modulates 26S proteasome assembly (PubMed:23622245).

Catalytic Activity

NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide
L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide

Subunit

Interacts (via ANK repeats) with PI31.

Keywords

ANK repeat   Complete proteome   Glycosyltransferase   Metal-binding   NAD   Reference proteome   Repeat   Transferase   Zinc  

Feature

chain  Poly [ADP-ribose] polymerase tankyrase

Uniprot

H9JJ54   A0A194QFN1   A0A2H1W288   A0A2A4JX48   A0A067RRJ4   K7IPE9   + More
A0A1Y1MGQ1   A0A182Q4E3   A0A2C9GRX3   A0A1B6DFS8   A0A1Y9IS44   A0A2M4D0F1   A0A2M4AGI6   A0A2M4BAR1   A0A084VS43   A0A2M4CUJ3   A0A2M4CUA0   A0A2M4BAB1   A0A0C9R2U6   D6WBK7   A0A0N0U793   A0A182YG88   A0A1B6FUG2   A0A158NZ41   A0A1B6J0W2   A0A151ICA6   A0A151JP23   A0A195BRD1   A0A1Q3G2S5   Q17FK9   E9IFR3   A0A088ADB5   A0A182J3K7   E2A4P2   B0XD66   A0A026W9G4   A0A0J7KX10   F4W9V3   W8BL91   E0VSK5   A0A034VM28   A0A0K8W8W9   A0A0K8VHM1   A0A1I8PA53   A0A151WKM1   A0A1B0G6T3   A0A0A1WJK6   N6TLM3   A0A2J7Q4G5   A0A1B0AAF0   A0A2P8XK96   A0A2A3EDN9   A0A1A9YK49   A0A1B0BBW7   A0A224X5D7   T1I1W7   A0A310SPD0   A0A1L8DIT8   A0A1I8NB60   A0A023F473   A0A146ME76   E2BZX4   A0A1A9UTL6   B4K4W1   I3RSE8   A0A1A9WJJ4   B4ICC0   A0A1B0GJW3   B4QVC8   A0A0B4KI19   Q9VBP3   Q295L9   A0A1W4VM02   A0A3B0KET7   B4GG04   B4JHT7   B3P6G9   B4PTI2   A0A087UUU1   B3LYN0   A0A154P3V6   A0A195EZ59   B4NJD5   A0A0M4EN42   A0A0P6BW04   A0A0P6ECE0   A0A0P6IFQ4   A0A0P5TIP7   A0A2C9JDF7   A0A0P4WV31   A0A2T7P7U8   A0A0P5LQD1   A0A0P5CL19   A0A0P5FQ91   K1QV17   A0A0P5MVL6   A0A0P5LID2   A0A2R5LDL0   A0A210QC45   A0A336MTV3  

EC Number

2.4.2.-
2.4.2.30

Pubmed

19121390    26354079    24845553    20075255    28004739    24438588    + More
18362917    19820115    25244985    21347285    17510324    21282665    20798317    24508170    30249741    21719571    24495485    20566863    25348373    25830018    23537049    29403074    25315136    25474469    26823975    17994087    22328714    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    10731138    23622245    15632085    17550304    15562597    22992520    28812685   

EMBL

BABH01040453    BABH01040454    BABH01040455    BABH01040456    BABH01040457    BABH01040458    + More
BABH01040459    BABH01040460    KQ459249    KPJ02276.1    ODYU01005759    SOQ46942.1    NWSH01000465    PCG76214.1    KK852508    KDR22389.1    GEZM01035988    JAV83056.1    AXCN02000193    APCN01002058    GEDC01012798    JAS24500.1    GGFL01006400    MBW70578.1    GGFK01006574    MBW39895.1    GGFJ01000930    MBW50071.1    ATLV01015799    ATLV01015800    ATLV01015801    ATLV01015802    KE525036    KFB40787.1    GGFL01004747    MBW68925.1    GGFL01004746    MBW68924.1    GGFJ01000832    MBW49973.1    GBYB01007147    JAG76914.1    KQ971311    EEZ98998.2    KQ435706    KOX80121.1    GECZ01015929    JAS53840.1    ADTU01000870    ADTU01000871    GECU01014882    JAS92824.1    KQ978060    KYM97722.1    KQ978765    KYN28533.1    KQ976423    KYM88769.1    GFDL01000945    JAV34100.1    CH477270    EAT45334.1    GL762889    EFZ20592.1    GL436716    EFN71576.1    DS232744    EDS45320.1    KK107321    QOIP01000002    EZA52680.1    RLU25868.1    LBMM01002452    KMQ94809.1    GL888033    EGI69089.1    GAMC01007023    JAB99532.1    DS235751    EEB16361.1    GAKP01016359    JAC42593.1    GDHF01005034    JAI47280.1    GDHF01013915    JAI38399.1    KQ983012    KYQ48357.1    CCAG010013866    GBXI01015250    JAC99041.1    APGK01019502    KB740107    KB631715    ENN81354.1    ERL85556.1    NEVH01018382    PNF23481.1    PYGN01001866    PSN32427.1    KZ288271    PBC29847.1    JXJN01011729    GFTR01008730    JAW07696.1    ACPB03016273    KQ760549    OAD59863.1    GFDF01007706    JAV06378.1    GBBI01002421    JAC16291.1    GDHC01000890    JAQ17739.1    GL451708    EFN78751.1    CH933806    EDW16114.2    JQ611724    AFK29233.1    CH480828    EDW45016.1    AJWK01022423    AJWK01022424    AJWK01022425    CM000364    EDX14454.1    AE014297    AGB96343.1    AF132196    BT044171    AAD34784.1    AAF56487.1    ACH92236.1    CM000070    EAL28690.2    OUUW01000007    SPP83571.1    CH479182    EDW34539.1    CH916369    EDV92845.1    CH954182    EDV53639.1    CM000160    EDW98722.2    KK121746    KFM81130.1    CH902617    EDV42945.2    KQ434803    KZC05918.1    KQ981909    KYN33192.1    CH964272    EDW84966.2    CP012526    ALC46965.1    GDIP01008769    JAM94946.1    GDIQ01066089    JAN28648.1    GDIQ01006715    JAN88022.1    GDIP01166171    GDIP01125736    LRGB01001581    JAL77978.1    KZS11173.1    GDIP01251208    JAI72193.1    PZQS01000005    PVD29491.1    GDIQ01169999    JAK81726.1    GDIP01169014    JAJ54388.1    GDIQ01253631    JAJ98093.1    JH816438    EKC35064.1    GDIQ01173191    JAK78534.1    GDIQ01173190    JAK78535.1    GGLE01003495    MBY07621.1    NEDP02004212    OWF46301.1    UFQT01001759    SSX31687.1   

Proteomes

UP000005204    UP000053268    UP000218220    UP000027135    UP000002358    UP000075886    + More
UP000075840    UP000075903    UP000030765    UP000007266    UP000053105    UP000076408    UP000005205    UP000078542    UP000078492    UP000078540    UP000008820    UP000005203    UP000075880    UP000000311    UP000002320    UP000053097    UP000279307    UP000036403    UP000007755    UP000009046    UP000095300    UP000075809    UP000092444    UP000019118    UP000030742    UP000235965    UP000092445    UP000245037    UP000242457    UP000092443    UP000092460    UP000015103    UP000095301    UP000008237    UP000078200    UP000009192    UP000091820    UP000001292    UP000092461    UP000000304    UP000000803    UP000001819    UP000192221    UP000268350    UP000008744    UP000001070    UP000008711    UP000002282    UP000054359    UP000007801    UP000076502    UP000078541    UP000007798    UP000092553    UP000076858    UP000076420    UP000245119    UP000005408    UP000242188   

PRIDE

H9JJ54    Q9VBP3   

Pfam

PF00023   Ank        + More
PF00536   SAM_1
PF00644   PARP
PF12796   Ank_2
PF07647   SAM_2
PF13606   Ank_3
PF00046   Homeodomain
PF06911   Senescence
PF00076   RRM_1

Interpro

IPR012317   Poly(ADP-ribose)pol_cat_dom        + More
IPR001660   SAM       
IPR002110   Ankyrin_rpt       
IPR013761   SAM/pointed_sf       
IPR036770   Ankyrin_rpt-contain_sf       
IPR028731   TANK1       
IPR020683   Ankyrin_rpt-contain_dom       
IPR009057   Homeobox-like_sf       
IPR001356   Homeobox_dom       
IPR017970   Homeobox_CS       
IPR009686   Senescence/spartin       
IPR000504   RRM_dom       
IPR012677   Nucleotide-bd_a/b_plait_sf       
IPR003954   RRM_dom_euk       
IPR035979   RBD_domain_sf       

SUPFAM

SSF48403   SSF48403        + More
SSF47769   SSF47769       
SSF46689   SSF46689       
SSF54928   SSF54928       

Gene 3D

1.10.150.50     1.25.40.20     3.30.70.330    

CDD

cd00204  ANK
cd00086  homeodomain

ProteinModelPortal

H9JJ54   A0A194QFN1   A0A2H1W288   A0A2A4JX48   A0A067RRJ4   K7IPE9   + More
A0A1Y1MGQ1   A0A182Q4E3   A0A2C9GRX3   A0A1B6DFS8   A0A1Y9IS44   A0A2M4D0F1   A0A2M4AGI6   A0A2M4BAR1   A0A084VS43   A0A2M4CUJ3   A0A2M4CUA0   A0A2M4BAB1   A0A0C9R2U6   D6WBK7   A0A0N0U793   A0A182YG88   A0A1B6FUG2   A0A158NZ41   A0A1B6J0W2   A0A151ICA6   A0A151JP23   A0A195BRD1   A0A1Q3G2S5   Q17FK9   E9IFR3   A0A088ADB5   A0A182J3K7   E2A4P2   B0XD66   A0A026W9G4   A0A0J7KX10   F4W9V3   W8BL91   E0VSK5   A0A034VM28   A0A0K8W8W9   A0A0K8VHM1   A0A1I8PA53   A0A151WKM1   A0A1B0G6T3   A0A0A1WJK6   N6TLM3   A0A2J7Q4G5   A0A1B0AAF0   A0A2P8XK96   A0A2A3EDN9   A0A1A9YK49   A0A1B0BBW7   A0A224X5D7   T1I1W7   A0A310SPD0   A0A1L8DIT8   A0A1I8NB60   A0A023F473   A0A146ME76   E2BZX4   A0A1A9UTL6   B4K4W1   I3RSE8   A0A1A9WJJ4   B4ICC0   A0A1B0GJW3   B4QVC8   A0A0B4KI19   Q9VBP3   Q295L9   A0A1W4VM02   A0A3B0KET7   B4GG04   B4JHT7   B3P6G9   B4PTI2   A0A087UUU1   B3LYN0   A0A154P3V6   A0A195EZ59   B4NJD5   A0A0M4EN42   A0A0P6BW04   A0A0P6ECE0   A0A0P6IFQ4   A0A0P5TIP7   A0A2C9JDF7   A0A0P4WV31   A0A2T7P7U8   A0A0P5LQD1   A0A0P5CL19   A0A0P5FQ91   K1QV17   A0A0P5MVL6   A0A0P5LID2   A0A2R5LDL0   A0A210QC45   A0A336MTV3  

PDB

5JHQ     E-value=1.59663e-146,     Score=1333

KEGG

101740141    K10799 tankyrase [EC:2.4.2.30] | (RefSeq) tankyrase

GO

GO:0003950   GO:0043565   GO:0006355   GO:0005634   GO:0006471   GO:0090263   GO:0005737   GO:0070198   GO:1904355   GO:0016491   GO:0016787   GO:0046872   GO:0097110   GO:2000060   GO:0090364   GO:0070212   GO:0016055   GO:0051225   GO:0032212   GO:0003723   GO:0005515   GO:0016717   GO:0008270   GO:0003677   GO:0006101   GO:0003824   GO:0008152   GO:0015930  

PANTHER

PTHR24180:SF3  

Subcellular location

Nucleus  

Length:

506

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00204

Exp number, first 60 AAs:

5e-05

Total prob of N-in:

0.00205

outside

1  -  506

 

 

Pi

198.899982

Theta

169.975993

Tajima's D

1.183553

CLR

0.484654

CSRT

0.707814609269537

Interpretation

Uncertain