Gene

KWMTBOMO14622

Pre Gene Modal

BGIBMGA009556

Annotation

uncharacterized_protein_LOC692458_[Bombyx_mori]

Location

Bomo_Chr24(+):11411684-11415522      View in EpiBrowser

Full name

Acyl-CoA Delta(11) desaturase       + More
(11Z)-hexadec-11-enoyl-CoA conjugase      

Alternative Name

Acyl-CoA Delta-11 desaturase
SlsZ/E11
Acyl-CoA Z/E11 desaturase
Acyl-CoA Delta(11) desaturase
Acyl-CoA Z11/delta10,12 desaturase

Location in the cell

PlasmaMembrane   Reliability : 4.271

CDS

ATGGAAGCGAAACAAAACAATCTCGCACCGACCTTAGAGGAGGAAGCACAGTTCGAAAAACTTATAGCGCCACAAGCTTCAGATAGAAAACACGAGATAATCTACGCGAATCTCATAACATTTGCTTACGGGCATATATCTGCACTGTACGGCTTATATCTTTGCTTCAGTAGTGCGAAATGGGCGACGATAATTATGGCCTACGTCATATTGATAGCGGCAGAGGTCGGAGTGACGGCAGGCGCCCATCGACTCTGGACCCACCGGGCGTACAAAGCCAAGAGGCCACTGCAGATCATACTAATGGTAATGAACTCGTTCGCCTTCCAAAACTCGGCCATCACTTGGATCCGGGACCATCGGATGCACCACAGATACAGCGACACGGACGCCGACCCTCACAACGCTACCAGAGGCTTCTTCTACTCGCACATAGGATGGTTGCTGGTCAGGAAACATCCGGAGGTGAAGAGGAGGGGCAAAACAATTGATATGTCGGACATTTACAGTAATCCTGTTTTGGTCTTCCAAAAGAAATACGCGATACCATTCATAGGAGCTGTTTGCTTTGTTATACCGACTCTCGTACCCATCTACTTCTGGGGTGAGACGCTGACCAACGCCTGGCACATCACCTTGCTGCGATATATCATCAGCCTTCACGTGACCTTCTTGGTGAACAGCGCCGCTCACCTCTGGGGAACGAGGGCTTACGACAAACGAATTTTCCCAGCGCAGAACCTGATCGTATCCCTGCTGGCGGTCGGTGAGGGATTCCACAACTACCACCACGTTTTCCCGTGGGACTACCGCACGGCAGAACTGGGGAACAACTATTTGAACTTGACCACGAAATTCATTGATTTCTTCGCGTGGCTAGGGTGGGCCTACGATCTGAAATCGGTGCCGGATAGTGCGGTCCAAAGCAGAGCCGCTAGGACTGGTGACGGTACGAACTCGTGGGGTTGGCCAGAGGAGGACGCAAATGAAGACATTCTTAAGCAAACTCCACCTTTATAG

Protein

MEAKQNNLAPTLEEEAQFEKLIAPQASDRKHEIIYANLITFAYGHISALYGLYLCFSSAKWATIIMAYVILIAAEVGVTAGAHRLWTHRAYKAKRPLQIILMVMNSFAFQNSAITWIRDHRMHHRYSDTDADPHNATRGFFYSHIGWLLVRKHPEVKRRGKTIDMSDIYSNPVLVFQKKYAIPFIGAVCFVIPTLVPIYFWGETLTNAWHITLLRYIISLHVTFLVNSAAHLWGTRAYDKRIFPAQNLIVSLLAVGEGFHNYHHVFPWDYRTAELGNNYLNLTTKFIDFFAWLGWAYDLKSVPDSAVQSRAARTGDGTNSWGWPEEDANEDILKQTPPL

Description

Catalyzes the formation of delta(11) fatty acyl precursors in the pheromone gland, and has high activity towards palmitic acid and stearic acid.
Catalyzes the formation of Delta(11) fatty acyl precursors in the pheromone gland.
Catalyzes the formation of Delta(11) fatty acyl precursors in the pheromone gland, with a preference for myristic acid.
Fatty acid desaturase that catalyzes 2 consecutive steps in the biosynthesis of bombykol, a sex pheromone produced by the moth. First acts as an acyl-CoA Delta(11) desaturase (1) by catalyzing the formation of Delta(11) fatty acyl precursors. Then acts as a (11Z)-hexadec-11-enoyl-CoA conjugase (2) by converting a single cis double bond at position 11 of (11Z)-hexadec-11-enoyl-CoA into conjugated 10 trans and 12 cis double bonds.

Catalytic Activity

2 [Fe(II)-cytochrome b5] + an 11,12-saturated fatty acyl-CoA + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an (11Z)-Delta(11)-fatty acyl-CoA + 2 H2O
(11Z)-hexadecenoyl-CoA + AH2 + O2 = (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O

Cofactor

Fe cation
Fe(2+)

Similarity

Belongs to the fatty acid desaturase type 1 family.

Keywords

Fatty acid biosynthesis   Fatty acid metabolism   Iron   Lipid biosynthesis   Lipid metabolism   Membrane   Metal-binding   Oxidoreductase   Transmembrane   Transmembrane helix   Endoplasmic reticulum   Complete proteome   Reference proteome  

Feature

chain  Acyl-CoA Delta(11) desaturase

Uniprot

Q75PL5   H9JF74   A0A0K2GV16   T1RTE1   G8FQ79   M4PTD0   + More
A0A068FKA4   G8FQ76   G8FQ77   A0A1V0M868   Q6US81   A0A0N1PJV1   G8FQ78   D2SNV3   T1RU40   A0A076FRH6   U5KFQ4   A0A2A4JG15   A0A0U2F3F2   Q9NB26   A0A0U2F3E1   Q8MZZ2   O44390   A0A291P0P5   A9YRX6   E3UYX8   A0A212FJD3   A0A0K0N452   Q6A4M5   W5QM97   E3UYX7   A0A1L8D6M1   Q2YHQ4   A0A075BRA0   Q8ISS3   B6CBS5   B7SB74   E3TMU8   Q95VE7   Q95UJ3   S4WAY4   Q4A181   A0A0L7L2G4   A0A194Q9S9   A0A1L8D6B5   A8QVZ1   Q75PL7   Q9GU82   A0A1L8D6L2   Q95UU3   A0A0F7R6V4   G8FQ82   A0A0F7R6V7   Q2V0N6   Q8WPC0   Q7KEQ2   A0A059TBF7   B8Q500   G8FQ83   A0A0F7R1B4   A0A0F7R1B9   A0A0M3L9T2   D8L7A6   A0A1L8D6C0   A0A059TBF6   G8FQ74   C0STP4   A0A059TBF9   G8FQ72   A4KWE9   D8L626   G8FQ75   A4KWE7   Q9NG28   A0A0E3VMW5   G8FQ63   Q4A182   A0A0F7R2Q5   G8FQ73   D8UUU1   G8FQ64   A0A212FG51   H9JLG4   I3QPX9   Q75PL6   A0A1E1VYJ4   G8FQ62   S4PEM6   A9ZSZ7   Q7K403   Q9NGQ7   A0A0M3L9S4   Q8ITE5   Q9NB25   A0A0U2F3B9   A0A291P0G3   T1RTF5   D8UUT5   Q9NGQ8   Q8ITE4  

EC Number

1.14.19.5
1.14.19.15

Pubmed

19121390    24500170    22291612    26385554    28349297    15544945    + More
26354079    20074338    24817326    24053512    28986331    11483431    12524345    12770579    9860961    18405835    25796477    21331247    22118469    15527989    24862548    26417103    15455060    18831750    20403437    20691782    11805319    24569486    17517337    26227816    17921252    10767556    15173596    12213232    16360168    12237399    19257880    21444802    17360547    23622113    24211206    28756777   

EMBL

BABH01040457    AB166853    BAD18124.1    BABH01026838    BABH01026839    BABH01026840    + More
KP890026    ALA65425.1    JX531667    AGO45852.1    JN022489    AER29854.1    KC422668    AGH12217.1    KJ622051    AID66659.1    JN022486    AER29851.1    JN022487    AER29852.1    KU755471    ARD71181.1    AY362879    KQ460301    KPJ16138.1    JN022488    AER29853.1    EZ407237    ACX53794.1    JX531654    AGO45839.1    KF960741    AII21943.1    JX989153    AGR49312.1    NWSH01001511    PCG71017.1    KP008124    MF687587    AKU76411.1    ATJ44513.1    AF272342    AAF81787.1    KP008117    AKU76404.1    AF482908    AAM28483.2    AF035375    AF297114    AF297113    MF687528    ATJ44454.1    EU285580    KM283200    ABX90049.1    AIU96339.1    HM636634    ADP21588.1    AGBW02008279    OWR53845.1    KM378664    AKJ32408.1    AF518014    AAQ12891.1    JQ978772    AGD98720.1    HM636633    ADP21587.1    GEYN01000135    JAV01994.1    AM158251    CAJ43430.2    JX679209    AGP26038.1    AF545481    FJ999625    EU152335    ABX71630.1    EU152400    FJ466458    ABX71809.1    ACS69071.1    GU952763    ADO85596.1    AF416738    AAL16642.1    AY049741    AAL11496.1    JX964774    AGO96562.1    AM076339    CAJ27976.2    JTDY01003403    KOB69615.1    KQ459249    KPJ02273.1    GEYN01000136    JAV01993.1    EF150363    ABO43722.1    AF157627    AB166851    BABH01015400    AAF80355.1    BAD18122.1    AF182405    AAG16901.1    GEYN01000122    JAV02007.1    AY017379    AAG54077.1    LC020022    BAR72984.1    JN022491    JN022492    AER29861.1    LC020024    BAR72989.1    AB232855    BAE66602.1    AF441861    AAL32060.1    AF441221    AAL35331.1    KF022093    AHW98354.1    EU350083    EU350084    GQ166860    ACA81687.1    ACA81688.1    ADE97413.1    JN022493    AER29862.1    LC020021    BAR72981.1    LC020023    BAR72986.1    KM366789    AIM40219.1    FJ999626    ADC53486.1    GEYN01000123    JAV02006.1    KF022096    AHW98357.1    JN022484    AER29858.1    AB465511    BAH56286.1    BAR72983.1    KF022097    AHW98358.1    JN022482    AER29856.1    EF113395    EF113396    ABO45228.1    ABO45229.1    FJ906800    ADB25212.1    JN022485    AER29855.1    EF113393    EF113394    ABO45226.1    ABO45227.1    AF268275    JN022476    AAF73073.1    AER29845.1    AB910048    BAR45527.1    JN022473    AER29842.1    AM076338    CAJ27975.1    BAR72990.1    JN022483    AER29857.1    GQ225753    ADE58526.1    JN022474    JN022475    AER29843.1    AGBW02008720    OWR52703.1    BABH01005826    JQ729998    AFK13830.1    JQ729997    AB166852    AFK13829.1    BAD18123.1    GDQN01011259    GDQN01009722    GDQN01007857    JAT79795.1    JAT81332.1    JAT83197.1    JN022472    AER29841.1    GAIX01006995    JAA85565.1    AB373031    BAF97042.1    AY057862    AAL27033.1    AF243047    AAF44710.1    KM366791    AIM40221.1    AF518020    AAN39700.1    AF272343    AAF81788.1    KP008120    MF687582    AKU76407.1    ATJ44508.1    MF687527    KZ149911    ATJ44453.1    PZC78117.1    JX531653    NWSH01001519    AGO45838.1    PCG70996.1    GQ225747    GQ225749    ADE58520.1    AF243046    AAF44709.1    AF518021    AAN39701.1   

Proteomes

UP000005204    UP000053240    UP000218220    UP000007151    UP000037510    UP000053268    + More

PRIDE

Q75PL5    H9JF74    T1RTE1    Q75PL7    Q9GU82    H9JLG4    + More
Q75PL6   

Pfam

PF00487   FA_desaturase

Interpro

IPR015876   Acyl-CoA_DS        + More
IPR005804   FA_desaturase_dom       
IPR001522   FADS-1_CS       

CDD

cd03505  Delta9-FADS-like

ProteinModelPortal

Q75PL5   H9JF74   A0A0K2GV16   T1RTE1   G8FQ79   M4PTD0   + More
A0A068FKA4   G8FQ76   G8FQ77   A0A1V0M868   Q6US81   A0A0N1PJV1   G8FQ78   D2SNV3   T1RU40   A0A076FRH6   U5KFQ4   A0A2A4JG15   A0A0U2F3F2   Q9NB26   A0A0U2F3E1   Q8MZZ2   O44390   A0A291P0P5   A9YRX6   E3UYX8   A0A212FJD3   A0A0K0N452   Q6A4M5   W5QM97   E3UYX7   A0A1L8D6M1   Q2YHQ4   A0A075BRA0   Q8ISS3   B6CBS5   B7SB74   E3TMU8   Q95VE7   Q95UJ3   S4WAY4   Q4A181   A0A0L7L2G4   A0A194Q9S9   A0A1L8D6B5   A8QVZ1   Q75PL7   Q9GU82   A0A1L8D6L2   Q95UU3   A0A0F7R6V4   G8FQ82   A0A0F7R6V7   Q2V0N6   Q8WPC0   Q7KEQ2   A0A059TBF7   B8Q500   G8FQ83   A0A0F7R1B4   A0A0F7R1B9   A0A0M3L9T2   D8L7A6   A0A1L8D6C0   A0A059TBF6   G8FQ74   C0STP4   A0A059TBF9   G8FQ72   A4KWE9   D8L626   G8FQ75   A4KWE7   Q9NG28   A0A0E3VMW5   G8FQ63   Q4A182   A0A0F7R2Q5   G8FQ73   D8UUU1   G8FQ64   A0A212FG51   H9JLG4   I3QPX9   Q75PL6   A0A1E1VYJ4   G8FQ62   S4PEM6   A9ZSZ7   Q7K403   Q9NGQ7   A0A0M3L9S4   Q8ITE5   Q9NB25   A0A0U2F3B9   A0A291P0G3   T1RTF5   D8UUT5   Q9NGQ8   Q8ITE4  

PDB

4YMK     E-value=2.55612e-83,     Score=786

KEGG

692458    K00507 stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1] | (RefSeq) uncharacterized LOC692

PATHWAY

01040    Biosynthesis of unsaturated fatty acids - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01212    Fatty acid metabolism - Bombyx mori (domestic silkworm)

GO

GO:0016717   GO:0016021   GO:0006633   GO:0017105   GO:0046872   GO:0042811   GO:0006631   GO:0055114   GO:0005789   GO:0004768   GO:0006629   GO:0005515   GO:0008270   GO:0003677   GO:0006101   GO:0003824   GO:0008152   GO:0016491   GO:0015930  

PANTHER

PTHR11351  

Subcellular location

Membrane  
Endoplasmic reticulum membrane  

Length:

339

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

103.98304

Exp number, first 60 AAs:

21.96794

Total prob of N-in:

0.67705

POSSIBLE N-term signal

sequence

inside

1  -  32

TMhelix

33  -  54

outside

55  -  63

TMhelix

64  -  86

inside

87  -  179

TMhelix

180  -  202

outside

203  -  211

TMhelix

212  -  234

inside

235  -  339

 

 

Pi

25.152781

Theta

29.641958

Tajima's D

-0.722542

CLR

1012.973687

CSRT

0.191790410479476

Interpretation

Uncertain