Gene

KWMTBOMO14621

Pre Gene Modal

BGIBMGA009555

Annotation

PREDICTED:_tankyrase-2_[Amyelois_transitella]

Location

Bomo_Chr24(-):11385335-11411203      View in EpiBrowser

Full name

Poly [ADP-ribose] polymerase       + More
Poly [ADP-ribose] polymerase tankyrase-1      

Alternative Name

ADP-ribosyltransferase diphtheria toxin-like 5
Protein poly-ADP-ribosyltransferase tankyrase-1
TRF1-interacting ankyrin-related ADP-ribose polymerase 1
Tankyrase-1

Location in the cell

Mitochondrial   Reliability : 1.925 Nuclear   Reliability : 1.283

CDS

ATGGCGGAGAATTTTAGGTCTGCCGCAGATGCTTGCACTAACGCGGCGGCAGTCCGGCTGCTAGAAGCTGCTCGCACTGGTGACGTGGAGACAGCCCGAGCGATCCTCGACTCGCGACCGAGACTCGTCAACTGCAGAGATGTCGACGGGCGGCATTCGACGCCCCTGCATTTCGCTGCCGGGTACAATCGACTTCCATTGGCTCAGTTACTACTTCAGCGTGGAGCTGATGTACACGCGAAAGATAAGGGAGGTCTGGTCCCGCTTCACAACGCGTGCTCCTACGGCCATTACGAGGTCACCGAGCTCCTCGTGTCTGCCGGAGCCGGTGTGAACGCCGCGGACCTCTGGAGGTTCTCACCCTTGCACGAGGCAGCGGCTAAAGGCAAGGCGGATATCGTGAGATTGCTGCTCAAGCATGGGGCGGATCCCACCCGGAGGAACAGGGACGGACTCACGCCGCTGCAACTGGTGCGAGCGGGAGACAGCGACACGGCTGACGCGCTGCGGGGTGATGCTGCGCTACTGGACGCTGCCAAGAGAGGGGACCTCGCTCGAGCCAGGAAACTGATAACTCCTCAAAACGTGAACTGCCGGGACGCGCACGGACGTAACTCCACGCCCTTGCATTTGGCTGCCGGGTATAACAACCTGGAGGTGGCCGAGGCTCTGCTGGAGGCGGGCGCGCTGGTGTCGGCGCGCGACAAGGGCGGGCTGGTGCCGCTGCACAATGCGGCCTCATACGGGCACCTCGAGCTGGCGGCGCTGCTGCTGCGCGCGGGCACGCCGCCCAACGCCGCCGACCGCTGGGGCTTCACGCCCCTGCACGAGGCCGCGCACAAGGCCAGGACCCAGCTCTGCGCGCTGCTGCTGGCCCACGGAGCGGACCCGTTCCTCAAGAACCAGGAGGGGCAGACGGCTCTTGAACTGTCCGGGGCCGAGGACGTGAGGTCGCTGCTGCAGGACGCGATGACGTCATCGGCCGGTGACGTGACGTCATCGTCCGCGCCCGTCCCTCCGCCGGCTCCGCTGCCGCCCCCCTCGCACCCCGTGCTCATGCCGAGCGGGGACACGGTGCAGTTGGCGTTGCCGGTCCTGCCCAGCAACTACTGGGCGGAGGGGTCCAGGGGCAGCTTGGAAGACGCAGCCGGGAGGCCGGCGTCGGCCCTCTCCACCTCGGAGTCCCTGCAGACATTCCTGGCGAGCGTCGGACTGGAGCAGCTGGGGCCGCTGCTGGAGCGAGAGCAGATAACGGTGGACATCCTGTGCGAGATGTCGCACGAGGATCTGCGCGCGGTCGGCGTTGCGGCCTACGGACATCGGCATCGGTTGCTAAAGGCGGCCCGGCGCACCGCCCACGCCGCCAACGAATGGTACGGCGGCACGACCCTCGTAGAGGTGACCCCGAGCGGCGAGGGGGGCGAGTACGCGGTGCTCGAGAGGGAGATGCAGGCCTCCGTGCGCGCGCACCGGGAGCACGCCGGGGGCCACTTCACGCACTACAACGTCGTCAAGATCCAGAAGATCGTGAACGGTCGGGTCTGGGAGCGGTACCAGCACCGGCGGCGCGAGGTCGCAGAGGAGGCCGGCGGCGACAACGAGCGCATGCTCTTCCACGGCTCGCCCTTCATCAACGCCATCGTGCAGAAGGGCTTCGACGAGAGGCACGCCTACATCGGGGGCATGTTCGGCGCCGGGATATACTTCGCGGAGCACTCCTCGAAGAGCAACCAGTACGTGTACGGGTTCGGCGGTGGCTCGGGCTGCCCCGCGCACAAGGACCGGAGCTGCTACCTCTGCCACAGACAGATGCTGCTGTGCCGCGTGACCCTGGGCCGCGGGTTCCAGCTGCTGAGCGCGATGAAGATGGCGCACGCGCCGCCCGGGCACCACTCGGTGGCGGGCCGGCCCTCGCAGGGGGGGCTCTGCTTTCCGGAGTACGTGGTCTACAGGGGGGAGCAGGCCTACCCCGAGTACCTGATCACGTATCAGATCGTGAGCAGCGAGAGCGGCCCGGGCGAGGTGTGA

Protein

MAENFRSAADACTNAAAVRLLEAARTGDVETARAILDSRPRLVNCRDVDGRHSTPLHFAAGYNRLPLAQLLLQRGADVHAKDKGGLVPLHNACSYGHYEVTELLVSAGAGVNAADLWRFSPLHEAAAKGKADIVRLLLKHGADPTRRNRDGLTPLQLVRAGDSDTADALRGDAALLDAAKRGDLARARKLITPQNVNCRDAHGRNSTPLHLAAGYNNLEVAEALLEAGALVSARDKGGLVPLHNAASYGHLELAALLLRAGTPPNAADRWGFTPLHEAAHKARTQLCALLLAHGADPFLKNQEGQTALELSGAEDVRSLLQDAMTSSAGDVTSSSAPVPPPAPLPPPSHPVLMPSGDTVQLALPVLPSNYWAEGSRGSLEDAAGRPASALSTSESLQTFLASVGLEQLGPLLEREQITVDILCEMSHEDLRAVGVAAYGHRHRLLKAARRTAHAANEWYGGTTLVEVTPSGEGGEYAVLEREMQASVRAHREHAGGHFTHYNVVKIQKIVNGRVWERYQHRRREVAEEAGGDNERMLFHGSPFINAIVQKGFDERHAYIGGMFGAGIYFAEHSSKSNQYVYGFGGGSGCPAHKDRSCYLCHRQMLLCRVTLGRGFQLLSAMKMAHAPPGHHSVAGRPSQGGLCFPEYVVYRGEQAYPEYLITYQIVSSESGPGEV

Description

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity.

Catalytic Activity

NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide
L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide

Subunit

Oligomerizes and associates with TNKS2. Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles. Binds to the N-terminus of telomeric TERF1 via the ANK repeats. Found in a complex with POT1; TERF1 and TINF2. Interacts with AXIN1. Interacts with AXIN2. Interacts with BLZF1 and CASC3. Interacts with NUMA1.

Keywords

3D-structure   ADP-ribosylation   Alternative splicing   ANK repeat   Cell cycle   Cell division   Chromosome   Complete proteome   Cytoplasm   Cytoskeleton   Glycosyltransferase   Golgi apparatus   Membrane   Metal-binding   Mitosis   mRNA transport   NAD   Nuclear pore complex   Nucleus   Phosphoprotein   Protein transport   Reference proteome   Repeat   Telomere   Transferase   Translocation   Transport   Ubl conjugation   Wnt signaling pathway   Zinc  

Feature

chain  Poly [ADP-ribose] polymerase
splice variant  In isoform 2.

Uniprot

H9JJ54   A0A1Y1MGQ1   D6WBK7   Q17FK9   A0A2J7R2K4   A0A067RRJ4   + More
A0A087UUU1   E2A4P2   A0A026W9G4   E9IFR3   A0A151ICA6   F4W9V3   A0A158NZ41   A0A151WKM1   A0A151JP23   A0A0C9QYT9   A0A195BRD1   A0A1Q3G2S5   A0A182YG88   A0A336MPT4   A0A0K8T3I0   A0A182PQV5   A0A0C9R2U6   A0A146ME76   A0A182J3K7   A0A2M4BAR1   A0A2M4BAB1   A0A182MSV2   A0A2M4CUA0   A0A154P3V6   A0A1Y9IS44   A0A2M4AGI6   A0A2M4D0F1   A0A2M4CUJ3   W5JE54   A0A2M4CPG4   A0A336MN10   Q7PYH8   A0A2C9GRX3   T1I1W7   A0A1B6DFS8   A0A1L8DJ06   K1QV17   A0A1L8DIT8   A0A023F473   K7IPE9   A0A0K2UZT5   A0A1B0GJW3   W8BL91   L7LZZ4   A0A232FGN2   A0A2A3EDN9   N6TLM3   A0A088ADB5   A0A210QC45   V5HT76   I6L4N1   A0A0L8GA82   A0A0L0CBM5   A0A1A8FWD1   A0A182VR25   A0A3B3IBB7   A0A1I8PA53   H2TPE9   H2TPF0   H3DNG1   A0A3B3HQ19   A0A3B3I5D9   A0A060X381   L5LS37   A0A182N620   A0A1A9UTL6   S7P8B6   A0A182RXK5   A0A2S2PK85   A0A3P4NNU1   A0A182HBN8   A0A2C9JDF7   A0A384BQD6   Q6PFX9-2   G1N930   A0A1A8HT28   G1LHI1   A0A3Q2I900   A0A182F895   A0A0P7XKI1   A0A2K6NKJ4   A0A1A8PSE2   A0A147A1E8   A0A3L7IJA5   A0A341D1L1   A0A2Y9N107   A0A146QX23   A0A146WDV9   A0A1A8L606   V9KDB3   A0A1A8RV89   G3H624   A0A2K6M6H4   W5PKC3  

EC Number

2.4.2.-
2.4.2.30

Pubmed

19121390    28004739    18362917    19820115    17510324    24845553    + More
20798317    24508170    30249741    21282665    21719571    21347285    25244985    26823975    20920257    23761445    12364791    14747013    17210077    22992520    25474469    20075255    24495485    25576852    28648823    23537049    28812685    25765539    9215903    26108605    17554307    21551351    15496914    24755649    26483478    15562597    16141072    19468303    15489334    20838655    20010809    19892987    25362486    29704459    24402279    21804562    20809919   

EMBL

BABH01040453    BABH01040454    BABH01040455    BABH01040456    BABH01040457    BABH01040458    + More
BABH01040459    BABH01040460    GEZM01035988    JAV83056.1    KQ971311    EEZ98998.2    CH477270    EAT45334.1    NEVH01007830    PNF35046.1    KK852508    KDR22389.1    KK121746    KFM81130.1    GL436716    EFN71576.1    KK107321    QOIP01000002    EZA52680.1    RLU25868.1    GL762889    EFZ20592.1    KQ978060    KYM97722.1    GL888033    EGI69089.1    ADTU01000870    ADTU01000871    KQ983012    KYQ48357.1    KQ978765    KYN28533.1    GBYB01008974    JAG78741.1    KQ976423    KYM88769.1    GFDL01000945    JAV34100.1    UFQT01001759    SSX31685.1    GBRD01005747    JAG60074.1    GBYB01007147    JAG76914.1    GDHC01000890    JAQ17739.1    GGFJ01000930    MBW50071.1    GGFJ01000832    MBW49973.1    AXCM01002785    GGFL01004746    MBW68924.1    KQ434803    KZC05918.1    GGFK01006574    MBW39895.1    GGFL01006400    MBW70578.1    GGFL01004747    MBW68925.1    ADMH02001488    ETN62341.1    GGFL01002620    MBW66798.1    SSX31686.1    AAAB01008987    EAA01120.5    APCN01002058    ACPB03016273    GEDC01012798    JAS24500.1    GFDF01007744    JAV06340.1    JH816438    EKC35064.1    GFDF01007706    JAV06378.1    GBBI01002421    JAC16291.1    HACA01025880    CDW43241.1    AJWK01022423    AJWK01022424    AJWK01022425    GAMC01007023    JAB99532.1    GACK01008571    JAA56463.1    NNAY01000286    OXU29487.1    KZ288271    PBC29847.1    APGK01019502    KB740107    KB631715    ENN81354.1    ERL85556.1    NEDP02004212    OWF46301.1    GANP01007090    JAB77378.1    AFYH01184463    AFYH01184464    AFYH01184465    AFYH01184466    AFYH01184467    AFYH01184468    AFYH01184469    AFYH01184470    AFYH01184471    AFYH01184472    KQ423006    KOF73754.1    JRES01000624    KNC29813.1    HAEB01015887    SBQ62414.1    FR904938    CDQ73931.1    KB108646    ELK28891.1    KE162005    EPQ06383.1    GGMR01017240    MBY29859.1    CYRY02027197    VCW99007.1    JXUM01125409    JXUM01125410    JXUM01125411    KQ566943    KXJ69712.1    AK048860    AC122458    BC057370    HAED01002529    SBQ88374.1    ACTA01108263    ACTA01116263    ACTA01124263    ACTA01132263    ACTA01140263    ACTA01148262    ACTA01156261    ACTA01164260    ACTA01172258    ACTA01180256    JARO02001424    KPP75515.1    HAEG01009311    SBR84186.1    GCES01013909    JAR72414.1    RAZU01000044    RLQ78167.1    GCES01126062    JAQ60260.1    GCES01059208    JAR27115.1    HAEF01001937    SBR39319.1    JW863396    AFO95913.1    HAEH01019937    SBS10000.1    JH000169    EGV98450.1    AMGL01073033    AMGL01073034    AMGL01073035    AMGL01073036    AMGL01073037    AMGL01073038   

Proteomes

UP000005204    UP000007266    UP000008820    UP000235965    UP000027135    UP000054359    + More
UP000000311    UP000053097    UP000279307    UP000078542    UP000007755    UP000005205    UP000075809    UP000078492    UP000078540    UP000076408    UP000075885    UP000075880    UP000075883    UP000076502    UP000075903    UP000000673    UP000007062    UP000075840    UP000015103    UP000005408    UP000002358    UP000092461    UP000215335    UP000242457    UP000019118    UP000030742    UP000005203    UP000242188    UP000008672    UP000053454    UP000037069    UP000075920    UP000001038    UP000095300    UP000005226    UP000007303    UP000193380    UP000075884    UP000078200    UP000075900    UP000069940    UP000249989    UP000076420    UP000261680    UP000000589    UP000001645    UP000008912    UP000002281    UP000069272    UP000034805    UP000233200    UP000265000    UP000273346    UP000252040    UP000248483    UP000001075    UP000233180    UP000002356   

PRIDE

H9JJ54    Q6PFX9    G3H624   

Pfam

PF00023   Ank        + More
PF00536   SAM_1
PF00644   PARP
PF12796   Ank_2
PF13606   Ank_3
PF07647   SAM_2
PF06911   Senescence
PF00046   Homeodomain

Interpro

IPR012317   Poly(ADP-ribose)pol_cat_dom        + More
IPR001660   SAM       
IPR002110   Ankyrin_rpt       
IPR013761   SAM/pointed_sf       
IPR036770   Ankyrin_rpt-contain_sf       
IPR028731   TANK1       
IPR020683   Ankyrin_rpt-contain_dom       
IPR009686   Senescence/spartin       
IPR009057   Homeobox-like_sf       
IPR001356   Homeobox_dom       
IPR017970   Homeobox_CS       

SUPFAM

SSF48403   SSF48403        + More
SSF47769   SSF47769       
SSF46689   SSF46689       

Gene 3D

1.10.150.50     1.25.40.20    

CDD

cd00204  ANK
cd00086  homeodomain

ProteinModelPortal

H9JJ54   A0A1Y1MGQ1   D6WBK7   Q17FK9   A0A2J7R2K4   A0A067RRJ4   + More
A0A087UUU1   E2A4P2   A0A026W9G4   E9IFR3   A0A151ICA6   F4W9V3   A0A158NZ41   A0A151WKM1   A0A151JP23   A0A0C9QYT9   A0A195BRD1   A0A1Q3G2S5   A0A182YG88   A0A336MPT4   A0A0K8T3I0   A0A182PQV5   A0A0C9R2U6   A0A146ME76   A0A182J3K7   A0A2M4BAR1   A0A2M4BAB1   A0A182MSV2   A0A2M4CUA0   A0A154P3V6   A0A1Y9IS44   A0A2M4AGI6   A0A2M4D0F1   A0A2M4CUJ3   W5JE54   A0A2M4CPG4   A0A336MN10   Q7PYH8   A0A2C9GRX3   T1I1W7   A0A1B6DFS8   A0A1L8DJ06   K1QV17   A0A1L8DIT8   A0A023F473   K7IPE9   A0A0K2UZT5   A0A1B0GJW3   W8BL91   L7LZZ4   A0A232FGN2   A0A2A3EDN9   N6TLM3   A0A088ADB5   A0A210QC45   V5HT76   I6L4N1   A0A0L8GA82   A0A0L0CBM5   A0A1A8FWD1   A0A182VR25   A0A3B3IBB7   A0A1I8PA53   H2TPE9   H2TPF0   H3DNG1   A0A3B3HQ19   A0A3B3I5D9   A0A060X381   L5LS37   A0A182N620   A0A1A9UTL6   S7P8B6   A0A182RXK5   A0A2S2PK85   A0A3P4NNU1   A0A182HBN8   A0A2C9JDF7   A0A384BQD6   Q6PFX9-2   G1N930   A0A1A8HT28   G1LHI1   A0A3Q2I900   A0A182F895   A0A0P7XKI1   A0A2K6NKJ4   A0A1A8PSE2   A0A147A1E8   A0A3L7IJA5   A0A341D1L1   A0A2Y9N107   A0A146QX23   A0A146WDV9   A0A1A8L606   V9KDB3   A0A1A8RV89   G3H624   A0A2K6M6H4   W5PKC3  

PDB

5OWT     E-value=1.38294e-86,     Score=817

KEGG

101740141    K10799 tankyrase [EC:2.4.2.30] | (RefSeq) tankyrase

GO

GO:0003950   GO:0006471   GO:0090263   GO:0005634   GO:0005737   GO:0070198   GO:1904355   GO:0016055   GO:0051225   GO:0032212   GO:0043565   GO:0006355   GO:0016021   GO:0042593   GO:0031670   GO:0051028   GO:0000209   GO:0005654   GO:0018107   GO:0016604   GO:0005794   GO:0070212   GO:1904357   GO:0018105   GO:1904908   GO:0051301   GO:0008270   GO:0097431   GO:0005643   GO:1990404   GO:0005815   GO:0005829   GO:0042393   GO:0051973   GO:0031965   GO:0000139   GO:1904743   GO:0000781   GO:0000784   GO:0015031   GO:0045944   GO:0070213   GO:0005515   GO:0003677   GO:0006101   GO:0003824   GO:0008152   GO:0016491   GO:0015930  

PANTHER

PTHR24180:SF3  

Subcellular location

Nucleus  
Cytoplasm   Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1. Localizes to spindle poles at mitosis onset via interaction with NUMA1.   With evidence from 3 publications.
Golgi apparatus membrane   Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1. Localizes to spindle poles at mitosis onset via interaction with NUMA1.   With evidence from 3 publications.
Cytoskeleton   Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1. Localizes to spindle poles at mitosis onset via interaction with NUMA1.   With evidence from 3 publications.
Microtubule organizing center   Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1. Localizes to spindle poles at mitosis onset via interaction with NUMA1.   With evidence from 3 publications.
Centrosome   Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1. Localizes to spindle poles at mitosis onset via interaction with NUMA1.   With evidence from 3 publications.
Nuclear pore complex   Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1. Localizes to spindle poles at mitosis onset via interaction with NUMA1.   With evidence from 3 publications.
Chromosome   Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1. Localizes to spindle poles at mitosis onset via interaction with NUMA1.   With evidence from 3 publications.
Telomere   Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1. Localizes to spindle poles at mitosis onset via interaction with NUMA1.   With evidence from 3 publications.
Spindle pole   Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1. Localizes to spindle poles at mitosis onset via interaction with NUMA1.   With evidence from 3 publications.

Length:

675

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01161

Exp number, first 60 AAs:

7e-05

Total prob of N-in:

0.00045

outside

1  -  675

 

 

Pi

19.538582

Theta

19.049921

Tajima's D

-1.813804

CLR

1009.048485

CSRT

0.0264486775661217

Interpretation

Uncertain