SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO14596
Pre Gene Modal
BGIBMGA008760
Annotation
Uncharacterized_protein_OBRU01_06184_[Operophtera_brumata]
Full name
Zinc finger protein 208       + More
Zinc finger protein 729      
Zinc finger protein Xfin      
Zinc finger protein 91      
Zinc finger protein 850      
Zinc finger protein 721      
Zinc finger protein 62      
Zinc finger protein 62 homolog      
Zinc finger protein 26      
Zinc finger protein 845      
Zinc finger protein 546      
Zinc finger protein 160      
Zinc finger protein 700      
Zinc finger protein 658      
Zinc finger protein 616      
Zinc finger protein 43      
Zinc finger protein 27      
Zinc finger protein 585A      
Zinc finger protein 11      
Zinc finger protein 658B      
Zinc finger protein 585B      
Zinc finger protein 836      
Zinc finger protein 573      
Zinc finger protein 814      
Zinc finger protein 624      
Zinc finger protein 728      
Zinc finger protein 555      
Zinc finger protein 665      
Zinc finger protein 227      
Zinc finger protein 808      
Zinc finger protein 564      
Zinc finger protein 99      
Zinc finger protein 780B      
Zinc finger protein 841      
Oocyte zinc finger protein XlCOF7.1      
Zinc finger protein 521      
Zinc finger protein 84      
Zinc finger protein 268      
Zinc finger protein 347      
Zinc finger protein 234      
Zinc finger protein 569      
Zinc finger protein 16      
Zinc finger protein 337      
Zinc finger protein 425      
Zinc finger protein 420      
Gastrula zinc finger protein xFG20-1      
Zinc finger protein 600      
Zinc finger protein 879      
Zinc finger protein 197      
Zinc finger protein 271      
Zinc finger protein 595      
Zinc finger protein 45      
Zinc finger protein 252      
Zinc finger protein 226      
Zinc finger protein 345      
Zinc finger protein 59      
Zinc finger protein 184      
Zinc finger protein 107      
Zinc finger protein 594      
Zinc finger protein 132      
Zinc finger protein 418      
Zinc finger protein 699      
Zinc finger protein 41      
Zinc finger protein 799      
Zinc finger protein 443      
Zinc finger protein 607      
Zinc finger protein 709      
Zinc finger protein 224      
Zinc finger protein 708      
Zinc finger protein 225      
Gastrula zinc finger protein XlCGF58.1      
Zinc finger protein 429      
Zinc finger protein 791      
Zinc finger protein 93      
Zinc finger protein 135      
Zinc finger protein 85      
Zinc finger protein 676      
Zinc finger protein 60      
Zinc finger protein 726      
Zinc finger protein 14      
Zinc finger protein 493      
Zinc finger protein 615      
Alternative Name
Zinc finger protein 91-like
Xenopus fingers protein
Zinc finger protein HPF7
Zinc finger protein HTF10
ZT3
Protein mKR3
Zinc finger protein 49
Zinc finger protein HZF5
Zinc finger protein Kr18
Zinc finger protein 39
Zinc finger protein HTF6
Zinc finger protein KOX27
Protein mKR4
Zinc finger protein Krox-6.1A/6.1B+/6.1B-
zinc finger protein 41-like protein
Zinc finger protein 779
Zinc finger protein 160-like
Early hematopoietic zinc finger protein
LYST-interacting protein 3
Zinc finger protein HPF2
Zinc finger protein HZF3
Zinc finger protein 1111
Zinc finger protein 269
Zinc finger protein HZF4
Mszf21
Zinc finger protein 74
XlCGF20.1
Zinc finger protein with KRAB and SCAN domains 9
ZnF20
pVHL-associated KRAB domain-containing protein
Zinc finger protein 35
Zinc finger protein KOX9
BRC1744
Zinc finger protein 13
Zinc finger protein KOX5
Zinc finger protein HZF10
Zinc finger protein Mfg-2
Ecotropic viral integration site 3 protein
Zinc finger protein 588
Zinc finger protein ZFD25
Zinc finger protein HZF18
Hangover homolog
Zinc finger protein 842
Krueppel-type zinc finger protein ZK1
Bone marrow zinc finger 2
Zinc finger protein 233
Zinc finger protein 255
Zinc finger protein 27
Zinc finger protein KOX22
Zinc finger protein 15
Zinc finger protein 15-like 1
Zinc finger protein KOX8
Zinc finger protein 505
Zinc finger protein HTF34
Zinc finger protein HPF4
Zinc finger protein HTF1
Zinc finger protein Mfg-3
Gonadotropin-inducible ovary transcription repressor 4
Zinc finger protein KOX6
Transcription factor
Location in the cell
Nuclear   Reliability : 3.042
 

Sequence

CDS
ATGGAGTTGCTGGCAAGCCCGCAGTTGTCCGTCAAAAGGAAGGCCCCGGCTCAAACTAAAACTGTTTCCGTCAAAAAGGTGAAGGTCATCAAAAAAGATGCTAGAGGCAAACCGACCACTAGCAAGGCTGCCCAGAAAAATGAGGACAAGAAGAAAAAAGACGAGACTATCGATACGGCGCGCCGTAACGCCCAGACTATATTGAGATGCACGTCGGCGTATCCGTTTAGGGTGAACGACAAATCGATATTGTGCGTCTACTGTCAGGAGCTGTACGACGATCCTATTGTGTTTCGCGATCACATGGACGCCGAACACGAGTACTTCAGCTTGAAGGTCGTGTTTCACAATCTGCCGAAGCCGGAGTTTATAAAGGCGGACCTGACGAACCTACGATGCAGACTATGCTCTGAGCGCTTCCAAACTCTGGAGATTGTCGCCGAACATTTGAAGAGCGTTCACGGCGAGAGCATTGACCTGCAATCGAAGTTGGGCGTTATGCCGTATCTGCTCAAGAAGGACGTTTTCGTGTGCGCGGTTTGCGGGAAGAATCAACCGTCGCTGTTCCATTTGAATCGGCACACGATAACGCATTTTCTGAGCTACGTTTGCCACGTGTGCGGGAGCAGCTACGTGGCGACCACCGGTCTGCTACGTCACGTCCGAATGAAGCATCAGGACTACCAGGTCGTCTGCAAGAAGTGCCGCAAGGTCTTTCCCACTATGGAAGCGAAGGAGAAGCACCGGCGCACCGAAAAGTCTTGCATGCCGTATTGCTGCCCTAAATGCTTGGAAAGGTTTTTAGATTACAAATCGAGGAAGAAGCACTTGGAAACGGCCCACGGGCAGAGCAAGCGCACGTATCGGATATCGGGTCAGAGATTGATGTGTGTTTACTGCGACGAAAAATTTGCCATACCCGCAGACTTCAGGAGCCACATGAAAGAGCAGCACAAAGTGTTTAAGGAAAAAGCCGCTTACGCCCACATTAGTTACTTGGCATTGGAAATCAAAGTTGACTGTACCGAGTTGAAATGTCTTTTGTGCCCGATGCAGTTTGATACTTTAGAAGCGATGGCCGAACATTTGAGTCGGACGCACGAGAAAGGTATTAACCTCGACGAGCGGATTGCGATACAGCCGTTCGTGTTCCGAGACAAGGGTTGGTCGTGTGCGCTGTGCTCGCTGAAGTTCTCGTGCCTGAAGGAGCTGAGCAAGCACACGATGTCGCACTTCCACAAATCGACGTGCGACAGTTGCGGGAAGTCTTTCGCCGACAACTGCGGCCTGAAAAAGCACATGGCAACGGCCCACATTACAGGGAAAGTGTGCCCGAAGTGTTTGCAGGTGTTCGCGACTAATGAGCTCCGATGGAACCACGTTCTGAAGTCGCCGGCCTGCTGGAGGTACATCTGCTCGATTTGCGGCGAGAGATTGATGACGGAGAAGATGAAAACGAATCACATGCTCGCGGTCCACGGTGTGAACACTAAAGTGCAGAAGTGTTACGAGTGTGACGCGGAGTTTCCCAACGCGAAGGTGTATCGTAAGCATTTCGTCACGGTGCACACGGATTCGGGTTACGAATGCGCCACGTGCGCAGTCAAATTCTCGGCAGAGGCCGATTACCTTGAGCACAAGACGAAACACACGAAAGAGAGGCCCTTCCAGTGCAGGGTCTGCTCTAAATCGTTTCCGCGCAAGAAGACGCTGGAGCAACACATGTGGATACACAGCGAGACGAAAAGGATCAACGGGCAAAACATGGTGTGCGTTTACTGCAATGCCAAGTATGAAGCGCCAGCCGAATATAGGAGACACATGAAGGAGAAACATAGATTCATCAGGAAACTGGCTTACGTACATTTGAAAAGTCCCGAAGCGTATATGAAGGTTGATTGCACGGAGATGAGCTGCAGCATTTGTTCGAGAAAGTTCGATAACGTCAGAGCCATTGCTGAACACTTGCGCTTCGCCCACGGCAAGACCGTGACCTTACACGAGGAGATCGCGATACACCCGTACGTGTTCGGCGAGAAACTGTGGGCCTGCGCCATCTGTCCTATGCAGCTGACCTGTCTCCGAGGACTCAGTATACACACGTCGACCCATTTCAATAGATCAACGTGCGAAACGTGCGGCAAATCGTTTGTTAATTCACACAGCCTACAGAGACACATAGCCGGTGCCCATTACAACGAGAAGATCTGCGAGAAATGCAAGAAACGTTTCCCGACAAACGCCGAAAGGCACAAGCACTTGACCGAATCGCCGGCGTGCTGGCGTTATATTTGTCGGGTATGCGGACAGCGATGCATGAACCAGAAGAGGAAAGACGCCCACATGAGGGAAGTGCACGGACAAGAGAAGACCCGTATATGCACGGAATGCGGTCTCCAATTCACCAGATGGGAGCTGTACACGCACCATTTTATAACGACCCACACCGACAGAGCCTATGAATGCACTTTTTGCGGTCTGAAACTGTCCACGAAGAAGAAGTTTGAAGATCACAAAACTGTGCACACCAAAGAGAAGCCTTTTGACTGTCATGTTTGTTACAAGGCCTTTCCCACCAGGAAGACCCTAACACAGCATATGTGGGTTCACAGCGAATACAAGCGCTTCGAATAACTAAGTCCGATGCACTACGCGAGACAAAACGCCCGGACGATAGTACAGTACACCACCGCATATCCCTTTAGGCTACCCGAAAGCGAGATGATGTGCGTATACTGCTGTGACAAATATCCCAGCCCCGAGGTGTTCAGGAAACACATGGAGGACACACATCCAGCCGCCAATCATAGGACCTCCTTCTTCCATCACACCGAGGGCTACGTAAAAGCGGACTGCACCGAATTAAGATGTCGCATATGCGGCGAGAACTTTGATAAGTTACGCGCGATCGCGGAACATTTGAAGTTAGCCCACAATAAAAACGTTAAGTTGGAATACGGATTCGGCTTGCAGCCGTACAAATTGAGAATGGACCGGATGTGGTGCGGGATATGTGGTTACAAATCGGTGCAGCTACGTTCGTTGAGTAAACATTTGCAAACGCATTATTTACAGTTTACGTGTGAGTCTTGTGGCAAGTCGTATGCCACGAATACTTCCCTGCAGCACCATATTAAGTATTCGTGTTCTCGGGTCGGCAACAAGCCCATGTGCAGAACGTGTCGCCGGGAATTCGATAATCTAGAGGACAAAAGGCATCACTACAAGGACTCTAGCCATTGTCGGTTGTACGTCTGCCAGGAGTGTGGCGAGAGATTTGCGTACAACCGCGAGAAAGCCGCGCATTTGGAGAAGGTTCACGATGTTCCGCTCAAGCAACACAAATGCCCCGAGTTGCCAGACACGAATATGGTGTGTGTTTATTGCGCTGAAGGCTACGAGGTTCCGACCATGTTCAGAAGACACATGGAAACCGAACACCAGCTGTTTAATCCTCGTATGGCGTTCGCGCATTTACCAGAGGGATATATAAAAGTTGACTGTACCGATATACGTTGTCGGATATGCTCAGAGCATTTTGTTACTCTAGAGGAAATAGGTTCGCACCTGCAGTCTGTGCACTACAAGCATTTCGACTTGAATACTGAAATCGGAGCCCAACCCTTCAAGTTTGAGAACGATCGGTTCAAATGTTCGATTTGTAATAAGAAGACCCTAGGGTTGAGGCAGTTAAGTCGACACATGCACACGCATTTCCTAAAGTACACTTGCGACTCGTGCGGGAAGTCTTATGCTACCAACACGGCTCTGAGAGCTCACACTCGTTACACCCATTCCAGGGAGGGGCACATTTGTAGGAAATGTAAAACGTCGTTTTCCTCAGCAGAAGCTTTAAGGGCGCACCGTTTGGAATCACGCAGGTGCTGGCAGTATTTGTGCAATGTGTGCGGCGAGAGGTTCGTCAATTGGGAGCTGAAGGAGAACCATCGTAGAGAGATTCATGGAGTTGAGAAGCGTGCTTACAATTGTTTGGAGTGTGGCGAAAGTTTTGCCTGCCGGAAAAAGTTTCAAACTCATTTCAAGGTTTCGCACACGGACGACAGCTACATGTGCCCGTTTTGCGGAGTCAAATTCCCAACGCGAAGGATCTTGGAGGATCACAGGGTCGTTCATACTAAAGAGAAACTCTTCCCTTGCATGGTGTGCCTGAAGGCGTTTTCCAGGAAGAAGAATCTCGTTCAGCACATGTGGATGCATAGCGAATACAAACGCTTCGAATGCAAAATGTGCAACAAACAGTTCAACCAACGCGTCAGCTGGAAGTCTCACATGAAATCTTACCACCCGGATTTGTCTGTGTCGGAGCAACAGGGAAAGAACAATAACACAAAATTGTTAAATACCGAACTTGTGACCAAAAGCGTTTCTGTTGTTCTAGAGCAATTCGGATCGACCGGTCGACGGAACGCCGCGGTCATTTTGCAGAATGTCACGGCGTATCCTTTCCGGCTACCGGAAGCGACAATAATGTGCGTTTACTGTTGCGAGGACTTTCCCGATCCCGTAGATTTTCGGTCACACATGGCCACCGAACACGATTTCGTTAAAGTCGACGTAGCGTTTGCGCATTGCCGCGAGGGCTACCTGAAGACGGACTGCACGGAATTACGTTGCAGAATATGCTCTAAGGAGCATTCAAATTTGGAGCACGTAGCGAGACATTTAATCGATGACCACGGCTTCGAATTAGCCGGTGGAGATTTTGGTCTGCATCCGTTTAAATTTAAAAACGATAAACTCCTCTGCGGGATCTGCGAGAAAAACTTTCCGTGCATGCGTCAGCTGAGCAGACACATGGCGGCTCATTATAAAAACTTCACCTGCGAATCGTGCGGGAAAGCGTACACGACAAACAACGCTCTGAGGCAACATTTGAGATTCTCGCACATCGACAATGAACGTATATGCAGGCGTTGCAAGGAGACGTTTTGTTCTTTAGAAGCGAAGAAGGAGCACGTGGCTTCTTCGCCGTCATGCTGGAGCTACCGTTGCGGCGCGTGCTCACAGCGATTCATAACGTGGAATGAGAAACAGGCTCATCTCATCCGGGCACACGGCCATACTAGAAAGTCGCATTCGTGTCCGGAATGCAGGGAGGTTTTTCATTCAAGGAACAAATACCGGCACCATTTTTCGACGGTGCATAACAACGTGTGCTTTGTTTGCTCGTTTTGCGGCCGAAAGTTTTCGACCAGACGTTATTTGGAACAACACAATGTGGTGCATTCGGGCATCAAACAGTACCAATGTGAGGTCTGTTCGAGGTCGTTTTCTCGGAAGGACTACCTCACTAAGCACGTGCTCATACATTCTGACGCTAGGAAGTTTGAATGCGCTTTGTGCAAAATGGAACCGCATTTAAGAGCGAAAAGGAATGCTGAAGTCGTATTGAAATATTCGACGATTTATCCCTTCAGAATGCGAGCGAAGTGGTTGATGTGCGTCTACTGCTGCGATGAGTTCGAAGACCCGGCTTTATTCCGCAGGCACGTAGACGAGGCCCACGAGAATTTCACAATATCGACAGCGTTCGCACATCTCGGCCGAGGCAAAGATTACCTGAAGGTTGACTGCTCAAATATGAAATGCAGAATATGCTCCGAACCTGCCGATACTCTCGAGGAAATGGCCTCACACATCATCGACTACCACCGTAACAAATCCACTTACCAAATGAACTTGGAATACCAGATAGGGCTTCACCCTTACAGATTGGAGAAGGATCGGTGGCTGTGTTTTCTCTGTAGCGAAAAACTACCTTCTCTGATCAAATTGTGTCGGCATACCACTTCCCATTACTTGGATTATACTTGCGACACGTGCGGCCGGAGGTATCTGACGGTTGACGCTCTTAAATACCACATAAAATGCAGTCATACCGGACGCTACATCTGCAGGAAATGCTGGAAGGATTTTCCGTCGCCCCAAACGAAAAGGGAACACGTGAAATCAACAAAAACGTGCTGGCCCTTCTCTTGTGTTTACTGCGGCGATAGGTTCCTGTCGTGGGAACAAAAACAAAGGCACTTAGTCGAGAGTCACGGACGTCCCGAAACTTCGTACACGTGTCCAGAATGCACATTAGTGTTTCAGTCACGCAAACTATTCTACAACCATTACAAGGTGTCACATACTGATGATAGTTTCATGTGTACCTGCTGCGGACTCAGGTTCGAGTCTAAGAACCGCCTGGAAGACCACCGATTAGGGTCCACACTGCGATTACGCGGACGCAATGAAAATGAGCATGAACCAAAAAAGAAAATTGTCCTTGTTTACCAAACGCCTCAGAGGCGAAACGCTGAACTGATTCTCAGATTCTCGACAGCTTGTCCGTTTAAAACGCGTTTCAGTCAAATACTGTGCGCCTATTGTCATACAGAGTTCGGTGCTCTGGCCGACCTCCGGTACCACATGAGGGACGAACACACGAATTCGGACTTCAAAAATGTCTTTTATAGAGTCAAAGATAATTTGCTCAAGATCGACATAACTGACCTTAAATGCAAGGTCTGTTCGCAGAATATGCAAGACGTGGATTCGTTGATGGCCCATCTATTTAGGGAGCACGAGAAGCCGGTGAATTTTAACGCGAGACACGGGTCCACACTGCGATTACGCGGACGCAATGAAAATGAGCATGAATCGAAAAAGAAAATTGTCCTTGTTTACCAAACGCCTCAGAGGCGAAACGCTGAACTGATTCTCAGATTCTCGACAGCATGTCCGTTCAAAACACGTTTCAGTCAAATACTGTGCGCCTATTGTCATACAGAGTTCGGTGCTCTGGCCGACCTCCGATACCACATGAGGGGCGAACACACGAATTCGGACTTCAAAAATGTATTTTATAGAGTCAAAGATAATTTGCTCAAGATCGACATAACTGACCTTAAATGCAAGATCTGTTCGCAGAATATGCAAGACGTGGATTCGTTGATGGCCCATTTATTTAGGGAGCACGAAAAGCCGGTGAAGTTTAACGCGAGACACGGCGTGTTGCCTTATAAGCAGGACGCTGACAATAACTGGCTCTGCGTGTATTGTCCTAGGGTATTCACCGAGTTTATTCTGTTCAAACGTCACATAGGAACTCATTTTATGAGCGTCAGCTGCGATAAATGTGGTACAATGTTTGTTTCTGAGCACGCGTTGCGCGACCATCAACGCCAAGTTAAATGCTTCAGAACTACGTACAAGCCGCGCAATGGAAAAGTTCTGAAGCCGCGAACGAATGCCGAAATTGTATTACAATGCTCGACGGCATGTCCGTTTCGAACTTGGAAGACGAATTTTAATTGCGTTTTTTGTAGACTGCAAACGAGCGACCCTAATTTCTTGAGGGTCCACATGGCGACGCGCCACGCGAACTTTGACGTTCAAGCGGCTTTCTACAAGAAACTAGGTAAAGACTTTCTGAACATCGACATTACGGATCTTCAATGTAAACTTTGCTTTATGCCCGTTGACAATTTTGATACTTTAACGTACCATTTGAGAAATGACCACGAGCAACCGATCAATTTAGATGCTCAGATAGGCGTACTCCCGTTTCGTCTGAACGACGGCTCGGTTTGGCGGTGCACGATCTGTCCGAATGAGTTCAAAGACTTCATGTCGCTGAAGAAGCACACGGCCGAACATTTCCAGAACTACGTCTGCGACACGTGCGGCGAAGGTTTCATAACGGAATCGGCAATGGTGGCCCACTCGAAGATACCTCACGAAAACAAATACAACTGCAGTAGGTGCGTCGCAACGTTTTCGACGCTAGACGAACGAAATGTTCACGTTAAGACGCAGCACACGTCGATGCCGTACATGTGCGTTTACTGCAAGGAGAAGCCGCGCTTCGCTAACTGGGAACTCCGGCGGAGGATGAAAAGAGACGCGTTAAGCGACGCGGATAGTAAACCGAAACAGAAACTGTTTGAGAGATCGGTTAACCAGAACCCCCGTAAGCAAAACGCGGTGTTGACCTTAAAATATTCCACTGCCTTCCCTTTTAAGACGCGTTTCAATCGTATCATTTGCTCGTACTGCCACGACGAGTTCGATATAATGGCTTCGCTGAGGGAGCACATGAAAAACGAACACGCCAACGCTGATTTCAATAGCGCCTTCTACAAGGTTGACGTGTTGAAAGTCAATATAACAGATTTTAAATGCACGATTTGCGAACAGACGATGAGTGACGTTGAAACGTTTATGGCTCATATTTCGCGGGATCACGGTATATCGGTTAACTTTGACGTGCCTTTCGGCGTTCTGCCATATCGTCAGGACTCGACCGGCATGTGGACTTGTCTGAAGTGCGACAAACTGTATCCCGAGTTCGCCCAAATCAACGGTCACATACGTACTCACGTTAAAATTTACACGTGCGAGAAGTGTGGCGCCACGTTCTTGTCGGAGCACGGTTTACGCCAGCACGAAAGGAACTTAAAATGCTACAAGCTGACATACAAGCCACGTTTCGGGAAAGCGTTGAAACATCGGAGCAACGCGGAAATTATCCTGCAATGCTCCACAGCGACGCCGTTTCGGACCTGGGGTCAGAATTTTAATTGCGTCCTCTGCAGGGTGCAGTCGTACGACCCGAACGGCCTGAGAATGCACATGGCGAGCCGTCATGCGACTTACGACATTGAGCACGTGTTCAGCAGAAAACTACGTAAAGAGTTCCTCAAGGTTGACATTACCGACCTTCAGTGTAAGCTGTGTTTCATGCCGATCGATACCTTGGACGAATTGCTCTCTCACCTCCGTAACGACCACAAGCAGCCTATAAACGCGGACGTCCAACCCGGCGTCCTTCCTTACAAGCTAAACGACGGCTCTGTGTGGAAATGCGCCATATGCAAAGCGCAGTTTACAGATTTTATATCTCTCAAGAAGCACACGTCGGAGCACTATCAGAATTTTGTTTGCGACACCTGCGGGGAGGGCTTTATAACGGAATCGGCGCTCTTGGCCCACACCAGGATACCGCACGACAACAAATACTCGTGCAGCAGATGCGTCGCAACGTTCTCGACCCTGGAGGAGAGGAATATGCACGTTAAAACCCAGCACACGAATTCGCCGTACATGTGCGCGTACTGTAAAGATAGACCAAGGTTTACAACTTGGGAGCTCAGGAAGCGGCACCTCATGGAGTTCCACAATTACAGGGCCGGCGCCGATATTTACGAGTGCATGACTTGCCACATGACTTTCAAGACGAGGTCGCAGAAGTACCACCACAACGTGAAAGCGCACAGGACCAAGAAAGAGTCTGAATACAGCTATCAGTGCGGCAGCTGTTCGAGGGCTTTTGCTTCTAAGCTTTCCCTTGACAAGCATATCGCGAAAAAGCATTTTCATGTTTGA
Protein
MELLASPQLSVKRKAPAQTKTVSVKKVKVIKKDARGKPTTSKAAQKNEDKKKKDETIDTARRNAQTILRCTSAYPFRVNDKSILCVYCQELYDDPIVFRDHMDAEHEYFSLKVVFHNLPKPEFIKADLTNLRCRLCSERFQTLEIVAEHLKSVHGESIDLQSKLGVMPYLLKKDVFVCAVCGKNQPSLFHLNRHTITHFLSYVCHVCGSSYVATTGLLRHVRMKHQDYQVVCKKCRKVFPTMEAKEKHRRTEKSCMPYCCPKCLERFLDYKSRKKHLETAHGQSKRTYRISGQRLMCVYCDEKFAIPADFRSHMKEQHKVFKEKAAYAHISYLALEIKVDCTELKCLLCPMQFDTLEAMAEHLSRTHEKGINLDERIAIQPFVFRDKGWSCALCSLKFSCLKELSKHTMSHFHKSTCDSCGKSFADNCGLKKHMATAHITGKVCPKCLQVFATNELRWNHVLKSPACWRYICSICGERLMTEKMKTNHMLAVHGVNTKVQKCYECDAEFPNAKVYRKHFVTVHTDSGYECATCAVKFSAEADYLEHKTKHTKERPFQCRVCSKSFPRKKTLEQHMWIHSETKRINGQNMVCVYCNAKYEAPAEYRRHMKEKHRFIRKLAYVHLKSPEAYMKVDCTEMSCSICSRKFDNVRAIAEHLRFAHGKTVTLHEEIAIHPYVFGEKLWACAICPMQLTCLRGLSIHTSTHFNRSTCETCGKSFVNSHSLQRHIAGAHYNEKICEKCKKRFPTNAERHKHLTESPACWRYICRVCGQRCMNQKRKDAHMREVHGQEKTRICTECGLQFTRWELYTHHFITTHTDRAYECTFCGLKLSTKKKFEDHKTVHTKEKPFDCHVCYKAFPTRKTLTQHMWVHSEYKRFEXLSPMHYARQNARTIVQYTTAYPFRLPESEMMCVYCCDKYPSPEVFRKHMEDTHPAANHRTSFFHHTEGYVKADCTELRCRICGENFDKLRAIAEHLKLAHNKNVKLEYGFGLQPYKLRMDRMWCGICGYKSVQLRSLSKHLQTHYLQFTCESCGKSYATNTSLQHHIKYSCSRVGNKPMCRTCRREFDNLEDKRHHYKDSSHCRLYVCQECGERFAYNREKAAHLEKVHDVPLKQHKCPELPDTNMVCVYCAEGYEVPTMFRRHMETEHQLFNPRMAFAHLPEGYIKVDCTDIRCRICSEHFVTLEEIGSHLQSVHYKHFDLNTEIGAQPFKFENDRFKCSICNKKTLGLRQLSRHMHTHFLKYTCDSCGKSYATNTALRAHTRYTHSREGHICRKCKTSFSSAEALRAHRLESRRCWQYLCNVCGERFVNWELKENHRREIHGVEKRAYNCLECGESFACRKKFQTHFKVSHTDDSYMCPFCGVKFPTRRILEDHRVVHTKEKLFPCMVCLKAFSRKKNLVQHMWMHSEYKRFECKMCNKQFNQRVSWKSHMKSYHPDLSVSEQQGKNNNTKLLNTELVTKSVSVVLEQFGSTGRRNAAVILQNVTAYPFRLPEATIMCVYCCEDFPDPVDFRSHMATEHDFVKVDVAFAHCREGYLKTDCTELRCRICSKEHSNLEHVARHLIDDHGFELAGGDFGLHPFKFKNDKLLCGICEKNFPCMRQLSRHMAAHYKNFTCESCGKAYTTNNALRQHLRFSHIDNERICRRCKETFCSLEAKKEHVASSPSCWSYRCGACSQRFITWNEKQAHLIRAHGHTRKSHSCPECREVFHSRNKYRHHFSTVHNNVCFVCSFCGRKFSTRRYLEQHNVVHSGIKQYQCEVCSRSFSRKDYLTKHVLIHSDARKFECALCKMEPHLRAKRNAEVVLKYSTIYPFRMRAKWLMCVYCCDEFEDPALFRRHVDEAHENFTISTAFAHLGRGKDYLKVDCSNMKCRICSEPADTLEEMASHIIDYHRNKSTYQMNLEYQIGLHPYRLEKDRWLCFLCSEKLPSLIKLCRHTTSHYLDYTCDTCGRRYLTVDALKYHIKCSHTGRYICRKCWKDFPSPQTKREHVKSTKTCWPFSCVYCGDRFLSWEQKQRHLVESHGRPETSYTCPECTLVFQSRKLFYNHYKVSHTDDSFMCTCCGLRFESKNRLEDHRLGSTLRLRGRNENEHEPKKKIVLVYQTPQRRNAELILRFSTACPFKTRFSQILCAYCHTEFGALADLRYHMRDEHTNSDFKNVFYRVKDNLLKIDITDLKCKVCSQNMQDVDSLMAHLFREHEKPVNFNARHGSTLRLRGRNENEHESKKKIVLVYQTPQRRNAELILRFSTACPFKTRFSQILCAYCHTEFGALADLRYHMRGEHTNSDFKNVFYRVKDNLLKIDITDLKCKICSQNMQDVDSLMAHLFREHEKPVKFNARHGVLPYKQDADNNWLCVYCPRVFTEFILFKRHIGTHFMSVSCDKCGTMFVSEHALRDHQRQVKCFRTTYKPRNGKVLKPRTNAEIVLQCSTACPFRTWKTNFNCVFCRLQTSDPNFLRVHMATRHANFDVQAAFYKKLGKDFLNIDITDLQCKLCFMPVDNFDTLTYHLRNDHEQPINLDAQIGVLPFRLNDGSVWRCTICPNEFKDFMSLKKHTAEHFQNYVCDTCGEGFITESAMVAHSKIPHENKYNCSRCVATFSTLDERNVHVKTQHTSMPYMCVYCKEKPRFANWELRRRMKRDALSDADSKPKQKLFERSVNQNPRKQNAVLTLKYSTAFPFKTRFNRIICSYCHDEFDIMASLREHMKNEHANADFNSAFYKVDVLKVNITDFKCTICEQTMSDVETFMAHISRDHGISVNFDVPFGVLPYRQDSTGMWTCLKCDKLYPEFAQINGHIRTHVKIYTCEKCGATFLSEHGLRQHERNLKCYKLTYKPRFGKALKHRSNAEIILQCSTATPFRTWGQNFNCVLCRVQSYDPNGLRMHMASRHATYDIEHVFSRKLRKEFLKVDITDLQCKLCFMPIDTLDELLSHLRNDHKQPINADVQPGVLPYKLNDGSVWKCAICKAQFTDFISLKKHTSEHYQNFVCDTCGEGFITESALLAHTRIPHDNKYSCSRCVATFSTLEERNMHVKTQHTNSPYMCAYCKDRPRFTTWELRKRHLMEFHNYRAGADIYECMTCHMTFKTRSQKYHHNVKAHRTKKESEYSYQCGSCSRAFASKLSLDKHIAKKHFHV

Summary

Description
Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidence is required to confirm this result in vivo (PubMed:11470777).
May be involved in transcriptional regulation.
May play a role in differentiating skeletal muscle.
Mediates transcriptional repression in response to zinc. Represses several genes, including SLC30A5, SLC30A10 and CBWD1, by binding to the zinc transcriptional regulatory element (ZTRE) (5'-C[AC]C[TAG]CC[TC]-N(0-50)-[GA]G[ATC]G[TG]G-3') found in the promoter region. May play a role in the control of ribosome biogenesis, regulating predominantly rRNA levels, as well as those of several ribosomal proteins, thus coordinating this highly zinc-demanding process with the available zinc supply.
Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes.
Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis (By similarity).
Acts as a transcriptional repressor.
Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis.
May have a role during differentiation processes.
Transcriptional repressor.
May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.
Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305).
May be a transcriptional repressor.
Subunit
Interacts with EBF1. Interacts with SMAD1 and SMAD4.
Interacts (via the KRAB domain) with TRIM28 (via the RBCC domain); the interaction increases ZNF268 nuclear localization activity. Isoform 2 interacts with CHUK and IKBKB; the interaction is further increased in a TNF-alpha-dependent manner.
Interacts with INCA1; the interaction inhibits INCA1 activity and induces the cell cycle process.
Interacts with EBF1. Interacts with SMAD1 and SMAD4 (By similarity).
Interacts with WT1. Interacts with DEPDC1A.
Miscellaneous
ZNF91 is only present in primates and emerged in the last common ancestor of humans and Old-World monkeys. It underwent structural changes between 8-12 Million years ago, probably to improve the protein's ability to bind and repress SINE-VNTR-Alu (SVA) retrotransposons elements (PubMed:25274305).
ZNF93 is only present in primates and evolved to repress the primate L1 lineage until 12.5 million years. Evolution stopped when the L1PA3-subfamily of retrotransposons, that escape repression by ZNF93 through the removal of the ZNF93-binding site, appeared (PubMed:25274305).
Confers resistance to ET-743 (trabectedin, Yondelis) and PM00104 (Zalypsis), 2 marine derived compounds with antitumor activity in cancer cell lines.
Similarity
Belongs to the krueppel C2H2-type zinc-finger protein family.
Keywords
Alternative splicing   Complete proteome   DNA-binding   Metal-binding   Nucleus   Polymorphism   Reference proteome   Repeat   Transcription   Transcription regulation   Zinc   Zinc-finger   3D-structure   Cytoplasm   Phosphoprotein   RNA-binding   Repressor   Isopeptide bond   Ubl conjugation   Ribosome biogenesis   Activator   Chromosomal rearrangement   Developmental protein   Differentiation   Proto-oncogene   Acetylation   Cell cycle   Cell division   Mitogen   Spermatogenesis  
Feature
chain  Zinc finger protein 208
splice variant  In isoform 2.
sequence variant  In dbSNP:rs2007506.
Pubmed
9724325    15057824    17974005    2826129    1782138    8398678    + More
7692399    2506074    2503871    8467795    14702039    2023909    7479878    11470777    16606703    23665872    25274305    15815621    11853319    28112733    16141072    15489334    8808410    21183079    15372022    25218447    25772364    25755297    3143103    16959974    11410164    10997877    11214971    7865130    11230166    15164053    25582195    1711675    2288909    2452975    10718198    16625196    19468303    2503827    2509712    14630787    17344859    11984006    19413330    19690332    23186163    2505992    1945843    21406692    11311945    12200376    16865230    18949428    16541075    12822888    15547661    16787922    16735226    18774934    18375384    18677094    23091055    22235304    23946776    12743021    9630514    11780052    11574149    8001572    9380504    12682018    16641997    2104800    2249852    16628192    19608861    19763908    21468593    21874239    9067431    1559709    21266108    12853948    10964405    16793018    1505991    8547218    2512579    12393497    15449545    15580294    10673043    11347906    12168954    7557990    10449920    15772651    2037297    14628291    23871722    9731181    10585455    12239212    20587513    19742314    9839802    8674531   
EMBL
AC003973    AC011494    AC073539    BX956721    X06021    L11672    + More
AK300294    AK291256    AC010300    AC016628    AC022409    AC093058    M61871    AC020928    AL834155    AC092574    DA309597    AB075862    AK028351    AK048619    AK088060    AK154767    BC022935    BC065692    L36315    Z67747    AK091550    AK295714    AK303450    DA323041    AC022413    AL832408    BC140761    BC171780    AK141740    AK220539    M36514    X12592    AK295079    AC010467    BC007307    AK292528    CH471126    BC045649    AC010328    CH471135    BC000807    BC094880    AF277623    AB046831    AK024442    X78928    AL136732    CH471106    BC136777    AK022636    AK057375    BX664608    AL353770    BC031626    AL110217    AK092266    BC033199    BC125099    AL832969    X59244    BT009756    AK291353    CR933640    AC010617    AC092364    BC006528    M61869    X52358    AK028500    AK135293    AK147732    BC059037    M36515    X12593    CR857771    AK032872    AK085077    BC058553    BC094590    BC139312    BC139315    M20755    M20756    M20757    AK056389    AK074345    AC012309    BC063820    AK095694    BX248098    AY147015    BC093625    AK027834    AC010320    AC011468    AK131308    AK055483    AK074539    AC093227    AC016582    BC015418    BC042170    BC051263    BC064962    AK300483    AC010326    AB037770    AK131401    AC092714    AC098850    BC103943    BC103944    BC103946    CR858827    AC159264    AC163667    BC062958    AK093163    AK292954    BX647423    AC006130    BC022022    CR859627    BC126592    CR749856    AC022150    BC033230    BC130351    BC130353    AK092760    BC028367    BC065023    BC136728    BC136729    AC008626    AC007842    BC136960    AK093512    AK129938    AK131334    AK131409    BC136254    M25866    AK024407    AK291403    AJ518106    AK021452    AK027354    AK074046    EF445043    CH471088    BC113622    BC113648    DQ845345    AL117615    AF141339    M27878    X60156    AK314232    CH471218    BC036656    BC048350    BC062552    AF317549    AF385187    AF432217    AC026785    DQ057356    DQ057357    DQ057358    DQ057359    DQ057360    X78926    AY029765    AK096623    AC092070    BC136255    AL713691    AK289843    BC007303    AF228417    X78927    AC074331    AC149283    BC050048    AB010334    DQ976502    AK299811    AL031673    BC021298    AL049942    AB046644    BC133352    X82643    AK131231    BX640933    AC008813    AK300504    AC104117    AF011573    AY074878    AK314196    AC099669    CH471055    X17617    M36146    M36145    AF244088    DQ117529    AK127625    CH471162    BC010996    X52340    DQ977377    AK056753    AK315728    AC008733    AC010632    BC026210    BX537887    AC253576    BC036110    BC043151    CAD97883.1    L75847    AC035150    BC037575    M67509    X52336    AY621067    AK056498    AC073422    BC125189    AJ388557    AY835704    AK056615    AK289987    AC008806    BC117219    M88363    AF228418    AK023091    AC138470    BC017786    BC024197    X78933    BC032863    L16904    M28514    BC148089    AY147406    AK131130    BC021376    AK077697    AK081096    AB027251    BC047243    DQ977236    AB058774    AY500358    U09411    AC012313    BC109107    BC109108    AY695825    AB075836    AK056113    BC112244    BC113707    BC109267    BC109268    AK095463    X60155    AJ010017    AJ010018    AJ010019    AJ010020    AJ010021    AJ010022    AJ010023    AK290021    AK294858    AL590223    AL590283    CH471164    BC015023    M92443    AL832890    AC008758    BC009517    AB011414    BC032753    BC053084    AK131557    AK131559    AK027708    BC014850    AK095600    AK290911    BC136746    BC136751    AF187990    AC084219    AC114266    BC051902    AF067164    AY148489    X52353    AC021092    AK131527    AK095062    AC022432    X52339    AF187991    AK223477    AK292437    BC108912    AC010615    AY269786    AF325191    BM996292    CR857542    AK022550    AK096342    AC007204    AC011477    BC136718    BC136719    M61873    BC103362    BC123758    U35376    AC008739    BC068066    M61866    M61868    AK097798    U48721    M28515    AC011503    BC046415    AB021644    AC011458    BC136323    X52337    AK095616    AK127476    AK128494    AB209086    BX648842    BC006408    CR859597    CR860164    CR861238    AK128361    AK131494    CR936612    AC011460    BC105100    BC105102    BC143429    AK092253    AK299266    AK316048    BC047570   
Pfam
PF00096   zf-C2H2        + More
PF01352   KRAB
PF16622   zf-C2H2_11
PF02023   SCAN
Interpro
IPR001909   KRAB        + More
IPR036236   Znf_C2H2_sf       
IPR036051   KRAB_dom_sf       
IPR013087   Znf_C2H2_type       
IPR041697   Znf-C2H2_11       
IPR017125   Znf_PRDM5-like       
IPR003309   SCAN_dom       
IPR038269   SCAN_sf       
IPR003656   Znf_BED       
IPR017114   YY-1-like       
SUPFAM
SSF109640   SSF109640        + More
SSF57667   SSF57667       
Gene 3D
PDB
5V3M     E-value=4.14251e-21,     Score=258

Ontologies

Topology

Subcellular location
Nucleus  
Cytoplasm  
Length:
3130
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.0386
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00182
outside
1  -  3130
 
 

Population Genetic Test Statistics

Pi
276.394021
Theta
196.030187
Tajima's D
1.319713
CLR
0.272531
CSRT
0.743962801859907
Interpretation
Uncertain
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