Gene

KWMTBOMO14570  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008736

Annotation

hemolin_[Bombyx_mori]

Location

Bomo_Chr24(+):10467789-10473791      View in EpiBrowser

Full name

Hemolin       + More
Neuroglian      

Alternative Name

Hemocyte aggregation inhibitor
Protein P4

Location in the cell

Extracellular   Reliability : 2.272

CDS

ATGAATTCCTGGACGTTATTAGTTTTGGGAACATGTGTTATTTACACTACGGGGCAGCCCGTTAATTCCGGAGACAAGGTTCCCGTTCTCAAGGAGGCACCGGCCGAGGTATTGTTCAGAGAGGGACAGGCCACGAGGCTGGAGTGCGCCACAGAGGGAGACGACAGTGGTGTCGAATACTCGTGGCGAAAAGACGGCATGCATTTTAGTGTCGGTCAAGACACGCTCACCACTATCGACGCTGGCTCTCTTGTCTTCACCCAAACCAAAGCTTCGGACGAAGGCGAGTACCAGTGCTTCGCCAAAAGCGACTTTGGGGTCGCCAGCACAAGGGCCACTAAGCTCCGCCGTACGTACATAGAGACTCCTGCATTTGAGGAGAAAAAAGTGACGGTGGTCGAAGGAAAACCCTTTGAACTCCGCTGTCCAGTGCCCGGGGGCTACCCGAAGCCGACCATAAGCTGGATGAGACATCATGACGAGGACGGCTCCACTGAGAACTTCATGGACAGAAGAGCGACTTATTCACCCGAGGGAACCCTGTACTTTTCCAATGCGAGTCTTGACGATGCCAACGATAAAACCAAGCTGGTCTGCATGGCCTCTTCTCCTGCCGCCGACGAGGGTGTGCCCATAGTCACGTATTACATCACGCAAGTGACTCCCGCCTCGGAGCCCACGTATGGAGAGCTGATCCCTCAGTACTTGAGTGACCACGTGGTGGCGAAAGTTGGCGATCTGACGTATCTATACTGCATTTATGGCGGAACTCCCCTAGCCCACCCAAGCTGGTCCAAGGACGGTGTAAACGTGGACAATACCTACAAGGATCGCATAACCCGCCACAACAGGTCCTCTGGGAGGAGACTGGTCATCAAGGAGGTTTGGGCAGAGGACGCGGGCACTTACACGTGCGATGTAGACAATCAGGCCGGCAGAAGACTGCAACACACAATCACCTTTAGTGTTGTCAGTGCACCAACCTTCACGACTAAACCAGAGAAACGAACGCTGGCAACCCAAGGCGAGGACGTCACAATACCTTGTAAGGCGACAGGAATTCCGTCACCTCTAGTTTCGTGGACTTACAACGGCGAACCCGTGACCGAAGGGGTCACTGGTGACGGACTGGTGATCAAGGCTGTCAATAAATCTAATCAAGGCTACTACGGGTGTACTGCCTCGAATGAGCACGGCGCAGAATACGCCGAAACGGCTCTTCAAGTCGCTTAA

Protein

MNSWTLLVLGTCVIYTTGQPVNSGDKVPVLKEAPAEVLFREGQATRLECATEGDDSGVEYSWRKDGMHFSVGQDTLTTIDAGSLVFTQTKASDEGEYQCFAKSDFGVASTRATKLRRTYIETPAFEEKKVTVVEGKPFELRCPVPGGYPKPTISWMRHHDEDGSTENFMDRRATYSPEGTLYFSNASLDDANDKTKLVCMASSPAADEGVPIVTYYITQVTPASEPTYGELIPQYLSDHVVAKVGDLTYLYCIYGGTPLAHPSWSKDGVNVDNTYKDRITRHNRSSGRRLVIKEVWAEDAGTYTCDVDNQAGRRLQHTITFSVVSAPTFTTKPEKRTLATQGEDVTIPCKATGIPSPLVSWTYNGEPVTEGVTGDGLVIKAVNKSNQGYYGCTASNEHGAEYAETALQVA

Description

Insect-immune protein with antimicrobial activity (PubMed:16731347). Forms a protein complex at the bacterial surface. Can inhibit hemocyte aggregation.
The long isoform may play a role in neural and glial cell adhesion in the developing embryo. The short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. Vital for embryonic development. Essential for septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation.

Subunit

Forms a complex with Nrx and Cont.

Keywords

Disulfide bond   Glycoprotein   Immunity   Immunoglobulin domain   Innate immunity   Repeat   Secreted   Signal   3D-structure   Direct protein sequencing   Alternative splicing   Cell adhesion   Cell junction   Cell membrane   Complete proteome   Developmental protein   Membrane   Reference proteome   Tight junction   Transmembrane   Transmembrane helix  

Feature

chain  Hemolin
splice variant  In isoform A.

Uniprot

C4PAW6   Q4FAT1   Q6R3M0   Q6R3L9   Q6R3M2   Q7YZA7   + More
H9JGT9   Q27418   P31398   Q1HLC2   Q1HLC0   Q1HLC1   A0A1N7T5L0   Q4H1G8   Q1HLC3   Q26438   P25033   Q0Q033   A0A0B5JK89   Q699P0   B3U103   A0A2A4K722   B3U102   A0A3G2ST65   A0A212ESK0   A0A1B1RSB4   D1KJ59   Q8WR61   O96360   D1KJ60   A0A2H1VRI9   A0A2H1VCL5   C7ASJ3   A0A0N1IBF3   A0A0N1IGX5   A0A2W1BES1   A0A096ZGV9   D4HNF1   A0A3B0J7M4   A0A3B0JXM4   A0A3B0J8C5   A0A0R3P7J0   Q29FM1   B4HA25   C0PTX6   A0A1W4VUK4   B4IJX8   M9NEZ5   P20241-2   E1JJF9   A0A1W4VGI6   E1JJF8   P20241   A0A0Q5TJA2   B3NVG5   A0A0Q5THL2   A0A0Q9WUV5   B4NCI8   A0A0Q5T3I4   A0A0P8ZS96   T1PPT7   B4Q0A3   B3N0B0   A0A0R1EHL1   A0A0R1EHH6   A0A1I8M4Q6   A0A1I8PSB9   A0A1I8PS80   A0A0Q9WVH7   A0A0Q9X0E4   A0A0M5J3D9   B4L315   U5EU82   B4M1M9   A0A0K8VTH5   A0A0L0C8N9   W8ARL3   A0A0K8WB81   A0A034V7N8   A0A0K8W814   A0A0A1XPS4   B4R6J8   A0A1B0A5I7   A0A1A9V6L8   A0A1B0AXR8   A0A1B0G439   A0A1L8DM81   A0A1B6DIS0   K7IUL4   E0VWB3   A0A2J7PJ23   A0A2J7PJ24   B4JP14   A0A0K8W8M7   A0A1A9WVD0   A0A1J1IL05   A0A154P2X8   A0A0P4VF33  

Pubmed

19121390    7551193    1790333    12706633    14728663    16731347    + More
17126583    7601154    2270488    9703515    16857061    15271212    15978282    19540262    22118469    9818384    19414015    26354079    28756777    15632085    17994087    23185243    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    2805067    9666073    12537569    1693086    15459097    17893096    19349973    7512815    26109357    26109356    17550304    18057021    25315136    26108605    24495485    25348373    25830018    20075255    20566863    27129103   

EMBL

FJ911550    ACQ82817.2    DQ096295    AAZ03611.1    AY515321    AY515322    + More
AAS00444.1    AAS00445.1    AY515323    AAS00446.1    AY515320    AAS00443.1    AB115084    BAC79387.1    BABH01037858    BABH01037859    U09650    U11879    AAC46916.1    M64346    DQ479433    ABF21071.1    DQ479435    ABF21073.1    DQ479434    ABF21072.1    KF938917    AIC33834.1    AB220992    BAE07175.1    DQ479432    ABF21070.1    S78712    AAB34817.1    M63398    DQ666497    ABG72701.1    KM885983    AJG03076.1    AY529704    AAS99343.1    EU477859    ACC91898.1    NWSH01000101    PCG79553.1    EU477858    ACC91897.1    MH033856    AYO51050.1    AGBW02012775    OWR44473.1    KU549180    ANU04686.1    GQ223117    ACZ04355.1    AF453868    AAL49765.1    AF023276    AAD09287.1    GQ223118    ACZ04356.1    ODYU01003993    SOQ43417.1    ODYU01001824    SOQ38555.1    FJ609299    ACU09501.1    KQ459348    KPJ01314.1    KQ459805    KPJ19896.1    KZ150113    PZC73318.1    KF752426    AIR96005.1    FJ687752    ACN69054.1    OUUW01000003    SPP78107.1    SPP78106.1    SPP78105.1    CH379066    KRT07328.1    EAL31379.2    KRT07327.1    CH479235    EDW36693.1    BT071821    ACN58584.1    CH480850    EDW51334.1    AE014298    AFH07295.1    M28231    AF050085    AF050084    AY058284    BT024971    X76243    X76244    ACZ95239.1    ACZ95241.1    AGB95180.1    ACZ95240.1    AGB95181.1    CH954180    KQS29946.1    EDV46357.1    KQS29947.1    CH964239    KRF99636.1    EDW82547.1    KQS29945.1    CH902640    KPU77357.1    KA650098    AFP64727.1    CM000162    EDX02240.1    KRK06659.1    EDV38314.2    KPU77356.1    KRK06658.1    KRK06660.1    CH933810    KRF94268.1    KRF94266.1    CP012528    ALC49261.1    EDW07901.2    KRF94267.1    GANO01002435    JAB57436.1    CH940651    EDW65583.2    GDHF01010156    JAI42158.1    JRES01000755    KNC28615.1    GAMC01019325    GAMC01019324    GAMC01019323    GAMC01019322    JAB87233.1    GDHF01030716    GDHF01014633    GDHF01004025    JAI21598.1    JAI37681.1    JAI48289.1    GAKP01020419    GAKP01020418    JAC38534.1    GDHF01029359    GDHF01024218    GDHF01005058    JAI22955.1    JAI28096.1    JAI47256.1    GBXI01000988    JAD13304.1    CM000366    EDX17428.1    JXJN01005350    CCAG010021144    GFDF01006522    JAV07562.1    GEDC01011705    JAS25593.1    AAZX01014469    DS235818    EEB17669.1    NEVH01024950    PNF16341.1    PNF16340.1    CH916371    EDV92457.1    GDHF01004882    JAI47432.1    CVRI01000055    CRL00919.1    KQ434809    KZC06285.1    GDKW01004159    JAI52436.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000053240    UP000268350    + More
UP000001819    UP000008744    UP000192221    UP000001292    UP000000803    UP000008711    UP000007798    UP000007801    UP000002282    UP000095301    UP000095300    UP000009192    UP000092553    UP000008792    UP000037069    UP000000304    UP000092445    UP000078200    UP000092460    UP000092444    UP000002358    UP000009046    UP000235965    UP000001070    UP000091820    UP000183832    UP000076502   

PRIDE

C4PAW6    Q4FAT1    Q6R3M0    Q6R3M2    Q7YZA7    H9JGT9    + More
P31398    P25033    C0PTX6    M9NEZ5    P20241    E1JJF9    E1JJF8   

Pfam

PF07679   I-set        + More
PF04148   Erv26
PF13882   Bravo_FIGEY
PF00047   ig
PF00041   fn3
PF13895   Ig_2
PF02820   MBT
PF12140   SLED

Interpro

IPR013098   Ig_I-set        + More
IPR013783   Ig-like_fold       
IPR003599   Ig_sub       
IPR007110   Ig-like_dom       
IPR036179   Ig-like_dom_sf       
IPR003598   Ig_sub2       
IPR007277   Svp26/Tex261       
IPR003961   FN3_dom       
IPR013151   Immunoglobulin       
IPR036116   FN3_sf       
IPR026966   Neurofascin/L1/NrCAM_C       
IPR037604   Scm-like-4MBT1/2_SAM       
IPR004092   Mbt       
IPR021987   SLED       
IPR038348   SLED_sf       
IPR013761   SAM/pointed_sf       

SUPFAM

SSF48726   SSF48726        + More
SSF49265   SSF49265       
SSF47769   SSF47769       

Gene 3D

2.60.40.10     1.10.150.50     1.20.1380.20    

CDD

cd00063  FN3
cd09581  SAM_Scm-like-4MBT1_2

ProteinModelPortal

C4PAW6   Q4FAT1   Q6R3M0   Q6R3L9   Q6R3M2   Q7YZA7   + More
H9JGT9   Q27418   P31398   Q1HLC2   Q1HLC0   Q1HLC1   A0A1N7T5L0   Q4H1G8   Q1HLC3   Q26438   P25033   Q0Q033   A0A0B5JK89   Q699P0   B3U103   A0A2A4K722   B3U102   A0A3G2ST65   A0A212ESK0   A0A1B1RSB4   D1KJ59   Q8WR61   O96360   D1KJ60   A0A2H1VRI9   A0A2H1VCL5   C7ASJ3   A0A0N1IBF3   A0A0N1IGX5   A0A2W1BES1   A0A096ZGV9   D4HNF1   A0A3B0J7M4   A0A3B0JXM4   A0A3B0J8C5   A0A0R3P7J0   Q29FM1   B4HA25   C0PTX6   A0A1W4VUK4   B4IJX8   M9NEZ5   P20241-2   E1JJF9   A0A1W4VGI6   E1JJF8   P20241   A0A0Q5TJA2   B3NVG5   A0A0Q5THL2   A0A0Q9WUV5   B4NCI8   A0A0Q5T3I4   A0A0P8ZS96   T1PPT7   B4Q0A3   B3N0B0   A0A0R1EHL1   A0A0R1EHH6   A0A1I8M4Q6   A0A1I8PSB9   A0A1I8PS80   A0A0Q9WVH7   A0A0Q9X0E4   A0A0M5J3D9   B4L315   U5EU82   B4M1M9   A0A0K8VTH5   A0A0L0C8N9   W8ARL3   A0A0K8WB81   A0A034V7N8   A0A0K8W814   A0A0A1XPS4   B4R6J8   A0A1B0A5I7   A0A1A9V6L8   A0A1B0AXR8   A0A1B0G439   A0A1L8DM81   A0A1B6DIS0   K7IUL4   E0VWB3   A0A2J7PJ23   A0A2J7PJ24   B4JP14   A0A0K8W8M7   A0A1A9WVD0   A0A1J1IL05   A0A154P2X8   A0A0P4VF33  

PDB

1BIH     E-value=5.46414e-103,     Score=956

KEGG

692643    no KO assigned | (RefSeq) hemolin

GO

GO:0045087   GO:0050829   GO:0006955   GO:0005615   GO:0009617   GO:0016021   GO:0016319   GO:0098609   GO:0045924   GO:0072499   GO:0050808   GO:0048813   GO:0048675   GO:0007158   GO:0030175   GO:0008045   GO:0007560   GO:0048036   GO:0005918   GO:0005886   GO:0007409   GO:0019991   GO:0061343   GO:0005509   GO:0008050   GO:0021682   GO:0005923   GO:0035151   GO:0050839   GO:0005887   GO:0008049   GO:0008366   GO:0005919   GO:0060857   GO:0035011   GO:0006355   GO:0005634   GO:0042393   GO:0003714   GO:0005515   GO:0008536   GO:0005488   GO:0003676   GO:0006085   GO:0006101   GO:0003824   GO:0008152   GO:0016491   GO:0015930  

PANTHER

PTHR13144  

Subcellular location

Secreted  
  
Cell membrane  
Cell junction  
Tight junction  

SignalP

Position:   1 - 18,         Likelihood:  0.982725

 

 

Length:

410

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0894000000000001

Exp number, first 60 AAs:

0.08883

Total prob of N-in:

0.00617

outside

1  -  410

 

 

Pi

262.526597

Theta

176.833731

Tajima's D

1.466457

CLR

0.030265

CSRT

0.777561121943903

Interpretation

Uncertain