Gene

KWMTBOMO14500  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000167

Annotation

PREDICTED:_lactoylglutathione_lyase_[Papilio_polytes]

Location

Bomo_Chr24(+):8445099-8449796      View in EpiBrowser

Full name

Lactoylglutathione lyase      

Alternative Name

Glyoxalase I
Aldoketomutase
Ketone-aldehyde mutase
Methylglyoxalase
S-D-lactoylglutathione methylglyoxal lyase

Location in the cell

Cytoplasmic   Reliability : 1.687

CDS

ATGGCCCAAGGGATTTCTCCACAAGAAATAGAGGCTCTATGCCAGACGCCAGATCCCACTACCAAGGATTTTATGTTCCAACAAACAATGTACAGGATCAAAGATCCAAGGAAGACTATACCTTTTTACACTGGTGTCCTCGGAATGACATTACTTAAGCAACTGCATTTTCCAGCAATGAAGTTTTCGTTGTTCTTTATGGGCTATGAGAATCCAGCTGAAGTACCGAGAGACGATGACGCCAGAACTAAATGGGCCATGACTAGGAAAGCCACGTTGGAATTGACATATAACTGGGGAACAGAGAGCGACGACTCAAGCTACCACAACGGTAATTCAGATCCTCGCGGTTTCGGACATATTGGTATACTTGTGCCGGATGTGGATGTGGCGTGTGCTAGATTTGAGCAGCTAGGTGTTAAATTTATTAAACGTCCCAACGATGGTAAAATGAAAGGCCTAGCTTTCATTCAAGACCCGGACGGTTACTGGATAGAAATATTCACAAGTAATGTTGTTTGA

Protein

MAQGISPQEIEALCQTPDPTTKDFMFQQTMYRIKDPRKTIPFYTGVLGMTLLKQLHFPAMKFSLFFMGYENPAEVPRDDDARTKWAMTRKATLELTYNWGTESDDSSYHNGNSDPRGFGHIGILVPDVDVACARFEQLGVKFIKRPNDGKMKGLAFIQDPDGYWIEIFTSNVV

Description

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity).
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis.

Catalytic Activity

(R)-S-lactoylglutathione = glutathione + methylglyoxal

Cofactor

Zn(2+)

Subunit

Homodimer.

Miscellaneous

Expressed at higher levels in CD-1 mice which have been bred for low-anxiety-related behavior than in those which have been bred for high-anxiety-related behavior.

Similarity

Belongs to the glyoxalase I family.

Keywords

Acetylation   Complete proteome   Direct protein sequencing   Disulfide bond   Glutathionylation   Lyase   Metal-binding   Phosphoprotein   Reference proteome   Zinc   3D-structure  

Feature

chain  Lactoylglutathione lyase

Uniprot

H9ISE0   I4DJZ6   A0A0N1I7U4   S4P8F7   A0A212EK31   A0A0N0P9N5   + More
A0A0L0CQF7   A0A1I8NAP6   A0A1I8P266   A0A1L8EER8   A0A034WRU6   A0A1B0AGD6   A0A0C9QHA5   A0A1L8E1V2   A0A0K8TTL5   A0A1A9XFG1   A0A1A9WR34   A0A1B0CWR5   A0A0K8V541   A0A0K8WLK0   W8C8F4   B3MI71   B4P1N4   A0A0A1XNB4   A0A1W4V108   B4J6N5   B4KNE1   A0A1L8E2B8   B4LMA0   U5ERW2   B3NA03   B4MR75   A0A1B0FE17   R4WQX5   A0A1B6FGH2   A0A1B6I8Z5   A0A1B6BWJ1   A0A1B0AGE6   A0A162SUJ7   A0A1S3CXY6   A1Z6X6   A0A1J1I4L4   A0A0P4W2W8   E9HSG6   A0A224XLM9   A0A0M3QUL6   A0A3B0J277   B4HQT5   B4QE88   A0A0Q3PMZ0   Q28BX7   A0A1B0G6Z7   A0A1B6KHS6   B5E0X3   B4GGM8   A0A2P8XVK5   Q5BL69   A0A2H1VUV9   A0A069DPK7   A0A1A9V386   A0A226EMY4   A0A1S4G1K4   A0A0B8RTN5   I3LDM7   Q16GF9   J9NRV6   A0A1B0AGG6   A0A1A9V3A8   K7F913   A0A1L1RZK1   A0A023F9U0   A0A182G6B7   Q6P7Q4   U3I6H4   A0A093G8X9   A0A2Y9SK07   A0A3M0KIS4   A0A1W4X1J7   R4FLZ2   A0A2I0MAE4   A5GZX3   Q9CPU0   A0A1V4JJR5   A0A098LZ64   U3K9F4   A0A340X9Z3   A0A2U4CJ44   A0A2Y9NX72   A0A2Y9JEG9   A0A091D921   F6Y7I6   A0A226PAL2   A0A0B8RRB0   A0A091JUL6   T1P962   A0A384BEX9   A0A226NE20   F7ECV7   J3SEL3   T1DKP2  

EC Number

4.4.1.5

Pubmed

19121390    22651552    26354079    23622113    22118469    26108605    + More
25315136    25348373    26369729    24495485    17994087    17550304    25830018    23691247    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    21292972    22936249    15632085    29403074    26334808    17510324    16341006    17381049    15592404    25474469    26483478    15489334    23371554    12040188    21183079    23806337    16141072    15858064    18695250    18464734    24621616    25476704    17495919    23025625    23758969    25727380   

EMBL

BABH01024381    BABH01024382    AK401614    BAM18236.1    KQ460501    KPJ14166.1    + More
GAIX01005956    JAA86604.1    AGBW02014345    OWR41836.1    KQ459286    KPJ02040.1    JRES01000049    KNC34608.1    GFDG01001654    JAV17145.1    GAKP01002042    JAC56910.1    GBYB01002889    JAG72656.1    GFDF01001440    JAV12644.1    GDAI01000110    JAI17493.1    AJWK01032776    GDHF01018318    JAI33996.1    GDHF01000347    JAI51967.1    GAMC01003074    JAC03482.1    CH902619    EDV35916.1    CM000157    EDW89170.1    GBXI01001947    JAD12345.1    CH916367    EDW00938.1    CH933808    EDW09994.1    GFDF01001429    JAV12655.1    CH940648    EDW60978.1    GANO01002647    JAB57224.1    CH954177    EDV59699.1    CH963849    EDW74614.1    CCAG010017792    AK418086    BAN21301.1    GECZ01020494    JAS49275.1    GECU01037144    GECU01034632    GECU01033622    GECU01024292    GECU01016033    GECU01012191    GECU01007728    JAS70562.1    JAS73074.1    JAS74084.1    JAS83414.1    JAS91673.1    JAS95515.1    JAS99978.1    GEDC01031636    GEDC01024624    JAS05662.1    JAS12674.1    LRGB01000024    KZS21640.1    AE013599    AAF59267.1    CVRI01000039    CRK94698.1    GDRN01092021    JAI60175.1    GL732751    EFX65323.1    GFTR01003049    JAW13377.1    CP012524    ALC40843.1    OUUW01000001    SPP73132.1    CH480816    EDW46745.1    CM000362    CM002911    EDX05997.1    KMY91959.1    LMAW01002759    KQK77428.1    CR942582    CAJ83987.1    CCAG010003750    GEBQ01028998    GEBQ01021307    JAT10979.1    JAT18670.1    CM000071    EDY69054.1    CH479183    EDW35648.1    PYGN01001280    PSN36047.1    BC090582    AAH90582.1    ODYU01004591    SOQ44627.1    GBGD01003129    JAC85760.1    LNIX01000002    OXA59045.1    GBZA01000248    JAG69520.1    AEMK02000055    CH478282    EAT33325.1    AAEX03008305    AGCU01109535    AGCU01109536    AGCU01109537    AADN05000005    GBBI01001024    JAC17688.1    JXUM01147679    KQ570417    KXJ68365.1    BC061570    KL215801    KFV66665.1    QRBI01000106    RMC12541.1    ACPB03022597    GAHY01001929    JAA75581.1    AKCR02000024    PKK26650.1    DQ487161    DQ487162    CH466542    ABF48483.1    ABF48484.1    EDL08651.1    AK002386    AK003567    AK005055    AK031832    AK049703    BC024663    BC081432    LSYS01007194    OPJ72431.1    GBSI01001241    JAC95255.1    AGTO01000388    KN123046    KFO26998.1    AWGT02000117    OXB76612.1    GBSH01001441    JAG67585.1    KK529555    KFP27603.1    KA645321    AFP59950.1    MCFN01000529    MCFN01000081    OXB57707.1    OXB65794.1    JU174920    GBEX01001751    AFJ50446.1    JAI12809.1    GAAZ01001233    GBKC01001843    GBKD01001113    JAA96710.1    JAG44227.1    JAG46505.1   

Proteomes

UP000005204    UP000053240    UP000007151    UP000053268    UP000037069    UP000095301    + More
UP000095300    UP000092445    UP000092443    UP000091820    UP000092461    UP000007801    UP000002282    UP000192221    UP000001070    UP000009192    UP000008792    UP000008711    UP000007798    UP000092444    UP000076858    UP000079169    UP000000803    UP000183832    UP000000305    UP000092553    UP000268350    UP000001292    UP000000304    UP000051836    UP000001819    UP000008744    UP000245037    UP000078200    UP000198287    UP000008227    UP000008820    UP000002254    UP000007267    UP000000539    UP000069940    UP000249989    UP000002494    UP000053875    UP000248484    UP000269221    UP000192223    UP000015103    UP000053872    UP000000589    UP000190648    UP000016665    UP000265300    UP000245320    UP000248483    UP000248482    UP000028990    UP000002279    UP000198419    UP000261681    UP000198323    UP000002280   

PRIDE

H9ISE0    A1Z6X6    I3LDM7    J9NRV6    Q6P7Q4    Q9CPU0    + More

Pfam

PF00903   Glyoxalase

Interpro

IPR018146   Glyoxalase_1_CS        + More
IPR004360   Glyas_Fos-R_dOase_dom       
IPR037523   VOC       
IPR029068   Glyas_Bleomycin-R_OHBP_Dase       
IPR004361   Glyoxalase_1       

SUPFAM

SSF54593   SSF54593       

Gene 3D

3.10.180.10    

ProteinModelPortal

H9ISE0   I4DJZ6   A0A0N1I7U4   S4P8F7   A0A212EK31   A0A0N0P9N5   + More
A0A0L0CQF7   A0A1I8NAP6   A0A1I8P266   A0A1L8EER8   A0A034WRU6   A0A1B0AGD6   A0A0C9QHA5   A0A1L8E1V2   A0A0K8TTL5   A0A1A9XFG1   A0A1A9WR34   A0A1B0CWR5   A0A0K8V541   A0A0K8WLK0   W8C8F4   B3MI71   B4P1N4   A0A0A1XNB4   A0A1W4V108   B4J6N5   B4KNE1   A0A1L8E2B8   B4LMA0   U5ERW2   B3NA03   B4MR75   A0A1B0FE17   R4WQX5   A0A1B6FGH2   A0A1B6I8Z5   A0A1B6BWJ1   A0A1B0AGE6   A0A162SUJ7   A0A1S3CXY6   A1Z6X6   A0A1J1I4L4   A0A0P4W2W8   E9HSG6   A0A224XLM9   A0A0M3QUL6   A0A3B0J277   B4HQT5   B4QE88   A0A0Q3PMZ0   Q28BX7   A0A1B0G6Z7   A0A1B6KHS6   B5E0X3   B4GGM8   A0A2P8XVK5   Q5BL69   A0A2H1VUV9   A0A069DPK7   A0A1A9V386   A0A226EMY4   A0A1S4G1K4   A0A0B8RTN5   I3LDM7   Q16GF9   J9NRV6   A0A1B0AGG6   A0A1A9V3A8   K7F913   A0A1L1RZK1   A0A023F9U0   A0A182G6B7   Q6P7Q4   U3I6H4   A0A093G8X9   A0A2Y9SK07   A0A3M0KIS4   A0A1W4X1J7   R4FLZ2   A0A2I0MAE4   A5GZX3   Q9CPU0   A0A1V4JJR5   A0A098LZ64   U3K9F4   A0A340X9Z3   A0A2U4CJ44   A0A2Y9NX72   A0A2Y9JEG9   A0A091D921   F6Y7I6   A0A226PAL2   A0A0B8RRB0   A0A091JUL6   T1P962   A0A384BEX9   A0A226NE20   F7ECV7   J3SEL3   T1DKP2  

PDB

4PV5     E-value=5.73999e-66,     Score=632

KEGG

101743580    K01759 lactoylglutathione lyase [EC:4.4.1.5] | (RefSeq) lactoylglutathione lyase

PATHWAY

00620    Pyruvate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004462   GO:0046872   GO:0043066   GO:0005829   GO:0005634   GO:0005886   GO:0008270   GO:0006749   GO:0005975   GO:0009438   GO:0030316   GO:0006357   GO:0019243   GO:0051213   GO:0016491   GO:0043565   GO:0005524   GO:0005507   GO:0004713   GO:0015930  

Length:

173

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

9.24630999999999

Exp number, first 60 AAs:

9.2117

Total prob of N-in:

0.49998

outside

1  -  173

 

 

Pi

250.864342

Theta

167.60775

Tajima's D

1.677607

CLR

0

CSRT

0.821308934553272

Interpretation

Uncertain