Gene

KWMTBOMO14478  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000074

Annotation

PREDICTED:_rRNA_2'-O-methyltransferase_fibrillarin_[Amyelois_transitella]

Location

Bomo_Chr24(-):7553263-7554478      View in EpiBrowser

Full name

rRNA 2'-O-methyltransferase fibrillarin      

Alternative Name

Histone-glutamine methyltransferase

Location in the cell

Cytoplasmic   Reliability : 2.122

CDS

ATGTTAGTTGGCATGGTGGACACAATATTCGCTGATGTCGCGCAACCCGACCAAGCTAGGATTGTCAGTTTGAATGCACAGCATTTTTTGAAGAATGGTGGACATTTTGTTATCTCAATTAAGGCATCCTGTATAGACTCAACTGCCCAGCCCGAAGCCGTATTCGCAGCGGAAGTAAAGAAATTACAGGCGGACAAATTAAAACCACAAGAACAGTTGACATTGGAGCCCTACGAAAGAGATCACGCTGTTGTCGTTGGAGTCTTCAGACCACCGCCTAAGAAATAA

Protein

MLVGMVDTIFADVAQPDQARIVSLNAQHFLKNGGHFVISIKASCIDSTAQPEAVFAAEVKKLQADKLKPQEQLTLEPYERDHAVVVGVFRPPPKK

Description

S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (By similarity).

Catalytic Activity

L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine

Subunit

Component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. It is associated with the U3, U8 and U13 small nuclear RNAs.

Similarity

Belongs to the methyltransferase superfamily. Fibrillarin family.

Keywords

Complete proteome   Methylation   Methyltransferase   Nucleus   Reference proteome   Ribonucleoprotein   RNA-binding   rRNA processing   S-adenosyl-L-methionine   Transferase  

Feature

chain  rRNA 2'-O-methyltransferase fibrillarin

Uniprot

H9IS48   A0A3S2NLA7   A0A2H1V073   S4PXM5   A0A0N0P9Z7   A0A194RK51   + More
I4DP62   A0A212F7Q4   U5EFF6   T1P850   A0A336N671   A0A1L8DFY3   A0A1L8DG03   Q2PQQ6   A0A1L8E7L2   A0A1L8E7J1   A0A1L8E7E9   A0A1L8E7P7   A0A1L8E7R8   A0A1B0D717   B4J5L7   A0A0P6ILH7   W8CEE9   A0A1B0B3I0   A0A1A9YGK9   B4LL69   A0A1W4XUK7   B4KPH5   A0A1A9VSP8   A0A0M5J0A4   A0A1B0FFP7   E4NKN3   B4P923   B4I8G0   Q9W1V3   B4MNL3   B4QI53   B3MF29   A0A0K8WKS0   A0A1W4VRE0   T1H0I1   A0A067R3V5   A0A0A1XF96   A0A0L0BLL0   Q8I1F4   A0A1A9WR81   A0A1B0AB13   A0A1I8M4R9   A0A1I8QCZ8   D6WFV6   A0A2J7RE83   A0A2A4IZ76   A0A088ALP1   A0A154P6S1   B5DZN8   B4GA31   A0A3B0JJA6   A0A1Y1M2L7   A0A0K8VJQ4   E0VJR8   A0A151WNK4   A0A0A9WA68   A0A232EU58   K7ISA0   V5I834   A0A170YM34   F4WHJ0   A0A158N913   A0A151JA65   A0A195BU10   A0A0C9RQ13   A0A151IBH5   A0A146KVU1   A0A0T6B0U0   A0A2A3EU43   A0A182Q7H3   A0A1B3PDL6   A0A182LHJ2   Q7QHL9   A0A182HG18   A0A182WR79   A0A182UNP3   A0A182SPG6   A0A195FVR1   A0A0J7L1Z8   A0A182TNW8   A0A182RXM6   A0A2R7VXS1   A0A0P5HVA8   A0A182WDB7   A0A182MMT7   A0A0L7QRZ3   A0A2B4S192   F7A5J2   T1E967   A0A2M3Z4E4   A0A2M4BU83   A0A2M4ACW8   A0A226ERX4   A0A2M4ADG0  

EC Number

2.1.1.-

Pubmed

19121390    23622113    26354079    22651552    22118469    16907828    + More
17994087    24495485    17550304    10731132    12537572    12537569    2884623    22936249    24845553    25830018    26108605    12537575    25315136    18362917    19820115    15632085    28004739    20566863    25401762    28648823    20075255    21719571    21347285    26823975    20966253    12364791    14747013    17210077    12481130    15114417   

EMBL

BABH01024288    RSAL01000009    RVE53793.1    ODYU01000054    SOQ34176.1    GAIX01004778    + More
JAA87782.1    KQ459286    KPJ02028.1    KQ460118    KPJ17715.1    AK403437    BAM19702.1    AGBW02009857    OWR49739.1    GANO01003871    JAB56000.1    KA644739    AFP59368.1    UFQS01002786    UFQT01002786    SSX14671.1    SSX34068.1    GFDF01008725    JAV05359.1    GFDF01008701    JAV05383.1    DQ307167    ABC25067.1    GFDG01004247    JAV14552.1    GFDG01004195    JAV14604.1    GFDG01004152    JAV14647.1    GFDG01004153    JAV14646.1    GFDG01004154    JAV14645.1    AJVK01026531    CH916367    EDW00780.1    GDIQ01002530    JAN92207.1    GAMC01000316    JAC06240.1    JXJN01007863    CH940648    EDW60806.2    CH933808    EDW10171.1    CP012524    ALC42261.1    CCAG010013366    BT125830    ADR83715.1    CM000158    EDW92263.1    CH480824    EDW56885.1    AE013599    BT001738    X05285    AAF46950.1    AAN71493.1    CAA28903.1    CH963848    EDW73702.1    CM000362    CM002911    EDX08307.1    KMY95955.1    CH902619    EDV37657.1    GDHF01000593    JAI51721.1    CAQQ02083643    KK853004    KDR12598.1    GBXI01004223    JAD10069.1    JRES01001695    KNC20912.1    AY190941    CH954179    AAO01021.1    KQ971328    EEZ99789.1    NEVH01005277    PNF39137.1    NWSH01004433    PCG65125.1    KQ434827    KZC07635.1    CM000071    EDY68836.1    CH479181    EDW31783.1    OUUW01000001    SPP73529.1    GEZM01041943    JAV80092.1    GDHF01013559    JAI38755.1    DS235226    EEB13624.1    KQ982907    KYQ49459.1    GBHO01038955    JAG04649.1    NNAY01002165    OXU21895.1    GALX01005380    JAB63086.1    GEMB01003166    JAS00044.1    GL888161    EGI66344.1    ADTU01009025    KQ979317    KYN21955.1    KQ976405    KYM91892.1    GBYB01009261    JAG79028.1    KQ978095    KYM97016.1    GDHC01018015    JAQ00614.1    LJIG01016316    KRT80968.1    KZ288189    PBC34571.1    AXCN02001700    KU660001    AOG17799.1    AAAB01008816    EAA05232.4    APCN01005461    KQ981268    KYN43944.1    LBMM01001332    KMQ96494.1    KK854073    PTY10725.1    GDIQ01222913    JAK28812.1    AXCM01007145    KQ414775    KOC61276.1    LSMT01000176    PFX24454.1    EAAA01001987    GAMD01001607    JAA99983.1    GGFM01002639    MBW23390.1    GGFJ01007360    MBW56501.1    GGFK01005315    MBW38636.1    LNIX01000002    OXA60385.1    GGFK01005337    MBW38658.1   

Proteomes

UP000005204    UP000283053    UP000053268    UP000053240    UP000007151    UP000092462    + More
UP000001070    UP000092460    UP000092443    UP000008792    UP000192223    UP000009192    UP000078200    UP000092553    UP000092444    UP000002282    UP000001292    UP000000803    UP000007798    UP000000304    UP000007801    UP000192221    UP000015102    UP000027135    UP000037069    UP000008711    UP000091820    UP000092445    UP000095301    UP000095300    UP000007266    UP000235965    UP000218220    UP000005203    UP000076502    UP000001819    UP000008744    UP000268350    UP000009046    UP000075809    UP000215335    UP000002358    UP000007755    UP000005205    UP000078492    UP000078540    UP000078542    UP000242457    UP000075886    UP000075882    UP000007062    UP000075840    UP000076407    UP000075903    UP000075901    UP000078541    UP000036403    UP000075902    UP000075900    UP000075920    UP000075883    UP000053825    UP000225706    UP000008144    UP000198287   

PRIDE

H9IS48    E4NKN3    Q9W1V3    Q8I1F4    A0A088ALP1   

Pfam

PF01269   Fibrillarin

Interpro

IPR020813   Fibrillarin_CS        + More
IPR000692   Fibrillarin       
IPR029063   SAM-dependent_MTases       

SUPFAM

SSF53335   SSF53335       

ProteinModelPortal

H9IS48   A0A3S2NLA7   A0A2H1V073   S4PXM5   A0A0N0P9Z7   A0A194RK51   + More
I4DP62   A0A212F7Q4   U5EFF6   T1P850   A0A336N671   A0A1L8DFY3   A0A1L8DG03   Q2PQQ6   A0A1L8E7L2   A0A1L8E7J1   A0A1L8E7E9   A0A1L8E7P7   A0A1L8E7R8   A0A1B0D717   B4J5L7   A0A0P6ILH7   W8CEE9   A0A1B0B3I0   A0A1A9YGK9   B4LL69   A0A1W4XUK7   B4KPH5   A0A1A9VSP8   A0A0M5J0A4   A0A1B0FFP7   E4NKN3   B4P923   B4I8G0   Q9W1V3   B4MNL3   B4QI53   B3MF29   A0A0K8WKS0   A0A1W4VRE0   T1H0I1   A0A067R3V5   A0A0A1XF96   A0A0L0BLL0   Q8I1F4   A0A1A9WR81   A0A1B0AB13   A0A1I8M4R9   A0A1I8QCZ8   D6WFV6   A0A2J7RE83   A0A2A4IZ76   A0A088ALP1   A0A154P6S1   B5DZN8   B4GA31   A0A3B0JJA6   A0A1Y1M2L7   A0A0K8VJQ4   E0VJR8   A0A151WNK4   A0A0A9WA68   A0A232EU58   K7ISA0   V5I834   A0A170YM34   F4WHJ0   A0A158N913   A0A151JA65   A0A195BU10   A0A0C9RQ13   A0A151IBH5   A0A146KVU1   A0A0T6B0U0   A0A2A3EU43   A0A182Q7H3   A0A1B3PDL6   A0A182LHJ2   Q7QHL9   A0A182HG18   A0A182WR79   A0A182UNP3   A0A182SPG6   A0A195FVR1   A0A0J7L1Z8   A0A182TNW8   A0A182RXM6   A0A2R7VXS1   A0A0P5HVA8   A0A182WDB7   A0A182MMT7   A0A0L7QRZ3   A0A2B4S192   F7A5J2   T1E967   A0A2M3Z4E4   A0A2M4BU83   A0A2M4ACW8   A0A226ERX4   A0A2M4ADG0  

PDB

2IPX     E-value=1.18757e-37,     Score=386

KEGG

101742289    K14563 rRNA 2'-O-methyltransferase fibrillarin [EC:2.1.1.-] | (RefSeq) rRNA 2'-O-methyltransferase f

GO

GO:0008168   GO:0006364   GO:0003723   GO:0005730   GO:0015030   GO:0001651   GO:0005732   GO:0030532   GO:0032040   GO:1990259   GO:0000494   GO:0031428   GO:0031167   GO:1990258   GO:0008649   GO:0008033   GO:0016020   GO:0005524   GO:0005507   GO:0004713   GO:0016491   GO:0015930  

Subcellular location

   Fibrillar region of the nucleolus.   With evidence from 1 publications.

Length:

95

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0013

Exp number, first 60 AAs:

0.0013

Total prob of N-in:

0.10011

outside

1  -  95

 

 

Pi

314.755523

Theta

203.88754

Tajima's D

1.696181

CLR

0.616015

CSRT

0.825708714564272

Interpretation

Uncertain