Gene
KWMTBOMO14475
Pre Gene Modal
BGIBMGA000152
Annotation
PREDICTED:_ALK_tyrosine_kinase_receptor_[Bombyx_mori]
Full name
Tyrosine-protein kinase receptor
Location in the cell
Cytoplasmic Reliability : 1.311 Nuclear Reliability : 1.759
Sequence
CDS
ATGGTGGTGAAATCGCCACCATTTCGAGGTTTATGGGAGTTTTGTAAGTTCGAAGCTCTGCTGCACCAGAGAATGATGCAGAACGCCAGCATCAGACTGATATCAGAGTCTACCATATCTGAAGTGCAATGGATCCTACAGGAGGTTGCCGGGAACAATGCCGAGAACTGGTACCCGATGCGCTTCATGATCGGAAAGGTCCAGCAAGAGGTCAGGATCATCATAGAGATAACCCGACCGAACTACGTGAGTCTGGCGCAGCCCCTCCCGCACATCGCCATAGACAACATCAGGATGATCGACTGCGTCCCGGAGCCACCAGTCTACAATGGCGAATGCAACCCTGGACAACTCAAGTGCAAGATAATGAACAGGGAGTCGTGTATCAAGCTGCACCAAGTCTGCGATCTGGTGAAGGACTGTGACGACGGCAGCGACGAGCAGAAGAACTGCGATAAAATGCCGTATGGATCTTATTGTAACTTCGAACAGGACAGTTGCGGATTTGTCGACGTGCCTCAGCCGATCCTGAAATGGTCCCGCCATAGGGGACCGACTCCGACGGACAAAACCGGCCCCAACTACGACCACACTTGCGGCCCCCCAACCCAACCCAACCTCAACCCAACAAAGAAAGTTCCTCCCCTGACCCCCCCCTTCCATATGCACTGCGCCGGGTACTATTTCTTTGTGAACATGAACGTTACCGGCCCCAATAAAGAGAAAGCCGATTTCGCATCGACCGCCGTTATGAAGACCGTCATTTTTAACCCGCCTCCGAAGGTCCATGGGGATGTCGCGTCCAAGTATTACAACTGCTGCATGGTAAGGTTTTACTACCAGCAAAACGGACGTAACTATGGCTCTTTAAGCGTGGACGTGGTAGAGCTGACAGCCAGAGGGAACATCAGCACTTCAGTTTGGTTCTCCACTAAGGACAAAGGCGAGAACTGGTACAGAGCTTCCATCTTCCTTCCTAACGTAACTAGGAGATATTACCTCCAGTTCAAGACCCGTATGGGGATGCGGATCTATTCGGATTCCGCCATCGACGACTTCTCGATGTCGCCGGAGTGCTTCGGTCTGAACGTGGACCCGGAGGAACTGGGAGACTACAACTATTACGATCCGGTTTTCGACGAGAAGACCACGCCGCATAAAGATTTCACCGGTCGGGTCTATTACAGGTTCACGCCGTGCGGCGCGTCCGGTCGGTACGGACCCAACCAGACCATGTGCGACGCGGCCTACAACAACACGCCGGTCGATGTTAATGTCCTCCACACCCATCCGTACACCGGCGTCCAAGTCTGGGAGGTTCCCGAGGAGGGGCTATACACGATAATAGCCACAGGCGCGAGTGGGGGTCTGGGCTCGGCCTGGGCGGGCGTGTCTCATGGGGCGCAGGCCCGGGCCCTCCTCGAGCTGCACAGGAGTGAGCTGGTCTACATGTTAATCGGACAGCAGGGCATCAACGCCTGCAAAAAGACCTTATCGGCCCAGGAGAGTCAAGAATGTTCCAGAAAGCCCTCGAACGAGAGCCTCCAAGTGTTCACGAGTAAGACACACGAGGTCAGGAATACTCACGTCATAGACGGAGGAGGGGGAGGGGGCGGAGGAACTTTCGTGTTTCTGATGGACAAAGAGGGCCGCCCGTTCCCGCTGGTCGTGGCCGGAGGAGGCGGGGGTATATCCGTGGGCATCTTCCGCGACGACGGCTCCCAGCACGGGAAACCCCACACGAATTCCACTCCTGAATCTGGGTACATGTACGGCCAGCCAGACAAGACCTCAGGAGCGGGTGGCGGGTGGGTGGCCAGGTCGGGGCCCATCACGCCGGGGTCCGAGCGAGTGCGGGGCGCGGCGCTGAGGGAGGGGGCGGTGGGCGGAGGGGCGTGCGTGGGGCGCGCTGCGGGGGGCTTCGGGGGCGGAGGGGGCGGATGTCTCAAGGGAGGCGCCGGCGGGGGGTACATGGGTGGTAACACTAACGAGGGCGAACATGGCGGAGGGGGCTGGTCCTATATAGACGGCAGCCGCGCCCTCCGCGTGTACAGTGACGTCAGCGTGGCACCACGCACCGGGCCCGGCGAGGTGCTCATCATCCCGGCCATACACGACTGCGGCTGCGACTACCGGTGCGTGGCCCTCAACGAATTCAGGAGCGAGGTGCGGTGCTATTGTCCCTCCTCCTGGGTCTTCAACCCCATGGACCCCGGGAAGTGTGTCTATCCGAACACTTGGTTCACAGTGGAAGGAGAATGGAGCACATTCACGTGGACCATTGTGGCGTCTTCTATAGGGTGTGTGGTGCTGGGGGCTCTGGTGTCCCTCTCCTTGGTGCTATACAATCGCTACCAAAAGAAGAGGGAAGCGAGACAGGCACAGAAGCGGATCATGGAACAAGAGGTCCAACTGCACAGACTCAGGAACGCTCCGGGAGGAAACGACAACGCGCTGGCAATGGCTTTCAACCCTCACTACGGGAGCGAAAGCTTCCTACCTCAAGGGATCGATGTGAGAGGACTCCCGCAAGTCTCGAGGGAAAGCTTAAAGCTTGTCAAAGCATTAGGCCAGGGCGCCTTCGGCGAAGTCTACCAGGGCCTGTACCGGCACCGCTCGGCCGACGCCGCGGAGATGCCGGTCGCGGTCAAGACCCTTCCCGAGCTGTCCACCGGCCAGGCCGAGTCCGACTTCCTGATGGAGGCCGCCATCATGGCCAAGTTCAACCACGCCAACATAGTCCACCTCATCGGCGTTTGCTTCGATCGACACCCGAGGTTCATTGTGCTAGAATTGCTGGCCGGCGGCGATCTGAAGAACTTCCTTCGCGAGAGTCGCCCCAAGCCGGAGCGGGCCAGCGCCCTCACCATGAAGGACCTGCTTCTCTGCTCGGTGGACGTCTGCAAGGGATGCCGGTACTTGGAAACTAAGAGATTCATACACAGGGACATAGCGGCGAGGAACTGTCTGCTGACGTCCCGGGGCCCGGGCCGCGTGGTCAAGATAGCGGACTTCGGTATGGCTCGAGACATATACCGCGCCGACTACTACAAGAAGGGCGGGAAGGCCATGCTGCCCATCAAGTGGATGCCACCCGAAGCTTACATTGACGGAGTCTTCACCACTAAGACGGACGTCTGGTCATTCGGCGTGCTGCTATGGGAGGTATTTTCGTTAGGCGTGATGCCGTACACCGGATGCGCCAACCGGGAGGTCATGGAGCTGGTCTCTGGTGGAGGAAGACTGGAGAAACCGTACGGTTGTCCCCCGGAGATATACCGCATGATGTGCGGCTGCTGGAACCCGACACCAAGCGACAGGCCGTCCTTCGCTACGATGACGGAAATGCTGCAAAGGTTCATACAGGACCCGACCATAGTGAGCGCGCCGCTGCCCGTCGTGCGCTCGCTGTTACCGCCCTCGCACACGCACCCCATCTCTAACGGACACCAGCCATCGGCGGCGTGCGACTACCTCGTCCCGATGTCGCCGCAGGACGCCACGCAACATCCGGATAGTACAATGGATCAGCTGGGAGTTCATAGCAGACCGCAAACGGCGACACGCAACAAGGAGGAAGAAGAGGACTTACAATATCTACCTCTGCTGAGAGCATCACAAGAATATGGCAACATTCCAATAAGCGCGGAGCCCAGCGTAAGGCACGTAGACGTCGTTGTTTCCGCCGAAACAAGGAACACCAACAAGTTTCTGCCGTCTAACTCTACTGACAGGCTATTGAGTTCAGTGGAGGAAGCTCATATCGATGATGAGTCGTTGTCGGAAGTGGACGAAAAGCCCGTCGTGTGGGAGACCTCATTCACAGTGATACCACCCGTGCTGCCGAAGCCACAACGTGACGAAGGCCCCGCGGTGGAAAAACTGATAAGCATAACACCCACAACGCCAAAGCCGCCTGAAAATGCTTTAACGAAAGCAATCGACGCCACAGTCATCGACAAAACCAACCACAAGAACGCTCTCGTACCGGACAGGAAGACGGCTCCGATAGCGTCGCCGGACCCGCCGCGCATTAACGCTTGGAGCCAGGACCCTCCTAAATTAAACCCTAAACCGAAGCCCCTTTGTCTGGACGCAGCCAAGCTGGAACAAAACCTGAACGCCCTAAAGAAGAACAGCGGATCAGTGAACTTGAACACCATGAACATTCTCCCTCCGTACATCAACGTCGTCACTCCGAATAAGCTAAGCGAATCGAAGACCATACAGATAGATCCAAAGAAAGCTGTCATAGACGATAGCCTGACTACTAAGACTAAGTTGAAGCAGTCTAACTCGGCGGCCAGTCTGCTAAACGGGCCAATGACGGACGTACCATACGTCGACAGCGACAACACCTCATCATCGAGCAGTAACAACGCGAAGAACGGAAGGAACTTAATTAAAAAACAGGGTAGTGATGCTGAGGTAGCCGATTCCGAGATAAGTTGCTGA
Protein
MVVKSPPFRGLWEFCKFEALLHQRMMQNASIRLISESTISEVQWILQEVAGNNAENWYPMRFMIGKVQQEVRIIIEITRPNYVSLAQPLPHIAIDNIRMIDCVPEPPVYNGECNPGQLKCKIMNRESCIKLHQVCDLVKDCDDGSDEQKNCDKMPYGSYCNFEQDSCGFVDVPQPILKWSRHRGPTPTDKTGPNYDHTCGPPTQPNLNPTKKVPPLTPPFHMHCAGYYFFVNMNVTGPNKEKADFASTAVMKTVIFNPPPKVHGDVASKYYNCCMVRFYYQQNGRNYGSLSVDVVELTARGNISTSVWFSTKDKGENWYRASIFLPNVTRRYYLQFKTRMGMRIYSDSAIDDFSMSPECFGLNVDPEELGDYNYYDPVFDEKTTPHKDFTGRVYYRFTPCGASGRYGPNQTMCDAAYNNTPVDVNVLHTHPYTGVQVWEVPEEGLYTIIATGASGGLGSAWAGVSHGAQARALLELHRSELVYMLIGQQGINACKKTLSAQESQECSRKPSNESLQVFTSKTHEVRNTHVIDGGGGGGGGTFVFLMDKEGRPFPLVVAGGGGGISVGIFRDDGSQHGKPHTNSTPESGYMYGQPDKTSGAGGGWVARSGPITPGSERVRGAALREGAVGGGACVGRAAGGFGGGGGGCLKGGAGGGYMGGNTNEGEHGGGGWSYIDGSRALRVYSDVSVAPRTGPGEVLIIPAIHDCGCDYRCVALNEFRSEVRCYCPSSWVFNPMDPGKCVYPNTWFTVEGEWSTFTWTIVASSIGCVVLGALVSLSLVLYNRYQKKREARQAQKRIMEQEVQLHRLRNAPGGNDNALAMAFNPHYGSESFLPQGIDVRGLPQVSRESLKLVKALGQGAFGEVYQGLYRHRSADAAEMPVAVKTLPELSTGQAESDFLMEAAIMAKFNHANIVHLIGVCFDRHPRFIVLELLAGGDLKNFLRESRPKPERASALTMKDLLLCSVDVCKGCRYLETKRFIHRDIAARNCLLTSRGPGRVVKIADFGMARDIYRADYYKKGGKAMLPIKWMPPEAYIDGVFTTKTDVWSFGVLLWEVFSLGVMPYTGCANREVMELVSGGGRLEKPYGCPPEIYRMMCGCWNPTPSDRPSFATMTEMLQRFIQDPTIVSAPLPVVRSLLPPSHTHPISNGHQPSAACDYLVPMSPQDATQHPDSTMDQLGVHSRPQTATRNKEEEEDLQYLPLLRASQEYGNIPISAEPSVRHVDVVVSAETRNTNKFLPSNSTDRLLSSVEEAHIDDESLSEVDEKPVVWETSFTVIPPVLPKPQRDEGPAVEKLISITPTTPKPPENALTKAIDATVIDKTNHKNALVPDRKTAPIASPDPPRINAWSQDPPKLNPKPKPLCLDAAKLEQNLNALKKNSGSVNLNTMNILPPYINVVTPNKLSESKTIQIDPKKAVIDDSLTTKTKLKQSNSAASLLNGPMTDVPYVDSDNTSSSSSNNAKNGRNLIKKQGSDAEVADSEISC
Summary
Catalytic Activity
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]
Similarity
Belongs to the protein kinase superfamily. Tyr protein kinase family.
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Feature
chain Tyrosine-protein kinase receptor
Uniprot
EC Number
2.7.10.1
EMBL
Proteomes
PRIDE
Interpro
IPR002172
LDrepeatLR_classA_rpt
+ More
IPR036055 LDL_receptor-like_sf
IPR013320 ConA-like_dom_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011009 Kinase-like_dom_sf
IPR017441 Protein_kinase_ATP_BS
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR023415 LDLR_class-A_CS
IPR000719 Prot_kinase_dom
IPR000998 MAM_dom
IPR002011 Tyr_kinase_rcpt_2_CS
IPR036055 LDL_receptor-like_sf
IPR013320 ConA-like_dom_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011009 Kinase-like_dom_sf
IPR017441 Protein_kinase_ATP_BS
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR023415 LDLR_class-A_CS
IPR000719 Prot_kinase_dom
IPR000998 MAM_dom
IPR002011 Tyr_kinase_rcpt_2_CS
Gene 3D
ProteinModelPortal
PDB
4FOC
E-value=7.9457e-105,
Score=977
Ontologies
KEGG
GO
GO:0005524
GO:0016021
GO:0004713
GO:0007169
GO:0004714
GO:0045664
GO:0005887
GO:0043235
GO:0061176
GO:0071212
GO:0042051
GO:0090328
GO:1900074
GO:0045792
GO:0007411
GO:0007498
GO:0040008
GO:0048565
GO:0000186
GO:0061177
GO:0070374
GO:0007522
GO:0016020
GO:0000187
GO:0048666
GO:0004672
GO:0006468
GO:0005515
GO:0005507
GO:0016491
GO:0015930
Topology
Length:
1484
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
33.6996899999999
Exp number, first 60 AAs:
0.00014
Total prob of N-in:
0.00015
outside
1 - 1484
Population Genetic Test Statistics
Pi
218.399737
Theta
178.661908
Tajima's D
1.141453
CLR
0.61874
CSRT
0.705664716764162
Interpretation
Uncertain
