Gene

KWMTBOMO14466  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000081

Annotation

DNA_polymerase_epsilon_subunit_3_[Bombyx_mandarina]

Location

Bomo_Chr24(-):7194681-7195368      View in EpiBrowser

Full name

DNA polymerase epsilon subunit 3      

Alternative Name

DNA polymerase II subunit 3
DNA polymerase epsilon subunit p17
Arsenic-transactivated protein
Chromatin accessibility complex 17 kDa protein
NF-YB-like protein
YB-like protein 1

Location in the cell

Cytoplasmic   Reliability : 1.109 Nuclear   Reliability : 1.21

CDS

ATGGCTGAAAAACTCGAAGATTTGAATTTACCACTCACAGTTGTAACTAGAATCGTAAAAGAAGCTCTTCCCAGTGGCGTATCGATATCAAAAGAGGCGCGAACTGGCCTCGCTAAGGCGGCTTCAGTTTTTGTACTTTATGTGACTTCAGCAGCTACAAATATTGTTAAGAACAAAAAAAGGAAGGCTCTCACTGGGCAGGACGTGATAGATGCTATGAAAGACATCGAATTTGATAGATTTGTGGAACCTTTAGGAGAAGCTCTGGAACATTACAAGACCATGGCTTCGGCACGAAAATCCGCTTCTATGAAGAAAAAAGATGAACAAGAAGACGCTGAGATTATAGAAGACGATTGA

Protein

MAEKLEDLNLPLTVVTRIVKEALPSGVSISKEARTGLAKAASVFVLYVTSAATNIVKNKKRKALTGQDVIDAMKDIEFDRFVEPLGEALEHYKTMASARKSASMKKKDEQEDAEIIEDD

Description

Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1.

Catalytic Activity

a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)

Subunit

Component of the epsilon DNA polymerase complex consisting of four subunits: POLE, POLE2, POLE3 and POLE4. Interaction with POLE4 is a prerequisite for further binding with POLE and POLE2. Interacts with CHRAC1. Together with CHRAC1, ACF1 and ISWI/SNF2H proteins, it forms the ISWI chromatin-remodeling complex, CHRAC (By similarity).
Component of the epsilon DNA polymerase complex consisting of four subunits: POLE, POLE2, POLE3 and POLE4. Interaction with POLE4 is a prerequisite for further binding with POLE and POLE2. Interacts with CHRAC1. Together with CHRAC1, ACF1 and ISWI/SNF2H proteins, it forms the ISWI chromatin-remodeling complex, CHRAC.

Keywords

Acetylation   Coiled coil   Complete proteome   DNA-binding   DNA-directed DNA polymerase   Nucleotidyltransferase   Nucleus   Phosphoprotein   Reference proteome   Transferase   Direct protein sequencing   Polymorphism  

Feature

chain  DNA polymerase epsilon subunit 3
sequence variant  In dbSNP:rs36023979.

Uniprot

A0A075DA27   A0A075D847   H9IS55   A0A075DA16   A0A075DB57   A0A075D852   + More
A0A075DA32   A0A075DB67   A0A075D9D4   A0A2H1VXU8   A0A2W1BC06   A0A2A4K179   A0A212F3Z4   A0A0L7LAB6   S4P4D0   A0A0N1I9H0   A0A0N0P9M8   E2BSU6   A0A2A3E3D6   A0A088A5N7   A0A0L7R9C2   A0A154PMQ9   A0A0J7KXT9   E2AN99   A0A0N0BEN9   A0A310SH20   A0A151WQV3   F4W555   A0A151I4Q7   A0A158NYZ2   A0A195FT22   T1JJN7   A0A195D0P5   A0A151JLM6   A0A341CVR8   A0A2U3V899   A0A340WQ97   A0A2Y9EVK6   A0A2Y9NP82   E9J7J3   A0A384BG50   A0A1U7QM76   A0A091D6T8   A0A1S3KCV7   L5LG49   K9IG13   L9L6T9   A0A3L7I795   F1SN88   L8I4S1   G1PS53   Q642A5   A0A2K6DZM7   A0A2K6MTL7   G3QRK2   G1S438   A0A2K5YRF9   A0A0D9RJ77   A0A2K5DGQ8   A0A2K6Q9X0   A0A2K5NWD2   H0XNA5   W5P8E2   A0A2K5RX40   A0A2K5HSW4   A0A212CN04   A0A2K6UY63   A0A2J8WRX2   G7PRM1   G2HEE7   F7EVY7   A0A024R829   Q5R4W3   Q9NRF9   Q3SZN5   A0A384DGV8   A0A2Y9HCI1   A0A2U3XUN3   A0A2Y9J7A5   M3Y960   A0A3Q7W934   D2H2I7   A0A2Y9DDQ0   A0A2R9CDA1   M3XC08   A0A2K6GSW9   R7TVV9   A0A3Q2ICV7   A0A3Q7QQ23   A0A2U3VPQ6   A0A0R4J091   A0A164NZC7   A0A286XAE1   L5KA46   A0A1S2ZYZ9   J9P0Z6   A0A1U7TP20   Q9JKP7   G5B1Z8   F6TIZ6  

EC Number

2.7.7.7

Pubmed

25123546    19121390    28756777    22118469    26227816    23622113    + More
26354079    20798317    21719571    21347285    21282665    23385571    29704459    22751099    21993624    15489334    22673903    22398555    25362486    20809919    17194215    22002653    16136131    21484476    17431167    25319552    11181995    10880450    10801849    14702039    15164053    18669648    19413330    20068231    21269460    21406692    16305752    24813606    20010809    22722832    17975172    23254933    19892987    12040188    19468303    21183079    23258410    16341006    11000277    21993625    25243066   

EMBL

KF703558    KF703559    KF703560    KF703561    AHH91062.1    AHH91063.1    + More
AHH91064.1    AHH91065.1    KF703557    AHH91061.1    BABH01024255    KF703567    KF703568    KF703569    KF703570    AHH91071.1    AHH91072.1    AHH91073.1    AHH91074.1    KF703565    AHH91069.1    KF703556    AHH91060.1    KF703562    AHH91066.1    KF703563    AHH91067.1    KF703566    AHH91070.1    KF703564    AHH91068.1    ODYU01005114    SOQ45660.1    KZ150181    PZC72508.1    NWSH01000293    PCG77678.1    AGBW02010484    OWR48433.1    JTDY01002005    KOB72350.1    GAIX01009102    JAA83458.1    KQ460128    KPJ17571.1    KQ459286    KPJ02017.1    GL450269    EFN81238.1    KZ288400    PBC26263.1    KQ414627    KOC67472.1    KQ434972    KZC12744.1    LBMM01002238    KMQ95088.1    GL441149    EFN65101.1    KQ435828    KOX71891.1    KQ769940    OAD52732.1    KQ982821    KYQ50188.1    GL887605    EGI70651.1    KQ976448    KYM85876.1    ADTU01004412    KQ981276    KYN43591.1    JH431939    KQ977004    KYN06488.1    KQ978993    KYN26690.1    GL768539    EFZ11212.1    KN123095    KFO26762.1    KB112777    ELK24608.1    GABZ01008375    JAA45150.1    KB320489    ELW70603.1    RAZU01000090    RLQ74056.1    AEMK02000005    JH881972    ELR51510.1    AAPE02016217    BC081988    BC083800    CABD030065952    ADFV01019711    AQIB01022397    AAQR03034664    AMGL01047119    MKHE01000016    OWK07361.1    NDHI03003380    PNJ72484.1    PNJ72485.1    AQIA01023729    AB170211    CM001290    BAE87274.1    EHH57137.1    AACZ04069042    AK305111    GABC01006272    GABF01008439    GABD01000857    GABE01000340    NBAG03000232    BAK62105.1    JAA05066.1    JAA13706.1    JAA32243.1    JAA44399.1    PNI69606.1    PNI69607.1    JSUE03014414    JU320645    JU320646    JU470579    JU470580    JV043795    JV043796    CM001267    AFE64401.1    AFH27383.1    AFI33866.1    EHH23849.1    CH471090    EAW87382.1    CR861128    AF226077    AF261689    AY720898    AK074629    AK074762    AK074782    DQ072116    AL137066    BC003166    BC004170    BT030577    BC102772    AEYP01022990    ACTA01178982    GL192443    EFB15511.1    AJFE02119091    AANG04004382    AMQN01010745    KB308469    ELT97819.1    AL732594    CH466527    EDL31135.1    LRGB01002761    KZS06376.1    AAKN02050013    KB030911    ELK08242.1    AAEX03008085    AF230806    BC024996    JH168050    GEBF01001156    EHB03300.1    JAO02477.1    GAMT01000156    GAMS01004215    GAMS01004214    GAMR01006129    GAMR01006128    GAMQ01004390    JAB11705.1    JAB18921.1    JAB27803.1    JAB37461.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000037510    UP000053240    UP000053268    + More
UP000008237    UP000242457    UP000005203    UP000053825    UP000076502    UP000036403    UP000000311    UP000053105    UP000075809    UP000007755    UP000078540    UP000005205    UP000078541    UP000078542    UP000078492    UP000252040    UP000245320    UP000265300    UP000248484    UP000248483    UP000261681    UP000189706    UP000028990    UP000085678    UP000011518    UP000273346    UP000008227    UP000001074    UP000002494    UP000233120    UP000233180    UP000001519    UP000001073    UP000233140    UP000029965    UP000233020    UP000233200    UP000233060    UP000005225    UP000002356    UP000233040    UP000233080    UP000233220    UP000009130    UP000233100    UP000002277    UP000006718    UP000001595    UP000005640    UP000009136    UP000261680    UP000291021    UP000248481    UP000245341    UP000248482    UP000000715    UP000286642    UP000008912    UP000248480    UP000240080    UP000011712    UP000233160    UP000014760    UP000002281    UP000286641    UP000245340    UP000000589    UP000076858    UP000005447    UP000010552    UP000079721    UP000002254    UP000189704    UP000006813    UP000008225   

PRIDE

H9IS55    F1SN88    Q642A5    Q9NRF9    Q3SZN5    Q9JKP7    + More

Pfam

PF00808   CBFD_NFYB_HMF

Interpro

IPR009072   Histone-fold        + More
IPR003958   CBFA_NFYB_domain       

SUPFAM

SSF47113   SSF47113       

Gene 3D

1.10.20.10    

ProteinModelPortal

A0A075DA27   A0A075D847   H9IS55   A0A075DA16   A0A075DB57   A0A075D852   + More
A0A075DA32   A0A075DB67   A0A075D9D4   A0A2H1VXU8   A0A2W1BC06   A0A2A4K179   A0A212F3Z4   A0A0L7LAB6   S4P4D0   A0A0N1I9H0   A0A0N0P9M8   E2BSU6   A0A2A3E3D6   A0A088A5N7   A0A0L7R9C2   A0A154PMQ9   A0A0J7KXT9   E2AN99   A0A0N0BEN9   A0A310SH20   A0A151WQV3   F4W555   A0A151I4Q7   A0A158NYZ2   A0A195FT22   T1JJN7   A0A195D0P5   A0A151JLM6   A0A341CVR8   A0A2U3V899   A0A340WQ97   A0A2Y9EVK6   A0A2Y9NP82   E9J7J3   A0A384BG50   A0A1U7QM76   A0A091D6T8   A0A1S3KCV7   L5LG49   K9IG13   L9L6T9   A0A3L7I795   F1SN88   L8I4S1   G1PS53   Q642A5   A0A2K6DZM7   A0A2K6MTL7   G3QRK2   G1S438   A0A2K5YRF9   A0A0D9RJ77   A0A2K5DGQ8   A0A2K6Q9X0   A0A2K5NWD2   H0XNA5   W5P8E2   A0A2K5RX40   A0A2K5HSW4   A0A212CN04   A0A2K6UY63   A0A2J8WRX2   G7PRM1   G2HEE7   F7EVY7   A0A024R829   Q5R4W3   Q9NRF9   Q3SZN5   A0A384DGV8   A0A2Y9HCI1   A0A2U3XUN3   A0A2Y9J7A5   M3Y960   A0A3Q7W934   D2H2I7   A0A2Y9DDQ0   A0A2R9CDA1   M3XC08   A0A2K6GSW9   R7TVV9   A0A3Q2ICV7   A0A3Q7QQ23   A0A2U3VPQ6   A0A0R4J091   A0A164NZC7   A0A286XAE1   L5KA46   A0A1S2ZYZ9   J9P0Z6   A0A1U7TP20   Q9JKP7   G5B1Z8   F6TIZ6  

PDB

2BYM     E-value=1.51465e-13,     Score=178

KEGG

101741556    K02326 DNA polymerase epsilon subunit 3 [EC:2.7.7.7] | (RefSeq) DNA polymerase epsilon subunit 3

PATHWAY

03030    DNA replication - Bombyx mori (domestic silkworm)
03410    Base excision repair - Bombyx mori (domestic silkworm)
03420    Nucleotide excision repair - Bombyx mori (domestic silkworm)

GO

GO:0005634   GO:0046982   GO:0043966   GO:0005671   GO:0008622   GO:0042766   GO:0071480   GO:0006974   GO:0070869   GO:0034080   GO:0003887   GO:0016573   GO:0003677   GO:0000082   GO:0005654   GO:0006270   GO:0006260   GO:0032201   GO:0005524   GO:0006468   GO:0004672   GO:0005507   GO:0004713   GO:0016491   GO:0015930  

Subcellular location

Nucleus  

Length:

119

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

4.73743

Exp number, first 60 AAs:

4.73743

Total prob of N-in:

0.07504

outside

1  -  119

 

 

Pi

223.859597

Theta

202.949129

Tajima's D

0.324332

CLR

4.542336

CSRT

0.461426928653567

Interpretation

Uncertain