Gene

KWMTBOMO14458  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000082

Annotation

PREDICTED:_actin-related_protein_2_[Bombyx_mori]

Location

Bomo_Chr24(-):6965205-6976114      View in EpiBrowser

Full name

Actin-related protein 2      

Alternative Name

Actin-like protein 14D
Actin-like protein 2

Location in the cell

Cytoplasmic   Reliability : 3.885

CDS

ATGGACGACAAAGGACGGAAAGTTATCGTTTGCGACAACGGTACCGGCTTTGTGAAATGTGGCTTCGCTGGTAGCAATTTTCCGGCATTTATATTCCCTTCCATGGTCGGCAGGCCGATCATACGCGCTGAAAACAAAATAGGAGATATTGATGTTAAGGACTTGATGGTGGGCGATGAAGCATCCAAACTGCGATCCATGCTTGAAGTTAGCTACCCTATGGAGAATGGGGTCGTACGTAATTGGGAGGACATGTGCCACGTGTGGGACTACACATTCGGTCCGAGCAAGATGAACGTAGATCCGAAAGAGACGAAGATTTTGCTCACCGAACCCCCGATGAATCCAACTAAGAATCGAGAGAAAATGATCGAGGTGATGTTTGAAAAGTATGAGTTCGACAGCGCTTACGTCGCGATACAAGCTGTGCTCACGTTGTACGCTCAGGGACTGATATCGGGAGTGGTCGTGGACTCGGGAGACGGTGTGACGCACATTTGTCCCGTGTATGAAGAGTTTGCGCTGCCTCATCTCACCAGGAGGCTGGACATAGCCGGGCGAGATATCACGAGGTATCTCATCAAATTGCTTCTGCTCCGAGGGTATGCTTTCAATCATTCCGCTGACTTCGAGACGGTGAGGATGATGAAGGAAAAGCTCTGCTACATCGGGTACAACATTGAGCAGGAGCAACGGCTGGCGCTGGAGACCACCGTGCTGGTGGAGCCCTACACGTTGCCGGACGGTCGAGTGATCAAGGTGGGGGGCGAGAGGTTTGAGGCGCCCGAGGCTCTGTTCCAGCCGCACCTCATCAACGTGGAGGGGCAGGGCATCGCGGAGCTGGTCTTCAACACCATACAGGCGGCCGACATAGACATGCGCAACGAGCTGTACAAGCACATCGTGCTGTCCGGGGGCTCCACCATGTACCCGGGCCTCCCGTCGCGGCTCGAGCGCGAGATCAAGCAGCTGTATCTGGAGCGGGTGCTGCGGAACGAATGCGATAAGCTATCGAAATTTAAGATCAGAGTGGAAGATCCTCCCCGGCGCAAGGACATGGTGTTCATCGGAGGCGCCGTCCTGGCCGAGGTCTGCAAGAACAGGGACAACTTCTGGCTCTCCAGGAACGAGTACCTCGAGCAGGGACTGTCCTGTCTCAGGAAGCTGGGTCCGCGGGCGAGTTAA

Protein

MDDKGRKVIVCDNGTGFVKCGFAGSNFPAFIFPSMVGRPIIRAENKIGDIDVKDLMVGDEASKLRSMLEVSYPMENGVVRNWEDMCHVWDYTFGPSKMNVDPKETKILLTEPPMNPTKNREKMIEVMFEKYEFDSAYVAIQAVLTLYAQGLISGVVVDSGDGVTHICPVYEEFALPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMMKEKLCYIGYNIEQEQRLALETTVLVEPYTLPDGRVIKVGGERFEAPEALFQPHLINVEGQGIAELVFNTIQAADIDMRNELYKHIVLSGGSTMYPGLPSRLEREIKQLYLERVLRNECDKLSKFKIRVEDPPRRKDMVFIGGAVLAEVCKNRDNFWLSRNEYLEQGLSCLRKLGPRAS

Description

ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).

Subunit

Component of the Arp2/3 complex.

Similarity

Belongs to the actin family. ARP2 subfamily.

Keywords

Actin-binding   Alternative splicing   ATP-binding   Complete proteome   Cytoplasm   Cytoskeleton   Nucleotide-binding   Reference proteome  

Feature

chain  Actin-related protein 2
splice variant  In isoform A.

Uniprot

A0A2H1VYJ7   X4ZE67   A0A2A4J3R3   A0A3S2TSD6   H9IS56   S4PY01   + More
A0A0N1IFY0   G1C2J5   B0W0L4   A0A1Q3FX85   Q16P63   A0A023ESJ5   A0A182VFX1   A0A084VJG3   A0A182IUM6   A0A182LIG6   Q7QHZ9   A0A182IDQ4   A0A182RM36   A0A182K896   A0A067RAG3   A0A182PKY1   A0A0K8TLY3   W8AQE9   A0A0K8UY59   A0A034VQ86   A0A1I8PH15   U5EW37   A0A2M4CT75   A0A2M3Z555   A0A2M4ABH7   N6SWU0   T1PGD5   A0A0L0CKB4   V5G301   A0A2J7R7K8   A0A2M4BQL8   A0A182XNG6   A0A1L8E4V3   A0A182N0U1   W8BD15   A0A0C4UR61   A0A0K8ULJ3   A0A182MD05   W5JD48   A0A1I8MCG4   A0A224XRK1   A0A0N7Z9G9   A0A023FAX7   A0A069DST4   R4FNP5   A0A0M3QYU9   A0A2J7R7L5   D3TND2   A0A3B0JQD4   Q29HM7   D6WDF4   B3MSH6   R4WT27   B4M1N9   A0A0T6B6B3   A0A1W4VVT8   B4L2U2   A0A146LBQ5   A0A0A9WL03   B4JNU7   A0A1Y1L1L2   B4NEP0   P45888-2   B4PXU2   B3NX31   A0A1A9X1G9   A0A1A9YNU2   A0A3B0JY56   A0A1A9ULA0   A0A1B0APL8   A0A1B0AEB2   A0A0R3P4H6   A0A0P8XKA5   A0A0Q9WN72   A0A1W4VJ30   A0A0Q9WY23   A0A2H8TIH7   A0A2S2QYB4   A0A1B6MQZ8   A0A087UK69   A0A0Q5TJ10   A0A0R1EAR5   P45888   J9K2X7   A0A1B6EVZ3   B4IF92   A0A1W4XJF7   A0A1B6LKL0   F4X4T7   A0A195ET75   E2BKT6   A0A0J7K5M0   E2A0S9   A0A0L7RBL9  

Pubmed

19121390    23622113    26354079    17510324    24945155    26483478    + More
24438588    20966253    12364791    14747013    17210077    24845553    26369729    24495485    25348373    23537049    25315136    26108605    25692689    20920257    23761445    27129103    25474469    26334808    20353571    15632085    17994087    18362917    19820115    23691247    26823975    25401762    28004739    8064864    10731132    12537572    12537569    17550304    18057021    23185243    21719571    20798317   

EMBL

ODYU01004927    SOQ45304.1    KJ187399    AHV90274.1    NWSH01003278    PCG66631.1    + More
RSAL01000009    RVE53805.1    BABH01024233    BABH01024234    GAIX01004148    JAA88412.1    KQ460129    KPJ17553.1    JF728814    AEJ38216.1    DS231818    EDS41316.1    GFDL01002848    JAV32197.1    CH477793    EAT36135.1    JXUM01055298    JXUM01055299    GAPW01001852    KQ561861    JAC11746.1    KXJ77300.1    ATLV01013559    KE524867    KFB38107.1    AXCP01006502    AAAB01008811    EAA04899.5    APCN01004769    KK852820    KDR15589.1    GDAI01002450    JAI15153.1    GAMC01015525    JAB91030.1    GDHF01020836    JAI31478.1    GAKP01014695    JAC44257.1    GANO01001607    JAB58264.1    GGFL01004287    MBW68465.1    GGFM01002910    MBW23661.1    GGFK01004647    MBW37968.1    APGK01053690    KB741231    KB632387    ENN72259.1    ERL94359.1    KA647200    AFP61829.1    JRES01000290    KNC32706.1    GALX01004066    JAB64400.1    NEVH01006731    PNF36819.1    GGFJ01006171    MBW55312.1    GFDF01000317    JAV13767.1    GAMC01015524    JAB91031.1    KJ534553    AIY54294.1    GDHF01024893    JAI27421.1    AXCM01000244    ADMH02001582    ETN61981.1    GFTR01005795    JAW10631.1    GDKW01000579    JAI56016.1    GBBI01000528    JAC18184.1    GBGD01001736    JAC87153.1    ACPB03001383    GAHY01000498    JAA77012.1    CP012528    ALC48313.1    PNF36820.1    EZ422934    ADD19210.1    OUUW01000003    SPP77660.1    CH379064    EAL31731.1    KQ971321    EEZ99562.1    CH902622    EDV34731.1    AK417882    BAN21097.1    CH940651    EDW65593.1    LJIG01009782    KRT82391.1    CH933810    EDW06909.1    GDHC01012836    JAQ05793.1    GBHO01035130    JAG08474.1    CH916371    EDV92390.1    GEZM01069087    JAV66651.1    CH964239    EDW82209.1    X78486    AE014298    AY061256    BT126051    CM000162    EDX01928.1    CH954180    EDV46860.1    SPP77661.1    JXJN01001482    JXJN01001483    KRT06493.1    KPU75259.1    KRF82302.1    KRF93872.1    GFXV01001263    MBW13068.1    GGMS01013525    MBY82728.1    GEBQ01001610    JAT38367.1    KK120200    KFM77758.1    KQS30148.1    KRK06459.1    ABLF02006475    ABLF02006476    ABLF02006477    GECZ01027660    JAS42109.1    CH480832    EDW46146.1    GEBQ01015781    JAT24196.1    GL888679    EGI58510.1    KQ981993    KYN31084.1    GL448826    EFN83685.1    LBMM01013629    KMQ85554.1    GL435626    EFN72982.1    KQ414617    KOC68233.1   

Proteomes

UP000218220    UP000283053    UP000005204    UP000053240    UP000002320    UP000008820    + More
UP000069940    UP000249989    UP000075903    UP000030765    UP000075880    UP000075882    UP000007062    UP000075840    UP000075900    UP000075881    UP000027135    UP000075885    UP000095300    UP000019118    UP000030742    UP000095301    UP000037069    UP000235965    UP000076407    UP000075884    UP000075883    UP000000673    UP000015103    UP000092553    UP000268350    UP000001819    UP000007266    UP000007801    UP000008792    UP000192221    UP000009192    UP000001070    UP000007798    UP000000803    UP000002282    UP000008711    UP000091820    UP000092443    UP000078200    UP000092460    UP000092445    UP000054359    UP000007819    UP000001292    UP000192223    UP000007755    UP000078541    UP000008237    UP000036403    UP000000311    UP000053825   

PRIDE

H9IS56    P45888   

Pfam

PF00022   Actin

Interpro

IPR004000   Actin        + More
IPR027306   Arp2       
IPR020902   Actin/actin-like_CS       
IPR004001   Actin_CS       

ProteinModelPortal

A0A2H1VYJ7   X4ZE67   A0A2A4J3R3   A0A3S2TSD6   H9IS56   S4PY01   + More
A0A0N1IFY0   G1C2J5   B0W0L4   A0A1Q3FX85   Q16P63   A0A023ESJ5   A0A182VFX1   A0A084VJG3   A0A182IUM6   A0A182LIG6   Q7QHZ9   A0A182IDQ4   A0A182RM36   A0A182K896   A0A067RAG3   A0A182PKY1   A0A0K8TLY3   W8AQE9   A0A0K8UY59   A0A034VQ86   A0A1I8PH15   U5EW37   A0A2M4CT75   A0A2M3Z555   A0A2M4ABH7   N6SWU0   T1PGD5   A0A0L0CKB4   V5G301   A0A2J7R7K8   A0A2M4BQL8   A0A182XNG6   A0A1L8E4V3   A0A182N0U1   W8BD15   A0A0C4UR61   A0A0K8ULJ3   A0A182MD05   W5JD48   A0A1I8MCG4   A0A224XRK1   A0A0N7Z9G9   A0A023FAX7   A0A069DST4   R4FNP5   A0A0M3QYU9   A0A2J7R7L5   D3TND2   A0A3B0JQD4   Q29HM7   D6WDF4   B3MSH6   R4WT27   B4M1N9   A0A0T6B6B3   A0A1W4VVT8   B4L2U2   A0A146LBQ5   A0A0A9WL03   B4JNU7   A0A1Y1L1L2   B4NEP0   P45888-2   B4PXU2   B3NX31   A0A1A9X1G9   A0A1A9YNU2   A0A3B0JY56   A0A1A9ULA0   A0A1B0APL8   A0A1B0AEB2   A0A0R3P4H6   A0A0P8XKA5   A0A0Q9WN72   A0A1W4VJ30   A0A0Q9WY23   A0A2H8TIH7   A0A2S2QYB4   A0A1B6MQZ8   A0A087UK69   A0A0Q5TJ10   A0A0R1EAR5   P45888   J9K2X7   A0A1B6EVZ3   B4IF92   A0A1W4XJF7   A0A1B6LKL0   F4X4T7   A0A195ET75   E2BKT6   A0A0J7K5M0   E2A0S9   A0A0L7RBL9  

PDB

2P9K     E-value=0,     Score=1730

KEGG

101740851    K17260 actin-related protein 2 | (RefSeq) actin-related protein 2

GO

GO:0034314   GO:0003779   GO:0005737   GO:0005885   GO:0005524   GO:0030479   GO:0051489   GO:0005200   GO:0007015   GO:0005884   GO:0045887   GO:0007010   GO:0072553   GO:0000902  

PANTHER

PTHR11937:SF149   PTHR11937  

Subcellular location

  

Length:

394

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

4.18959999999998

Exp number, first 60 AAs:

3.23478

Total prob of N-in:

0.19652

outside

1  -  394

 

 

Pi

215.288082

Theta

191.606199

Tajima's D

1.614926

CLR

0.300841

CSRT

0.806359682015899

Interpretation

Uncertain