Gene

KWMTBOMO14457

Pre Gene Modal

BGIBMGA000999

Annotation

PREDICTED:_tyrosine-protein_kinase-like_otk_[Bombyx_mori]

Location

Bomo_Chr24(+):6911405-6956689      View in EpiBrowser

Full name

Receptor protein-tyrosine kinase       + More
Inactive tyrosine-protein kinase 7      

Alternative Name

Kinase-like protein
Protein-tyrosine kinase 7
Pseudo tyrosine kinase receptor 7
Tyrosine-protein kinase-like 7

Location in the cell

Cytoplasmic   Reliability : 1.186 Nuclear   Reliability : 1.879

CDS

ATGGAGTTGAACAGCTCTGGGAAGATACATTGTAAAGTGGCAGGCGGAGTTTCACCCACCATACAGTGGTATCTGAACGACGCGGATCCGCTTCCGGACGGAGTTACATCGGCTAATGGAACCCTAATGGTTTCGGAAGCTTCTAAACGCCACGCAGGCCTGTACACTTGCAAGGCTGTAGACGGAGACAAGAAGATTGAATCGAAAATCACTCTAGATGTAGTCGTGTCGCCGAGGATAACGGAGCCCGTTCAAGATCAGAACGTGCAGGTCACCGCAGGACAGGACGTCGTGCTGAACTGCGTCGCGTCCGGCGACCCCCCGCCCACGATGCAGTGGGACAAGAACAGCGATATACTCACTCAGATACAGAATGGCGTGGCCAATGAAGCTAGTGCCAACGCCTCGACTGCCAGTGTGGTGCTCCTCAACAACGGGTCTCTTCTGCTGAGGAATGTGTCGGAGAAGACCAGCGCTCACTACGGGTGCACGGCTGGGAGCGCCGCGGGGCTGGTGCGCCACGAGCTGCTACTCACAGTCGCACCACGACACGAGTCAAACGGCGTGGCGGGGAAAGCCGTCGTCGTTTCTATATCGGTGGCCGGCGCCTACATGGTGCTGGTGCTCGCGCTGATGGTCTACTGCAGGAGACGAAGACTGAAACGTCGGCAGCGAGGTGAAAAAATGGAACTGGAAATGGTGGAGGGTCGAGAGAAGCTGGTGGAGGACGGCGAGACTGACGCGGTGAAGGTGAACGGAGGACCAGCGCAGAATGGACGACTGTTGCCCCACGAGAAGGACAGCGGTCCTGATAATTCAGAAGTGTCCCGAGCCTCGAAGAAGTCTGGGAACTTTGAACGTCTCTCGCTGCCGCGGACCCTACTCACCGATCCAATCACACTAGGTCGCGGCGAGTTCGGCGAAGTGCTCCTGGCCAAGATCGACATGAGCCAGGTCGCCAAGCTGCGCAAGTCCGAGGGCGCCGATGCGGAGCCGAACCCGCGGCCCGTGCTCGTCAAGTCACTCACCACTAAAGACGAGGTACAGCTGGCGGAGTTCCGTCGTCAGCTGGACGTGTTCGGGCGCGCCCGGCACAGCAACGTGGTCGCGCTCATCGGCTTGTGCAGCGAGATGGACCCGCACTACATGCTGTTGGAGCACACGGACTGGGGAGATCTGAAGAGCTTCCTGCTGGCGACCCGCGGCCCCGACCCGGAAGAGGATGCGGGCGCCTCTTCCCCCCGCCCCCCGGCGCTCCGCCCTCCGCATCTGGCGTTGTTGGCGGCGCACCTGGCGGCCGCGGCGGCGCACCTCGCCGGGCACCGCCTCACGCACAGGGACATAGCCGCCCGAAACTGTCTCATAACGTCGAAGCTTCAGCTGAAGCTGTCCTGCCCGGCCCTGACCCGCGGGCCGCTGTCTCGCGAGTACTACAAGCTGCACGACCAGGTGATCCCTCTCCGTTGGTGTCCGCTAGAAGTGGTCCTTGAAGGAGACTACTCAACCAAATCAGATGTTTACATGTACGCCGCCACCGTGTGGGAGATGTACACGCAAGCCGAGCTGCCTTTTGCGAAACTGAACGATAGCTCGGTGCTGGATCGGCTGAAGACCGGGGCGCTGGAGTGGAGCGTGCCAGCCTCCATGCCACAATCGGTTGCCGACATACTTAAACGCTGTTGGAGCCAGTCGCCAACGGATCGCCCGCAGTTCGCGGAGGTCTGTGAAGAGATCAACATTGTCCTACAGGAGACCACATCAGAAAACGCTTCAACGAAATCTCAGAAGACGGACGAGGATAATTGA

Protein

MELNSSGKIHCKVAGGVSPTIQWYLNDADPLPDGVTSANGTLMVSEASKRHAGLYTCKAVDGDKKIESKITLDVVVSPRITEPVQDQNVQVTAGQDVVLNCVASGDPPPTMQWDKNSDILTQIQNGVANEASANASTASVVLLNNGSLLLRNVSEKTSAHYGCTAGSAAGLVRHELLLTVAPRHESNGVAGKAVVVSISVAGAYMVLVLALMVYCRRRRLKRRQRGEKMELEMVEGREKLVEDGETDAVKVNGGPAQNGRLLPHEKDSGPDNSEVSRASKKSGNFERLSLPRTLLTDPITLGRGEFGEVLLAKIDMSQVAKLRKSEGADAEPNPRPVLVKSLTTKDEVQLAEFRRQLDVFGRARHSNVVALIGLCSEMDPHYMLLEHTDWGDLKSFLLATRGPDPEEDAGASSPRPPALRPPHLALLAAHLAAAAAHLAGHRLTHRDIAARNCLITSKLQLKLSCPALTRGPLSREYYKLHDQVIPLRWCPLEVVLEGDYSTKSDVYMYAATVWEMYTQAELPFAKLNDSSVLDRLKTGALEWSVPASMPQSVADILKRCWSQSPTDRPQFAEVCEEINIVLQETTSENASTKSQKTDEDN

Description

Inactive tyrosine kinase involved in Wnt signaling. pathway (By similarity).

Catalytic Activity

ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family.
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Keywords

Cell adhesion   Complete proteome   Disulfide bond   Glycoprotein   Immunoglobulin domain   Membrane   Receptor   Reference proteome   Repeat   Signal   Transmembrane   Transmembrane helix   Wnt signaling pathway  

Feature

chain  Inactive tyrosine-protein kinase 7

Uniprot

A0A2W1BST3   A0A0N0PAC2   A0A0N0PDQ4   A0A2H1W2S2   A0A212EMT9   A0A158NDK4   + More
A0A195BQ63   U4U2Q4   A0A139WLU9   F4W538   A0A0T6AYQ9   A0A067QT27   A0A154PGT0   A0A151XEF6   A0A0C9QAQ2   A0A088A2M2   A0A1B0AGA3   E2AQR1   A0A026VV94   A0A3L8DZ90   A0A1A9XMD3   E2BXZ7   A0A195CL79   A0A1B0B1X3   A0A1A9V1U3   K7J5H9   Q7PMY4   A0A293LER2   A0A1B0G716   A0A087UN17   A0A182YK02   A0A2P8ZJL7   A0A1D2NN27   A0A182LT88   A0A0M4EWL4   A0A182P5G3   A0A182HNH4   A0A182VCA6   A0A182LPE7   A0A336N0U2   A0A0A1WRI3   A0A1I8JVP5   A0A336L2R0   A0A336L4V4   A0A2A3E6C9   A0A0M9A237   A0A232EVK3   T1HZ35   A0A195F4T1   A0A2P6LAM7   D1LXC2   T1TF52   G1KDC3   A0A0P7UFR2   A0A210QHX2   A0A1W4ZZA4   E7F2R9   A0A3N0XRF5   F1NLV8   Q91048   A0A3Q0FJU3   G1MXS0   A0A091WF73   A0A094MUV5   G5E7N2   A0A091RUW5   A0A091TEX0   A0A091G3Q9   A0A091U343   A0A2K6SQD0   A0A1S3A7B1   A0A091MBL6   A0A2D0QP17   A0A3M0K9Q8   A0A091R2S7   A0A093PCJ1   M3WBZ1   A0A2J8Y4F7   A0A2J8Y4E9   A0A2K5YV54   A0A091F5M4   A0A2K5MS69   A0A3P4MZ22   A0A2J8Y4I4   A0A096NIB2   A0A2K6FFD3   A0A2I3M952   H0Z2Y2   A0A2K6FFG6   A0A2K5DMY5   A0A087QQX9   A0A2K5MS25   A0A2K5MS46   A0A2K5YV71   A0A2K5DNA5   A0A096NIB0   A0A2K5YV55   F7EGB6  

EC Number

2.7.10.1

Pubmed

28756777    26354079    22118469    21347285    23537049    18362917    + More
19820115    21719571    24845553    20798317    24508170    30249741    20075255    12364791    25244985    29403074    27289101    20966253    25830018    28648823    23533179    28812685    23594743    15592404    1711213    20838655    17975172    20360741   

EMBL

KZ149963    PZC76267.1    KQ458978    KPJ04510.1    KQ460129    KPJ17557.1    + More
ODYU01005924    SOQ47323.1    AGBW02013807    OWR42789.1    ADTU01012665    KQ976424    KYM88278.1    KB632033    ERL88174.1    KQ971319    KYB28864.1    GL887596    EGI70734.1    LJIG01022593    KRT79751.1    KK852984    KDR12850.1    KQ434899    KZC11022.1    KQ982254    KYQ58751.1    GBYB01011563    JAG81330.1    GL441804    EFN64250.1    KK108333    EZA46749.1    QOIP01000002    RLU25435.1    GL451363    EFN79431.1    KQ977600    KYN01458.1    JXJN01007361    AAAB01008966    EAA13056.5    GFWV01001601    MAA26331.1    CCAG010003761    KK120654    KFM78756.1    PYGN01000035    PSN56697.1    LJIJ01000001    ODN06678.1    AXCM01000360    CP012524    ALC42220.1    APCN01001931    UFQT01004128    SSX35521.1    GBXI01012628    GBXI01010537    JAD01664.1    JAD03755.1    UFQS01001603    UFQT01001603    SSX11566.1    SSX31133.1    SSX11565.1    SSX31132.1    KZ288367    PBC26832.1    KQ435793    KOX74249.1    NNAY01001988    OXU22377.1    ACPB03007542    KQ981820    KYN35177.1    MWRG01000621    PRD35641.1    GU076099    ACY92628.1    KF006327    AGT63300.1    JARO02005375    KPP66880.1    NEDP02003587    OWF48337.1    CU638692    RJVU01067364    ROI83722.1    AADN05000009    M63437    KK735482    KFR14347.1    KL258070    KFZ58291.1    KK934177    KFQ46415.1    KK450233    KFQ73135.1    KL447795    KFO77185.1    KK414248    KFQ84851.1    KK525447    KFP67959.1    QRBI01000119    RMC07790.1    KK808435    KFQ33773.1    KL668896    KFW74623.1    AANG04003966    NDHI03003283    PNJ89160.1    PNJ89151.1    KK719538    KFO63879.1    CYRY02015315    VCW85390.1    PNJ89159.1    AHZZ02024674    ABQF01123100    KL225818    KFM03633.1   

Proteomes

UP000053268    UP000053240    UP000007151    UP000005205    UP000078540    UP000030742    + More
UP000007266    UP000007755    UP000027135    UP000076502    UP000075809    UP000005203    UP000092445    UP000000311    UP000053097    UP000279307    UP000092443    UP000008237    UP000078542    UP000092460    UP000078200    UP000002358    UP000007062    UP000092444    UP000054359    UP000076408    UP000245037    UP000094527    UP000075883    UP000092553    UP000075885    UP000075840    UP000075903    UP000075882    UP000076407    UP000242457    UP000053105    UP000215335    UP000015103    UP000078541    UP000001646    UP000034805    UP000242188    UP000192224    UP000000437    UP000000539    UP000189705    UP000001645    UP000053605    UP000053760    UP000233220    UP000079721    UP000221080    UP000269221    UP000053258    UP000011712    UP000233140    UP000052976    UP000233060    UP000028761    UP000233160    UP000007754    UP000233020    UP000053286    UP000008225   

Pfam

PF07714   Pkinase_Tyr        + More
PF07679   I-set
PF07686   V-set
PF13087   AAA_12
PF13086   AAA_11
PF00046   Homeodomain
PF13895   Ig_2

Interpro

IPR011009   Kinase-like_dom_sf        + More
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR007110   Ig-like_dom       
IPR003599   Ig_sub       
IPR013783   Ig-like_fold       
IPR020635   Tyr_kinase_cat_dom       
IPR003598   Ig_sub2       
IPR036179   Ig-like_dom_sf       
IPR008266   Tyr_kinase_AS       
IPR000719   Prot_kinase_dom       
IPR013098   Ig_I-set       
IPR013106   Ig_V-set       
IPR041679   DNA2/NAM7-like_AAA       
IPR027417   P-loop_NTPase       
IPR041677   DNA2/NAM7_AAA_11       
IPR017970   Homeobox_CS       
IPR001356   Homeobox_dom       
IPR009057   Homeobox-like_sf       
IPR017441   Protein_kinase_ATP_BS       

SUPFAM

SSF48726   SSF48726        + More
SSF56112   SSF56112       
SSF52540   SSF52540       
SSF46689   SSF46689       

Gene 3D

2.60.40.10    

CDD

cd00086  homeodomain

ProteinModelPortal

A0A2W1BST3   A0A0N0PAC2   A0A0N0PDQ4   A0A2H1W2S2   A0A212EMT9   A0A158NDK4   + More
A0A195BQ63   U4U2Q4   A0A139WLU9   F4W538   A0A0T6AYQ9   A0A067QT27   A0A154PGT0   A0A151XEF6   A0A0C9QAQ2   A0A088A2M2   A0A1B0AGA3   E2AQR1   A0A026VV94   A0A3L8DZ90   A0A1A9XMD3   E2BXZ7   A0A195CL79   A0A1B0B1X3   A0A1A9V1U3   K7J5H9   Q7PMY4   A0A293LER2   A0A1B0G716   A0A087UN17   A0A182YK02   A0A2P8ZJL7   A0A1D2NN27   A0A182LT88   A0A0M4EWL4   A0A182P5G3   A0A182HNH4   A0A182VCA6   A0A182LPE7   A0A336N0U2   A0A0A1WRI3   A0A1I8JVP5   A0A336L2R0   A0A336L4V4   A0A2A3E6C9   A0A0M9A237   A0A232EVK3   T1HZ35   A0A195F4T1   A0A2P6LAM7   D1LXC2   T1TF52   G1KDC3   A0A0P7UFR2   A0A210QHX2   A0A1W4ZZA4   E7F2R9   A0A3N0XRF5   F1NLV8   Q91048   A0A3Q0FJU3   G1MXS0   A0A091WF73   A0A094MUV5   G5E7N2   A0A091RUW5   A0A091TEX0   A0A091G3Q9   A0A091U343   A0A2K6SQD0   A0A1S3A7B1   A0A091MBL6   A0A2D0QP17   A0A3M0K9Q8   A0A091R2S7   A0A093PCJ1   M3WBZ1   A0A2J8Y4F7   A0A2J8Y4E9   A0A2K5YV54   A0A091F5M4   A0A2K5MS69   A0A3P4MZ22   A0A2J8Y4I4   A0A096NIB2   A0A2K6FFD3   A0A2I3M952   H0Z2Y2   A0A2K6FFG6   A0A2K5DMY5   A0A087QQX9   A0A2K5MS25   A0A2K5MS46   A0A2K5YV71   A0A2K5DNA5   A0A096NIB0   A0A2K5YV55   F7EGB6  

PDB

6FER     E-value=8.7535e-28,     Score=309

KEGG

101742691    K05127 PTK7 protein tyrosine kinase 7 [EC:2.7.10.1] | (RefSeq) tyrosine-protein kinase-like otk

GO

GO:0004713   GO:0001736   GO:1904929   GO:0005887   GO:0060026   GO:0005524   GO:0004672   GO:0016021   GO:0003401   GO:0005911   GO:0043565   GO:0006355   GO:0005634   GO:0004714   GO:0090660   GO:0035282   GO:0090090   GO:0001501   GO:2000040   GO:0003402   GO:0031532   GO:0060976   GO:0016477   GO:0045198   GO:0071300   GO:0003281   GO:0042060   GO:0090263   GO:0010976   GO:0090103   GO:0060484   GO:0090179   GO:0016301   GO:0007155   GO:0006468   GO:0005515   GO:0005507   GO:0016491   GO:0015930  

Subcellular location

Nucleus  
Membrane  

Length:

601

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

23.5732899999999

Exp number, first 60 AAs:

0.00217

Total prob of N-in:

0.26281

outside

1  -  192

TMhelix

193  -  215

inside

216  -  601

 

 

Pi

251.644555

Theta

172.501064

Tajima's D

1.096566

CLR

0.540686

CSRT

0.691415429228539

Interpretation

Uncertain