Gene

KWMTBOMO14456  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000138

Annotation

deoxyhypusine_synthase_[Bombyx_mori]

Location

Bomo_Chr24(+):6909255-6910508      View in EpiBrowser

Full name

Probable deoxyhypusine synthase      

Location in the cell

PlasmaMembrane   Reliability : 1.667

CDS

ATGGAAATCCCGTGCAACGTCGAAAAACCTGTTAAAGTAGCCCCAAATATTGCCGTAAATGCGGTTCTGCAACCGAGCCAAGATTTACCTGCAGAAACACCGATAGTCGCGGGCTACGACTGGGAAAATGGAACCGATTACAATAAAATACTCGAATCTTACGCTAACTCCGGATTTCAGGCCACGAATTTCGGTAAAACTGTCGTCGAAATCAATAATATGCTCAAAAGCCGAGCGGTTCCGTTAACCGAAGAAAACAGCGATTGTTATGAAGAAGACCAGTTTATTAAGAAGAAAACTAACTGTACTATATTCCTCGGGTATACTTCTAACATGATATCCTCGGGACTGAGAGACACGATCCGTTTTTTAGTTAAAAATAAGCTTGTGGATGTGATTGTGACTACAGCTGGAGGGATCGAGGAAGACTTGATAAAATGCATCGCTCCGACCTATGTAGGTGATTTTAATTTAAGCGGGAAAGTGTTAAGAACACGAGGTATAAACAGGATAGGCAATTTGTTGGTGCCAAATGATAATTATTGTTTGTTTGAGGAGTGGGTCACTCCATTGTTGGACGAGATGATCTCTGAACAGATGAAAGAGGGTACTGTTTGGAGTCCGTCGCGCATCACAGCCCGGTTAGGGGAGAGGATTAACAATGAGAGCTCAGTGTGCTATTGGGCTTGGAGGAACAACATACCTATATTTAGTCCCGCATTGACTGATGGATCCTTAGGCGACATGATGTACTTCCACTCGTTTAAGCGTCCCGGACTGATCATAGACATATTGGGAGACCTGCGCAGATTGAACACCATGGCCGTCAAAGCCAACAACACTGGAGTCATAATATTAGGTGGGGGTTTGATCAAACATCATATTTGTAACGCAAATCTGATGCGTAATGGTGCTGATTACGCTGTGTACGTGAACACGGCCAGTGAATTTGACGGCAGTGATGCAGGTGCCAGGCCCGACGAAGCAGTCTCGTGGGGCAAAATCAGACCTAATGCGAATCCAGTGAAGCTATATGCAGATGCTACGTTAGTGTTCCCCTTGATCGTAGCTCAAACATTTGCTAAACATCATTTTAGCAGTAAGAAAAATGTTTAA

Protein

MEIPCNVEKPVKVAPNIAVNAVLQPSQDLPAETPIVAGYDWENGTDYNKILESYANSGFQATNFGKTVVEINNMLKSRAVPLTEENSDCYEEDQFIKKKTNCTIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCIAPTYVGDFNLSGKVLRTRGINRIGNLLVPNDNYCLFEEWVTPLLDEMISEQMKEGTVWSPSRITARLGERINNESSVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKRPGLIIDILGDLRRLNTMAVKANNTGVIILGGGLIKHHICNANLMRNGADYAVYVNTASEFDGSDAGARPDEAVSWGKIRPNANPVKLYADATLVFPLIVAQTFAKHHFSSKKNV

Description

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

Catalytic Activity

[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine

Cofactor

NAD(+)

Similarity

Belongs to the deoxyhypusine synthase family.

Keywords

Complete proteome   Hypusine biosynthesis   NAD   Reference proteome   Transferase  

Feature

chain  Probable deoxyhypusine synthase

Uniprot

B5U1G9   A0A0L7LAG2   A0A2A4JHM6   A0A2W1BMV9   A0A2H1W2K7   A0A212ER49   + More
A0A0N0PA07   A0A0N0PE11   S4P9B0   B0W851   A0A1J1I595   A0A0M9A691   A0A0A1WU90   A0A182IQF1   B4LCB4   W5JCV2   A0A182NIW0   A0A084WML8   A0A154PBP2   R4FP41   B4L933   A0A182X4C3   A0A3B0KQP4   A0A2A3ENU7   A0A1I8MG00   B4J215   A0A182VAX5   Q7Q5B3   A0A182WBW0   A0A0L7R9J5   A0A1B6I1W8   B3M9N0   A0A182MLP7   A0A182UF31   A0A067QIV3   A0A1B6FFZ7   A0A087ZRT5   A0A182I4B8   A0A0M3QWX4   Q16QM1   A0A224XII6   A0A1I8PFH9   B5DP22   Q9VSF4   A0A182JVT6   A0A1A9WLL2   B4H171   B4PGJ5   A0A2J7QSV9   A0A1W4UEB7   A0A1A9ZDX2   B4MKQ6   A0A1A9UKR0   B4QLJ8   A0A182GFB2   B4HJE2   A0A1B6M5G2   A0A0L0CAD5   B3NFW2   A0A1B0C6P8   A0A3Q0JCJ7   A0A1A9XJV6   A0A336M7P4   A0A182Y7X3   D3TQ86   A0A293LNU7   T1J796   E9HAW4   A0A0P5XWB0   A0A0P5LTM4   A0A164ZV65   A0A0N8DMV4   A0A069DT87   A0A2H8TF80   A0A182FFE2   C4WS47   A0A1Y1LH70   A0A182LKL3   A0A0A9XNZ3   A0A2S2QFW8   A0A1E1XRS5   A0A0K8SL72   A0A146KVE2   A0A0K8SL13   A0A023GLK3   A0A146L376   A0A182PRZ2   A0A023F8D9   A0A310SN71   L7M7U6   A0A232EQD1   A0A0P6E565   A0A1B6CH48   A0A0P6DMB5   W8CE17   A0A1E1X4T1   A0A0P5SXR7   A0A1B0GJL8   A0A131XG47   A0A1B6E0I2  

EC Number

2.5.1.46

Pubmed

19121390    26227816    28756777    22118469    26354079    23622113    + More
25830018    17994087    20920257    23761445    24438588    25315136    12364791    14747013    17210077    24845553    17510324    15632085    23185243    10731132    12537572    17550304    22936249    26483478    26108605    25244985    20353571    21292972    26334808    28004739    20966253    25401762    29209593    26823975    25474469    25576852    28648823    24495485    28503490    28049606   

EMBL

BABH01024231    FJ156236    ACH95798.1    JTDY01001952    KOB72462.1    NWSH01001379    + More
PCG71471.1    KZ149963    PZC76268.1    ODYU01005924    SOQ47325.1    AGBW02013121    OWR43955.1    KQ458995    KPJ04422.1    KQ460129    KPJ17558.1    GAIX01005581    JAA86979.1    DS231857    EDS38676.1    CVRI01000042    CRK95461.1    KQ435742    KOX76699.1    GBXI01012096    JAD02196.1    CH940647    EDW68759.1    ADMH02001882    ETN60659.1    ATLV01024482    KE525352    KFB51462.1    KQ434869    KZC09253.1    ACPB03017427    GAHY01001064    JAA76446.1    CH933816    EDW17208.1    OUUW01000012    SPP87541.1    KZ288202    PBC33483.1    CH916366    EDV95940.1    AAAB01008960    EAA11387.4    KQ414625    KOC67533.1    GECU01026851    JAS80855.1    CH902618    EDV39036.1    AXCM01000273    KK853297    KDR08786.1    GECZ01020664    JAS49105.1    APCN01002300    CP012525    ALC44933.1    CH477744    EAT36696.1    GFTR01005562    JAW10864.1    CH379067    EDY73273.1    KRT07349.1    AE014296    BT010229    CH479202    EDW30048.1    CM000159    EDW93213.1    NEVH01011219    PNF31653.1    CH963847    EDW72762.2    CM000363    CM002912    EDX09658.1    KMY98314.1    JXUM01000836    JXUM01000837    CH480815    EDW40666.1    GEBQ01008817    JAT31160.1    JRES01000681    KNC29217.1    CH954178    EDV50724.1    JXJN01026846    UFQS01000509    UFQT01000509    SSX04489.1    SSX24853.1    EZ423588    ADD19864.1    GFWV01005673    MAA30403.1    JH431916    GL732613    EFX71102.1    GDIP01066318    JAM37397.1    GDIQ01165834    JAK85891.1    LRGB01000687    KZS16814.1    GDIP01018215    JAM85500.1    GBGD01001933    JAC86956.1    GFXV01000962    MBW12767.1    ABLF02013770    AK340044    BAH70717.1    GEZM01058748    JAV71690.1    GBHO01021147    JAG22457.1    GGMS01006879    MBY76082.1    GFAA01001678    JAU01757.1    GBRD01011826    JAG53998.1    GDHC01019423    JAP99205.1    GBRD01011827    JAG53997.1    GBBM01001450    JAC33968.1    GDHC01015665    JAQ02964.1    GBBI01001147    JAC17565.1    KQ762031    OAD56379.1    GACK01004663    JAA60371.1    NNAY01002808    OXU20532.1    GDIQ01082262    JAN12475.1    GEDC01024540    JAS12758.1    GDIQ01076603    JAN18134.1    GAMC01000976    JAC05580.1    GFAC01004909    JAT94279.1    GDIP01142048    GDIP01140901    JAL62813.1    AJWK01021979    GEFH01003436    JAP65145.1    GEDC01005860    JAS31438.1   

Proteomes

UP000005204    UP000037510    UP000218220    UP000007151    UP000053268    UP000053240    + More
UP000002320    UP000183832    UP000053105    UP000075880    UP000008792    UP000000673    UP000075884    UP000030765    UP000076502    UP000015103    UP000009192    UP000076407    UP000268350    UP000242457    UP000095301    UP000001070    UP000075903    UP000007062    UP000075920    UP000053825    UP000007801    UP000075883    UP000075902    UP000027135    UP000005203    UP000075840    UP000092553    UP000008820    UP000095300    UP000001819    UP000000803    UP000075881    UP000091820    UP000008744    UP000002282    UP000235965    UP000192221    UP000092445    UP000007798    UP000078200    UP000000304    UP000069940    UP000001292    UP000037069    UP000008711    UP000092460    UP000079169    UP000092443    UP000076408    UP000000305    UP000076858    UP000069272    UP000007819    UP000075882    UP000075885    UP000215335    UP000092461   

PRIDE

B5U1G9    Q9VSF4   

Pfam

PF01916   DS        + More
PF04628   Sedlin_N
PF00106   adh_short
PF09446   VMA21
PF13932   GIDA_assoc

Interpro

IPR036982   Deoxyhypusine_synthase_sf        + More
IPR029035   DHS-like_NAD/FAD-binding_dom       
IPR002773   Deoxyhypusine_synthase       
IPR006722   Sedlin       
IPR011012   Longin-like_dom_sf       
IPR002347   SDR_fam       
IPR036291   NAD(P)-bd_dom_sf       
IPR019013   Vma21       
IPR026904   GidA-assoc_3       
IPR004416   MnmG       
IPR020595   MnmG-rel_CS       
IPR002218   MnmG-rel       
IPR036188   FAD/NAD-bd_sf       

SUPFAM

SSF52467   SSF52467        + More
SSF64356   SSF64356       
SSF51735   SSF51735       
SSF51905   SSF51905       

Gene 3D

3.40.910.10     3.50.50.60    

ProteinModelPortal

B5U1G9   A0A0L7LAG2   A0A2A4JHM6   A0A2W1BMV9   A0A2H1W2K7   A0A212ER49   + More
A0A0N0PA07   A0A0N0PE11   S4P9B0   B0W851   A0A1J1I595   A0A0M9A691   A0A0A1WU90   A0A182IQF1   B4LCB4   W5JCV2   A0A182NIW0   A0A084WML8   A0A154PBP2   R4FP41   B4L933   A0A182X4C3   A0A3B0KQP4   A0A2A3ENU7   A0A1I8MG00   B4J215   A0A182VAX5   Q7Q5B3   A0A182WBW0   A0A0L7R9J5   A0A1B6I1W8   B3M9N0   A0A182MLP7   A0A182UF31   A0A067QIV3   A0A1B6FFZ7   A0A087ZRT5   A0A182I4B8   A0A0M3QWX4   Q16QM1   A0A224XII6   A0A1I8PFH9   B5DP22   Q9VSF4   A0A182JVT6   A0A1A9WLL2   B4H171   B4PGJ5   A0A2J7QSV9   A0A1W4UEB7   A0A1A9ZDX2   B4MKQ6   A0A1A9UKR0   B4QLJ8   A0A182GFB2   B4HJE2   A0A1B6M5G2   A0A0L0CAD5   B3NFW2   A0A1B0C6P8   A0A3Q0JCJ7   A0A1A9XJV6   A0A336M7P4   A0A182Y7X3   D3TQ86   A0A293LNU7   T1J796   E9HAW4   A0A0P5XWB0   A0A0P5LTM4   A0A164ZV65   A0A0N8DMV4   A0A069DT87   A0A2H8TF80   A0A182FFE2   C4WS47   A0A1Y1LH70   A0A182LKL3   A0A0A9XNZ3   A0A2S2QFW8   A0A1E1XRS5   A0A0K8SL72   A0A146KVE2   A0A0K8SL13   A0A023GLK3   A0A146L376   A0A182PRZ2   A0A023F8D9   A0A310SN71   L7M7U6   A0A232EQD1   A0A0P6E565   A0A1B6CH48   A0A0P6DMB5   W8CE17   A0A1E1X4T1   A0A0P5SXR7   A0A1B0GJL8   A0A131XG47   A0A1B6E0I2  

PDB

1RQD     E-value=4.17666e-125,     Score=1146

KEGG

100190959    K00809 deoxyhypusine synthase [EC:2.5.1.46] | (RefSeq) Dhs; deoxyhypusine synthase

GO

GO:0008612   GO:0034038   GO:0005737   GO:0006888   GO:0070072   GO:0016021   GO:0050660   GO:0002098   GO:0005524   GO:0006468   GO:0043631   GO:0004652   GO:0005634   GO:0005507   GO:0004713   GO:0016491   GO:0015930  

PANTHER

PTHR11703   PTHR11806   PTHR11806:SF0  

Length:

371

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.43956

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01476

outside

1  -  371

 

 

Pi

240.916608

Theta

191.929157

Tajima's D

0.637732

CLR

42.847604

CSRT

0.556172191390431

Interpretation

Uncertain