Gene

KWMTBOMO14454  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000136

Annotation

PREDICTED:_MAP/microtubule_affinity-regulating_kinase_3-like_isoform_X5_[Bombyx_mori]

Location

Bomo_Chr24(+):6812745-6853182      View in EpiBrowser

Full name

Non-specific serine/threonine protein kinase      

Location in the cell

Nuclear   Reliability : 4.379

CDS

ATGAAAATGCTTGATCATCCGAACATTGTGAAGCTCTTCCAAGTTATAGAGACTGAAAAGACACTTTACCTGGTCATGGAATATGCTTCGGGTGGAGAGGTGTTCGACTATTTAGTGCTACACGGCCGCATGAAGGAGAAGGAGGCCCGTGCTAAGTTCAGGCAGATAGTTTCGGCCGTCCAATACTGCCACCAGAAACGGATCATACATAGGGATCTCAAGGCCGAGAATCTTTTATTAGACGGCGAGATGAACATTAAGATTGCCGATTTCGGTTTCTCTAACGAGTTCACGCCGGGAGCGAAGCTGGACACCTTCTGTGGCAGTCCGCCCTATGCAGCCCCTGAACTGTTCCAAGGCAAGAAATACGACGGTCCCGAGGTCGACGTGTGGTCTCTGGGCGTGATCCTCTACACGCTGGTCTCCGGCTCGCTGCCCTTCGACGGCTCCACGCTCCGGGAGCTACGCGAGAGGGTGCTGCGAGGGAAATACAGAATACCGTTCTACATGTCAACGGACTGCGAGAATCTTTTAAAGAAATTCCTCGTCCTGAATCCTGCGAAGCGTGCGTCCCTAGAGAGCATAATGCGAGACAAATGGATGAACACCGGATACGAGGAGGACGAACTCAGGCCCTACGTCGAGCCGCAGCAGGACTTCAAGGACCACAAGCGGATAGAGGCGTTAGTCTGCCTGGGCTACAACAGACAAGAGATTGAATACTCCCTGGCTGAAGCGAAATACGATGACGTATTCGCCACATACTTACTGCTCGGAAGGAAAAGTACCGATCCGGAGTCCGATGGCAGTCGCTCGGGCTCGTCTCTGTCCCTACGGACGTCGGCCGCCGCCAACCAGACCCAGCAGCAGCAGCAGACCAACTCGCACGCAGGGTCGGGCTCGCCGTCGCACCGCGGCGTGCAGCGCTCCATCTCGGCGAGTGCGAGGCCTCAGCCCTCGCGCCGAGCCTCCTCCGGCGCTGAGGTCCTCAGGACCCAAGTTGGTACGACGACGACCGCGTCAAACAGTACGACTTCAACGGCGACCACTACCGCTTCTAATTTCAAAAGACAGAACACAATCGACTCGGCGTCGATCAAAGAAAACACAGCACGGATCGCTCAAATGCAAGTACAAAGCACGACTCGTCCGACTAGCGCCCAGCCCAAGCTAGAGCCGCGGTCTCGCACGTTGACGGGTGGTGCGCGGCGCTCCCACGCCAACTACGAGCCGCCCGCGCACGCGCCCAAGCTGTCGCCGCCGCACGATGCGCCCAGTTTGAACACGCAGTTGACAGTGACTGGCGCCAGTACTGGCACCGGCTCGGCTGCGAGTGCGGCCAGACGCGAGTTCCCCAACCAGCTCGTCTTCCCCAGGAACGTACCTTCGCGCTCCACCTTCCACTCAGGGCAGACGCGGTCGCGCGGGGCGGGCGGCGCGGCGGGGTACGGGGAGGGTGGCTCCCCGCACCAACCACGGCCCTCATTCTTCTCCAAACTGTCCTCGCGGTTCTCTAAACGTTTGTCGGTGCTGGGAGAGTCGACTGGTCGTCAGAAACCTCGTATTTTTTCCTCTCTGGACATACAGCGGAGACAAGGAAACGAGGAACAAGTGAAGCCCAGGGTGCTTCGCTTCACGTGGAGCATGAAGACGACCTCGTCGCGGGACCCGAATGAGATCATGGCTGAGATCAGGAAGGTGCTCGATGCGAACAACTGCGATTACGAGCAGCGCGAGAGGTTCTTATTGCTGTGCGTGCACGGCGACCCCAACGCGGACTCGCTGGTGCAGTGGGAGATCGAGGTCTGCAAGCTGCCGCGCCTCTCGCTCAACGGGGTGCGCTTCAAGAGGATATCCGGAACAAGCATCGGCTTCAAGAACATTGCGTCAAAGATAGCGAACGAACTCAAGCTCCTGCGCCTCTCCGCCGAAGACATGGTGCTGATCGCCAACGGGGGCCAGCGGACGTCCTCCGGCGCGCTGGCTCACTTCCTGGCCGCGTACAGTCCGGCCGAGCTGTCTCTGGCCCGCAGCGACTACCTGCGGCCGCCGGGCTCCCCGCCCCGCCTCCACCCCCGCTCGGCCCTGTCCCTGCGCGCCGACAGCGCCGACGTGCCCTCCCCCTACCGCGTGGCTTACTCCAGCACGCACACGCTGCGCCGACAGCCCCGCGCCCTCTCGCCCCCCACACCCCCGTCACCGTGCGACTGTCTGCCCCTCGAGCCGATCCCCCCTCCTGAGCTGTTCGATTTTTAA

Protein

MKMLDHPNIVKLFQVIETEKTLYLVMEYASGGEVFDYLVLHGRMKEKEARAKFRQIVSAVQYCHQKRIIHRDLKAENLLLDGEMNIKIADFGFSNEFTPGAKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLKKFLVLNPAKRASLESIMRDKWMNTGYEEDELRPYVEPQQDFKDHKRIEALVCLGYNRQEIEYSLAEAKYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRTSAAANQTQQQQQTNSHAGSGSPSHRGVQRSISASARPQPSRRASSGAEVLRTQVGTTTTASNSTTSTATTTASNFKRQNTIDSASIKENTARIAQMQVQSTTRPTSAQPKLEPRSRTLTGGARRSHANYEPPAHAPKLSPPHDAPSLNTQLTVTGASTGTGSAASAARREFPNQLVFPRNVPSRSTFHSGQTRSRGAGGAAGYGEGGSPHQPRPSFFSKLSSRFSKRLSVLGESTGRQKPRIFSSLDIQRRQGNEEQVKPRVLRFTWSMKTTSSRDPNEIMAEIRKVLDANNCDYEQRERFLLLCVHGDPNADSLVQWEIEVCKLPRLSLNGVRFKRISGTSIGFKNIASKIANELKLLRLSAEDMVLIANGGQRTSSGALAHFLAAYSPAELSLARSDYLRPPGSPPRLHPRSALSLRADSADVPSPYRVAYSSTHTLRRQPRALSPPTPPSPCDCLPLEPIPPPELFDF

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Uniprot

A0A2A4K5G1   A0A2A4K436   A0A2A4K421   A0A2A4K5G8   A0A2A4K5R1   A0A2A4K4L1   + More
A0A2A4K4Q8   A0A1Y1MCF9   A0A1Y1MFA2   A0A1Y1MAG8   A0A1Y1MDQ7   A0A139WKE6   A0A224X7R3   A0A069DWX6   A0A139WKN2   A0A2A4K523   A0A139WKM7   A0A1I8PKX9   A0A1I8PKR7   A0A1I8N449   T1PE90   B3MHB1   A0A0Q9XI31   A0A0R3NSN4   A0A0Q9W3X6   A0A1I8PKZ0   A0A0Q9W4L7   A0A0Q9W403   A0A0R3NTE4   A0A1I8PKY4   A0A1W4V4K6   A0A0Q9WRA8   A0A195EYD1   A0A139WKC9   A0A0Q9WC24   B4LNW1   A0A0Q9XIQ8   A0A1I8PKV9   A0A1I8PKX0   A0A0Q9WGE2   A0A0Q9W4Z7   A0A0Q9XM92   A0A0Q9XMA6   A0A1W4V441   A0A0Q9X928   A0A0Q9XLQ6   A0A0T6BGE6   A0A336LST4   A0A1W4V4J6   A0A0Q9X9W0   A0A0Q9X913   V5FZW2   V5GGV9   V5GSL6   A0A0Q9WDC6   A1ZBL7   A0A0Q9XGB3   A0A1B6CAK5  

EC Number

2.7.11.1

Pubmed

28004739    18362917    19820115    26334808    25315136    17994087    + More
15632085    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867   

EMBL

NWSH01000151    PCG79013.1    PCG79017.1    PCG79011.1    PCG79023.1    PCG79012.1    + More
PCG79009.1    PCG79016.1    GEZM01037681    JAV81985.1    GEZM01037679    JAV81987.1    GEZM01037678    JAV81988.1    GEZM01037680    JAV81986.1    KQ971328    KYB28374.1    GFTR01008040    JAW08386.1    GBGD01000519    JAC88370.1    KYB28375.1    PCG79018.1    KYB28377.1    KA646999    AFP61628.1    CH902619    EDV36888.2    CH933808    KRG04932.1    CM000071    KRT02061.1    CH940648    KRF79801.1    KRF79794.1    KRF79802.1    KRT02051.1    CH963850    KRF98141.1    KQ981906    KYN33228.1    KYB28376.1    KRF79799.1    EDW61130.2    KRG04946.1    KRF79797.1    KRF79798.1    KRG04931.1    KRG04947.1    KRG04934.1    KRG04936.1    LJIG01000519    KRT86421.1    UFQT01000094    SSX19649.1    KRG04933.1    KRG04939.1    GALX01005231    JAB63235.1    GALX01005237    JAB63229.1    GALX01005233    JAB63233.1    KRF79793.1    AE013599    AAS64800.1    KRG04938.1    GEDC01026805    GEDC01024913    JAS10493.1    JAS12385.1   

Proteomes

UP000218220    UP000007266    UP000095300    UP000095301    UP000007801    UP000009192    + More
UP000001819    UP000008792    UP000192221    UP000007798    UP000078541    UP000000803   

PRIDE

A1ZBL7   

Pfam

PF00069   Pkinase        + More
PF02149   KA1

Interpro

IPR000719   Prot_kinase_dom        + More
IPR001772   KA1_dom       
IPR028375   KA1/Ssp2_C       
IPR008271   Ser/Thr_kinase_AS       
IPR011009   Kinase-like_dom_sf       
IPR017441   Protein_kinase_ATP_BS       
IPR015940   UBA       

SUPFAM

SSF56112   SSF56112        + More
SSF103243   SSF103243       

ProteinModelPortal

A0A2A4K5G1   A0A2A4K436   A0A2A4K421   A0A2A4K5G8   A0A2A4K5R1   A0A2A4K4L1   + More
A0A2A4K4Q8   A0A1Y1MCF9   A0A1Y1MFA2   A0A1Y1MAG8   A0A1Y1MDQ7   A0A139WKE6   A0A224X7R3   A0A069DWX6   A0A139WKN2   A0A2A4K523   A0A139WKM7   A0A1I8PKX9   A0A1I8PKR7   A0A1I8N449   T1PE90   B3MHB1   A0A0Q9XI31   A0A0R3NSN4   A0A0Q9W3X6   A0A1I8PKZ0   A0A0Q9W4L7   A0A0Q9W403   A0A0R3NTE4   A0A1I8PKY4   A0A1W4V4K6   A0A0Q9WRA8   A0A195EYD1   A0A139WKC9   A0A0Q9WC24   B4LNW1   A0A0Q9XIQ8   A0A1I8PKV9   A0A1I8PKX0   A0A0Q9WGE2   A0A0Q9W4Z7   A0A0Q9XM92   A0A0Q9XMA6   A0A1W4V441   A0A0Q9X928   A0A0Q9XLQ6   A0A0T6BGE6   A0A336LST4   A0A1W4V4J6   A0A0Q9X9W0   A0A0Q9X913   V5FZW2   V5GGV9   V5GSL6   A0A0Q9WDC6   A1ZBL7   A0A0Q9XGB3   A0A1B6CAK5  

PDB

2QNJ     E-value=1.20625e-131,     Score=1206

KEGG

101740714    K08798 MAP/microtubule affinity-regulating kinase [EC:2.7.11.1] | (RefSeq) serine/threonine-protein

GO

GO:0004674   GO:0000226   GO:0030010   GO:0005524   GO:0051124   GO:0050321   GO:0045172   GO:0030860   GO:0016323   GO:0061174   GO:0005938   GO:0007298   GO:0045169   GO:0016325   GO:0007317   GO:0007294   GO:0035331   GO:0090176   GO:0001737   GO:0001932   GO:0031594   GO:0030709   GO:0007318   GO:0019730   GO:0005737   GO:0035556   GO:0009798   GO:0030707   GO:0006468   GO:0009948   GO:0009994   GO:0045451   GO:0004672   GO:0043631   GO:0004652   GO:0005634   GO:0005507   GO:0004713   GO:0016491   GO:0015930  

Length:

751

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.46162

Exp number, first 60 AAs:

0.17413

Total prob of N-in:

0.02111

outside

1  -  751

 

 

Pi

239.791996

Theta

194.744896

Tajima's D

0.827876

CLR

0.304156

CSRT

0.614169291535423

Interpretation

Uncertain