Gene

KWMTBOMO14446  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000086

Annotation

LRP16_protein_[Bombyx_mori]

Location

Bomo_Chr24(-):6550341-6554867      View in EpiBrowser

Full name

ADP-ribose glycohydrolase MACROD2      

Alternative Name

MACRO domain-containing protein 2
O-acetyl-ADP-ribose deacetylase MACROD2
[Protein ADP-ribosylaspartate] hydrolase MACROD2
[Protein ADP-ribosylglutamate] hydrolase MACROD2

Location in the cell

Cytoplasmic   Reliability : 1.754 Mitochondrial   Reliability : 1.077 Nuclear   Reliability : 1.141

CDS

ATGGTTAATTCTACTAAGTGGGAAATAGAAAAGAACAGGATTCTTAAACTTTCATTAGAAGAGAAGAGAAAAATCTATAAATCTTCTGATTTCATAGATTTAGAGAATGTTGATCCTTGGAGTAAATATCTTAACAAAAGTCAAGGAATTGATTCCAAGAAAAGCACCACAGACGATTTGAAGGAGTTTGAGAAGATAAAGATAAACACAGAGAAGAATAAATCCATTTCTGAGCGCGTTTCTATTTTTAAAGGAGACATAACTAAGCTGGAAATTGATGCAGTTGTGAATGCTGCTAATTCAAGACTAAAGGCTGGAGGTGGTGTCGATGGAGCCATACACCGGGCTGCAGGTCCCTTTTTACAGGCAGAATGCGATTCTATAGGCGGATGTCCAACAGGAGATGCCAAAGTTACTGGTGGTTACAATTTACCAGCTAAATATATCATCCACACTGTTGGGCCCCAAGATGGATCGGCAGAGAAACTAGAATCCTGCTACGAAAAATGCCTGTCATTCCAACAGGAATACCAAATAAAATCGATCGCTTTTCCGTGTATATCCACTGGAATTTACGGTTTTCCGAATCGTCTCGCAGCACACATAGCGCTACGTACAGCTAGGAAGTTTCTAGAAACGAATACAGAAATGAACCGAATTATATTTTGCACGTTCTTACCTATCGATGTGGAGATTTACGAGACGTTGATGCAACTATACTTTCCTACACTTTAA

Protein

MVNSTKWEIEKNRILKLSLEEKRKIYKSSDFIDLENVDPWSKYLNKSQGIDSKKSTTDDLKEFEKIKINTEKNKSISERVSIFKGDITKLEIDAVVNAANSRLKAGGGVDGAIHRAAGPFLQAECDSIGGCPTGDAKVTGGYNLPAKYIIHTVGPQDGSAEKLESCYEKCLSFQQEYQIKSIAFPCISTGIYGFPNRLAAHIALRTARKFLETNTEMNRIIFCTFLPIDVEIYETLMQLYFPTL

Description

Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins.

Catalytic Activity

2''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+)
4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O = ADP-D-ribose + H(+) + L-aspartyl-[protein]
5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = ADP-D-ribose + H(+) + L-glutamyl-[protein]

Subunit

Interacts with ADP-ribosylated PARP1.

Keywords

Complete proteome   DNA damage   Hydrolase   Isopeptide bond   Nucleus   Reference proteome   Ubl conjugation  

Feature

chain  ADP-ribose glycohydrolase MACROD2

Uniprot

H9IS60   Q1HPZ5   S4P8Y2   A0A0N1IHF9   A0A0N1PHE1   A0A212F743   + More
A0A2H1VS96   A0A2A4K9G0   A0A2W1BLD8   A0A2L2Y8W3   A0A087T7L1   A0A067QYM6   D6X1V2   E2AVU0   A0A226E2B3   R4WJN2   V9IDA7   A0A0J7LAB6   A0A131ZD45   A0A131XPL2   A0A146LEE7   A0A2A3EP00   A0A088AU96   A0A131Z4N3   F4W7Z0   A0A224Z3A3   A0A1E1XBL8   A0A0A9VSM3   A0A195EZC4   A0A1B6CL41   E2BKS9   A0A195D7T8   A0A1B6F8Y7   A0A0A9YWS5   A0A0A9VSM6   A0A1B6FER4   A0A1B6F0H1   A0A3L8DFK8   A0A0A9YV72   A0A026WR31   A0A1Z5L2I7   B7PF53   A0A1B6JZ62   A0A131Y1D1   A0A1S3JK74   A0A195C534   A0A1B6IAR3   A0A1B6MFK4   G3MI23   A0A1B6LMS9   N6TNC6   A0A2D4MGF9   A0A158NDU1   U4UYG7   A0A0V0G4D9   J3JWP8   A0A0P4VLG1   R4G5Y2   A0A1S3JLI6   A0A1Y1MS46   A0A151X471   A0A154PG99   A0A2J7Q4B6   A0A218URH4   A0A2J7Q4D0   A0A2C9K3W2   A0A091J3H5   A0A293LAS1   A0A2Y9QV05   A0A195BQM5   K7ISE1   A0A2R5LCE7   A2AS33   A0A2J7Q4B5   A0A3B4GDL3   A0A3B4GC55   A0A3P9B7V4   A0A3Q2VJ10   A0A3Q2WQA1   A0A1B6JN87   A0A232EN17   G3PXL1   A0A166BW11   A0A2D0RID8   A0A2D0RID7   Q3UYG8   A0A3B4UY62   A0A2Y9HXW7   A0A2Y9IRG6   A0A3P9MJC0   A0A0P6GIQ1   A0A0P5QIS9   A0A3P9I856   A0A2Y9PSM4   A0A162P386   A0A3Q7SNK7   A0A3B4BUI3   A0A3B4XX66  

Pubmed

19121390    23622113    26354079    22118469    28756777    26561354    + More
24845553    18362917    19820115    20798317    23691247    26830274    28049606    26823975    21719571    28797301    28503490    25401762    30249741    24508170    28528879    22216098    23537049    21347285    22516182    27129103    28004739    15562597    20075255    19468303    21183079    25186727    28648823    26659563    16141072    17586838    17554307   

EMBL

BABH01024199    DQ443257    ABF51346.1    GAIX01003979    JAA88581.1    KQ460195    + More
KPJ17208.1    KQ458995    KPJ04411.1    AGBW02009925    OWR49562.1    ODYU01004135    SOQ43689.1    NWSH01000010    PCG80925.1    KZ150182    PZC72493.1    IAAA01011206    IAAA01011207    IAAA01011208    LAA04619.1    KK113815    KFM61100.1    KK852820    KDR15591.1    KQ971371    EFA09957.2    GL443213    EFN62362.1    LNIX01000007    OXA51703.1    AK417780    BAN20995.1    JR039304    AEY58627.1    LBMM01000059    KMR05131.1    GEDV01000141    JAP88416.1    GEFH01000426    JAP68155.1    GDHC01012041    JAQ06588.1    KZ288203    PBC33447.1    GEDV01002619    JAP85938.1    GL887888    EGI69660.1    GFPF01009548    MAA20694.1    GFAC01002589    JAT96599.1    GBHO01044880    JAF98723.1    KQ981906    KYN33224.1    GEDC01023185    GEDC01000019    JAS14113.1    JAS37279.1    GL448826    EFN83678.1    KQ981153    KYN08928.1    GECZ01023158    JAS46611.1    GBHO01007533    JAG36071.1    GBHO01044875    GBHO01007534    GBHO01007527    JAF98728.1    JAG36070.1    JAG36077.1    GECZ01021074    GECZ01009389    JAS48695.1    JAS60380.1    GECZ01026071    JAS43698.1    QOIP01000008    RLU19250.1    GBHO01044888    GBHO01007530    JAF98715.1    JAG36074.1    KK107126    EZA58433.1    GFJQ02005739    JAW01231.1    ABJB010183252    ABJB010520409    DS699372    EEC05225.1    GECU01003225    JAT04482.1    GEFM01003960    JAP71836.1    KQ978251    KYM95977.1    GECU01023698    JAS84008.1    GEBQ01008392    GEBQ01005302    JAT31585.1    JAT34675.1    JO841524    AEO33141.1    GEBQ01015010    JAT24967.1    APGK01058003    APGK01058004    APGK01058005    KB741285    ENN70745.1    IACM01100255    LAB32464.1    ADTU01012982    KB632425    ERL95355.1    GECL01003225    JAP02899.1    BT127666    AEE62628.1    GDKW01003109    JAI53486.1    GAHY01000120    JAA77390.1    GEZM01027147    JAV86816.1    KQ982548    KYQ55235.1    KQ434899    KZC10906.1    NEVH01018385    PNF23426.1    MUZQ01000159    OWK56407.1    PNF23425.1    KL218527    KFP06336.1    GFWV01000128    MAA24858.1    KQ976424    KYM88438.1    GGLE01002901    MBY07027.1    AL731795    AL837516    AL844562    AL844582    AL928700    AL929027    AL929380    AL953906    BX294658    BX296531    PNF23424.1    GECU01007002    JAT00705.1    NNAY01003253    OXU19728.1    KV424619    KZV65532.1    AK134694    AL845530    AL928823    AL929443    GDIQ01032683    JAN62054.1    GDIQ01134590    JAL17136.1    LRGB01000512    KZS18480.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000007151    UP000218220    UP000054359    + More
UP000027135    UP000007266    UP000000311    UP000198287    UP000036403    UP000242457    UP000005203    UP000007755    UP000078541    UP000008237    UP000078492    UP000279307    UP000053097    UP000001555    UP000085678    UP000078542    UP000019118    UP000005205    UP000030742    UP000075809    UP000076502    UP000235965    UP000197619    UP000076420    UP000054308    UP000248480    UP000078540    UP000002358    UP000000589    UP000261460    UP000265160    UP000264840    UP000215335    UP000007635    UP000077086    UP000221080    UP000261420    UP000248481    UP000248482    UP000265180    UP000265200    UP000248483    UP000076858    UP000286640    UP000261440    UP000261360   

PRIDE

H9IS60    Q1HPZ5    A0A088AU96    A2AS33    Q3UYG8   

Pfam

PF01661   Macro

Interpro

IPR002589   Macro_dom       

ProteinModelPortal

H9IS60   Q1HPZ5   S4P8Y2   A0A0N1IHF9   A0A0N1PHE1   A0A212F743   + More
A0A2H1VS96   A0A2A4K9G0   A0A2W1BLD8   A0A2L2Y8W3   A0A087T7L1   A0A067QYM6   D6X1V2   E2AVU0   A0A226E2B3   R4WJN2   V9IDA7   A0A0J7LAB6   A0A131ZD45   A0A131XPL2   A0A146LEE7   A0A2A3EP00   A0A088AU96   A0A131Z4N3   F4W7Z0   A0A224Z3A3   A0A1E1XBL8   A0A0A9VSM3   A0A195EZC4   A0A1B6CL41   E2BKS9   A0A195D7T8   A0A1B6F8Y7   A0A0A9YWS5   A0A0A9VSM6   A0A1B6FER4   A0A1B6F0H1   A0A3L8DFK8   A0A0A9YV72   A0A026WR31   A0A1Z5L2I7   B7PF53   A0A1B6JZ62   A0A131Y1D1   A0A1S3JK74   A0A195C534   A0A1B6IAR3   A0A1B6MFK4   G3MI23   A0A1B6LMS9   N6TNC6   A0A2D4MGF9   A0A158NDU1   U4UYG7   A0A0V0G4D9   J3JWP8   A0A0P4VLG1   R4G5Y2   A0A1S3JLI6   A0A1Y1MS46   A0A151X471   A0A154PG99   A0A2J7Q4B6   A0A218URH4   A0A2J7Q4D0   A0A2C9K3W2   A0A091J3H5   A0A293LAS1   A0A2Y9QV05   A0A195BQM5   K7ISE1   A0A2R5LCE7   A2AS33   A0A2J7Q4B5   A0A3B4GDL3   A0A3B4GC55   A0A3P9B7V4   A0A3Q2VJ10   A0A3Q2WQA1   A0A1B6JN87   A0A232EN17   G3PXL1   A0A166BW11   A0A2D0RID8   A0A2D0RID7   Q3UYG8   A0A3B4UY62   A0A2Y9HXW7   A0A2Y9IRG6   A0A3P9MJC0   A0A0P6GIQ1   A0A0P5QIS9   A0A3P9I856   A0A2Y9PSM4   A0A162P386   A0A3Q7SNK7   A0A3B4BUI3   A0A3B4XX66  

PDB

4IQY     E-value=2.42728e-59,     Score=577

KEGG

732954    K23518 O-acetyl-ADP-ribose deacetylase [EC:3.1.1.106] | (RefSeq) LRP16 protein

GO

GO:0005840   GO:0003968   GO:0019213   GO:0005813   GO:0140291   GO:0006974   GO:0009617   GO:0051725   GO:0140293   GO:0042278   GO:0005730   GO:0016798   GO:0007420   GO:0005634  

Subcellular location

Nucleus   Recruited to DNA lesions, probably via mono-APD-ribosylated proteins.   With evidence from 1 publications.

Length:

244

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.94879

Exp number, first 60 AAs:

0

Total prob of N-in:

0.11855

outside

1  -  244

 

 

Pi

185.036329

Theta

154.80693

Tajima's D

0.415669

CLR

337.28118

CSRT

0.490325483725814

Interpretation

Uncertain