Gene

KWMTBOMO14443

Pre Gene Modal

BGIBMGA000088

Annotation

Seipin_[Papilio_xuthus]

Location

Bomo_Chr24(-):6519959-6535727      View in EpiBrowser

Full name

Seipin      

Location in the cell

Cytoplasmic   Reliability : 1.659

CDS

ATGCCTAATATAACACATCAGCGTACTGTACATTTTCAATTTAAGCCATGTGAAGAAACCATGGGGATATGTTCTTTTCCATATGCCTACGTGCAATTGACAAGAAAGAGCTCCATACTGATGTCAGGCCAGTTGTACCGCATAAGGCTAATTTTGGAAATGCCAGAGTCAAATGTCAACAAGGATCTCGGAATGTTCATGGTGTGCACACAGATGAGAGCAAAGGGTGGAGTTTTAGTGTCTTCATCATGTCGCTCAACTATGTTAAGATACAGGTCGAAACTCCACGAATACATCCGCACAGCGGTCATGGCGCCTCTCCTCATGTCGGACGTGGTGGAAGAGAAGCAGACCATCCAAGTCGATTTGTTCACGGAATTCGATGATGATCCCAATCAACCCGTTACGGACGCGTACGTCGAACTCCAGTCGCGCTACGTGCAAGTGTACGGAGGTCAGCTACACATCGAGGCTCACTTCACCGGCCTCCGTTACCTGATGTACAACTGGCCTAAGTTCTCGGCTCTCTTCGGCATCAGCACTAATCTGTTCTTCATAACGCTCGTGTTCGCGCTGAGCTGGTATCACCTACAGGAAGGGTTGCCAGAGTTTATCAAGAGTAAACTGGGTACGACGCCGGACAAAGATGAAGACAATAAGAAATTAATCGGAAAGATAAAATTAGAAAAAGAAGAGTCGCCTTCCATGTTTGAAGGCGACGTGCTTCTAGAAGAGTTTATGCAGCTCGAAGAGAAAGAGAAGAAGACATCGTAG

Protein

MPNITHQRTVHFQFKPCEETMGICSFPYAYVQLTRKSSILMSGQLYRIRLILEMPESNVNKDLGMFMVCTQMRAKGGVLVSSSCRSTMLRYRSKLHEYIRTAVMAPLLMSDVVEEKQTIQVDLFTEFDDDPNQPVTDAYVELQSRYVQVYGGQLHIEAHFTGLRYLMYNWPKFSALFGISTNLFFITLVFALSWYHLQEGLPEFIKSKLGTTPDKDEDNKKLIGKIKLEKEESPSMFEGDVLLEEFMQLEEKEKKTS

Description

Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; plays a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May participate in phosphatidic acid metabolism and subsequently down-regulate lipogenesis.

Keywords

3D-structure   Complete proteome   Endoplasmic reticulum   Lipid degradation   Lipid metabolism   Membrane   Reference proteome   Signal   Transmembrane   Transmembrane helix  

Feature

chain  Seipin

Uniprot

A0A2W1BH21   A0A0N1IAH1   A0A1E1WPI6   A0A2H1WAY8   A0A1E1WBA5   A0A2A4K9M2   + More
A0A1B6KSS0   A0A1B6HVA4   A0A067R0Z7   A0A1B6GRF3   A0A2P8YC43   A0A088AE92   A0A2A3ET98   A0A2J7R455   A0A1W4XS61   A0A1S3D724   K7JF93   A0A232EG66   A0A023FA80   A0A1Y1LIE7   A0A1Y1LIG9   A0A151IMA1   E2C419   A0A0T6B7S2   A0A1D2NKC8   A0A026W2T2   A0A154P6K5   A0A0P4VPG3   A0A0K8TWF7   A0A1A9X425   A0A0M8ZYE8   A0A0K8WLI6   A0A336MJT5   A0A195FCK4   W8C413   A0A034WAD4   A0A0M4EW59   A0A1A9ZFY6   A0A1B0FBL8   E9IJH8   A0A1A9V2Z0   A0A0A1XFG9   B4JLF3   A0A1I8N2L7   B4M3F5   A0A1I8PSZ1   Q9V3X4   V5I9U7   A0A158NBT0   B4L426   A0A195BG91   A0A151J9A0   E0VDD6   A0A0A9YMV8   A0A146M715   A0A3B0K831   Q29IM5   A0A0A9YH79   A0A3B0K9V8   A0A146MDX3   A0A146LYD4   B4N1K8   A0A1W4VTQ9   B3MYZ6   A0A151X9F0   A0A0A9YMV3   F4X8B5   B4I9X3   B3P937   A0A2R7X289   R4WEE9   A0A0J7L074   A0A224XYT7   A0A1L8DJI7   A0A1L8DJV7   A0A1B6CYY4   J3JWT9   V5GWQ7   A0A226EU41   T1PKQ2   A0A1Q3FG76   B0WB41   A0A1Q3FFK4   A0A0L0C6W5   A0A182XVJ4   A0A084VZX9   A0A2S2QVC6   A0A182K872   E9FSR3   A0A182QB60   A0A182MWD0   A0A182J0P3   A0A182PTM7   A0A182S6R6   A0A1Y9J159   Q7QBJ6   A0A182HJ35   A0A182UKU8  

Pubmed

28756777    26354079    24845553    29403074    20075255    28648823    + More
25474469    28004739    20798317    27289101    24508170    30249741    27129103    24495485    25348373    21282665    25830018    17994087    25315136    10731132    12537572    10731137    12537569    21533227    21347285    20566863    25401762    26823975    15632085    21719571    23691247    22516182    23537049    26108605    25244985    24438588    21292972    12364791    14747013    17210077   

EMBL

KZ150182    PZC72497.1    KQ458995    KPJ04408.1    GDQN01005789    GDQN01002129    + More
GDQN01000295    JAT85265.1    JAT88925.1    JAT90759.1    ODYU01007447    SOQ50228.1    GDQN01006837    JAT84217.1    NWSH01000010    PCG80931.1    GEBQ01025475    JAT14502.1    GECU01029102    JAS78604.1    KK852820    KDR15578.1    GECZ01004758    JAS65011.1    PYGN01000712    PSN41829.1    KZ288192    PBC34369.1    NEVH01007815    PNF35614.1    AAZX01000596    NNAY01004846    OXU17346.1    GBBI01000330    JAC18382.1    GEZM01054748    JAV73424.1    GEZM01054749    JAV73423.1    KQ977059    KYN06018.1    GL452364    EFN77405.1    LJIG01009419    KRT83117.1    LJIJ01000018    ODN05679.1    KK107459    QOIP01000004    EZA50387.1    RLU23713.1    KQ434827    KZC07497.1    GDKW01003552    JAI53043.1    GDHF01033525    JAI18789.1    KQ435794    KOX73640.1    GDHF01010467    GDHF01000405    JAI41847.1    JAI51909.1    UFQS01000668    UFQT01000668    SSX05971.1    SSX26328.1    KQ981673    KYN38370.1    GAMC01002542    JAC04014.1    GAKP01007699    GAKP01007697    GAKP01007695    GAKP01007693    JAC51257.1    CP012528    ALC49635.1    CCAG010010280    GL763802    EFZ19272.1    GBXI01004143    JAD10149.1    CH916370    EDW00406.1    CH940651    EDW65330.1    AE014298    AL121804    AY119182    AAF45798.1    AAM51042.1    CAB65856.1    GALX01002315    JAB66151.1    ADTU01011299    CH933810    EDW07304.1    KQ976500    KYM83180.1    KQ979433    KYN21597.1    DS235073    EEB11392.1    GBHO01011172    GBHO01011171    JAG32432.1    JAG32433.1    GDHC01003081    JAQ15548.1    OUUW01000021    SPP89493.1    CH379063    EAL32628.2    GBHO01011177    GBHO01011170    GBRD01010021    JAG32427.1    JAG32434.1    JAG55803.1    SPP89492.1    GDHC01001000    JAQ17629.1    GDHC01006001    JAQ12628.1    CH963925    EDW78247.1    CH902632    EDV32840.1    KQ982373    KYQ57015.1    GBHO01011176    GBHO01011175    GBRD01010023    JAG32428.1    JAG32429.1    JAG55801.1    GL888932    EGI57185.1    CH480825    EDW44004.1    CH954183    EDV45642.1    KK856503    PTY25917.1    AK418526    BAN21653.1    LBMM01001677    KMQ95904.1    GFTR01003177    JAW13249.1    GFDF01007456    JAV06628.1    GFDF01007460    JAV06624.1    GEDC01018641    JAS18657.1    APGK01053845    BT127707    KB741237    KB629998    KB631549    AEE62669.1    ENN72189.1    ERL83326.1    ERL84371.1    GALX01002314    JAB66152.1    LNIX01000002    OXA60574.1    KA648518    AFP63147.1    GFDL01008488    JAV26557.1    DS231877    EDS42106.1    GFDL01008718    JAV26327.1    JRES01000819    KNC28153.1    ATLV01019037    KE525259    KFB43523.1    GGMS01012482    MBY81685.1    GL732524    EFX89776.1    AXCN02000238    AXCM01001682    AXCP01008404    AAAB01008879    EAA08411.4    APCN01002123   

Proteomes

UP000053268    UP000218220    UP000027135    UP000245037    UP000005203    UP000242457    + More
UP000235965    UP000192223    UP000079169    UP000002358    UP000215335    UP000078542    UP000008237    UP000094527    UP000053097    UP000279307    UP000076502    UP000091820    UP000053105    UP000078541    UP000092553    UP000092445    UP000092444    UP000078200    UP000001070    UP000095301    UP000008792    UP000095300    UP000000803    UP000005205    UP000009192    UP000078540    UP000078492    UP000009046    UP000268350    UP000001819    UP000007798    UP000192221    UP000007801    UP000075809    UP000007755    UP000001292    UP000008711    UP000036403    UP000019118    UP000030742    UP000198287    UP000002320    UP000037069    UP000076408    UP000030765    UP000075881    UP000000305    UP000075886    UP000075883    UP000075880    UP000075885    UP000075901    UP000076407    UP000007062    UP000075840    UP000075902   

PRIDE

Q9V3X4   

Pfam

PF06775   Seipin        + More
PF00650   CRAL_TRIO

Interpro

IPR009617   Seipin        + More
IPR036273   CRAL/TRIO_N_dom_sf       
IPR036865   CRAL-TRIO_dom_sf       
IPR001251   CRAL-TRIO_dom       

SUPFAM

SSF52087   SSF52087        + More
SSF46938   SSF46938       

Gene 3D

3.40.525.10    

CDD

cd00170  SEC14

ProteinModelPortal

A0A2W1BH21   A0A0N1IAH1   A0A1E1WPI6   A0A2H1WAY8   A0A1E1WBA5   A0A2A4K9M2   + More
A0A1B6KSS0   A0A1B6HVA4   A0A067R0Z7   A0A1B6GRF3   A0A2P8YC43   A0A088AE92   A0A2A3ET98   A0A2J7R455   A0A1W4XS61   A0A1S3D724   K7JF93   A0A232EG66   A0A023FA80   A0A1Y1LIE7   A0A1Y1LIG9   A0A151IMA1   E2C419   A0A0T6B7S2   A0A1D2NKC8   A0A026W2T2   A0A154P6K5   A0A0P4VPG3   A0A0K8TWF7   A0A1A9X425   A0A0M8ZYE8   A0A0K8WLI6   A0A336MJT5   A0A195FCK4   W8C413   A0A034WAD4   A0A0M4EW59   A0A1A9ZFY6   A0A1B0FBL8   E9IJH8   A0A1A9V2Z0   A0A0A1XFG9   B4JLF3   A0A1I8N2L7   B4M3F5   A0A1I8PSZ1   Q9V3X4   V5I9U7   A0A158NBT0   B4L426   A0A195BG91   A0A151J9A0   E0VDD6   A0A0A9YMV8   A0A146M715   A0A3B0K831   Q29IM5   A0A0A9YH79   A0A3B0K9V8   A0A146MDX3   A0A146LYD4   B4N1K8   A0A1W4VTQ9   B3MYZ6   A0A151X9F0   A0A0A9YMV3   F4X8B5   B4I9X3   B3P937   A0A2R7X289   R4WEE9   A0A0J7L074   A0A224XYT7   A0A1L8DJI7   A0A1L8DJV7   A0A1B6CYY4   J3JWT9   V5GWQ7   A0A226EU41   T1PKQ2   A0A1Q3FG76   B0WB41   A0A1Q3FFK4   A0A0L0C6W5   A0A182XVJ4   A0A084VZX9   A0A2S2QVC6   A0A182K872   E9FSR3   A0A182QB60   A0A182MWD0   A0A182J0P3   A0A182PTM7   A0A182S6R6   A0A1Y9J159   Q7QBJ6   A0A182HJ35   A0A182UKU8  

PDB

6MLU     E-value=3.25607e-56,     Score=550

KEGG

101739859    K19365 seipin | (RefSeq) seipin

GO

GO:0016021   GO:0019915   GO:0010883   GO:0005789   GO:0046890   GO:0042594   GO:0090207   GO:0006635   GO:0048691   GO:0005783   GO:0046339   GO:0010884   GO:0008610   GO:0046473   GO:0032469   GO:0030176   GO:0034389   GO:0007186   GO:0004888   GO:0007166   GO:0016020   GO:0005507   GO:0004713   GO:0016491   GO:0015930  

PANTHER

PTHR21212  

Subcellular location

Endoplasmic reticulum membrane  

Length:

257

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

22.79686

Exp number, first 60 AAs:

0.01088

Total prob of N-in:

0.95649

inside

1  -  172

TMhelix

173  -  195

outside

196  -  257

 

 

Pi

214.511374

Theta

159.868496

Tajima's D

1.503737

CLR

0.173677

CSRT

0.790710464476776

Interpretation

Uncertain