Gene

KWMTBOMO14440  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000129

Annotation

actin-depolymerizing_factor_1_[Bombyx_mori]

Location

Bomo_Chr24(+):6450638-6490222      View in EpiBrowser

Full name

Cofilin/actin-depolymerizing factor homolog      

Alternative Name

Protein D61
Protein twinstar

Location in the cell

Cytoplasmic   Reliability : 1.561 Nuclear   Reliability : 2.065

CDS

ATGGCGTCTGGTGTGACAGTTTCGGACGCTTGCAAGACCACTTACGAAGAGATCAAGAAGGACAAGAAGCATCGTTACGTTGTCTTCTACATCCGTGACGAGAAACAGATCGACGTCGAGACGGTTGGCGAACGCAACGCCGAATACGAACAGTTCCTCGAGGATCTGCAGAAGGGCGGTACCGGGGAATGCAGATATGGCCTGTTTGACTTTGAATACACGCACCAGTGCCAGGGCACGTCGGAGGCTAGCAAGAAACAGAAGCTCTTCCTGATGTCGTGGTGCCCGGACACCGCCAAGGTTAAGAAGAAGATGTTGTACTCTAGCTCGTTCGACGCTCTGAAAAAGTCCCTTGTCGGAGTTCAGAAGTACATCCAAGCGACCGACCTCTCGGAAGCGTCTCAGGAGGCCGTCGAAGAGAAGCTCCGCGCCACCGATCGCCAATAA

Protein

MASGVTVSDACKTTYEEIKKDKKHRYVVFYIRDEKQIDVETVGERNAEYEQFLEDLQKGGTGECRYGLFDFEYTHQCQGTSEASKKQKLFLMSWCPDTAKVKKKMLYSSSFDALKKSLVGVQKYIQATDLSEASQEAVEEKLRATDRQ

Description

Exhibits F-actin depolymerizing activity and regulates actin cytoskeleton dynamics (PubMed:21205790). Required for cytokinesis in both mitotic and meiotic cells and for aster migration and separation (PubMed:8522587). Promotes cell motility during ovary development and oogenesis (PubMed:11175754). During larval development, required for the cell rearrangement needed for formation of terminal filaments which are stacks of somatic cells that are important for the initiation of ovarioles (PubMed:11175754). Also required for border cell migration during oogenesis (PubMed:11175754). During border cell migration, required for actin turnover and lamellipodial protrusion (PubMed:21205790). Required for the establishment of planar cell polarity (PCP) where cells adopt a uniform orientation within the plane of an epithelium (PubMed:16571634). During establishment of PCP, required for the redistribution of the PCP core proteins fz and stan/fmi to the proximodistal cell boundary (PubMed:16571634). During pupal development, required for elongation of the retinal cell body and for rhabdomere morphogenesis (PubMed:18423434). Required for mushroom body neuroblast proliferation and axon growth (PubMed:15572110). Plays a role in the positive regulation of protein secretion (PubMed:20026655). Plays a role in the regulation of nuclear localization of actin (PubMed:22323606). Required for the maintenance of epithelial integrity by controlling cell junctions and is also necessary for cell survival and tissue growth through regulation of JNK and yki signaling (PubMed:27041568).

Miscellaneous

The name 'twinstar' derives from the characteristic aberrant arrangement of asters seen in mutants.

Similarity

Belongs to the actin-binding proteins ADF family.

Keywords

3D-structure   Actin-binding   Cell cycle   Cell division   Complete proteome   Cytoplasm   Cytoskeleton   Nucleus   Phosphoprotein   Reference proteome  

Feature

chain  Cofilin/actin-depolymerizing factor homolog

Uniprot

Q1HPP5   A0A2W1BIB1   A0A0K8S4B2   I7F433   S4PHI6   E3UKQ9   + More
A0A212EKM5   A0A1E1W4F5   A0A2H1WEN9   A0A2A4K9H1   I4DMQ9   I4DIR4   K9J9U2   A0A0S1MMI8   A0A0P4VTG3   A0A0V0G4A8   A0A023F9W1   R4FQ09   R4V0V1   A0A069DPJ1   A0A0N0PDL5   R4WMX4   A0A0A9W4J4   A0A1B6DDG3   A0A0K8U3S3   A0A034WTM6   A0A0C9RPX9   A0A1A9WF25   A0A1J1J6S8   A0A1I8QDR5   A0A0L0CKX4   T1PHG4   Q1HQF5   A0A023EF56   D3TQ27   A0A1A9YGA0   A0A1B0B9X3   A0A1A9ZV27   B4MIX8   A0A0K8TNW6   W8BPV4   A0A1L8E5M1   A0A3F2YW04   T1D587   A0A1Q3FCD4   A0A182QEW3   A0A182VDX9   B0WGU5   A0A182WCZ5   A0A182KTD5   A0NGL9   A0A182RST5   E0VFR1   A0A1A9V6H1   B4LPE2   B4KLU9   T1EB21   A0A2M3ZGH2   A0A2M4A730   A0A2M4C248   A0A1W4V179   A0A1B2AKQ4   B3MDY0   B4I2B7   B3NQ62   B4QBH5   Q6XIL8   P45594   A0A182ISN7   A0A2M4CSV8   A0A1B0CCZ1   A0A182M3H3   A0A182YCC4   A0A3B0JIH2   Q28ZZ9   A0A182X7S3   A0A182HHY7   A0A084WJ14   A0A023EFB7   A0A182TT42   A0A1I9WLJ7   A0A182PRK7   A0A182FU99   W5JTT1   U5EWP1   B4GCI6   A0A2R7WD70   A0A195C6B3   A0A0T6B0N4   T1GYN3   D6WFR9   B4J6F4   J3JUZ3   N6UEP0   V5G4D3   A0A1D1YZQ3   G9HZ49   A0A1B6MRT6   A0A1B6F2Z6   A0A1D2MKI4  

Pubmed

28756777    23622113    22118469    22651552    27129103    25474469    + More
26334808    26354079    23691247    25401762    26823975    25348373    26108605    25315136    17204158    17510324    24945155    26483478    20353571    17994087    26369729    24495485    24330624    20966253    12364791    14747013    17210077    20566863    22936249    14525923    17550304    8183953    8522587    10731132    12537572    11027607    11175754    11832213    15572110    16571634    18423434    20026655    21205790    22912811    22323606    27041568    25244985    15632085    24438588    27538518    20920257    23761445    18362917    19820115    22516182    23537049    27289101   

EMBL

DQ443123    DQ443357    ABF51212.1    ABF51446.1    KZ150182    PZC72500.1    + More
GBRD01017690    JAG48137.1    JX087452    AFP36378.1    GAIX01003262    JAA89298.1    HM449933    ADO33068.1    AGBW02014229    OWR42049.1    GDQN01009222    JAT81832.1    ODYU01008109    SOQ51426.1    NWSH01000010    PCG80935.1    AK402577    BAM19199.1    AK401182    BAM17804.1    FJ905301    ADA79536.1    KR821073    ALL42060.1    GDKW01000698    JAI55897.1    GECL01003616    JAP02508.1    GBBI01000527    JAC18185.1    GAHY01000013    JAA77497.1    KC632448    AGM32262.1    GBGD01003352    JAC85537.1    KQ460195    KPJ17214.1    AK416976    BAN20191.1    GBHO01042201    GBRD01001412    GDHC01021085    JAG01403.1    JAG64409.1    JAP97543.1    GEDC01013570    JAS23728.1    GDHF01030945    JAI21369.1    GAKP01000953    JAC57999.1    GBYB01010555    JAG80322.1    CVRI01000074    CRL08088.1    JRES01000340    KNC32124.1    KA647333    AFP61962.1    DQ440489    CH477287    ABF18522.1    EAT44686.1    EAT44687.1    EAT44688.1    JXUM01051870    GAPW01005600    KQ561708    JAC07998.1    KXJ77756.1    EZ423529    ADD19805.1    JXJN01010634    CH963719    EDW72067.2    GDAI01001521    JAI16082.1    GAMC01005558    GAMC01005557    JAC00998.1    GFDF01000118    JAV13966.1    GALA01000643    JAA94209.1    GFDL01009809    JAV25236.1    AXCN02001104    DS231930    EDS27239.1    AAAB01008986    EAL38771.2    DS235123    EEB12217.1    CH940648    EDW61201.1    CH933808    EDW09759.2    GAMD01000458    JAB01133.1    GGFM01006895    MBW27646.1    GGFK01003268    MBW36589.1    GGFJ01010269    MBW59410.1    KX531942    ANY27752.1    CH902619    EDV37525.1    CH480820    EDW53912.1    CH954179    EDV56935.1    CM000362    CM002911    EDX08493.1    KMY96231.1    AY231812    CM000158    AAR09835.1    EDW92465.1    U08217    U24490    U24676    AE013599    BT089017    GGFL01004258    MBW68436.1    AJWK01007243    AJWK01007244    AJWK01007245    AJWK01007246    AJWK01007247    AJWK01007248    AXCM01009620    OUUW01000001    SPP73219.1    CM000071    EAL25463.3    APCN01002450    ATLV01023960    KE525347    KFB50208.1    GAPW01005601    JAC07997.1    KU932381    APA34017.1    ADMH02000467    ETN66360.1    GANO01001325    JAB58546.1    CH479181    EDW32463.1    KK854632    PTY17479.1    KQ978219    KYM96404.1    LJIG01016342    KRT80889.1    CAQQ02103186    CAQQ02103187    CAQQ02103188    CAQQ02103189    CAQQ02103190    KQ971319    EEZ99587.1    CH916367    EDW01955.1    BT127058    KB632338    AEE62020.1    ERL92911.1    APGK01038393    KB740954    ENN77107.1    GALX01003571    JAB64895.1    GDJX01007801    JAT60135.1    JN416117    AEW44191.1    GEBQ01001349    JAT38628.1    GECZ01025516    JAS44253.1    LJIJ01000960    ODM93539.1   

Proteomes

UP000007151    UP000218220    UP000053240    UP000091820    UP000183832    UP000095300    + More
UP000037069    UP000095301    UP000008820    UP000069940    UP000249989    UP000092443    UP000092460    UP000092445    UP000007798    UP000075884    UP000075886    UP000075903    UP000002320    UP000075920    UP000075882    UP000007062    UP000075900    UP000009046    UP000078200    UP000008792    UP000009192    UP000192221    UP000007801    UP000001292    UP000008711    UP000000304    UP000002282    UP000000803    UP000075880    UP000092461    UP000075883    UP000076408    UP000268350    UP000001819    UP000076407    UP000075840    UP000030765    UP000075902    UP000075885    UP000069272    UP000000673    UP000008744    UP000078542    UP000015102    UP000007266    UP000001070    UP000030742    UP000019118    UP000094527   

PRIDE

Q1HPP5    P45594   

Pfam

PF00241   Cofilin_ADF

Interpro

IPR029006   ADF-H/Gelsolin-like_dom_sf        + More
IPR017904   ADF/Cofilin       
IPR002108   ADF-H       

Gene 3D

3.40.20.10    

CDD

cd11286  ADF_cofilin_like

ProteinModelPortal

Q1HPP5   A0A2W1BIB1   A0A0K8S4B2   I7F433   S4PHI6   E3UKQ9   + More
A0A212EKM5   A0A1E1W4F5   A0A2H1WEN9   A0A2A4K9H1   I4DMQ9   I4DIR4   K9J9U2   A0A0S1MMI8   A0A0P4VTG3   A0A0V0G4A8   A0A023F9W1   R4FQ09   R4V0V1   A0A069DPJ1   A0A0N0PDL5   R4WMX4   A0A0A9W4J4   A0A1B6DDG3   A0A0K8U3S3   A0A034WTM6   A0A0C9RPX9   A0A1A9WF25   A0A1J1J6S8   A0A1I8QDR5   A0A0L0CKX4   T1PHG4   Q1HQF5   A0A023EF56   D3TQ27   A0A1A9YGA0   A0A1B0B9X3   A0A1A9ZV27   B4MIX8   A0A0K8TNW6   W8BPV4   A0A1L8E5M1   A0A3F2YW04   T1D587   A0A1Q3FCD4   A0A182QEW3   A0A182VDX9   B0WGU5   A0A182WCZ5   A0A182KTD5   A0NGL9   A0A182RST5   E0VFR1   A0A1A9V6H1   B4LPE2   B4KLU9   T1EB21   A0A2M3ZGH2   A0A2M4A730   A0A2M4C248   A0A1W4V179   A0A1B2AKQ4   B3MDY0   B4I2B7   B3NQ62   B4QBH5   Q6XIL8   P45594   A0A182ISN7   A0A2M4CSV8   A0A1B0CCZ1   A0A182M3H3   A0A182YCC4   A0A3B0JIH2   Q28ZZ9   A0A182X7S3   A0A182HHY7   A0A084WJ14   A0A023EFB7   A0A182TT42   A0A1I9WLJ7   A0A182PRK7   A0A182FU99   W5JTT1   U5EWP1   B4GCI6   A0A2R7WD70   A0A195C6B3   A0A0T6B0N4   T1GYN3   D6WFR9   B4J6F4   J3JUZ3   N6UEP0   V5G4D3   A0A1D1YZQ3   G9HZ49   A0A1B6MRT6   A0A1B6F2Z6   A0A1D2MKI4  

PDB

2MV2     E-value=9.52521e-65,     Score=620

KEGG

100101180    K05765 cofilin | (RefSeq) actin-depolymerizing factor 1

GO

GO:0030042   GO:0015629   GO:0003779   GO:0030032   GO:0008585   GO:0010669   GO:0007298   GO:0051299   GO:0050714   GO:0016319   GO:0010591   GO:0030041   GO:0000281   GO:0042067   GO:0042052   GO:0033206   GO:0036011   GO:0007409   GO:0001737   GO:0005654   GO:0001736   GO:0000915   GO:0001745   GO:0016363   GO:0048749   GO:0005829   GO:0007015   GO:0000902   GO:0016021   GO:0005622   GO:0006816   GO:0005507   GO:0004713   GO:0016491   GO:0015930  

PANTHER

PTHR11913  

Subcellular location

Cytoplasm  
Cytoskeleton  
Nucleus matrix  

Length:

148

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.18336

outside

1  -  148

 

 

Pi

222.067423

Theta

173.563298

Tajima's D

0.689771

CLR

1.389317

CSRT

0.565621718914054

Interpretation

Uncertain