Gene

KWMTBOMO14434

Pre Gene Modal

BGIBMGA000093

Annotation

sex_peptide_receptor_[Bombyx_mori]

Location

Bomo_Chr24(-):5993161-6037863      View in EpiBrowser

Full name

Sex peptide receptor      

Location in the cell

PlasmaMembrane   Reliability : 4.89

CDS

ATGGCGGTCACCATAGACAATTCAACGAACGACTTCGAATTCCAGAAGCCATTCAACTACTCAATTAACGAGAACATCACCTACTTCGATTACACGAACTTCACTTCGGACGATTTCTGCGCATCAAACAACTCACACGTATACTTAAACGTCACCTGTGAGTTCGCTATAAGCTATGCTGAGCCTATGTACGGGTACATCGCACCGTTTCTGCTAGCTACAACGACAGTTGCCAACACCCTGATCGTGGTGGTGCTATCGCGGAGGCACATGAGGACGCCCACCAATGCCGTGCTGATGGCGATGGCTCTTTGCGATATGTTCACCATGCTGTTCCCGGCGCCGTGGCTATTCTACATGTACACTTTTGGAAACCACTACAAGCCGCTAAGTCCCGTCAGAGCCTGCCAAGCTTGGAATTACATGAACGAGGTCATTCCAGCGATGTTCCACACGGCTAGTATCTGGTTGACGTTAGCCTTAGCCGTCCAGAGATATATCTACGTTTGCCACGCGCCCGTCGCCAGGACCTGGTGTACCATGCCCCGGGTGATGAAATGTCTGATCTACATAGGAATAGCGGCGTTTCTTCATCAGCTACCGCGGTTCTTCGACAGATGCTACACTCCCCACAAGACTGTGTGGCGGGGGCGCGTGGAGGAAGTCTGCAGAATCGAGATGGCGTCTTGGGTGAAAGCGCTCTCCGTCGACGCCTATTTCATCTCCTACTTCGGCTTCAGAGTTTTGTTCGTCCACTTAATCCCGTGCACATCTTTAGTTGTCCTGAACGTGCTCCTCTTCAGGGCCATGAGGACGGCCCAAATAAACAGACAGAAGCTGTTCAAAGAAAACCGAAAATCGGAGTGCAAGAGACTCAGAGATTCTAACTGCACCACCCTGATGTTGATAGTCGTGGTCACGGTTTTCCTCCTCGTGGAAATACCCGTGGCCGTCGTCACTATCCTCCACATAATATCCAGCACGATTGTCGAGATCTTGGACTACCATATCGCGAATATTCTCGTTCTGGTAACGAATTTCTTCATTATCGTTTCCTATCCAATCAACTTTGCTATATATTGCGGTATGTCGCGTCAATTCAGGGAGACCTTCAAAGAATTGTTTATCAGAGGCACGGTTACTAGTAGGAAGAACGGTGGCTCCAGTAGGTACTCTCTTGTCAATGGCCCGAGGACCTGTACAAACGAAACTGTGCTTTAA

Protein

MAVTIDNSTNDFEFQKPFNYSINENITYFDYTNFTSDDFCASNNSHVYLNVTCEFAISYAEPMYGYIAPFLLATTTVANTLIVVVLSRRHMRTPTNAVLMAMALCDMFTMLFPAPWLFYMYTFGNHYKPLSPVRACQAWNYMNEVIPAMFHTASIWLTLALAVQRYIYVCHAPVARTWCTMPRVMKCLIYIGIAAFLHQLPRFFDRCYTPHKTVWRGRVEEVCRIEMASWVKALSVDAYFISYFGFRVLFVHLIPCTSLVVLNVLLFRAMRTAQINRQKLFKENRKSECKRLRDSNCTTLMLIVVVTVFLLVEIPVAVVTILHIISSTIVEILDYHIANILVLVTNFFIIVSYPINFAIYCGMSRQFRETFKELFIRGTVTSRKNGGSSRYSLVNGPRTCTNETVL

Description

Receptor for two functionally unrelated ligands; SP (A70A) for controlling reproductive behaviors and MIP for controlling sleep behavior (PubMed:18066048, PubMed:20458515, PubMed:20308537, PubMed:24089336, PubMed:25333796). MIP-SPR pathway functions as a sleep homeostat which perceives the need for sleep and stabilizes it by providing a slow-acting inhibitory input to the fly arousal system that involve the pigment dispersing factor (pdf) neurons (PubMed:25333796). SP-SPR is one of the multiple SP pathways that induce female post-mating behavioral responses (PMR) such as the suppression of mating receptivity and initiation of egg laying (PubMed:18066048, PubMed:24089336). The PMR switch is achieved by mediating the synaptic output of neurons such as those expressing fruitless (fru), double sex (dsx) and pickpocket (ppk) (PubMed:18066048, PubMed:24089336).

Similarity

Belongs to the G-protein coupled receptor 1 family.

Keywords

Cell membrane   Complete proteome   G-protein coupled receptor   Membrane   Receptor   Reference proteome   Transducer   Transmembrane   Transmembrane helix  

Feature

chain  Sex peptide receptor

Uniprot

B0F4F1   M1KBS6   A0A0S1YDF7   I0AW25   E0A919   A0A0N1I6P7   + More
A0A194QE30   A0A212FD50   A0A1S3CY93   A0A1B6JXI3   A0A1B6LE68   G0ZGH2   A0A2J7RB67   A0A067RJM6   A0A023F5Z2   A0A2S2QQC0   A0A2P8ZJS8   U3U7M1   A0A2H8TQQ4   J9JSJ4   T1H9A3   G0ZGH1   A0A1Y1LIF7   E0VDC2   B0F4F2   A0A1B6DZV1   A0A1L8DK97   B0F4E9   Q29I83   A0A3B0J9B4   A0A182RD27   B4PZP9   A0A182FB29   B3MR14   B4NCZ3   B4JN65   B4M2J2   B4I0P1   B3NV47   B4R4Y8   Q8SWR3   B4L4M1   A0A1W4WUI1   A0A182JY91   A0A1W4VSA3   B0F4F0   A0A0M4EMH0   A0A1Y9IVJ8   A0A1L8DK23   A0A0L0C1L1   A0A1I8PMA8   A0A1B0ADX5   A0A1A9VLH6   A0A226EVS0   A0A1B0ANI1   A0A1I8MLC0   A0A1D2NN16   A0A034VH36   A0A0K8U8G9   A0A0T6BDH4   A0A1A9WL69   A0A087SZ34   W8C929   A0A0A1WWG3   A0A2L2YMB8   A0A0P4Z222   A0A0P5JPP2   A0A0P5TP65   A0A162CMJ5   W5JIG6   E9GCL6   A0A131Z615   A0A224YT96   L7MG47   L7MG28   A0A131XKL4   A0A1E1XKG9   A0A1E1X6I3   L7ZCA0   A0A0K8RRP0   L7ZA74   A0A0P6I0U9   A0A3R7M1D8   A0A2P6L8W4   A0A0P6E469   A0A1Z5L7P5   A0A293MAE0   B7PXI7   A0A293LM40   A0A1B0GIR2   A0A0P6CQU4   L7MGG5   A0A1J1HJE3   A0A182GS94   A0A0P5TKZ5   A0A182LTG4  

Pubmed

18066048    21426940    26354079    22118469    24845553    25474469    + More
29403074    23932938    25218475    25401762    28004739    20566863    18362917    19820115    15632085    17994087    23185243    17550304    18057021    10731132    12537572    12537569    20458515    20308537    24089336    25333796    12364791    26108605    25315136    27289101    25348373    24495485    25830018    26561354    20920257    23761445    21292972    26830274    28797301    25576852    28049606    29209593    28503490    23357681    28528879    26483478   

EMBL

EU106876    ABW86946.1    JX070670    AGE92037.1    KT031042    ALM88340.1    + More
JQ689079    AFH53182.1    HM567403    ADK79103.2    KQ461174    KPJ08003.1    KQ459144    KPJ03732.1    AGBW02009107    OWR51664.1    MG550199    AWT50633.1    GECU01007835    GECU01003817    JAS99871.1    JAT03890.1    GEBQ01017992    JAT21985.1    JF273643    AEK80440.1    NEVH01006563    PNF38070.1    KK852431    KDR24017.1    GBBI01002107    JAC16605.1    GGMS01010527    MBY79730.1    PYGN01000035    PSN56754.1    AB817293    BAO01060.1    GFXV01004722    MBW16527.1    ABLF02040252    ABLF02040268    ABLF02040269    ABLF02040270    ACPB03007534    KF958188    AIQ81191.1    JF273642    GBHO01025389    AEK80439.1    JAG18215.1    GEZM01054743    GEZM01054742    JAV73429.1    DS235073    EEB11378.1    EU106877    EU443244    KQ971321    ABW86947.1    ACC68841.1    EFA01285.2    GEDC01024257    GEDC01016961    GEDC01006108    JAS13041.1    JAS20337.1    JAS31190.1    GFDF01007287    JAV06797.1    EU106874    ABW86944.1    EU106873    CH379063    ABW86943.1    EAL32770.3    KRT06310.1    KRT06311.1    OUUW01000003    SPP78854.1    CM000162    EDX01116.1    KRK05960.1    KRK05961.1    KRK05962.1    KRK05963.1    CH902622    EDV34219.1    KPU75025.1    CH964239    EDW82702.2    CH916371    EDV92158.1    CH940651    EDW65896.1    CH480819    EDW53072.1    CH954180    EDV45895.1    CM000366    EDX17137.1    EU443243    AE014298    AY095526    AAM12257.1    ACC68840.1    CH933810    EDW07499.2    AAAB01008986    EU106875    ABW86945.1    CP012528    ALC48934.1    GFDF01007298    JAV06786.1    JRES01000997    KNC26253.1    LNIX01000002    OXA60696.1    JXJN01000834    LJIJ01000001    ODN06668.1    GAKP01016336    JAC42616.1    GDHF01029360    GDHF01017219    JAI22954.1    JAI35095.1    LJIG01001646    KRT85294.1    KK112619    KFM58123.1    GAMC01002519    JAC04037.1    GBXI01011462    GBXI01005475    JAD02830.1    JAD08817.1    IAAA01036746    IAAA01036747    LAA09243.1    GDIP01231237    JAI92164.1    GDIQ01201716    GDIP01114495    JAK50009.1    JAL89219.1    GDIP01126836    JAL76878.1    LRGB01000944    KZS14576.1    ADMH02001383    ETN62690.1    GL732539    EFX82580.1    GEDV01002332    JAP86225.1    GFPF01007823    MAA18969.1    GACK01002796    JAA62238.1    GACK01002247    JAA62787.1    GEFH01002375    JAP66206.1    GFAA01003614    JAT99820.1    GFAC01004309    JAT94879.1    KC422390    AGE11604.1    GADI01000514    JAA73294.1    KC422391    AGE11605.1    GDIQ01011073    JAN83664.1    QCYY01002449    ROT70219.1    MWRG01000907    PRD35009.1    GDIQ01069216    JAN25521.1    GFJQ02003523    JAW03447.1    GFWV01017979    MAA42707.1    ABJB010212851    ABJB010934302    DS814451    EEC11309.1    GFWV01004181    MAA28911.1    AJWK01015325    AJWK01015326    AJWK01015327    AJWK01015328    AJWK01015329    AJWK01015330    AJWK01015331    GDIP01010477    JAM93238.1    GACK01002671    JAA62363.1    CVRI01000006    CRK88141.1    JXUM01016857    JXUM01016858    JXUM01016859    JXUM01016860    JXUM01016861    KQ560467    KXJ82271.1    GDIP01128326    JAL75388.1    AXCM01012874   

Proteomes

UP000053240    UP000053268    UP000007151    UP000079169    UP000235965    UP000027135    + More
UP000245037    UP000007819    UP000015103    UP000009046    UP000007266    UP000001819    UP000268350    UP000075900    UP000002282    UP000069272    UP000007801    UP000007798    UP000001070    UP000008792    UP000001292    UP000008711    UP000000304    UP000000803    UP000009192    UP000192223    UP000075881    UP000192221    UP000092553    UP000075920    UP000037069    UP000095300    UP000092445    UP000078200    UP000198287    UP000092460    UP000095301    UP000094527    UP000091820    UP000054359    UP000076858    UP000000673    UP000000305    UP000283509    UP000001555    UP000092461    UP000183832    UP000069940    UP000249989    UP000075883   

PRIDE

B0F4F1    Q8SWR3   

Pfam

PF10324   7TM_GPCR_Srw        + More
PF00001   7tm_1

Interpro

IPR000276   GPCR_Rhodpsn        + More
IPR017452   GPCR_Rhodpsn_7TM       
IPR019427   7TM_GPCR_serpentine_rcpt_Srw       

ProteinModelPortal

B0F4F1   M1KBS6   A0A0S1YDF7   I0AW25   E0A919   A0A0N1I6P7   + More
A0A194QE30   A0A212FD50   A0A1S3CY93   A0A1B6JXI3   A0A1B6LE68   G0ZGH2   A0A2J7RB67   A0A067RJM6   A0A023F5Z2   A0A2S2QQC0   A0A2P8ZJS8   U3U7M1   A0A2H8TQQ4   J9JSJ4   T1H9A3   G0ZGH1   A0A1Y1LIF7   E0VDC2   B0F4F2   A0A1B6DZV1   A0A1L8DK97   B0F4E9   Q29I83   A0A3B0J9B4   A0A182RD27   B4PZP9   A0A182FB29   B3MR14   B4NCZ3   B4JN65   B4M2J2   B4I0P1   B3NV47   B4R4Y8   Q8SWR3   B4L4M1   A0A1W4WUI1   A0A182JY91   A0A1W4VSA3   B0F4F0   A0A0M4EMH0   A0A1Y9IVJ8   A0A1L8DK23   A0A0L0C1L1   A0A1I8PMA8   A0A1B0ADX5   A0A1A9VLH6   A0A226EVS0   A0A1B0ANI1   A0A1I8MLC0   A0A1D2NN16   A0A034VH36   A0A0K8U8G9   A0A0T6BDH4   A0A1A9WL69   A0A087SZ34   W8C929   A0A0A1WWG3   A0A2L2YMB8   A0A0P4Z222   A0A0P5JPP2   A0A0P5TP65   A0A162CMJ5   W5JIG6   E9GCL6   A0A131Z615   A0A224YT96   L7MG47   L7MG28   A0A131XKL4   A0A1E1XKG9   A0A1E1X6I3   L7ZCA0   A0A0K8RRP0   L7ZA74   A0A0P6I0U9   A0A3R7M1D8   A0A2P6L8W4   A0A0P6E469   A0A1Z5L7P5   A0A293MAE0   B7PXI7   A0A293LM40   A0A1B0GIR2   A0A0P6CQU4   L7MGG5   A0A1J1HJE3   A0A182GS94   A0A0P5TKZ5   A0A182LTG4  

PDB

6ME8     E-value=4.93206e-07,     Score=129

KEGG

100141439    no KO assigned | (RefSeq) Spr; sex peptide receptor

GO

GO:0016021   GO:0008528   GO:0007218   GO:0005886   GO:0048042   GO:0045434   GO:0007186   GO:0050254   GO:0004930   GO:0006816   GO:0005507   GO:0004713   GO:0016491   GO:0015930  

Subcellular location

Cell membrane  

Length:

406

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

154.40645

Exp number, first 60 AAs:

0.09633

Total prob of N-in:

0.00756

outside

1  -  63

TMhelix

64  -  86

inside

87  -  97

TMhelix

98  -  120

outside

121  -  144

TMhelix

145  -  167

inside

168  -  186

TMhelix

187  -  204

outside

205  -  244

TMhelix

245  -  267

inside

268  -  299

TMhelix

300  -  322

outside

323  -  336

TMhelix

337  -  359

inside

360  -  406

 

 

Pi

260.069708

Theta

180.621133

Tajima's D

1.620935

CLR

0.256601

CSRT

0.817159142042898

Interpretation

Uncertain