Gene

KWMTBOMO14431  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000097

Annotation

PREDICTED:_calpain-A_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr24(-):5879294-5928813      View in EpiBrowser

Full name

Calpain-A      

Alternative Name

Calcium-activated neutral proteinase A

Location in the cell

Cytoplasmic   Reliability : 3.986

CDS

ATGGCAGGCCAAAATGGCGGTGGGAATTTTGGCGCCCTTATACAGGGCGCGGGAAAACAGTTGCTTAATCAAGGAGGCCAGGCTCTACTGAATTATGGTGCTCAAGCCCTCGGGAACATCATTAATGAGGTGTTCCAGAAGAAAGAGGTTGAACAGAAAAGGTTTCTGCCCAGTATCAAGAATTATAAAGTGCTAGGCGAAACCCGCCCGTCATCATTCGGTCCGGCTACGTATCAGGACTTCAAAGACATAAGATCGCGGTGCCTAGCTGAAGGTAGACTCTTCGAAGACCCCGAGTTTCCGGCCGTGGACCGCAGCCTCTACTACAAGGAGAGCCTGGACAGGCCCATCACTTGGCTCAGACCTGGGGAAATCAGCGACAACCCTCAACTTTTCGTCGAAGGCTACAGTCGCTTCGACGTCCAACAAGGAGAGTTGGGCGATTGTTGGCTGTTGGCTGCCGTTGCCAACTTGACACTTCATCGCAAGTTATTCTTCCAAGTTGTACCTGATGATCAGAGTTTCGATGAAGATTATGCGGGCGTCTTCCATTTCCGTTTCTGGCAGTACGGGCGCTGGGTGGACGTGGTCATCGACGACCGTCTCCCAACGTACCGAGGGAAACTGGTGTTCCTCCACTCGGCCGAGGCGAACGAGTTCTGGAGTGCTCTACTCGAGAAGGCATATGCGAAACTCCACGGATCGTACGAAGCCCTCAAGGGAGGCTCGACCTGCGAGGCCATGGAGGACTTCACCGGCGGCGTCACCGAAATGTACGAGATGTCCGAACTGCCGCCAAACTTCTACACGATCCTGCTGAAGGCGTACGAGAGGAACTCTCTTATGGGCTGCAGTATTGAGCCCGACCCCCACATCCTCGAGGCGGAGACTCCGGCGGGGCTCATCCGGGGGCACGCGTACTCCGTGACCCGGGTCAAGTACGTGGACATCGAGACGCCGGGCCGCGCCGGCAAGATCCCGCTGCTCCGCCTGCGCAACCCCTGGGGGAACGAGGCCGAGTGGAACGGACCTTGGAGCGACAAGTCTCCAGAGTGGCGCTACATCCCGGAGTCGGAGAAGGAGGAGCTCGGCCTGACGTTCGACGACGACGGCGAGTTCTGGATGTCGTTCAAGGACTTCGTCAACCACTTCTCGCGAGTGGAGATATGCAACTTGAACCCCGACTCTCTGGACCCCGAGGAGTGTCCCGAGGGCTGCACCAAGAAGTGGGAGATGTCGGTCTTCGAAGGCGAATGGGTTAGAGGCGTGACGGCCGGCGGCTGCAGGAACTTCCTGGAGACGTTCTGGCGGAACCCTCAGTACACCGTCACGTTGAGCGACCCCGACGAAGGAGACGACGAGAACAAATGTACCATAATCGTGGCGCTGATGCAGAAGAACCGTCGCTCGCAGCGCCACCAGGGCCTGGAGTGCCTCACCATCGGGTTCGCGGTGTACCGCCTCCCGGACTACGGGCACGTGCCCAAGCCGCTCGACGTCAACTTCTTCAAGTACAACGCGTCCGTCGGCAGGTCGCAGGCCTTCATCAACTTGAGGGAGGTCAGCGCCAGATTCAAGTTCGAGCCCGGCTCGTACGTGATAGTGCCCTCGACCTTCGACCCTGACGAGGAGGGAGAGTTCTTACTAAGAGTCTTCTCCGAAAAGGACAACAATATGGCTGAGAATGACGAGGACATCGGTATGGGCGATGTTGACGACAGAGTGAAGGAGCTGGCGCCGGACCCGGAGCCGGCCGACCCGGTCCGTGAGTTCTTCACGCGGCTCGCCGGCTCCGACGGGGAGGTCGACTGGCAGGAACTCAAGGAGATCTTGGACTACGCCATGAGGGAAGAACTTGCGATGCGGCACGGCGCATACGACGGGGGCGGCGGGGTCGCGGGCGGGGGGCCCTCCCCCCGGACCCCGCTCGGCCCCCCCGGCGGCCCCCCTCAGGAACAGAGCTGCCTCGAGCAAATCCTGTGCGCTCTCTGCACCCCTATATGCAAGGAGCTCGGCGTGGACCTGCAGCAAGCTCAGAACCAACCGGAGCAGGTGCATTTGAACCAGCCGCAGCCCTACGCCAACGCTCAAGAGTTGCAAGGTCAGGGTTTCTCCAAGGACGTCTGCCGTAGCATGATCGCGATGCTTGACAAGGACGGCTCCGGAGGACTTGGCTTCGAAGAGTTCAAGTCCCTGTGGATCGATCTGCGCAACTGGAGGGCCGTGTTCCGCCTGTACGACGTGGAGCGGCGGGGGGCCGTCCCCGCCAGCCACCTGCGTGACGCTCTGCACTCGGCCGGCTACACGGTCAACGCACACGTGCTCAACGTGCTGGCGCACAGATACGGCACCACCGACGGGTACATACAGTTCGATGACTTCATAATGTGCGCCGTGCGTCTCAAGACCATGATCGCAAACGGCGAGCCGTTGGAGAACCTCGAACGTGAACTGCAGCAGGCGCCCTGA

Protein

MAGQNGGGNFGALIQGAGKQLLNQGGQALLNYGAQALGNIINEVFQKKEVEQKRFLPSIKNYKVLGETRPSSFGPATYQDFKDIRSRCLAEGRLFEDPEFPAVDRSLYYKESLDRPITWLRPGEISDNPQLFVEGYSRFDVQQGELGDCWLLAAVANLTLHRKLFFQVVPDDQSFDEDYAGVFHFRFWQYGRWVDVVIDDRLPTYRGKLVFLHSAEANEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVTEMYEMSELPPNFYTILLKAYERNSLMGCSIEPDPHILEAETPAGLIRGHAYSVTRVKYVDIETPGRAGKIPLLRLRNPWGNEAEWNGPWSDKSPEWRYIPESEKEELGLTFDDDGEFWMSFKDFVNHFSRVEICNLNPDSLDPEECPEGCTKKWEMSVFEGEWVRGVTAGGCRNFLETFWRNPQYTVTLSDPDEGDDENKCTIIVALMQKNRRSQRHQGLECLTIGFAVYRLPDYGHVPKPLDVNFFKYNASVGRSQAFINLREVSARFKFEPGSYVIVPSTFDPDEEGEFLLRVFSEKDNNMAENDEDIGMGDVDDRVKELAPDPEPADPVREFFTRLAGSDGEVDWQELKEILDYAMREELAMRHGAYDGGGGVAGGGPSPRTPLGPPGGPPQEQSCLEQILCALCTPICKELGVDLQQAQNQPEQVHLNQPQPYANAQELQGQGFSKDVCRSMIAMLDKDGSGGLGFEEFKSLWIDLRNWRAVFRLYDVERRGAVPASHLRDALHSAGYTVNAHVLNVLAHRYGTTDGYIQFDDFIMCAVRLKTMIANGEPLENLERELQQAP

Description

Calcium-regulated non-lysosomal thiol-protease. Involved in the organization of the actin-related cytoskeleton during embryogenesis.

Miscellaneous

This protein binds calcium.

Similarity

Belongs to the peptidase C2 family.

Keywords

Alternative splicing   Autocatalytic cleavage   Calcium   Complete proteome   Cytoplasm   Direct protein sequencing   Hydrolase   Metal-binding   Protease   Reference proteome   Repeat   Thiol protease  

Feature

chain  Calpain-A
splice variant  In isoform A.

Uniprot

H9IS71   A0A2A4JR13   A0A2A4JSS0   A0A2A4JR22   A0A232EPC7   E9IT45   + More
A0A154P7M0   A0A2A3EC59   A0A1V1FQI9   F4WIE1   A0A195CM09   A0A158NZW0   A0A151WZU7   A0A195F2D8   A0A023F577   A0A2S2PUV8   A0A087ZX44   E2B6V2   A0A195BMV6   A0A069DWP5   A0A151J2F3   A0A0V0G920   A0A1V1FYP6   A0A2H8U124   A0A1V1FKP4   A0A1B6EYI1   J9K494   A0A1B6L7E6   A0A1B6LES0   A0A0N7Z8S7   A0A2S2NJB6   A0A224XKI4   A8DYJ3   A0A1S3D0P2   Q11002   B4PB86   B3NJU8   A0A0N0BD12   A0A0J9RGC7   A0A3B0IYJ0   A0A1W4VI19   B4KME2   B4HPG1   A0A0K8TLH3   A0A0B4LG26   A0A1B6MC38   B3MGG4   B4LNX1   B5E1I7   A0A1B6KU25   B4QE26   A0A2J7PFU7   A0A0M4ELT9   A0A1B6FAL9   A0A023EXW9   A0A1B6MQN3   A0A0L0CNB1   A0A1B6MLS4   A0A1B6KIY1   A0A1J1ID91   A0A034V3R5   A0A0K8WG76   A0A1S3D0R0   A0A1A9WAE2   A0A182JM21   A0A1Q3FYJ4   A0A2M4CW96   A0A182V9Z5   A0A1Q3FYI7   A0A2C9GPX7   A0A182KTC7   B4MRQ4   A0A1Q3FYI0   A0A182N3N7   T1PG94   A0A182QPZ2   A0A182YCB5   A0A336LSF9   A0A1I8Q0G3   A0A182MAF2   A0A336LNJ6   A0A1I8Q0G4   A0A182X088   A0A182WD06   A0A182GPP7   A0A182H350   A0A182RSU6   E0W233   V9I6P7   A0A182P1C9   A0A182U6E6   A0A1Q3FHZ5   A0A084WJ00   V9I8N5   W5JKC2   A0A1Q3FHZ1   A0A182FUA9   A0A0L7R949   A0A1A9UYF2  

EC Number

3.4.22.-

Pubmed

19121390    28648823    21282665    28410430    21719571    21347285    + More
25474469    20798317    26334808    27129103    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    7929201    7823949    12537569    10446155    17994087    17550304    18057021    22936249    26369729    15632085    24945155    26108605    25348373    20966253    25315136    25244985    26483478    20566863    24438588    20920257    23761445   

EMBL

BABH01024122    BABH01024123    BABH01024124    BABH01024125    BABH01024126    NWSH01000747    + More
PCG74431.1    PCG74442.1    PCG74441.1    NNAY01002968    OXU20203.1    GL765434    EFZ16284.1    KQ434835    KZC07929.1    KZ288292    PBC29064.1    FX985380    BAX07393.1    GL888175    EGI66072.1    KQ977580    KYN01745.1    ADTU01005049    KQ982629    KYQ53427.1    KQ981856    KYN34628.1    GBBI01002474    JAC16238.1    GGMS01000103    MBY69306.1    GL446009    EFN88593.1    KQ976440    KYM86514.1    GBGD01000574    JAC88315.1    KQ980404    KYN16217.1    GECL01001590    JAP04534.1    FX985376    BAX07389.1    GFXV01008084    MBW19889.1    FX985379    BAX07392.1    GECZ01026805    JAS42964.1    ABLF02019935    ABLF02019937    ABLF02019938    ABLF02019939    GEBQ01020335    JAT19642.1    GEBQ01017963    JAT22014.1    GDKW01002515    JAI54080.1    GGMR01004664    MBY17283.1    GFTR01007875    JAW08551.1    AE013599    ABV53854.1    X78555    Z46891    Z46892    AY051678    CM000158    EDW91499.1    KRJ99877.1    CH954179    EDV55207.2    KQS62184.1    KQ435883    KOX69792.1    CM002911    KMY95108.1    KMY95109.1    OUUW01000001    SPP73144.1    CH933808    EDW09830.1    CH480816    EDW48599.1    GDAI01002424    JAI15179.1    AHN56408.1    GEBQ01006528    JAT33449.1    CH902619    EDV35707.1    KPU75785.1    CH940648    EDW61140.1    CM000071    EDY68752.1    GEBQ01025059    JAT14918.1    CM000362    EDX07813.1    NEVH01025648    PNF15198.1    CP012524    ALC42605.1    GECZ01022500    JAS47269.1    GAPW01000214    JAC13384.1    GEBQ01001774    JAT38203.1    JRES01000153    KNC33776.1    GEBQ01003071    JAT36906.1    GEBQ01028560    JAT11417.1    CVRI01000047    CRK97524.1    GAKP01022183    GAKP01022180    JAC36772.1    GDHF01008835    GDHF01002469    JAI43479.1    JAI49845.1    GFDL01002432    JAV32613.1    GGFL01005422    MBW69600.1    GFDL01002434    JAV32611.1    APCN01003260    CH963850    EDW74793.1    GFDL01002438    JAV32607.1    KA647160    AFP61789.1    AXCN02001104    UFQT01000094    SSX19653.1    AXCM01005547    SSX19652.1    JXUM01078991    JXUM01078992    JXUM01078993    JXUM01078994    KQ563100    KXJ74464.1    JXUM01003532    JXUM01003533    JXUM01003534    KQ560160    KXJ84103.1    DS235874    EEB19689.1    JR035787    AEY56680.1    GFDL01007865    JAV27180.1    ATLV01023958    KE525347    KFB50194.1    JR035786    AEY56679.1    ADMH02000957    ETN64576.1    GFDL01007859    JAV27186.1    KQ414628    KOC67354.1   

Proteomes

UP000005204    UP000218220    UP000215335    UP000076502    UP000242457    UP000007755    + More
UP000078542    UP000005205    UP000075809    UP000078541    UP000005203    UP000008237    UP000078540    UP000078492    UP000007819    UP000000803    UP000079169    UP000002282    UP000008711    UP000053105    UP000268350    UP000192221    UP000009192    UP000001292    UP000007801    UP000008792    UP000001819    UP000000304    UP000235965    UP000092553    UP000037069    UP000183832    UP000091820    UP000075880    UP000075903    UP000075840    UP000075882    UP000007798    UP000075884    UP000095301    UP000075886    UP000076408    UP000095300    UP000075883    UP000075920    UP000069940    UP000249989    UP000075900    UP000009046    UP000075885    UP000075902    UP000030765    UP000000673    UP000069272    UP000053825    UP000078200   

PRIDE

H9IS71    A8DYJ3    Q11002   

Pfam

PF01067   Calpain_III        + More
PF00648   Peptidase_C2
PF13833   EF-hand_8
PF13405   EF-hand_6
PF13202   EF-hand_5

Interpro

IPR022682   Calpain_domain_III        + More
IPR036213   Calpain_III_sf       
IPR000169   Pept_cys_AS       
IPR033883   C2_III       
IPR038765   Papain-like_cys_pep_sf       
IPR022684   Calpain_cysteine_protease       
IPR022683   Calpain_III       
IPR001300   Peptidase_C2_calpain_cat       
IPR011992   EF-hand-dom_pair       
IPR002048   EF_hand_dom       
IPR018247   EF_Hand_1_Ca_BS       

SUPFAM

SSF54001   SSF54001        + More
SSF47473   SSF47473       
SSF49758   SSF49758       

CDD

cd00214  Calpain_III
cd00044  CysPc

ProteinModelPortal

H9IS71   A0A2A4JR13   A0A2A4JSS0   A0A2A4JR22   A0A232EPC7   E9IT45   + More
A0A154P7M0   A0A2A3EC59   A0A1V1FQI9   F4WIE1   A0A195CM09   A0A158NZW0   A0A151WZU7   A0A195F2D8   A0A023F577   A0A2S2PUV8   A0A087ZX44   E2B6V2   A0A195BMV6   A0A069DWP5   A0A151J2F3   A0A0V0G920   A0A1V1FYP6   A0A2H8U124   A0A1V1FKP4   A0A1B6EYI1   J9K494   A0A1B6L7E6   A0A1B6LES0   A0A0N7Z8S7   A0A2S2NJB6   A0A224XKI4   A8DYJ3   A0A1S3D0P2   Q11002   B4PB86   B3NJU8   A0A0N0BD12   A0A0J9RGC7   A0A3B0IYJ0   A0A1W4VI19   B4KME2   B4HPG1   A0A0K8TLH3   A0A0B4LG26   A0A1B6MC38   B3MGG4   B4LNX1   B5E1I7   A0A1B6KU25   B4QE26   A0A2J7PFU7   A0A0M4ELT9   A0A1B6FAL9   A0A023EXW9   A0A1B6MQN3   A0A0L0CNB1   A0A1B6MLS4   A0A1B6KIY1   A0A1J1ID91   A0A034V3R5   A0A0K8WG76   A0A1S3D0R0   A0A1A9WAE2   A0A182JM21   A0A1Q3FYJ4   A0A2M4CW96   A0A182V9Z5   A0A1Q3FYI7   A0A2C9GPX7   A0A182KTC7   B4MRQ4   A0A1Q3FYI0   A0A182N3N7   T1PG94   A0A182QPZ2   A0A182YCB5   A0A336LSF9   A0A1I8Q0G3   A0A182MAF2   A0A336LNJ6   A0A1I8Q0G4   A0A182X088   A0A182WD06   A0A182GPP7   A0A182H350   A0A182RSU6   E0W233   V9I6P7   A0A182P1C9   A0A182U6E6   A0A1Q3FHZ5   A0A084WJ00   V9I8N5   W5JKC2   A0A1Q3FHZ1   A0A182FUA9   A0A0L7R949   A0A1A9UYF2  

PDB

1QXP     E-value=2.45105e-152,     Score=1385

KEGG

100127019    K08585 calpain, invertebrate [EC:3.4.22.-] | (RefSeq) calpain protein

GO

GO:0004198   GO:0005509   GO:0005737   GO:0042335   GO:0008345   GO:0006508   GO:0009953   GO:0043025   GO:0015629   GO:0016322   GO:0008340   GO:0050832   GO:0007520   GO:0016540   GO:0005622   GO:0006816   GO:0016021   GO:0005507   GO:0004713   GO:0016491   GO:0015930  

Subcellular location

Cytoplasm  

Length:

822

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00528

Exp number, first 60 AAs:

0.0021

Total prob of N-in:

0.00013

outside

1  -  822

 

 

Pi

278.395107

Theta

172.070587

Tajima's D

2.213325

CLR

0.266524

CSRT

0.912404379781011

Interpretation

Uncertain