Gene

KWMTBOMO14416  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000104

Annotation

coatomer_protein_complex_subunit_delta_[Bombyx_mori]

Location

Bomo_Chr24(-):5650034-5658863      View in EpiBrowser

Full name

Coatomer subunit delta      

Alternative Name

Archain
Delta-coat protein

Location in the cell

Cytoplasmic   Reliability : 1.658 Nuclear   Reliability : 1.75

CDS

ATGTTTCGTACAGTGGGTCGTTCTGCCATGAAGCTCGGCAGCCGCGGCACAGACGCGGACTCGTTCGTGTCCCGACTCCGCAGCGAGGGTGACGTCACGGCGCCCGTAGCGTCGCCGGCGCAACACGACGCCGGCAAGCCCGTGCCCGCCGATCACAAGGATGTTCACTTGCGCTTCGAGGAGCGTTTAAACCTGATCGCCGGCCGCGACGGTGACATACAAACTTTTGAACTATCAGGTTTGCTGACGCTACGCATTAGCAACGAGCAGTTCGGTCGCATACACGTGCACGTCGACAACAAAGACTCGAGACCGTTACAGTTGCAGACCCATCCAAACGTGGACAAAGAAGCGTTCCGCTCGACCGGCGTGATTGGGCTGAAGCAGGCTCAACGCCCCTTCCCGATGCACAGCGACGTCGGAGTCCTCAAGTGGAGGCTGGCCACTACCAACGATGACAAGCTGGCTCCGCTTTCCGTAAACTGTTGGCCGTCCGAAGGCGTCAACGGAGGATGTGACGTCAATATCGAATACGAGCTGGAGCAGGATCACCTGGTGTTGACAGATGTCAATATCACCATACCGCTTCCTTCTGGCAACACTTCGGTGGTGGTGCACCAGTGGGAGGGTAGCTACACGCAGAAGGGACGCAACCTCATCTGGAGCATTCCGCTCGTGAGCAAACAACAGAAAACCGGGAGTCTTGAGTTCACCGTCACTCCGTCTATACCCAACGACTTCTTCCCGCTCTCCGTGACGTGGACATCGGAAACTTCACTTGCATTATTGACAGCTGTCAAAGTGACGCAAGCGGAAGACGGGTCGCCCGTTGACTTCTCTCAAGAGATCAGTTTCCACGCAGACAAATACGAGTTTGTTTAA

Protein

MFRTVGRSAMKLGSRGTDADSFVSRLRSEGDVTAPVASPAQHDAGKPVPADHKDVHLRFEERLNLIAGRDGDIQTFELSGLLTLRISNEQFGRIHVHVDNKDSRPLQLQTHPNVDKEAFRSTGVIGLKQAQRPFPMHSDVGVLKWRLATTNDDKLAPLSVNCWPSEGVNGGCDVNIEYELEQDHLVLTDVNITIPLPSGNTSVVVHQWEGSYTQKGRNLIWSIPLVSKQQKTGSLEFTVTPSIPNDFFPLSVTWTSETSLALLTAVKVTQAEDGSPVDFSQEISFHADKYEFV

Description

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).

Subunit

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

Similarity

Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
Belongs to the adaptor complexes medium subunit family.

Keywords

Acetylation   Complete proteome   Cytoplasm   Cytoplasmic vesicle   ER-Golgi transport   Golgi apparatus   Membrane   Phosphoprotein   Protein transport   Reference proteome   Transport   3D-structure  

Feature

chain  Coatomer subunit delta

Uniprot

D2Y4R5   H9IS78   A0A194RJA1   A0A2A4JU45   S4PM74   A0A194QHG6   + More
A0A212FA27   A0A1B6C3S5   A0A182PD95   A0A1B0CS10   A0A2J7RED7   A0A1L8DVU7   A0A182Y9M8   A0A182SWE8   D6WG69   Q16JS6   A0A182RW76   A0A182JX92   A0A182LU45   A0A182KV34   A0A182VKV3   A0A182WXW2   A0A182I5Y3   A0A195F1V9   A0A182N2N7   E2ATT7   A0A182U4B5   A0A158P0K0   A0A240PLG5   A0A151K362   V5IA31   A0A195BMS6   A0A195E064   W5JHI0   A0A2M4BK50   F4X3M1   A0A026WPU6   A0A0J7KYT2   A0A1B6LTS3   A0A1Q3G2N7   A0A2M3Z2U3   A0A154NYD9   A0A195CQJ6   A0A2M4A4T3   Q7QE04   A0A1S4H4R7   A0A2M4BK28   A0A151XJ53   A0A1W4WI86   J3JWP1   A0A336LZB0   A0A1B6HIZ8   A0A2M4BKV6   A0A336LRI8   A0A088AGY8   N6TDB2   A0A0T6AX21   A0A2A3EUF7   W8C4F1   A0A182QC70   T1EA65   K7IN83   U6CUU3   Q28E96   A0A337SD75   A0A0K8VQJ7   A0A1U8BQV2   A0A084WNK9   F7CT60   R4WD35   A0A034WWS1   Q8R1S6   A0A0L7RHL0   U5EYD0   A0A337SNU7   A0A2K6G198   W5U888   Q3TDU1   A0A0A1WU06   G3WFM6   A0A061I898   A0A1I8PCH3   A0A2U3YDK6   Q66H80   Q3U4S9   G3I5S7   Q5XJY5   A0A2K5PDL9   A0A2K6M812   A0A2K5ECG4   A0A2K6RKC2   E2BY86   A0A2I3HWW0   A0A250YJ64   A0A3Q0E518   A0A340XBI1   S7P2F6   F6S2S4   A0A2K5UMQ5   A0A2K5Z8W7  

Pubmed

20967265    19121390    26354079    23622113    22118469    25244985    + More
18362917    19820115    17510324    20966253    20798317    21347285    20920257    23761445    21719571    24508170    30249741    12364791    22516182    23537049    24495485    20075255    20431018    17975172    26319212    24438588    18464734    23691247    25348373    15489334    23127152    10349636    11042159    11076861    11217851    12466851    16141073    25830018    21709235    23929341    21804562    16141072    21183079    23806337    25362486    28087693   

EMBL

GU322818    ADB66737.1    BABH01024107    BABH01024108    KQ460124    KPJ17632.1    + More
NWSH01000581    PCG75521.1    GAIX01003715    JAA88845.1    KQ458859    KPJ04864.1    AGBW02009528    OWR50592.1    GEDC01029151    JAS08147.1    AJWK01025548    AJWK01025549    NEVH01005277    PNF39202.1    GFDF01003520    JAV10564.1    KQ971320    EFA00195.2    CH477994    EAT34535.1    AXCM01001811    APCN01003537    KQ981856    KYN34560.1    GL442691    EFN63170.1    ADTU01005193    ADTU01005194    LKEY01014896    KYN50522.1    GALX01001895    JAB66571.1    KQ976440    KYM86586.1    KQ979955    KYN18535.1    ADMH02001177    ETN63827.1    GGFJ01004286    MBW53427.1    GL888624    EGI58818.1    KK107139    QOIP01000003    EZA57676.1    RLU25135.1    LBMM01001976    KMQ95458.1    GEBQ01012906    JAT27071.1    GFDL01000983    JAV34062.1    GGFM01002017    MBW22768.1    KQ434775    KZC04094.1    KQ977394    KYN03018.1    GGFK01002419    MBW35740.1    AAAB01008848    EAA07068.4    GGFJ01004285    MBW53426.1    KQ982074    KYQ60442.1    BT127659    KB632005    AEE62621.1    ERL87931.1    UFQT01000051    SSX19028.1    GECU01033077    JAS74629.1    GGFJ01004287    MBW53428.1    SSX19027.1    APGK01034502    KB740914    ENN78349.1    LJIG01022618    KRT79602.1    KZ288189    PBC34691.1    GAMC01005554    JAC01002.1    AXCN02001080    GAMD01000707    JAB00884.1    HAAF01002639    CCP74465.1    AAMC01039972    BC135629    CR848379    AAI35630.1    CAJ83033.1    AANG04000369    GDHF01011191    JAI41123.1    ATLV01024620    KE525353    KFB51803.1    AK417174    BAN20389.1    GAKP01000739    JAC58213.1    BC024127    AAH24127.1    KQ414591    KOC70288.1    GANO01000438    JAB59433.1    JT406826    AHH37739.1    AK170005    BAE41508.1    GBXI01012399    JAD01893.1    AEFK01114342    AEFK01114343    AEFK01114344    AEFK01114345    AEFK01114346    KE675610    ERE75003.1    BC081979    AK154066    BAE32352.1    JH001318    EGW05721.1    AK028556    CH466522    BC017124    BC023728    BC033387    BC034754    BC083152    GL451420    EFN79365.1    ADFV01057015    ADFV01057016    ADFV01057017    ADFV01057018    ADFV01057019    ADFV01057020    ADFV01057021    GFFW01001113    JAV43675.1    KE161106    EPQ01792.1    AQIA01022408    AQIA01022409    AQIA01022410    AQIA01022411    AQIA01022412   

Proteomes

UP000005204    UP000053240    UP000218220    UP000053268    UP000007151    UP000075885    + More
UP000092461    UP000235965    UP000076408    UP000075901    UP000007266    UP000008820    UP000075900    UP000075881    UP000075883    UP000075882    UP000075903    UP000076407    UP000075840    UP000078541    UP000075884    UP000000311    UP000075902    UP000005205    UP000075880    UP000078492    UP000078540    UP000000673    UP000007755    UP000053097    UP000279307    UP000036403    UP000076502    UP000078542    UP000007062    UP000075809    UP000192223    UP000030742    UP000005203    UP000019118    UP000242457    UP000075886    UP000002358    UP000008143    UP000011712    UP000189706    UP000030765    UP000002279    UP000053825    UP000233160    UP000221080    UP000007648    UP000030759    UP000095300    UP000245341    UP000002494    UP000001075    UP000000589    UP000233040    UP000233180    UP000233020    UP000233200    UP000008237    UP000001073    UP000189704    UP000265300    UP000008225    UP000233100    UP000233140   

PRIDE

D2Y4R5    H9IS78    Q8R1S6    Q3TDU1    Q66H80    Q3U4S9    + More
G3I5S7    Q5XJY5   

Pfam

PF00928   Adap_comp_sub        + More
PF01217   Clat_adaptor_s
PF00227   Proteasome

Interpro

IPR011012   Longin-like_dom_sf        + More
IPR028565   MHD       
IPR027059   Coatomer_dsu       
IPR036168   AP2_Mu_C_sf       
IPR022775   AP_mu_sigma_su       
IPR016050   Proteasome_bsu_CS       
IPR029055   Ntn_hydrolases_N       
IPR023333   Proteasome_suB-type       
IPR000243   Pept_T1A_subB       
IPR001353   Proteasome_sua/b       

SUPFAM

SSF49447   SSF49447        + More
SSF64356   SSF64356       
SSF56235   SSF56235       

Gene 3D

3.60.20.10    

ProteinModelPortal

D2Y4R5   H9IS78   A0A194RJA1   A0A2A4JU45   S4PM74   A0A194QHG6   + More
A0A212FA27   A0A1B6C3S5   A0A182PD95   A0A1B0CS10   A0A2J7RED7   A0A1L8DVU7   A0A182Y9M8   A0A182SWE8   D6WG69   Q16JS6   A0A182RW76   A0A182JX92   A0A182LU45   A0A182KV34   A0A182VKV3   A0A182WXW2   A0A182I5Y3   A0A195F1V9   A0A182N2N7   E2ATT7   A0A182U4B5   A0A158P0K0   A0A240PLG5   A0A151K362   V5IA31   A0A195BMS6   A0A195E064   W5JHI0   A0A2M4BK50   F4X3M1   A0A026WPU6   A0A0J7KYT2   A0A1B6LTS3   A0A1Q3G2N7   A0A2M3Z2U3   A0A154NYD9   A0A195CQJ6   A0A2M4A4T3   Q7QE04   A0A1S4H4R7   A0A2M4BK28   A0A151XJ53   A0A1W4WI86   J3JWP1   A0A336LZB0   A0A1B6HIZ8   A0A2M4BKV6   A0A336LRI8   A0A088AGY8   N6TDB2   A0A0T6AX21   A0A2A3EUF7   W8C4F1   A0A182QC70   T1EA65   K7IN83   U6CUU3   Q28E96   A0A337SD75   A0A0K8VQJ7   A0A1U8BQV2   A0A084WNK9   F7CT60   R4WD35   A0A034WWS1   Q8R1S6   A0A0L7RHL0   U5EYD0   A0A337SNU7   A0A2K6G198   W5U888   Q3TDU1   A0A0A1WU06   G3WFM6   A0A061I898   A0A1I8PCH3   A0A2U3YDK6   Q66H80   Q3U4S9   G3I5S7   Q5XJY5   A0A2K5PDL9   A0A2K6M812   A0A2K5ECG4   A0A2K6RKC2   E2BY86   A0A2I3HWW0   A0A250YJ64   A0A3Q0E518   A0A340XBI1   S7P2F6   F6S2S4   A0A2K5UMQ5   A0A2K5Z8W7  

PDB

5NZV     E-value=6.37359e-75,     Score=713

KEGG

100379189    K20471 coatomer subunit delta | (RefSeq) COPD; coatomer protein complex subunit delta

GO

GO:0030126   GO:0000139   GO:0015031   GO:0006890   GO:0005829   GO:0051645   GO:0030137   GO:0006888   GO:0005839   GO:0004298   GO:0051603   GO:0005634   GO:0008344   GO:0021691   GO:0005783   GO:0043473   GO:0048193   GO:0005794   GO:0016192   GO:0030663  

PANTHER

PTHR10121  

Subcellular location

Cytoplasm  
Cytoplasmic vesicle  
COPI-coated vesicle membrane  
Golgi apparatus membrane  
Nucleus  

Length:

293

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00231

Exp number, first 60 AAs:

0

Total prob of N-in:

0.04637

outside

1  -  293

 

 

Pi

217.51124

Theta

178.32819

Tajima's D

0.142108

CLR

0.138911

CSRT

0.412279386030698

Interpretation

Uncertain