Gene

KWMTBOMO14414  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000106

Annotation

mitochondrial_intermembrane_space_translocase_subunit_Tim10_[Bombyx_mori]

Location

Bomo_Chr24(-):5637874-5640523      View in EpiBrowser

Full name

Mitochondrial import inner membrane translocase subunit Tim10      

Location in the cell

Nuclear   Reliability : 2.326

CDS

ATGGCAGTACCGCAGCTAGACCCTGCAAAGCTGCAATTGGTGCAGGAACTGGAGATTGAGATGATGTCCGACATGTACAACCGCTTGGTGAGCGCATGTCACCGGAAGTGCATACCAATTAAATATCATGAACCTGAATTAGGAAAAGGCGAATCTGTATGTTTAGATCGCTGTGTAGCCAAATACTTGGACGTACATGAACGCATAGGTAAGAAACTTTCCAATATGTCACAAGGAGAAACCGAAGATCTCACAAAGGTCAACATACCAGACAAAAAATAG

Protein

MAVPQLDPAKLQLVQELEIEMMSDMYNRLVSACHRKCIPIKYHEPELGKGESVCLDRCVAKYLDVHERIGKKLSNMSQGETEDLTKVNIPDKK

Description

Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).

Subunit

Heterohexamer; composed of 3 copies of Tim9 and 3 copies of Tim10, named soluble 70 kDa complex. The complex associates with the Tim22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit (By similarity).

Similarity

Belongs to the small Tim family.

Keywords

Chaperone   Complete proteome   Disulfide bond   Membrane   Metal-binding   Mitochondrion   Mitochondrion inner membrane   Protein transport   Reference proteome   Translocation   Transport   Zinc  

Feature

chain  Mitochondrial import inner membrane translocase subunit Tim10

Uniprot

Q2F5K3   A0A3S2LV35   I4DJZ5   A0A194RJV3   A0A212FA50   A0A194QH60   + More
A0A2A4JV82   A0A2H1VDU2   Q9Y0V4   E2AQP5   A0A087U6B3   A0A067QQ30   A0A2R5LHJ0   R4V508   A0A195D9W6   E0VY47   A0A195F540   A0A151IEZ5   F4W525   A0A195BQ48   A0A158NDJ4   A0A026W2F0   E2B619   A0A023G8F3   E9GAU9   A0A023FR62   A0A0K8R6Y7   A0A1Z5LE75   A0A151XEG9   A0A1E1XV82   A0A0P5ELG7   A0A023FP94   A0A023FVH6   A0A1E1X0C6   A0A131Z5G8   A0A224Z4J2   L7LXC6   A0A131XE60   A0A2J7QM11   A0A0C9QYR7   A0A182U576   U5EZ06   A0A293MEQ1   Q7QE31   A0A1B2AKF1   B4I7U7   B4QGJ5   Q9W2D6   B3MIZ0   T1DHV3   A0A0Q9WYL8   A0A1J1HX77   A0A1B0ARR9   K7IMJ3   A0A3S3NJ03   A0A0M3QV06   A0A182WY03   B4LNP8   A0A1A9WV14   B4JVF8   Q1HQZ1   A0A023EDY9   E9J336   A0A154PHR5   A0A2M3Z7I4   A0A2M4ATZ9   W5JQC8   A0A1B0FD43   A0A2R7W3S0   A0A023EB85   A0A182FVZ1   B4KTP5   A0A1Q3FD67   B0WTF8   A0A1A9ZR57   A0A182JQ62   A0A084WUG2   A0A182I623   A0A0U2TLH7   A0A182YAB3   A0A182PN56   A0A0P4VQ74   R4G4L5   A0A182LZ46   T1E892   A0A023F9G4   C1BP39   A0A224XUT1   C1BRK1   A0A0V0G8G8   A0A069DNN5   A0A0K2U8Z5   A0A182RLV6   A0A336LD03   A0A182NP99   A0A3B0JP97   Q292C1   B4G9X1   C1C134   A0A182WE87  

Pubmed

19121390    22651552    26354079    22118469    20798317    24845553    + More
20566863    21719571    21347285    24508170    30249741    21292972    28528879    29209593    28503490    26830274    28797301    25576852    28049606    26131772    12364791    14747013    17210077    17994087    22936249    10611480    10731132    12537572    12537569    24330624    20075255    17204158    17510324    24945155    26483478    21282665    20920257    23761445    24438588    26621068    25244985    27129103    25474469    26334808    15632085   

EMBL

BABH01024106    DQ311420    ABD36364.1    RSAL01000179    RVE44972.1    AK401613    + More
BAM18235.1    KQ460124    KPJ17615.1    AGBW02009528    OWR50589.1    KQ458859    KPJ04847.1    NWSH01000581    PCG75524.1    ODYU01002020    SOQ39008.1    AF150098    AAD40004.1    GL441804    EFN64234.1    KK118409    KFM72902.1    KK853149    KDR10665.1    GGLE01004874    MBY09000.1    KC741124    AGM32948.1    KQ981082    KYN09661.1    DS235843    EEB18303.1    KQ981820    KYN35189.1    KQ977830    KYM99400.1    GL887596    EGI70721.1    KQ976424    KYM88263.1    ADTU01012636    KK107474    QOIP01000002    EZA50173.1    RLU26109.1    GL445900    EFN88880.1    GBBM01006290    JAC29128.1    GL732537    EFX83320.1    GBBK01001372    JAC23110.1    GADI01007564    JAA66244.1    GFJQ02001729    JAW05241.1    KQ982254    KYQ58737.1    GFAA01000465    JAU02970.1    GDIP01144763    LRGB01000389    JAJ78639.1    KZS19400.1    GBBK01001373    JAC23109.1    GBBL01002562    JAC24758.1    GFAC01006463    JAT92725.1    GEDV01002552    JAP86005.1    GFPF01009814    MAA20960.1    GACK01008318    JAA56716.1    GEFH01004680    JAP63901.1    NEVH01013216    PNF29649.1    GBZX01002825    JAG89915.1    GANO01001655    JAB58216.1    GFWV01019469    MAA44197.1    AAAB01008848    EAA06991.2    KX531842    ANY27652.1    CH480824    EDW56672.1    CM000362    CM002911    EDX08114.1    KMY95624.1    AF150092    AE013599    AY061513    CH902619    EDV37056.1    GALA01001311    JAA93541.1    CH963719    KRF97484.1    CVRI01000033    CRK92629.1    JXJN01002564    NCKU01011698    NCKU01011636    RWS00346.1    RWS00376.1    CP012524    ALC41579.1    CH940648    EDW60118.1    CH916375    EDV98426.1    DQ440303    CH477663    ABF18336.1    EAT37572.1    JXUM01241297    GAPW01006592    KQ635200    JAC07006.1    KXJ62521.1    GL768055    EFZ12794.1    KQ434899    KZC11034.1    GGFM01003726    MBW24477.1    GGFK01010926    MBW44247.1    ADMH02000766    ETN65110.1    CCAG010002640    KK854300    PTY14364.1    GAPW01006721    JAC06877.1    CH933808    EDW09628.1    GFDL01009529    JAV25516.1    DS232085    EDS34396.1    ATLV01027083    KE525423    KFB53856.1    APCN01003547    KT755167    ALS05001.1    GDKW01001976    JAI54619.1    ACPB03008858    GAHY01001255    JAA76255.1    AXCM01001000    GAMD01002973    JAA98617.1    GBBI01001073    JAC17639.1    BT076368    ACO10792.1    GFTR01001512    JAW14914.1    BT077230    ACO11654.1    GECL01001870    JAP04254.1    GBGD01003618    JAC85271.1    HACA01017343    CDW34704.1    UFQS01002647    UFQT01002647    SSX14435.1    SSX33842.1    OUUW01000001    SPP75429.1    CM000071    EAL24941.1    CH479181    EDW31723.1    BT080563    ACO14987.1   

Proteomes

UP000005204    UP000283053    UP000053240    UP000007151    UP000053268    UP000218220    + More
UP000000311    UP000054359    UP000027135    UP000078492    UP000009046    UP000078541    UP000078542    UP000007755    UP000078540    UP000005205    UP000053097    UP000279307    UP000008237    UP000000305    UP000075809    UP000076858    UP000235965    UP000075902    UP000007062    UP000001292    UP000000304    UP000000803    UP000007801    UP000007798    UP000183832    UP000092460    UP000002358    UP000285301    UP000092553    UP000076407    UP000008792    UP000091820    UP000001070    UP000008820    UP000069940    UP000249989    UP000076502    UP000000673    UP000092444    UP000069272    UP000009192    UP000002320    UP000092445    UP000075881    UP000030765    UP000075840    UP000076408    UP000075885    UP000015103    UP000075883    UP000075900    UP000075884    UP000268350    UP000001819    UP000008744    UP000075920   

PRIDE

Q2F5K3    Q9Y0V4    Q9W2D6   

Pfam

PF02953   zf-Tim10_DDP        + More
PF15932   DUF4748

Interpro

IPR027100   Tim10        + More
IPR004217   Tim10-like       
IPR035427   Tim10-like_dom_sf       
IPR031833   DUF4748       

SUPFAM

SSF144122   SSF144122       

Gene 3D

1.10.287.810    

ProteinModelPortal

Q2F5K3   A0A3S2LV35   I4DJZ5   A0A194RJV3   A0A212FA50   A0A194QH60   + More
A0A2A4JV82   A0A2H1VDU2   Q9Y0V4   E2AQP5   A0A087U6B3   A0A067QQ30   A0A2R5LHJ0   R4V508   A0A195D9W6   E0VY47   A0A195F540   A0A151IEZ5   F4W525   A0A195BQ48   A0A158NDJ4   A0A026W2F0   E2B619   A0A023G8F3   E9GAU9   A0A023FR62   A0A0K8R6Y7   A0A1Z5LE75   A0A151XEG9   A0A1E1XV82   A0A0P5ELG7   A0A023FP94   A0A023FVH6   A0A1E1X0C6   A0A131Z5G8   A0A224Z4J2   L7LXC6   A0A131XE60   A0A2J7QM11   A0A0C9QYR7   A0A182U576   U5EZ06   A0A293MEQ1   Q7QE31   A0A1B2AKF1   B4I7U7   B4QGJ5   Q9W2D6   B3MIZ0   T1DHV3   A0A0Q9WYL8   A0A1J1HX77   A0A1B0ARR9   K7IMJ3   A0A3S3NJ03   A0A0M3QV06   A0A182WY03   B4LNP8   A0A1A9WV14   B4JVF8   Q1HQZ1   A0A023EDY9   E9J336   A0A154PHR5   A0A2M3Z7I4   A0A2M4ATZ9   W5JQC8   A0A1B0FD43   A0A2R7W3S0   A0A023EB85   A0A182FVZ1   B4KTP5   A0A1Q3FD67   B0WTF8   A0A1A9ZR57   A0A182JQ62   A0A084WUG2   A0A182I623   A0A0U2TLH7   A0A182YAB3   A0A182PN56   A0A0P4VQ74   R4G4L5   A0A182LZ46   T1E892   A0A023F9G4   C1BP39   A0A224XUT1   C1BRK1   A0A0V0G8G8   A0A069DNN5   A0A0K2U8Z5   A0A182RLV6   A0A336LD03   A0A182NP99   A0A3B0JP97   Q292C1   B4G9X1   C1C134   A0A182WE87  

PDB

2BSK     E-value=4.61872e-22,     Score=251

KEGG

692979    K17778 mitochondrial import inner membrane translocase subunit TIM10 | (RefSeq) Tim10; mitochondrial

GO

GO:0045039   GO:0042719   GO:0042721   GO:0046872   GO:0008565   GO:0005739   GO:0015031   GO:0005743   GO:0050829   GO:0045824   GO:0016021  

PANTHER

PTHR11038:SF16  

Subcellular location

Mitochondrion inner membrane  

Length:

93

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.18133

outside

1  -  93

 

 

Pi

239.624837

Theta

173.733504

Tajima's D

1.120728

CLR

18.220431

CSRT

0.690115494225289

Interpretation

Uncertain