Gene

KWMTBOMO14371  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013297

Annotation

PREDICTED:_ryanodine_receptor_44F_isoform_X23_[Bombyx_mori]

Location

Bomo_Chr24(-):3781636-3810416      View in EpiBrowser

Full name

Ryanodine receptor      

Alternative Name

Ryanodine receptor 44F

Location in the cell

Cytoplasmic   Reliability : 2.255

CDS

ATGGTGTGCCTCTCGTGTACCGCTACCGGGGAACGCGTGTGCCTCGCAGCTGAAGGATTTGGAAACCGGCACTGCTTCCTGGAGAACATCGCGGACAAGAACATACCACCCGATCTGTCGCAATGCGTCTTCGTCATAGAACAGGCGTTATCAGTGAGAGCTCTCCAAGAATTGGTGACGGCGGCCGGATCGGAAACCGGCAAGGGCACTGGATCCGGTCACAGGACACTGCTTTACGGAAACGCGATCCTTTTGAGACATCTCAACAGTGATATGTACTTGGCGTGCTTGTCGACATCATCATCTCAAGACAAACTGGCTTTCGACGTTGGTCTCCAAGAGCACTCCCAGGGTGAAGCGTGCTGGTGGACATTGCATCCGGCCAGTAAACAAAGATCGGAGGGTGAAAAAGTGCGAGTGGGAGATGATTTGATTCTTGTATCTGTTGCCACTGAGAGATATTTGCACACAACTAAAGAGAATGAAGTATCGATCGTCAATGCCTCGTTTCACGTGACACACTGGTCGGTCCAGCCATACGGAACCGGCATCTCGAGGATGAAATACGTCGGCTACGTCTTCGGGGGAGACGTTCTACGTTTCTTCCACGGAGGAGACGAATGCCTTACAATACCTAGCACTTGGACTCGGGATGGAGGACAGAATATTGTAGTATACGAAGGCGGATCGGTCATGTCACAAGCTCGTTCGCTATGGCGTTTGGAACTAGCTCGTACCAAATGGGCCGGAGGCTTTATCAACTGGTACCATCCAATGAGGATTCGGCACATCACTACGGGTCGATACTTGGGTGTTAACGACCAGAATGAACTCCATTTGGTCAGCAGAGAGGAAGCCACAACCGCTTCCTGCGCCTTTTGTCTTCGTCAAGAAAAAGATGATCAGAAACAAGTGCTTGAAGATAAAGATTTGGAAGTGATCGGAGCGCCAATTATTAAATACGGTGACTCAACAGTAATTGTGCAGCACTCTGAAACTGGCTTGTGGCTTTCATATAAGTCTTACGAAACAAAGAAGAAAGGCGTCGGTAAAGTAGAAGAGAAACAAGCCATACTACACGAAGAAGGTAAAATGGACGACGGCCTTGATTTCTCCAGGTCCCAAGAAGAAGAGTCGAGGACCGCCAGAGTCATCAGGAAGTGTTCTTCTTTATTCACTAAGTTCATCAATGGCCTTGAAACTCTTCAAGAAAACAGAAGACACTCGATGTTCTTCGCGTCCGTGAACTTAGGAGAGATGGTGATGTGCTTGGAGGATCTTATAAACTATTTCGCACAGCCCGATGAGGACATGGAACACGAAGAAAAGCAAAACAAGTTCCGTGCTCTTCGAAACCGCCAAGATCTTTTCCAAGAGGAGGGTATCCTGAATTTAATCCTGGAAGCAATCGACAAGATCAACGTGATCACGTCCCAGGGATTCCTTGCTGGGTTCCTAGCTGGAGACGAATCGGGACAGAGCTGGGAAATGATCTCTGGATACCTTTATCAGCTTTTAGCTGCTATTATAAAAGGAAACCACACGAACTGCGCACAGTTCGCAAACTCCAACCGTCTGAACTGGTTGTTCTCTAGACTCGGCTCACAGGCATCTGGCGAAGGAACTGGGATGCTGGACGTGTTGCATTGCGTGCTCATAGACTCGCCTGAAGCCTTGAATATGATGAGGGATGAGCACATAAAAGTAATCATAAGCTTATTAGAAAAGCACGGGCGTGACCCGAAAGTTCTCGACGTGCTGTGCTCGCTGTGCGTCGGCAACGGAGTGGCCGTGCGCTCGTCCCAGAACAACATCTGCGACTACTTGCTGCCAGGGAAGAACTTGCTACTGCAGACTCAGCTAGTAGACCACGTTTCCAGTGTGCGACCGAACATTTTCGTGGGCCGCGTCGAAGGATCAGCAGTGTACCGTAAATGGTACTTCGAAGTGACGATGGACCACATCGAGAAAACCACGCACATGATGCCCCATCTGCGCATAGGATGGGCTAACACTTCTGGATACGTACCGTATCCTGGTGGTGGCGAAAAGTGGGGCGGTAACGGTGTCGGTGATGATTTGTATTCCTTTGGTTTCGATGGAGCATATTTGTGGTCTGGTGGCAGGAAAACCCCGGTTAATCGCACTCACCACGAAGAACCTTATATCAGAAAAGGCGATGTGATTGGGTGCGCTCTGGACTTGAACGTTCCTTTAATCAACTTCATGTTCAACGGCGTCAGGGTGACCGGATCTTTCACCAACTTCAACTTGGAAGGCATGTTCTTCCCCGCCATCAGCTGCTCAAGTAAATTAAGTTGTCGGTTTCTATTCGGCGGCGAACATGGTCGTCTGCGTTACGCGGCTCCCGAGGGATACTCTCCGCTGGTTGAGTCGCTGCTTCCGCAACAGATCCTCAGTCTCGAACCCTGCTTCTATTTTGGCAACCTCAACAAGAGGGCTCTAGCTGGACCATCTTTAGTTCAAGATGATACCGCATTTGTGCCTACACCGGTTGATACGATGACGATATCTCTGCCAACATACGTGGAACAAATCAGGGATAAGCTAGCCGAAAATATTCACGAAATGTGGGCTATGAATAAGATTGAAGCCGGCTGGATGTACGGTGATCAGCGCGACGACATACATAAGATCCATCCTTGCTTGGTGCCCTTCGAGCGACTACCACCTGCTGAGAAGAGATACGATATCCAACTAGCTGTGCAAACATTGAAAACAATTCTTGCGCTTGGCTACTACATTACTTTGGATAAGCCACCAGCACGTATCCGCAACGTCCGACTTCCAAACGAACCATTTTTACAGTCAAACGGCTATAAACCAGCACCTTTAGACCTTGGTGCTGTTACTCTGACACCCAAAATGGATGAACTAGTGGACCAATTAGCTGAGAATACTCACAATCTTTGGGCCAGGGAAAGAATACAACAAGGTTGGACTTACGGTCTCAATGAGGATCCGGAGATGCATCGCTCCCCTCACTTAGTGCCGTATCCTAAAGTTGATGATGCCATAAAAAAAGCCAACCGAGACACCGCGTCTGAAACTGTCCGAACTTTATTGGTTTACGGATATAATCTGGATCCGCCCACTGGAGAACAGCATGAAGCTCTACTAGCGGAGGCTTCTAAGCAGAAACAAGCTGATTTCAGAACCTACAGGGCGGAAAAGAACTACGCCGTTAGTTCTGGGAAATGGTATTTCGAATTTGAAATATTAACGGCTGGGCCAATGAGGGTTGGTTGGGCTCATGCTGACATGGCTCCGGGCATGATGTTGGGACAAGACGAGAATTCTTGGGCGTTCGACGGATACAACTGCTTAAAATTACATGGCGGAACGAGCGACGCATTCGGTATACAGCTCAAAGTCGGGGATATTGTGGGCTGCTTCCTAGACGTCGTCGACCAAACAATTAGTGAGTCGATGGCTTAA

Protein

MVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDLSQCVFVIEQALSVRALQELVTAAGSETGKGTGSGHRTLLYGNAILLRHLNSDMYLACLSTSSSQDKLAFDVGLQEHSQGEACWWTLHPASKQRSEGEKVRVGDDLILVSVATERYLHTTKENEVSIVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSTWTRDGGQNIVVYEGGSVMSQARSLWRLELARTKWAGGFINWYHPMRIRHITTGRYLGVNDQNELHLVSREEATTASCAFCLRQEKDDQKQVLEDKDLEVIGAPIIKYGDSTVIVQHSETGLWLSYKSYETKKKGVGKVEEKQAILHEEGKMDDGLDFSRSQEEESRTARVIRKCSSLFTKFINGLETLQENRRHSMFFASVNLGEMVMCLEDLINYFAQPDEDMEHEEKQNKFRALRNRQDLFQEEGILNLILEAIDKINVITSQGFLAGFLAGDESGQSWEMISGYLYQLLAAIIKGNHTNCAQFANSNRLNWLFSRLGSQASGEGTGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLEKHGRDPKVLDVLCSLCVGNGVAVRSSQNNICDYLLPGKNLLLQTQLVDHVSSVRPNIFVGRVEGSAVYRKWYFEVTMDHIEKTTHMMPHLRIGWANTSGYVPYPGGGEKWGGNGVGDDLYSFGFDGAYLWSGGRKTPVNRTHHEEPYIRKGDVIGCALDLNVPLINFMFNGVRVTGSFTNFNLEGMFFPAISCSSKLSCRFLFGGEHGRLRYAAPEGYSPLVESLLPQQILSLEPCFYFGNLNKRALAGPSLVQDDTAFVPTPVDTMTISLPTYVEQIRDKLAENIHEMWAMNKIEAGWMYGDQRDDIHKIHPCLVPFERLPPAEKRYDIQLAVQTLKTILALGYYITLDKPPARIRNVRLPNEPFLQSNGYKPAPLDLGAVTLTPKMDELVDQLAENTHNLWARERIQQGWTYGLNEDPEMHRSPHLVPYPKVDDAIKKANRDTASETVRTLLVYGYNLDPPTGEQHEALLAEASKQKQADFRTYRAEKNYAVSSGKWYFEFEILTAGPMRVGWAHADMAPGMMLGQDENSWAFDGYNCLKLHGGTSDAFGIQLKVGDIVGCFLDVVDQTISESMA

Description

Intracellular calcium channel that is required for proper muscle function during embryonic development and may be essential for excitation-contraction coupling in larval body wall muscles.

Subunit

Homotetramer.

Miscellaneous

Channel activity is modulated by the alkaloid ryanodine that binds to the open Ca-release channel with high affinity and maintains the channel in an open conformation. The calcium release channel is modulated by calcium ions, magnesium ions, ATP and calmodulin (By similarity).

Similarity

Belongs to the ryanodine receptor (TC 1.A.3.1) family.

Keywords

Alternative splicing   Calcium   Calcium channel   Calcium transport   Complete proteome   Developmental protein   Ion channel   Ion transport   Ligand-gated ion channel   Membrane   Phosphoprotein   Receptor   Reference proteome   Repeat   Sarcoplasmic reticulum   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Ryanodine receptor
splice variant  In isoform C and isoform D.

Uniprot

I3VR31   H9CNL0   A0A0P0QM12   A0A2Z4EVR6   A0A0P0QLR0   A0A0P0QLT4   + More
V5RE97   A0A2A4JFR2   A0A212F8V6   A0A194QMY4   A0A0N7JQQ1   I6ZY07   M4T4G3   A0A2Z5BST2   A0A0P0QM17   A0A164LU87   I1XB02   A0A059XRP6   A0A059XMJ0   I3VR34   A0A059XHF1   A0A0E3XBL1   A0A2H4QGA9   A0A0H4P5L6   A0A0P0QM39   A0A0P0QM29   A0A1J0I9Q3   A0A0P0QLU2   A0A0S1Z233   A0A2H4QG92   A0A0P0QM31   X2GG79   A0A089FYX0   A0A0P0QLS4   G8IJI2   K7W8M2   G8EME4   G8EME3   I3NWV8   I3VR32   R9R5D5   A0A2A4JFT6   A0A097P7A6   A0A139WKL1   D6WF72   A0A158P0A3   A0A088AV96   A0A2A3ESZ8   A0A151IVU0   E2BZJ9   A0A195FCN9   A0A151K2J5   A0A195B655   A0A3L8D605   A0A059XRQ0   U3PWV7   A0A059XRL5   A0A023NE85   I3VR35   A0A059XLU6   A0A1I8MDA4   A0A1I8MDA1   A0A1I8MD94   A0A1I8MD98   A0A1I8MDB0   A0A026W7Q8   A0A1I8MD97   A0A0L0BUZ9   A0A1I8P9D0   A0A1I8P9K7   A0A1I8P9E0   A0A1I8P9D4   A0A1I8P9D5   A0A1I8MDA2   A0A1I8MDA3   A0A1I8MD99   A0A1I8MDA9   A0A1I8MD93   A0A023NEE5   A0A0Q9WXJ7   A0A1I8MDA6   B4MK53   A0A1I8MDB1   A0A0Q9X8Q5   A0A0Q9XKI2   A0A0R1DUL1   A0A0Q9XIC2   A0A0Q9X8Q4   A0A0R1DMA2   A0A0R1DTC6   A0A0R1DTS7   A0A0Q9X8P8   A0A0B4K715   A0A0R1DM53   B4P3C9   Q24498   Q24498-3   A0A0B4K7K0   A0A0B4K7U9   A0A1W4UJL1  

Pubmed

29891375    24267694    22118469    26354079    23603125    24098400    + More
29626986    22567170    27845250    22982600    22761165    29191465    23010195    25330781    18362917    19820115    21347285    20798317    30249741    24607641    25315136    24508170    26108605    24485316    17994087    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    8276118    1338312    10811919    18327897   

EMBL

JQ769302    AFK84955.1    JQ354988    AFC36359.1    KR815505    ALL55471.1    + More
MG712298    AWV67093.1    KR815501    ALL55467.1    KR815506    ALL55472.1    KF641862    AHB33498.1    NWSH01001744    PCG70263.1    AGBW02009672    OWR50158.1    KQ458859    KPJ04841.1    KR815502    ALL55468.1    JX082287    AFN70719.1    KC355370    AGH68757.1    MF623806    AXA98483.1    KR815499    ALL55465.1    KR088972    AMN82804.1    JQ799046    AFI80904.1    KJ573633    AIA23854.1    KJ573634    AIA23855.1    JQ769305    AFK84958.1    KJ573635    AIA23856.1    KP213290    AKC03558.2    MG013971    ATX64238.1    KP721560    AKP49172.1    KR815507    ALL55473.1    KR815503    ALL55469.1    KX519762    APC65631.1    KR815504    ALL55470.1    KT029915    ALM96708.1    MG013970    ATX64237.1    KR815498    ALL55464.1    KJ135037    AHN16453.1    KM034750    AIP90097.1    KR815500    ALL55466.1    JN801028    AET09964.1    JX467684    AFW97408.1    JF926694    AER25355.1    JF926693    AER25354.1    JF927788    AEI91094.1    JQ769303    AFK84956.1    JX481776    AGI62938.1    PCG70262.1    KM216386    AIU40166.1    KQ971327    KYB28433.1    EEZ99829.2    ADTU01004756    ADTU01004757    KZ288192    PBC34336.1    KQ980881    KYN11971.1    GL451627    EFN78897.1    KQ981685    KYN37967.1    LKEX01025115    KYN50349.1    KQ976587    KYM79740.1    QOIP01000012    RLU15601.1    KJ573638    AIA23859.1    KF306296    AGW82429.1    KJ573637    AIA23858.1    KF734670    AHW99830.1    JQ769306    AFK84959.1    KJ573636    AIA23857.1    KK107353    EZA52107.1    JRES01001421    KNC23059.1    KF734669    AHW99829.1    CH963846    KRF97582.1    EDW72492.2    CH933808    KRG04800.1    KRG04791.1    CM000157    KRJ98422.1    KRG04786.1    KRG04790.1    KRJ98394.1    KRJ98400.1    KRJ98403.1    KRG04795.1    AE013599    AFH07961.1    KRJ98399.1    EDW89402.1    D17389    Z18536    AAF59036.2    AFH07963.1    AFH07964.1   

Proteomes

UP000218220    UP000007151    UP000053268    UP000007266    UP000005205    UP000005203    + More
UP000242457    UP000078492    UP000008237    UP000078541    UP000078542    UP000078540    UP000279307    UP000095301    UP000053097    UP000037069    UP000095300    UP000007798    UP000009192    UP000002282    UP000000803    UP000192221   

PRIDE

Q24498   

Pfam

PF08709   Ins145_P3_rec        + More
PF02026   RyR
PF00622   SPRY
PF08454   RIH_assoc
PF02815   MIR
PF01365   RYDR_ITPR
PF00520   Ion_trans
PF06459   RR_TM4-6

Interpro

IPR003877   SPRY_dom        + More
IPR013333   Ryan_recept       
IPR003032   Ryanodine_rcpt       
IPR016093   MIR_motif       
IPR035761   SPRY1_RyR       
IPR036300   MIR_dom_sf       
IPR001870   B30.2/SPRY       
IPR013662   RIH_assoc-dom       
IPR000699   RIH_dom       
IPR014821   Ins145_P3_rcpt       
IPR011992   EF-hand-dom_pair       
IPR035762   SPRY3_RyR       
IPR013320   ConA-like_dom_sf       
IPR035910   RyR/IP3R_RIH_dom_sf       
IPR009460   Ryanrecept_TM4-6       
IPR035764   SPRY2_RyR       
IPR005821   Ion_trans_dom       
IPR018247   EF_Hand_1_Ca_BS       
IPR002048   EF_hand_dom       
IPR016024   ARM-type_fold       

SUPFAM

SSF47473   SSF47473        + More
SSF82109   SSF82109       
SSF49899   SSF49899       
SSF100909   SSF100909       
SSF48371   SSF48371       

CDD

cd12877  SPRY1_RyR
cd12879  SPRY3_RyR
cd12878  SPRY2_RyR

ProteinModelPortal

I3VR31   H9CNL0   A0A0P0QM12   A0A2Z4EVR6   A0A0P0QLR0   A0A0P0QLT4   + More
V5RE97   A0A2A4JFR2   A0A212F8V6   A0A194QMY4   A0A0N7JQQ1   I6ZY07   M4T4G3   A0A2Z5BST2   A0A0P0QM17   A0A164LU87   I1XB02   A0A059XRP6   A0A059XMJ0   I3VR34   A0A059XHF1   A0A0E3XBL1   A0A2H4QGA9   A0A0H4P5L6   A0A0P0QM39   A0A0P0QM29   A0A1J0I9Q3   A0A0P0QLU2   A0A0S1Z233   A0A2H4QG92   A0A0P0QM31   X2GG79   A0A089FYX0   A0A0P0QLS4   G8IJI2   K7W8M2   G8EME4   G8EME3   I3NWV8   I3VR32   R9R5D5   A0A2A4JFT6   A0A097P7A6   A0A139WKL1   D6WF72   A0A158P0A3   A0A088AV96   A0A2A3ESZ8   A0A151IVU0   E2BZJ9   A0A195FCN9   A0A151K2J5   A0A195B655   A0A3L8D605   A0A059XRQ0   U3PWV7   A0A059XRL5   A0A023NE85   I3VR35   A0A059XLU6   A0A1I8MDA4   A0A1I8MDA1   A0A1I8MD94   A0A1I8MD98   A0A1I8MDB0   A0A026W7Q8   A0A1I8MD97   A0A0L0BUZ9   A0A1I8P9D0   A0A1I8P9K7   A0A1I8P9E0   A0A1I8P9D4   A0A1I8P9D5   A0A1I8MDA2   A0A1I8MDA3   A0A1I8MD99   A0A1I8MDA9   A0A1I8MD93   A0A023NEE5   A0A0Q9WXJ7   A0A1I8MDA6   B4MK53   A0A1I8MDB1   A0A0Q9X8Q5   A0A0Q9XKI2   A0A0R1DUL1   A0A0Q9XIC2   A0A0Q9X8Q4   A0A0R1DMA2   A0A0R1DTC6   A0A0R1DTS7   A0A0Q9X8P8   A0A0B4K715   A0A0R1DM53   B4P3C9   Q24498   Q24498-3   A0A0B4K7K0   A0A0B4K7U9   A0A1W4UJL1  

PDB

5GOA     E-value=0,     Score=3099

KEGG

101739070    K04962 ryanodine receptor 2 | (RefSeq) ryanodine receptor 44F

GO

GO:0016020   GO:0005219   GO:0005623   GO:0016021   GO:0005509   GO:0034704   GO:0072347   GO:0048763   GO:0033017   GO:0006816   GO:0005886   GO:0042383   GO:0030659   GO:0060047   GO:0035206   GO:0030018   GO:0051209   GO:0006936   GO:0005790   GO:0007275   GO:0005515   GO:0005262   GO:0005507   GO:0004713   GO:0016491   GO:0015930   GO:0070588  

Subcellular location

Sarcoplasmic reticulum membrane   The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic.   With evidence from 1 publications.
Membrane   The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic.   With evidence from 1 publications.

Length:

1152

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03627

Exp number, first 60 AAs:

7e-05

Total prob of N-in:

0.00020

outside

1  -  1152

 

 

Pi

212.910035

Theta

20.093291

Tajima's D

0.181077

CLR

1.152531

CSRT

0.429728513574321

Interpretation

Uncertain