Gene

KWMTBOMO14364

Annotation

PREDICTED:_THAP_domain-containing_protein_1-like_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr24(+):3652267-3655660      View in EpiBrowser

Full name

THAP domain-containing protein 1 A       + More
THAP domain-containing protein 1      
THAP domain-containing protein 1 B      

Transcription factor

THAP

Location in the cell

Nuclear   Reliability : 2.668

CDS

ATGTACCTTTGTGATGATGCAAGAACTAACTGGATCCCAAGAAATGAGAGTAGAAAGAAAAAGTGGCTGGAAGCCATTAGAATGGAAAATATAAAGTCAAATGTAAAAGATGTTTATATTTGCTCGCGACATTTTGATGATAAATGTTTCAACAAAACTATGGATGTGATTCGACTACGAGATGATGCCGTGCCCTCGAAATTTACTGGCCTCCCACGGAATCCTGCTCCTGTTCCTATTTCTGAAACTTCAGAAGCTGCAACATCAGCACTCCCCATGACGACGACTGCCGTGTGTACTGCTTCTTTTGCTTCTGTCCCTGGCACCTCAGGAGTGGATAATCTACTGATCCAAACGCATAAAATAAAAAAACTTGAAGATAAATGTGATTTCTTAAGGAAGAAAGTAAAAAGACTACATGAAACAGTGCGGCGGCAAAAGATAAAAATTGTACAGTTCGAGAACATTATAAAATATATAATACAGAAAAAGCCTACAGGAAAGAACTGCCTGGCTTAA

Protein

MYLCDDARTNWIPRNESRKKKWLEAIRMENIKSNVKDVYICSRHFDDKCFNKTMDVIRLRDDAVPSKFTGLPRNPAPVPISETSEAATSALPMTTTAVCTASFASVPGTSGVDNLLIQTHKIKKLEDKCDFLRKKVKRLHETVRRQKIKIVQFENIIKYIIQKKPTGKNCLA

Description

DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes (By similarity).

Similarity

Belongs to the THAP1 family.

Keywords

Cell cycle   Coiled coil   DNA-binding   Metal-binding   Nucleus   Transcription   Transcription regulation   Zinc   Zinc-finger   Complete proteome   Reference proteome  

Feature

chain  THAP domain-containing protein 1 A

Uniprot

A0A194R2I1   A0A2A4JJP3   A0A2A4JJZ8   A0A1E1VY77   A0A3S2L5H9   A0A2H1X329   + More
A0A3S2PFD8   V9LHM9   A0A3P9A402   A0A1L8HXK5   Q5U560   Q6DIN8   A0A3Q0S040   A0A3Q4BAR6   W5NKS9   A0A2R5LNH2   Q6DDT6   A0A2Y9MX99   A0A2Y9NCU0   A0A2Y9TE72   A0A2U4A776   A0A2U4A774   A0A2U3V8C4   A0A2Y9FMX6   A0A341D1E5   A0A340X2H6   A0A2Y9N1M7   A0A2U4A801   A0A3B3Q252   A0A0C9RAV4   A0A341D423   A0A2Y9MX95   A0A2U4A768   A0A3B5AJQ2   A0A3B4CYV4   A0A1S2X2H6   B5XCB8   H2ZSE9   A0A3P8U4R3   A0A1L8H8F0   H3A877   A0A3N0Z627   A0A146NPS1   A0A3Q3IP85   A0A3Q3IGH5   A0A2I4D607   A0A3Q2GHV8   A0A3Q1C3Q8   H9GAH5   A0A2I4D624   Q1JPT7   A0A3Q2R051   A0A3Q1GB10   A0A060YSL4   G3Q340   A0A0Q3QYI7   A0A1A8UES3   A0A1A8KLG0   A0A3Q2XPX6   A0A3Q1HT45   G1SFB6   A0A1A8GXT2   A0A1A8MZG3   A0A1A8RPW1   A0A1A8I102   A0A1A8CDL3   A0A1A7ZBU7   A0A1A8FYN8   A0A3B1IRS6   K9IGL5   H3A2K5  

Pubmed

26354079    24402279    25069045    27762356    29240929    20433749    + More
9215903    21881562    24755649    21993624    25329095   

EMBL

KQ460845    KPJ11998.1    NWSH01001223    PCG72049.1    PCG72048.1    GDQN01011361    + More
GDQN01001966    GDQN01001730    JAT79693.1    JAT89088.1    JAT89324.1    RSAL01000137    RVE46193.1    ODYU01013029    SOQ59648.1    RSAL01000057    RVE49849.1    JW879913    AFP12430.1    CM004466    OCU00880.1    BC084824    CR762254    BC075499    AHAT01029872    GGLE01006913    MBY11039.1    BC077429    GBYB01013614    JAG83381.1    BT048687    AFYH01260805    AFYH01260806    CM004469    OCT92316.1    AFYH01190313    AFYH01190314    AFYH01190315    AFYH01190316    AFYH01190317    RJVU01007700    ROL53896.1    GCES01152499    JAQ33823.1    AAWZ02025447    EH532428    BC116602    FR913288    CDQ92454.1    LMAW01002684    KQK78185.1    HADY01018780    HAEJ01006148    SBS46605.1    HAEE01012454    SBR32504.1    HAEC01007192    SBQ75330.1    HAEF01021084    HAEG01013962    SBR62243.1    HAEH01018679    SBS08066.1    HAED01003573    SBQ89556.1    HADZ01012904    SBP76845.1    HADY01001599    SBP40084.1    HAEB01016692    SBQ63219.1    GABZ01007895    JAA45630.1    AFYH01256584   

Proteomes

UP000053240    UP000218220    UP000283053    UP000265140    UP000186698    UP000008143    + More
UP000261340    UP000261620    UP000018468    UP000248483    UP000245320    UP000248484    UP000252040    UP000265300    UP000261540    UP000261400    UP000261440    UP000087266    UP000008672    UP000265080    UP000261600    UP000192220    UP000265020    UP000257160    UP000001646    UP000000437    UP000265000    UP000257200    UP000193380    UP000007635    UP000051836    UP000264820    UP000265040    UP000001811    UP000018467   

PRIDE

Q6DIN8    B5XCB8    Q1JPT7   

Pfam

PF05485   THAP        + More
PF12017   Tnp_P_element

Interpro

IPR038441   THAP_Znf_sf        + More
IPR006612   THAP_Znf       
IPR021896   Transposase_37       
IPR026521   THAP2       
IPR026516   THAP1       
IPR014727   TopoI_cat_a/b-sub_euk       

Gene 3D

3.30.40.180     1.10.132.10    

ProteinModelPortal

A0A194R2I1   A0A2A4JJP3   A0A2A4JJZ8   A0A1E1VY77   A0A3S2L5H9   A0A2H1X329   + More
A0A3S2PFD8   V9LHM9   A0A3P9A402   A0A1L8HXK5   Q5U560   Q6DIN8   A0A3Q0S040   A0A3Q4BAR6   W5NKS9   A0A2R5LNH2   Q6DDT6   A0A2Y9MX99   A0A2Y9NCU0   A0A2Y9TE72   A0A2U4A776   A0A2U4A774   A0A2U3V8C4   A0A2Y9FMX6   A0A341D1E5   A0A340X2H6   A0A2Y9N1M7   A0A2U4A801   A0A3B3Q252   A0A0C9RAV4   A0A341D423   A0A2Y9MX95   A0A2U4A768   A0A3B5AJQ2   A0A3B4CYV4   A0A1S2X2H6   B5XCB8   H2ZSE9   A0A3P8U4R3   A0A1L8H8F0   H3A877   A0A3N0Z627   A0A146NPS1   A0A3Q3IP85   A0A3Q3IGH5   A0A2I4D607   A0A3Q2GHV8   A0A3Q1C3Q8   H9GAH5   A0A2I4D624   Q1JPT7   A0A3Q2R051   A0A3Q1GB10   A0A060YSL4   G3Q340   A0A0Q3QYI7   A0A1A8UES3   A0A1A8KLG0   A0A3Q2XPX6   A0A3Q1HT45   G1SFB6   A0A1A8GXT2   A0A1A8MZG3   A0A1A8RPW1   A0A1A8I102   A0A1A8CDL3   A0A1A7ZBU7   A0A1A8FYN8   A0A3B1IRS6   K9IGL5   H3A2K5  

PDB

2D8R     E-value=1.17058e-05,     Score=112

KEGG

101737340    K23203 THAP domain-containing protein 1/3 | (RefSeq) THAP domain-containing protein 1-like

GO

GO:0003677   GO:0006313   GO:0004803   GO:0043565   GO:0046872   GO:0005654   GO:0007049   GO:0006351   GO:0008270   GO:0000122   GO:0001935   GO:0042803   GO:0001650   GO:0007346   GO:0000978   GO:0003917   GO:0005694   GO:0006265   GO:0003676   GO:0006072   GO:0005975   GO:0016773   GO:0005488   GO:0005507   GO:0004713   GO:0016491   GO:0015930  

PANTHER

PTHR47696   PTHR46600:SF1   PTHR46600:SF3  

Subcellular location

  

Length:

172

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.05572

Exp number, first 60 AAs:

0

Total prob of N-in:

0.33536

outside

1  -  172

 

 

Pi

275.902379

Theta

210.242034

Tajima's D

0.896835

CLR

0.000011

CSRT

0.629318534073296

Interpretation

Uncertain