Gene

KWMTBOMO14352  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008203

Annotation

PREDICTED:_prostamide/prostaglandin_F_synthase-like_[Amyelois_transitella]

Location

Bomo_Chr24(+):2803310-2816238      View in EpiBrowser

Full name

Prostamide/prostaglandin F synthase      

Alternative Name

Peroxiredoxin-like 2B
Protein FAM213B

Location in the cell

Cytoplasmic   Reliability : 1.931

CDS

ATGTCTCCGGATATTAATCAGATCGGTACGCAAAAAGTGAGAAACGTTTCCAGTGGCGAAGTTTTAGAATTGAAGAGCTTCTGGGAGCAACAGAATGTGGCTATTGTATTCTTTCGTCGCTGGGGTTGCATGTTTTGTAGGCTCTGGGCTAAAGAGTTGAGCGAAATAGCGCCTATTCTCAAGCAGCACAACATCAAACTTGTCGGGGTTGGCGTCGAAGAGGCCGGATCCAAGGAGTTCAGCGAAGGAAAGTTTTTCGATGGAGATCTGTATTACGTCGAGAACATTTCAACTTACCAACAGTTGGGTTTTAAAAGGTTCAATGTTTTAACTATTTTAACTTCGCTGCTATGGAAGCAATCACGTGACGCCATTTCGAAAGGAAAAGCCATGGGCTTAAGTGGCGACATGAAGGGAGATTGGGTTCAAGTGGGTGGCGCCGCTCTGGTAGAAAAGGGCGGGAACTTGCTCCGCCATTTTGTGCAAACCGGACCGGCGGATCATCTGTCTAATTTGGAGATTTTGAAGCAATTCGGTTTGGAAAATGAGTACAAAAAAGATGCGGAGAACGAAAAGAATTCGAAGAAAAACGAAGACACCACAGAGACAGAAAAAGAGTAA

Protein

MSPDINQIGTQKVRNVSSGEVLELKSFWEQQNVAIVFFRRWGCMFCRLWAKELSEIAPILKQHNIKLVGVGVEEAGSKEFSEGKFFDGDLYYVENISTYQQLGFKRFNVLTILTSLLWKQSRDAISKGKAMGLSGDMKGDWVQVGGAALVEKGGNLLRHFVQTGPADHLSNLEILKQFGLENEYKKDAENEKNSKKNEDTTETEKE

Description

Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha).
Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity).

Catalytic Activity

[thioredoxin]-dithiol + prostaglandin H2 = [thioredoxin]-disulfide + prostaglandin F2alpha
[thioredoxin]-disulfide + prostamide F2alpha = [thioredoxin]-dithiol + prostamide H2

Biophysicochemical Properties

0.0076 mM for prostamide H(2)
0.0069 mM for prostaglandin H(2)

Similarity

Belongs to the peroxiredoxin-like PRXL2 family. Prostamide/prostaglandin F synthase subfamily.

Keywords

Complete proteome   Cytoplasm   Fatty acid biosynthesis   Fatty acid metabolism   Lipid biosynthesis   Lipid metabolism   NADP   Oxidoreductase   Phosphoprotein   Prostaglandin biosynthesis   Prostaglandin metabolism   Reference proteome   Alternative splicing  

Feature

chain  Prostamide/prostaglandin F synthase
splice variant  In isoform 3 and isoform 6.

Uniprot

H9JFA6   A0A2W1BDD1   A0A194Q702   A0A1E1WCC6   I4DR63   A0A3S2PFG0   + More
A0A212EJ08   A0A0N0PDA8   A0A1B6D4E4   A0A2H1WBS8   A0A1B6M9A7   A0A1B6EYU7   A0A1B6JQX3   F6ZXR1   A0A250YBW7   C3ZVQ0   A0A1S3A5B3   A0A3B4ZMU3   Q9DB60   A0A1S3WJN1   H0WBZ1   G3TNZ7   A0A340WPL8   A0A2Y9SXY0   Q28IJ3   A0A2Y9DZS0   D3ZVR7   A0A2Y9Q9B4   A0A2J8URL9   A0A3P9AP83   A0A2Y9QFP9   H0XJV3   Q8TBF2   A0A2P0CTB1   A0A3Q1BTG3   A0A3Q1GKI4   A0A2K6CY94   A0A2K5MX57   A0A1B1V5U4   A9CQL8   A0A1U7R4K1   H2PXV2   L8YGP9   Q6NV24   F1QSW9   F7G9T2   A0A2I3RSW9   W5M990   Q5R7S9   A0A2K5WTM5   G3IFJ9   A0A3P8X663   A0A3P8S336   A0A140T841   Q58CY6   A0A3Q3GM42   A0A2Y9H5R5   M3WXY8   A0A1L8FMM1   E6ZFD0   Q6AZG8   A0A3Q7SY94   K7F8H6   G9L3X6   G1M3W1   M3Y824   A0A3P9NFK6   A0A3B4WL33   A0A3P9NFR9   A0A0D9S8V1   A0A1S3P2L7   B5X9L9   H3BI27   A0A3P4M0C4   A0A3B4WW83   A0A087Y8D4   A0A1A8GDV6   A0A1A8C0J3   A0A1A8V6K5   A0A3B4UQL3   W4YIU2   A0A060WEU3   A0A384DGN9   A0A2Y9KFW8   A0A2U3XLX2   A0A1A8QGQ2   A0A1A8KWE0   A0A1A8N088   A0A3B3YQU0   A0A3P9I499   E2QXW7   A0A0E9X3R6   A0A2U9BF24   A0A2U3WFJ1   A0A3B4C9G3   A0A3B4GQT0   A0A3P8Q1F7   A0A3P9C9S6  

EC Number

1.11.1.20

Pubmed

19121390    28756777    26354079    22651552    22118469    17495919    + More
28087693    18563158    16141072    19468303    15489334    18006499    21183079    20950588    21993624    25069045    14702039    16710414    23186163    16136131    23385571    23594743    17431167    21804562    29704459    24487278    19393038    16305752    17975172    27762356    17381049    23236062    20010809    20433749    9215903    24755649    24813606    17554307    16341006    25613341    25186727   

EMBL

BABH01027029    BABH01027030    KZ150334    PZC71337.1    KQ459386    KPJ01159.1    + More
GDQN01006428    JAT84626.1    AK404961    BAM20403.1    RSAL01000055    RVE49907.1    AGBW02014547    OWR41450.1    KQ460254    KPJ16341.1    GEDC01016853    JAS20445.1    ODYU01007591    SOQ50497.1    GEBQ01029007    GEBQ01028018    GEBQ01022495    GEBQ01011608    GEBQ01007478    JAT10970.1    JAT11959.1    JAT17482.1    JAT28369.1    JAT32499.1    GECZ01026553    JAS43216.1    GECU01028505    GECU01006062    JAS79201.1    JAT01645.1    GFFW01003657    JAV41131.1    GG666691    EEN43392.1    AK005188    AL607032    BC030453    AAKN02055852    CR760360    CH473968    NDHI03003447    PNJ47890.1    AAQR03101132    AK057027    AK075273    AK291908    AK298926    AK303504    AK316243    AF425266    AL139246    CH471183    BC022547    KX444503    ANW12370.1    AB329665    AACZ04062807    GABD01005988    NBAG03000385    JAA27112.1    PNI31418.1    KB359209    ELV14245.1    BC068342    AL954137    JSUE03000068    AHAT01009756    AHAT01009757    CR860030    AQIA01006217    JH002406    RAZU01000081    EGW13170.1    RLQ74836.1    BT021811    BC114900    AANG04003082    CM004478    OCT72846.1    FQ310506    CBN80880.1    BC078028    AGCU01097725    JP023260    AES11858.1    ACTA01020114    AEYP01070627    AEYP01070628    AQIB01136152    BT047738    AFYH01000508    AFYH01000509    AFYH01000510    AFYH01000511    CYRY02004139    VCW68671.1    AYCK01000386    HAEB01021366    HAEC01001853    SBQ69930.1    HADZ01008440    HAEA01015856    SBP72381.1    HADY01016334    HAEJ01014979    SBS55436.1    AAGJ04047665    FR904518    CDQ65788.1    HAEH01011469    HAEI01014218    SBR92309.1    HAED01017636    HAEE01016672    SBR36722.1    HAEF01021344    HAEG01006332    SBR62503.1    AAEX03003869    GBXM01011451    JAH97126.1    CP026248    AWP02605.1   

Proteomes

UP000005204    UP000053268    UP000283053    UP000007151    UP000053240    UP000002280    + More
UP000001554    UP000079721    UP000261400    UP000000589    UP000005447    UP000007646    UP000265300    UP000248484    UP000008143    UP000248480    UP000002494    UP000248483    UP000265140    UP000005225    UP000005640    UP000257160    UP000257200    UP000233120    UP000233060    UP000008227    UP000189706    UP000002277    UP000011518    UP000000437    UP000006718    UP000018468    UP000001595    UP000233100    UP000001075    UP000273346    UP000265120    UP000265080    UP000009136    UP000261660    UP000248481    UP000011712    UP000186698    UP000286640    UP000007267    UP000008912    UP000000715    UP000242638    UP000261360    UP000029965    UP000087266    UP000008672    UP000028760    UP000261420    UP000007110    UP000193380    UP000261680    UP000291021    UP000248482    UP000245341    UP000261480    UP000265200    UP000002254    UP000246464    UP000245340    UP000261440    UP000261460    UP000265100    UP000265160   

PRIDE

H9JFA6    Q9DB60    D3ZVR7    Q8TBF2    A9CQL8    G3IFJ9    + More
Q58CY6   

Pfam

PF13911   AhpC-TSA_2        + More
PF16042   DUF4794

Interpro

IPR032801   PXL2A/B/C        + More
IPR036249   Thioredoxin-like_sf       
IPR032011   DUF4794       
IPR013766   Thioredoxin_domain       

SUPFAM

SSF52833   SSF52833       

ProteinModelPortal

H9JFA6   A0A2W1BDD1   A0A194Q702   A0A1E1WCC6   I4DR63   A0A3S2PFG0   + More
A0A212EJ08   A0A0N0PDA8   A0A1B6D4E4   A0A2H1WBS8   A0A1B6M9A7   A0A1B6EYU7   A0A1B6JQX3   F6ZXR1   A0A250YBW7   C3ZVQ0   A0A1S3A5B3   A0A3B4ZMU3   Q9DB60   A0A1S3WJN1   H0WBZ1   G3TNZ7   A0A340WPL8   A0A2Y9SXY0   Q28IJ3   A0A2Y9DZS0   D3ZVR7   A0A2Y9Q9B4   A0A2J8URL9   A0A3P9AP83   A0A2Y9QFP9   H0XJV3   Q8TBF2   A0A2P0CTB1   A0A3Q1BTG3   A0A3Q1GKI4   A0A2K6CY94   A0A2K5MX57   A0A1B1V5U4   A9CQL8   A0A1U7R4K1   H2PXV2   L8YGP9   Q6NV24   F1QSW9   F7G9T2   A0A2I3RSW9   W5M990   Q5R7S9   A0A2K5WTM5   G3IFJ9   A0A3P8X663   A0A3P8S336   A0A140T841   Q58CY6   A0A3Q3GM42   A0A2Y9H5R5   M3WXY8   A0A1L8FMM1   E6ZFD0   Q6AZG8   A0A3Q7SY94   K7F8H6   G9L3X6   G1M3W1   M3Y824   A0A3P9NFK6   A0A3B4WL33   A0A3P9NFR9   A0A0D9S8V1   A0A1S3P2L7   B5X9L9   H3BI27   A0A3P4M0C4   A0A3B4WW83   A0A087Y8D4   A0A1A8GDV6   A0A1A8C0J3   A0A1A8V6K5   A0A3B4UQL3   W4YIU2   A0A060WEU3   A0A384DGN9   A0A2Y9KFW8   A0A2U3XLX2   A0A1A8QGQ2   A0A1A8KWE0   A0A1A8N088   A0A3B3YQU0   A0A3P9I499   E2QXW7   A0A0E9X3R6   A0A2U9BF24   A0A2U3WFJ1   A0A3B4C9G3   A0A3B4GQT0   A0A3P8Q1F7   A0A3P9C9S6  

PDB

4DZA     E-value=0.0875019,     Score=80

KEGG

101742192    K15717 prostamide/prostaglandin F2alpha synthase [EC:1.11.1.20] | (RefSeq) prostamide/prostaglandin

PATHWAY

00590    Arachidonic acid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0055114   GO:0045454   GO:0005623   GO:0016209   GO:0043209   GO:0001516   GO:0005829   GO:0005783   GO:0047017   GO:0016616   GO:0005737   GO:0008379   GO:0070062   GO:0004601  

PANTHER

PTHR28630  

Subcellular location

  

Length:

206

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00919999999999998

Exp number, first 60 AAs:

0.00135

Total prob of N-in:

0.07060

outside

1  -  206

 

 

Pi

224.439652

Theta

153.077834

Tajima's D

1.344527

CLR

0.741621

CSRT

0.754162291885406

Interpretation

Uncertain