Gene

KWMTBOMO14347

Pre Gene Modal

BGIBMGA008124

Annotation

PREDICTED:_serine/threonine-protein_kinase_Genghis_Khan_[Bombyx_mori]

Location

Bomo_Chr24(-):2664966-2734589      View in EpiBrowser

Full name

Non-specific serine/threonine protein kinase      

Location in the cell

Nuclear   Reliability : 2.82

CDS

ATGTTCACGTCCCGTCGTCTCCAAGGTCCGAGAGCTCACACGTTAAGCGTCGAGACCCTGCTGGACGTCCTCTTGGTGTTGTACGACGAATGCTGTAACAGTTCCCTCAGAAGAGAAAAGGCAGTAGCCGATTTTATCCACTATGTGAAACCGGTGGCGACTGCTTTAAAACGTCTGCGATTGTCAAGGGACGACTTCGAGCTGGTGAAGGTCATAGGGCGCGGCGCCTTCGGTGAGGTGTGCGTGGTGCGAGCGTCGTTCATACAGGGTGGAGACGGTGGTGCTCCCGGCGCCGCCGCGGCCGGCGACAGGGTGTACGCCATGAAGATATTAAACAAATGGGAGATGTTGAAGAGGGCGGAAACGGCGTGTTTTCAAGAAGAAAGAGACGTCTTAGTTTTCGGCGACAGGAGATGGATCACGAATCTACACTACGCTTTCCAAGATGAACACAATCTGTACCTCGTGATGGACTACTACTGCGGCGGGGACCTGCTCACGTTGCTGTCCAAGTTCGAGGACCGGCTGCCGGAGGACATGGCCAAGTTCTACATCGCCGAGATGGTGCTGGCCATCCAGAGCGTGCACGAGCTGCGATACGTGCACAGAGATATCAAGCCGGACAACGTTCTGTTGGATGCAAGCGGTCACATCAGGCTGGCGGACTTCGGATCCTGTCTGAGGCTCGGCGATGATGGGAAGGTACAAAGCAACGTGGCTGTCGGCACGCCGGATTACATTTCACCGGAAATATTAAGAGCCATGGAGGATGGGCAGGGCAGGTACGGCCCGGAGTGCGACTGGTGGTCCTTGGGAGTGTGCATGTACGAGATGCTGTTCGGCGAGACCCCGTTCTACGCGGAGTCGCTGGTGGAGACCTACGGCAAGATCATGAACCACTCCAGGTCCTTCCAGTGTCCGCCGCCCGACGACCACGCCGCACAGGTGTCTGAAGAAGCCCAGGATCTCATTCGAAGGTTGATCTGCGGGTCGGAGAACAGACTCGGCAAGAACGGACTCCAAGACTTTAAGAGCCACCCCTGGTTCGGCGGCGTGGAGTGGGAGACGGTGCGCGAGGTGCAGGCCCCCTTCGTGCCGGACGTGTCCAGCCCCACGGACACCTCCAACTTCGACGTGGACGACACTGACGTCAGGTTGTCGGAGGCGGTGCCGCCGCCCCGCGCCAGCGCCGCGTTCTCCGGCGTGCACCTGCCCTTCGTGGGCTTCACGTACACGGGCGGCTCCGCGCTCAGCGACCTGGGCGCGCCCGCCCGCCCACTCAGCCCCGCCAAGAACGCCACCAGCCAGGCGCCGTCCAACGCCGGGGACCGCGCCGCCGTCAAAGCGCTCGAAAGGGAAAACGCGCTGTTGGCGCAGACCATAGCCGAGCTGCGGGCCGGGGGCGACGACCCCGCCAGCGACGAACTTATCACGCTGAAGGAGGAACTGGCGACGCTGTCCAAGAGGAACGCTGATCTCGAGGCGCAGTTGCGTTGTTACGAGCAGGTCGCGGTCTCAGCGGTCGGGCAGGATATTCCGTCAACGCCCCAGGATATGGCGGTTCGTTTGAGAGAAATGGAATTGATCGTTCAATCTCTGACCGCCGAGAAGGAGGAGCTCTTCAAAGAGCGGACTGACTCTATGGAAAAATTGAAACTTCAGGATAAGGAATTGAAGGATGCTATATCACAACGCAAGCTCGCCATGGCCGAATATAATGAGGTCACCGAGAGACTATCCGAGTTAAGACAGCAGAAGCAGAAATTGTCGCGGCAGGTCCGCGATAAAGAAGAAGAGTTGGAAGTGGCTATGCAGAAGATCGACGCGCTGCGCCAGGACATCAGGAGGGCGGACAAGGGGCGGCGGGAGCTGGAGGCGAGGCTGGACACGGCCATCGCTGAAGCCACCAAGGAACGTAAGCTGCGGGAGGAGTCCCTCCGCGGACAGCGCGCGGACGCCGCGGGAGGGACGGGCTCGACCGCCGACGTGGCGCGCCTGCAGGCCGAGGTCGAGGCTCTGGAGGTGCAGTACAAGGAGTCGCTGTCGCAGCAGCAGGCCCGCTTCGGCGCTGAGCTGGCCGCGCTCACCGAGCAGCTGCACGAGGGGGACGCGCTGCGCACCGTGCTCACCCGCGAGCTGCAGACCTCGAAGGAGAAGTTGGAGAATCGTCGTATGGAGCAGCTGAGCGACTCCGAGGACAGGCAGATGCTGATCAACGAGAACAGGAAGCTGGCCAAGGACCTGGACGCAATGGCGGAGAACGGTCGGCGCTGGCAGGCGGAGCGTCGCCAGATGGAGCTGGAGCTGGACGAGCTGCGGGCCAAGAGGGACACCATGCAGCACTGGGAGACACAGATAGCGGACATCATCCGGTGGGTGGCCGACGAGAAGGAGGCCCGGGGGTACCTCCAGGCGCTCGCCACTAAAATGACCGAAGAACTAGACTTCCTCAAGCACGCGAGTGTATCCCGTTCGTCGCCCGGCCCCCCGTCCCCCGCCGTGGGGGGGCCCGTGGGGGTGCCGGGGGGGGGCCCCGTGGGATCCCAAGCAGGGGGCGGCTGGAGGAACCGCCGCTCGCAGAAACTCGACAAGATGGAGATACTCACGCTGCAGTCCTCATTGCACTCTGAGATACAAGCCAAGCAGGTCGTCAGTGAAGAGCTCAGTCGAACCCGGGCGGAGTTACTAGCCAGCCAGAGGGAGTTACTGGAGACCCGTCAGCGCCTAGACTCGCTGGCGCACGATTTGAAGCGTAAGGAGCAGCACACGCGGGACCTCCAGGCCAGACTCGACGCCCCGCACGCCGCTGGCAACTCCTTCTTGGATCGTCCATCGTCACAGATGAGCTATCTTGATCAGTTCCTGAAGGAGGGTCCCGCGGAGAGGCACTACGACAACGTTGCGGCTATCAACGAACAAAAGCTAATGTACGGATCTCAGCAGTCGGGAGTATTGAGTGGCTCCGTTGAGTCTCAAGATGAAATGGAAGGTCCGAGAGCCTCCTCGCCGGCGTCCACGAAGAGCTCGCCCAGCGAGATGTCGACCGTTAGTCAATGTGACCCTTCGGCCGGGCCAGCCCTCCCCGGCAAGGAGAAGGTTCACCAGTTCCTCGTGAGAACGTTCAGCAGCCCCACCAAATGTAATCACTGCACGTCGTTGATGATCGGGCTGACGCGGCAGGGCGTGGTGTGCGAGCGCTGCGGCGTGGGCGTGCACGCGGCGTGCTGCGCGCTGCTGTGTGCGCGCTGCCCGCCGCCCGCGCGCGCGCGCCGCCCGCTCGGCATCGACCCCGCGCGGGGACAGGGGACCGCCTACGAGGGATACGTCAAGGTTCCGAAGCCGGGGGGAGTGAAGAAAGGTTGGATGCGGCAATTCGTAGTTGTATGTGATTTCAAATTGTTCCTGTACGACATATCACAAGATCGGAACGCTCTCCCGTCGGTCTGCGTGAGCCAGGTCCTCGACATGAGGGACCCTGAATTCAGCGTGACGTCAGTCAAGGATTCTGACGTCATACACGCCAGCAAACGGGACATACCCTGTATATTTAGGATATCGACGTCACAGATCGAGGGGGGCAAGCGCTCGCACACGCTCATGCTGGCAGAGTCCGACTCCGAGAAGACGAAGTGGGTGGTCGCGCTCAGCGAGCTGCACCGGATACTGAAGCGGAACAACCTGCCCGACAAATGTGTGTACAGCGCGTGCACGGTGGCGGACAGCGGCGCGGGCGCGGCGCTGCGGGGCGCGCTGTGCGCCTGCATCCTGGAGCGCACGCGGCTGTGCGTGGGCGGGGAGGCGGGGCTCGTGCTGCTGGACCTGGAGCGGGGCGAGCTCGTGCCCAAGCGGGGGCCGGCGCACGTGCACTCCGTGGTCTACGTGCCCAACGAGCAGCTGCTGGTTACAATTTCCGGTCGCGGTCGTCACGTGCGGCTGGTCCCCATTCGCGCGCTGGAGGCTGACGTGGACAGTGTCAAACTCCCCGAGACCAAGGGCGCGCTGACACTGGCAGCCGGCGCGACCAGAGCCGGCGCGTGCGGGTTCGCCGTTCTTTGCAAGAAACAGAACGCGTACATCGTGAACGTGTACGAGATAACGCGCACGGCGGCGCGCTGCGTGCGCATCGCGGAGCTGCGGGCGCCGTCCGCCGTGTACTGCGTGCAGCTGTCGGCCGCGCGCCTCGTGCTGGGGTACCGCGGCGGGTTCGCCAGCCACGCGCTGCCGCACCCGCGCCGCGACGCCGACCAGCCCGCGCGCAGTCTGGTGCATCCGGACAACCAGGTGAATCTGTTCCTGTCACACTCTGGCGCGCGGCCGCTGTGCTGCGCGGCGGTGGGCGGCTCCGGGGACACGCTGCTCGTGTTCAACACGCTCGCGCTGTACGTGGACCGGCACGGACACCGCGCGCGCGACGCCGAGCTCATGTACACGGCGCACCCCACGCACCACGCTATAAACGAGTCGCACCTCCTCATATTCACGCAAACACACATCGATATATACGACATCGAAACGAGCGAATGGGTGCAGACGATCAACATACCCAACGCCCGACCCCTGGACACGTCTGGCTGGCTGATCTGCGTGGGCGGCGGCAACAACGGCTTCCCCTTCTCTGGGGACGCCGCCCCCTACATCGTCTACCTGAAGCCGCTCATGAGCCAGGGTCCCCTGAATGCGGACTTGTTATCGTCGCGAACCGGCACCAGGCGACTAGCTGTGAGAGATCAGTCGCAGCACGCGCTAGACGCGCACACTCGACTTGCGGAGCGACGTTCCCGCCTGATCTCAGCCCCAACGAACTTCTCCCACGTGTCCCACATGGGGCCCGGCGACGGCATCCGCTCACAGAGGCTGCTCGACCTGCCCACCACATTGGAGACTGCAGACGAACAGCAGGCCTACAGCAGCAGGGAGAGCAGTAAGCGGACGTCTCCGCTGACGATATCGCACGGCACCGGCTCCTATAACGGTTCGTGGCGGGCGGCTCGCACGAAGGACGCGCCCCCCTCGCCGGTCCTGTCGCACCACCGGCCCATGGAGAGGTCCATAGGGGGAGGTTCGCAGGGGAGTGGCTCACTCCTCCTGGAGAGGTCCATAACGCCGCTGAGTCTGGGCAGCATGAGCTCCCTGCACGACGTGCTCAAGGTGGGGGCGGAGCTGGGGGAGGGCGCCCCGTCGGGGGACAGCAGCTGCGGCGCCTCGCCCCCCCACCCCGCGGACCCCTGA

Protein

MFTSRRLQGPRAHTLSVETLLDVLLVLYDECCNSSLRREKAVADFIHYVKPVATALKRLRLSRDDFELVKVIGRGAFGEVCVVRASFIQGGDGGAPGAAAAGDRVYAMKILNKWEMLKRAETACFQEERDVLVFGDRRWITNLHYAFQDEHNLYLVMDYYCGGDLLTLLSKFEDRLPEDMAKFYIAEMVLAIQSVHELRYVHRDIKPDNVLLDASGHIRLADFGSCLRLGDDGKVQSNVAVGTPDYISPEILRAMEDGQGRYGPECDWWSLGVCMYEMLFGETPFYAESLVETYGKIMNHSRSFQCPPPDDHAAQVSEEAQDLIRRLICGSENRLGKNGLQDFKSHPWFGGVEWETVREVQAPFVPDVSSPTDTSNFDVDDTDVRLSEAVPPPRASAAFSGVHLPFVGFTYTGGSALSDLGAPARPLSPAKNATSQAPSNAGDRAAVKALERENALLAQTIAELRAGGDDPASDELITLKEELATLSKRNADLEAQLRCYEQVAVSAVGQDIPSTPQDMAVRLREMELIVQSLTAEKEELFKERTDSMEKLKLQDKELKDAISQRKLAMAEYNEVTERLSELRQQKQKLSRQVRDKEEELEVAMQKIDALRQDIRRADKGRRELEARLDTAIAEATKERKLREESLRGQRADAAGGTGSTADVARLQAEVEALEVQYKESLSQQQARFGAELAALTEQLHEGDALRTVLTRELQTSKEKLENRRMEQLSDSEDRQMLINENRKLAKDLDAMAENGRRWQAERRQMELELDELRAKRDTMQHWETQIADIIRWVADEKEARGYLQALATKMTEELDFLKHASVSRSSPGPPSPAVGGPVGVPGGGPVGSQAGGGWRNRRSQKLDKMEILTLQSSLHSEIQAKQVVSEELSRTRAELLASQRELLETRQRLDSLAHDLKRKEQHTRDLQARLDAPHAAGNSFLDRPSSQMSYLDQFLKEGPAERHYDNVAAINEQKLMYGSQQSGVLSGSVESQDEMEGPRASSPASTKSSPSEMSTVSQCDPSAGPALPGKEKVHQFLVRTFSSPTKCNHCTSLMIGLTRQGVVCERCGVGVHAACCALLCARCPPPARARRPLGIDPARGQGTAYEGYVKVPKPGGVKKGWMRQFVVVCDFKLFLYDISQDRNALPSVCVSQVLDMRDPEFSVTSVKDSDVIHASKRDIPCIFRISTSQIEGGKRSHTLMLAESDSEKTKWVVALSELHRILKRNNLPDKCVYSACTVADSGAGAALRGALCACILERTRLCVGGEAGLVLLDLERGELVPKRGPAHVHSVVYVPNEQLLVTISGRGRHVRLVPIRALEADVDSVKLPETKGALTLAAGATRAGACGFAVLCKKQNAYIVNVYEITRTAARCVRIAELRAPSAVYCVQLSAARLVLGYRGGFASHALPHPRRDADQPARSLVHPDNQVNLFLSHSGARPLCCAAVGGSGDTLLVFNTLALYVDRHGHRARDAELMYTAHPTHHAINESHLLIFTQTHIDIYDIETSEWVQTINIPNARPLDTSGWLICVGGGNNGFPFSGDAAPYIVYLKPLMSQGPLNADLLSSRTGTRRLAVRDQSQHALDAHTRLAERRSRLISAPTNFSHVSHMGPGDGIRSQRLLDLPTTLETADEQQAYSSRESSKRTSPLTISHGTGSYNGSWRAARTKDAPPSPVLSHHRPMERSIGGGSQGSGSLLLERSITPLSLGSMSSLHDVLKVGAELGEGAPSGDSSCGASPPHPADP

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Similarity

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

Uniprot

A0A194Q6K8   A0A026WWL1   A0A0C9RXS8   E2BET6   A0A158NSR8   S6D9M9   + More
A0A154NXI7   E0W264   A0A1B6IWI0   A0A224X9H6   A0A023F3G7   D6W6E9   A0A1B6DQZ5   A0A1Y1K9C9   A0A1D2NL40   A0A1Y1KCF7   A0A212EJ03   A0A1I8PXQ8   A0A224YXW1   A0A131YW40   L7M965   A0A131XCY5   A0A2R5LLE3   V5HXS2   V5I4U7   A0A1E1XQT6   A0A131Y3B5   A0A3B3C6T1   A0A3B3DMF7   A0A1S3JW59   A0A3B3C6C0   A0A1V4JJ56   A0A3Q2UEY2   A0A3Q2U8G1   A0A1V4JKB6   A0A1V4JJ38   A0A3Q2U992   I3IY72   A0A2I4D2X4   A0A3Q2U4Y9   A0A3B4TRV3   A0A087SYK2   A0A3B4TQ89   A0A3B4TQQ1   A0A3Q2TYM8   A0A3Q3JY95   A0A3Q3KBE3   A0A3Q3LAH8   A0A3Q3LAG2   A0A3Q3R3V4   A0A3Q3LMB9   A0A3B3Q747   A0A3B3Q6Y5   A0A3B3Q7X9   A0A2K6PXV2   A0A3Q1I2T1   A0A3Q1HRJ7   A0A3B4C6J9   Q5TZ42   A0A2Y9DLE8   E1BP72   A0A3B4WEX7   A0A3Q3KZH9   A0A3Q3KYK8   A0A2K6KCD0  

EC Number

2.7.11.1

Pubmed

26354079    24508170    30249741    20798317    21347285    23938757    + More
20566863    25474469    18362917    19820115    28004739    27289101    22118469    28797301    26830274    25576852    28049606    25765539    29209593    29451363    15592404    25186727    29240929    25362486    23594743    19393038   

EMBL

KQ459386    KPJ01172.1    KK107078    QOIP01000011    EZA60465.1    RLU17139.1    + More
GBYB01012691    JAG82458.1    GL447857    EFN85802.1    ADTU01025036    ADTU01025037    HF586479    CCQ71366.1    KQ434778    KZC04323.1    DS235874    EEB19720.1    GECU01019140    GECU01016428    GECU01016088    JAS88566.1    JAS91278.1    JAS91618.1    GFTR01008872    JAW07554.1    GBBI01002834    JAC15878.1    KQ971319    EFA11391.2    GEDC01009207    JAS28091.1    GEZM01088582    JAV58082.1    LJIJ01000018    ODN05676.1    GEZM01088583    JAV58081.1    AGBW02014547    OWR41448.1    GFPF01011322    MAA22468.1    GEDV01005144    JAP83413.1    GACK01005400    JAA59634.1    GEFH01004641    JAP63940.1    GGLE01006175    MBY10301.1    GANP01000944    JAB83524.1    GANP01000945    JAB83523.1    GFAA01002123    JAU01312.1    GEFM01002821    JAP72975.1    LSYS01007194    OPJ72198.1    AADN05000005    OPJ72197.1    OPJ72199.1    AERX01005712    AERX01005713    AERX01005714    KK112545    KFM57941.1    BX510992    BC163554    AAI63554.1   

Proteomes

UP000053268    UP000053097    UP000279307    UP000008237    UP000005205    UP000076502    + More
UP000009046    UP000007266    UP000094527    UP000007151    UP000095300    UP000261560    UP000085678    UP000190648    UP000000539    UP000005207    UP000192220    UP000261420    UP000054359    UP000261600    UP000261640    UP000261540    UP000233200    UP000265040    UP000261440    UP000000437    UP000248480    UP000009136    UP000261360    UP000233180   

Pfam

PF00433   Pkinase_C        + More
PF15796   KELK
PF00780   CNH
PF00130   C1_1
PF00069   Pkinase
PF08826   DMPK_coil
PF00169   PH
PF00786   PBD

Interpro

IPR020454   DAG/PE-bd        + More
IPR000961   AGC-kinase_C       
IPR017892   Pkinase_C       
IPR000719   Prot_kinase_dom       
IPR001180   CNH_dom       
IPR031597   KELK       
IPR001849   PH_domain       
IPR014930   Myotonic_dystrophy_kinase_coil       
IPR011009   Kinase-like_dom_sf       
IPR011993   PH-like_dom_sf       
IPR002219   PE/DAG-bd       
IPR008271   Ser/Thr_kinase_AS       
IPR017441   Protein_kinase_ATP_BS       
IPR000095   CRIB_dom       
IPR036322   WD40_repeat_dom_sf       
IPR026611   Ser/Thr_kinase_MRCK_alpha       
IPR033232   MRCK_beta       

SUPFAM

SSF56112   SSF56112        + More
SSF50978   SSF50978       

Gene 3D

2.30.29.30    

CDD

cd00029  C1
cd00132  CRIB

ProteinModelPortal

A0A194Q6K8   A0A026WWL1   A0A0C9RXS8   E2BET6   A0A158NSR8   S6D9M9   + More
A0A154NXI7   E0W264   A0A1B6IWI0   A0A224X9H6   A0A023F3G7   D6W6E9   A0A1B6DQZ5   A0A1Y1K9C9   A0A1D2NL40   A0A1Y1KCF7   A0A212EJ03   A0A1I8PXQ8   A0A224YXW1   A0A131YW40   L7M965   A0A131XCY5   A0A2R5LLE3   V5HXS2   V5I4U7   A0A1E1XQT6   A0A131Y3B5   A0A3B3C6T1   A0A3B3DMF7   A0A1S3JW59   A0A3B3C6C0   A0A1V4JJ56   A0A3Q2UEY2   A0A3Q2U8G1   A0A1V4JKB6   A0A1V4JJ38   A0A3Q2U992   I3IY72   A0A2I4D2X4   A0A3Q2U4Y9   A0A3B4TRV3   A0A087SYK2   A0A3B4TQ89   A0A3B4TQQ1   A0A3Q2TYM8   A0A3Q3JY95   A0A3Q3KBE3   A0A3Q3LAH8   A0A3Q3LAG2   A0A3Q3R3V4   A0A3Q3LMB9   A0A3B3Q747   A0A3B3Q6Y5   A0A3B3Q7X9   A0A2K6PXV2   A0A3Q1I2T1   A0A3Q1HRJ7   A0A3B4C6J9   Q5TZ42   A0A2Y9DLE8   E1BP72   A0A3B4WEX7   A0A3Q3KZH9   A0A3Q3KYK8   A0A2K6KCD0  

PDB

4AW2     E-value=1.32642e-172,     Score=1563

KEGG

101746513    K16307 serine/threonine-protein kinase MRCK [EC:2.7.11.1] | (RefSeq) serine/threonine-protein kinase

GO

GO:0030036   GO:0046872   GO:0035556   GO:0005524   GO:0004674   GO:0016491   GO:0005737   GO:0018107   GO:0005856   GO:0031032   GO:0004697   GO:0016477   GO:0042641   GO:0044877   GO:0004672   GO:0006468   GO:0005488   GO:0005507   GO:0004713   GO:0015930  

PANTHER

PTHR22988:SF31   PTHR22988:SF34  

Length:

1742

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03714

Exp number, first 60 AAs:

0.00282

Total prob of N-in:

0.00056

outside

1  -  1742

 

 

Pi

264.330945

Theta

163.411899

Tajima's D

2.351936

CLR

0.278604

CSRT

0.930403479826009

Interpretation

Uncertain