Gene

KWMTBOMO14318

Pre Gene Modal

BGIBMGA001235

Annotation

GTP_cyclohydrolase_I_isoform_B_[Bombyx_mori]

Location

Bomo_Chr24(-):1792152-1820360      View in EpiBrowser

Full name

GTP cyclohydrolase 1      

Alternative Name

GTP cyclohydrolase I
Protein punch

Location in the cell

Cytoplasmic   Reliability : 1.773 Mitochondrial   Reliability : 1.755

CDS

ATGGCCGCCGTTAACGGAAAAGATTTGAACTCGGAAGCGGCAGTGCCGCCATCTTCGCTGATACGTCGCGTCAGTTCGCGATCCATACGTAATTCGATATCCGAGGAGAAAGAGAACGGTGACGCTCCTCAGAAGGGCTCGTTCGTTGGTAAATACAAAAAAGCTCCAGAAGCCCTGAAGAGCTTTAACTTGGCCGATGCGGAAAGTGAACTTGAAGTGCCCGGAACGCCAATGACGCCGAGGACTTCGACCACGCCTGGTCACGAGAACTGCACCTTCCACCATGACCTGGAACTGGACCACAGACCGCCCACCAGGGAGGCGTTGTTACCGGACATGGCTAACTCATACAGGCTTCTACTCACCGGCCTGGGGGAGGACCCTGAAAGGGCAGGGCTCTTGAAGACGCCCGAACGTGCCGCCAAAGCTATGCTCTTCTTCACGAAAGGATACGACCAAAGCTTGGAAGAGGTTCTGAACAACGCCATCTTCGATGAAGACACGGACGAGATGGTGGTCGTTAAGGATATCGAGATGTTTTCAATGTGCGAACATCATCTGGTGCCGTTTTACGGAAAGGTCTCCATCGGGTACCTGCCACAAGGAAAAATTCTGGGTCTCAGCAAACTGGCCAGGATCGTGGAAATATTCTCCCGCCGTCTTCAGGTACAAGAACGTCTGACGAAGCAGATAGCCATCGCGGTGACACAGGCCGTACGCCCGGCCGGCGTGGCGGTCGTCATTGAAGGAGTTCACATGTGCATGGTGATGCGAGGAGTCCAGAAGATCAACAGTAAGACGGTGACGTCGACGATGCTGGGCGTCTTCCGCGACGACCCGAAGACCCGGGAGGAGTTCCTCAACCTCGTCCACTCTAAGTGA

Protein

MAAVNGKDLNSEAAVPPSSLIRRVSSRSIRNSISEEKENGDAPQKGSFVGKYKKAPEALKSFNLADAESELEVPGTPMTPRTSTTPGHENCTFHHDLELDHRPPTREALLPDMANSYRLLLTGLGEDPERAGLLKTPERAAKAMLFFTKGYDQSLEEVLNNAIFDEDTDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPQGKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTQAVRPAGVAVVIEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLVHSK

Description

Isoform B is required for eye pigment production, Isoform C may be required for normal embryonic development and segment pattern formation.

Catalytic Activity

GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)

Subunit

Toroid-shaped homodecamer, composed of two pentamers of five dimers.

Similarity

Belongs to the GTP cyclohydrolase I family.

Keywords

Allosteric enzyme   Alternative splicing   Complete proteome   GTP-binding   Hydrolase   Metal-binding   Nucleotide-binding   Reference proteome   Tetrahydrobiopterin biosynthesis   Zinc  

Feature

chain  GTP cyclohydrolase 1
splice variant  In isoform B.

Uniprot

B7XAK4   A0A2H1W8H6   A0A2W1BVN8   A0A2A4J1K8   Q2V0Q0   S4NXA4   + More
A0A3S2NFR0   B7XAK3   Q2V0Q1   H9IVF5   A0A1L8DZK3   A0A2A4J2T3   C4WXZ2   A0A2H8TPE0   A0A034WCM0   A0A0A1XN58   A0A0K8TYB3   W8B4A3   A0A1B6I2H8   A0A212FFR9   U5EVK2   A0A0T6B9V2   A0A1Y1LIQ3   A0A1J1IAL9   D2CFW6   A0A0L0BUZ2   T1P848   A0A1I8N9Z7   A0A0P9BXL2   A0A195BVR9   A0A158N914   E0VJS1   A0A151IBH4   A0A1I8QDD9   A0A1W4UMH8   A0A1I8QDE6   B4MQN1   A0A0J9U7H6   A0A151WNR5   A0A0Q5VKT5   A0A336ML79   A0A0R1DX11   P48596   A0A0Q9WFC2   A0A1A9UH08   B4J6Q1   A0A1A9Y0P3   A0A1B0BNJ2   B5E1M2   A0A1A9ZWC8   A0A1W4WUL6   A0A0M4EFC0   A0A1Q3EW34   A0A1B0G7Q9   A0A1A9WIP8   A0A0J9RHY2   A0A0Q9XL40   A0A0Q5VLL2   A0A034WE62   A0A0K8WLM4   R4WSU4   A0A0R1DRB3   A0A0A1XE91   A0A151JA93   A0A1S4F159   Q17IQ8   A0A1Q3EVT8   A0A1Q3EVU9   A0A2M4AIB9   A0A182U658   A0A1Q3EW49   A7UU97   A0A2P8ZJN3   A0A182FFA7   A0A2M4CSB5   A0A2M4AHD4   A0A2M4CRM0   A0A182WC45   A0A182NJ51   Q7Q5H2   A0A1Y9HAK5   A0A182I422   A0A182LTC4   A0A1Q3FUU0   A0A2M4AR74   A0A023FCW8   A0A1W7R8E5   B0X6U3   A0A1Y9H9G6   A0A1Q3FUH8   A0A2M4CRU7   A0A226EU62   A0A182JDF1   A0A195FU39   A0A182X8Y9   A0A0J7L1F9   A0A182GXL6   A0A182V9I3   A0A182LL00   A0A2M4BSK0  

EC Number

3.5.4.16

Pubmed

18854583    28756777    16360951    26354079    23622113    19121390    + More
25348373    25830018    24495485    22118469    28004739    18362917    19820115    26108605    25315136    17994087    21347285    20566863    22936249    17550304    8262960    10731132    12537572    12537569    3080426    15632085    23691247    17510324    12364791    14747013    17210077    29403074    25474469    26483478    20966253   

EMBL

AB439288    BAH11150.1    ODYU01007026    SOQ49405.1    KZ149980    PZC75823.1    + More
NWSH01003616    PCG66047.1    AB220982    KQ459386    BAE66651.1    KPJ01199.1    GAIX01012242    JAA80318.1    RSAL01000055    RVE49934.1    AB439287    BAH11149.1    AB220981    BAE66650.1    BABH01001014    BABH01001015    GFDF01002186    JAV11898.1    PCG66046.1    ABLF02034660    AK342930    BAH72762.1    GFXV01004210    MBW16015.1    GAKP01006885    JAC52067.1    GBXI01001528    JAD12764.1    GDHF01033071    JAI19243.1    GAMC01013143    JAB93412.1    GECU01026641    JAS81065.1    AGBW02008773    OWR52579.1    GANO01001821    JAB58050.1    LJIG01002827    KRT84113.1    GEZM01054659    JAV73503.1    CVRI01000047    CRK97335.1    DS497670    EFA13034.1    JRES01001422    KNC23049.1    KA644752    AFP59381.1    CH902619    KPU76231.1    KQ976405    KYM91891.1    ADTU01009025    ADTU01009026    ADTU01009027    ADTU01009028    DS235226    EEB13627.1    KQ978095    KYM97014.1    CH963849    EDW74420.1    CM002911    KMY95460.1    KQ982907    KYQ49460.1    CH954179    KQS62256.1    UFQT01001613    SSX31162.1    CM000158    KRJ99769.1    U01118    U01119    AF159422    AY382619    AY382620    AY382622    AY382623    AY382624    AY382625    AY382626    AY382628    AE013599    AY051890    CH940648    KRF79723.1    CH916367    EDW00954.1    JXJN01017419    CM000071    EDY69524.1    CP012524    ALC40860.1    GFDL01015627    JAV19418.1    CCAG010016891    KMY95462.1    CH933808    KRG05015.1    KQS62257.1    GAKP01006884    JAC52068.1    GDHF01000236    JAI52078.1    AK417787    BAN21002.1    KRJ99767.1    GBXI01017147    GBXI01005015    GBXI01002966    JAC97144.1    JAD09277.1    JAD11326.1    KQ979317    KYN21954.1    CH477237    EAT46580.1    GFDL01015624    JAV19421.1    GFDL01015614    JAV19431.1    GGFK01007037    MBW40358.1    GFDL01015617    JAV19428.1    AAAB01008960    EDO63875.1    PYGN01000035    PSN56709.1    GGFL01003883    MBW68061.1    GGFK01006811    MBW40132.1    GGFL01003804    MBW67982.1    EAA11896.4    AXCN02000457    APCN01002270    AXCM01005878    GFDL01003832    JAV31213.1    GGFK01009952    MBW43273.1    GBBI01000193    JAC18519.1    GEHC01000238    JAV47407.1    DS232424    EDS41614.1    GFDL01003830    JAV31215.1    GGFL01003884    MBW68062.1    LNIX01000002    OXA60687.1    KQ981268    KYN43941.1    LBMM01001332    KMQ96496.1    JXUM01095715    JXUM01095716    JXUM01095717    KQ564213    KXJ72579.1    GGFJ01006898    MBW56039.1   

Proteomes

UP000218220    UP000053268    UP000283053    UP000005204    UP000007819    UP000007151    + More
UP000183832    UP000007266    UP000037069    UP000095301    UP000007801    UP000078540    UP000005205    UP000009046    UP000078542    UP000095300    UP000192221    UP000007798    UP000075809    UP000008711    UP000002282    UP000000803    UP000008792    UP000078200    UP000001070    UP000092443    UP000092460    UP000001819    UP000092445    UP000192223    UP000092553    UP000092444    UP000091820    UP000009192    UP000078492    UP000008820    UP000075902    UP000007062    UP000245037    UP000069272    UP000075920    UP000075884    UP000075886    UP000075840    UP000075883    UP000002320    UP000198287    UP000075880    UP000078541    UP000076407    UP000036403    UP000069940    UP000249989    UP000075903    UP000075882   

PRIDE

B7XAK4    B7XAK3    H9IVF5    P48596   

Pfam

PF01227   GTP_cyclohydroI        + More
PF03435   Sacchrp_dh_NADP

Interpro

IPR001474   GTP_CycHdrlase_I        + More
IPR020602   GTP_CycHdrlase_I_dom       
IPR018234   GTP_CycHdrlase_I_CS       
IPR005097   Sacchrp_dh_NADP       
IPR036291   NAD(P)-bd_dom_sf       

SUPFAM

SSF51735   SSF51735       

ProteinModelPortal

B7XAK4   A0A2H1W8H6   A0A2W1BVN8   A0A2A4J1K8   Q2V0Q0   S4NXA4   + More
A0A3S2NFR0   B7XAK3   Q2V0Q1   H9IVF5   A0A1L8DZK3   A0A2A4J2T3   C4WXZ2   A0A2H8TPE0   A0A034WCM0   A0A0A1XN58   A0A0K8TYB3   W8B4A3   A0A1B6I2H8   A0A212FFR9   U5EVK2   A0A0T6B9V2   A0A1Y1LIQ3   A0A1J1IAL9   D2CFW6   A0A0L0BUZ2   T1P848   A0A1I8N9Z7   A0A0P9BXL2   A0A195BVR9   A0A158N914   E0VJS1   A0A151IBH4   A0A1I8QDD9   A0A1W4UMH8   A0A1I8QDE6   B4MQN1   A0A0J9U7H6   A0A151WNR5   A0A0Q5VKT5   A0A336ML79   A0A0R1DX11   P48596   A0A0Q9WFC2   A0A1A9UH08   B4J6Q1   A0A1A9Y0P3   A0A1B0BNJ2   B5E1M2   A0A1A9ZWC8   A0A1W4WUL6   A0A0M4EFC0   A0A1Q3EW34   A0A1B0G7Q9   A0A1A9WIP8   A0A0J9RHY2   A0A0Q9XL40   A0A0Q5VLL2   A0A034WE62   A0A0K8WLM4   R4WSU4   A0A0R1DRB3   A0A0A1XE91   A0A151JA93   A0A1S4F159   Q17IQ8   A0A1Q3EVT8   A0A1Q3EVU9   A0A2M4AIB9   A0A182U658   A0A1Q3EW49   A7UU97   A0A2P8ZJN3   A0A182FFA7   A0A2M4CSB5   A0A2M4AHD4   A0A2M4CRM0   A0A182WC45   A0A182NJ51   Q7Q5H2   A0A1Y9HAK5   A0A182I422   A0A182LTC4   A0A1Q3FUU0   A0A2M4AR74   A0A023FCW8   A0A1W7R8E5   B0X6U3   A0A1Y9H9G6   A0A1Q3FUH8   A0A2M4CRU7   A0A226EU62   A0A182JDF1   A0A195FU39   A0A182X8Y9   A0A0J7L1F9   A0A182GXL6   A0A182V9I3   A0A182LL00   A0A2M4BSK0  

PDB

1FB1     E-value=3.82793e-78,     Score=740

KEGG

100270770    K01495 GTP cyclohydrolase IA [EC:3.5.4.16] | (RefSeq) GTP cyclohydrolase I

PATHWAY

00790    Folate biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0046654   GO:0005737   GO:0003934   GO:0008270   GO:0005525   GO:0006729   GO:2000274   GO:0035185   GO:0048067   GO:0008363   GO:0009880   GO:0006728   GO:0060308   GO:0048072   GO:0043095   GO:0035998   GO:0046872   GO:0016021   GO:0016491   GO:0005488   GO:0005507   GO:0004713   GO:0015930  

PANTHER

PTHR11109  

Length:

293

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.28647

Exp number, first 60 AAs:

0

Total prob of N-in:

0.04440

outside

1  -  293

 

 

Pi

177.349104

Theta

154.815892

Tajima's D

0.26018

CLR

0.92308

CSRT

0.446127693615319

Interpretation

Uncertain