SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO14302
Pre Gene Modal
BGIBMGA008181
Annotation
PREDICTED:_protein-glutamate_O-methyltransferase-like_[Bombyx_mori]
Full name
Protein-glutamate O-methyltransferase      
Alternative Name
Acidic residue methyltransferase 1
Location in the cell
Cytoplasmic   Reliability : 2.251 Extracellular   Reliability : 1.693
 

Sequence

CDS
ATGTTAATTTTCAGCAAAACTCTCAAGAATTTCGATCCGTTCGCTGACCAAAAGCAGAAATCGTTCGAAGGAAGCTTGGAGCTGATGTGTATTGTGGCCGATAAGCTAGTTAATATGTTATCTAAGAGCGATAAAGATAAATGTAAAAGTGATTTTGTTACTTTGCTGAAGCTCTGTCTGTGGGCCAACAAATGCGATTTGTCGTTGTCCAGTGGCGAGCAAGTGTTTTTGAACGGGAACAATGCTGACGGAAAAGCTACGACATCAAACATCATAGATCCATTCCAAATGATTCTCGATTTTAAGGATAAGTTATTAGTTGATGATACGTCAAAAATAGTCGATCAGGTGACGAATAAAGCTGAAGCCATGATGAAGAACTTAGAGGCGCCGGCTTCGGCTGCGGACGGCGCCAAAGGCTCTCCGCCCGAGACGCCCGCTGCTGAAGCCGCTGATGTCCCTTGTCCGACAAAGATGACATCACCTCAGCACGTCATGTTCGATATAGTATGCGATAATGCTGGGTACGAGTTATTCGCCGATTTGTGTTTAGCACATTTTCTGATATCACAGGGGATCGTGCAAAAGATTCGGTTCCACGTGAAGAACATACCTTGGTTTGTGTCTGACGTCACGCCCGTAGATTTTAAGTGGGTGATCGACTCATGCCTCAAAGCCAGCTACAGGAGAGAAGTCCCCCAGCAGCCGACAGAAGCGGCCGAGGGCGAGGTCCCCCCCGAGCCGGAGCCCCCCCGGGTGATAGGCGCGGACAATCTGCGCGCCCTGGCGGAGCAGTGGACCAAATACGTAGACGAAGGCACATTTGTAGTATTGCACGACGACTTCTGGACCTCCCCCCACGTGTACAGGGACATGAAAAGGCACGCGCCCTCTCTGTACCGCCAGCTGCAGTACGCGGTCGCGCTGCTGTTTAAGGGCGACCTCAACTACAGGAAGCTGCTCTGTGAGAAGAACGTGCCACCCACCAGTGGGCTGGAGGCCGCCTTGCAGGGCTTCCTCCCGGCTCCCGTGATCGCGGTGCGCACGGTGAAGGCCGACCTGATATGCGGGCTGCCGAAGGGTAAGTGGGACCAGCTGAACGCGCTCGACGACAAGTGGATGCAGAAGGGCGACTTCGGCGTGATTCAGTATTGCGGTAAAGTGGAACCACTAAAGGTAGCTGACCGGCCATGCGATCAGTACGGAGACGTCTGCAGGGGAGCCGGCTGTGGTCCACGGACCGATATGTGA
Protein
MLIFSKTLKNFDPFADQKQKSFEGSLELMCIVADKLVNMLSKSDKDKCKSDFVTLLKLCLWANKCDLSLSSGEQVFLNGNNADGKATTSNIIDPFQMILDFKDKLLVDDTSKIVDQVTNKAEAMMKNLEAPASAADGAKGSPPETPAAEAADVPCPTKMTSPQHVMFDIVCDNAGYELFADLCLAHFLISQGIVQKIRFHVKNIPWFVSDVTPVDFKWVIDSCLKASYRREVPQQPTEAAEGEVPPEPEPPRVIGADNLRALAEQWTKYVDEGTFVVLHDDFWTSPHVYRDMKRHAPSLYRQLQYAVALLFKGDLNYRKLLCEKNVPPTSGLEAALQGFLPAPVIAVRTVKADLICGLPKGKWDQLNALDDKWMQKGDFGVIQYCGKVEPLKVADRPCDQYGDVCRGAGCGPRTDM

Summary

Description
O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues.
O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Methylates PCNA, suggesting it is involved in the DNA damage response.
Catalytic Activity
L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine
Similarity
Belongs to the ARMT1 family.
Belongs to the nuclear hormone receptor family.
Keywords
Complete proteome   Methyltransferase   Reference proteome   S-adenosyl-L-methionine   Transferase   Acetylation   DNA damage   Phosphoprotein  
Feature
chain  Protein-glutamate O-methyltransferase
EC Number
2.1.1.-
EMBL
KQ459386    KPJ01213.1    ODYU01008121    SOQ51453.1    NWSH01000023    PCG80647.1    + More
AGBW02014889    OWR40935.1    GEZM01005626    JAV96030.1    GEZM01005625    JAV96032.1    NEVH01025150    PNF15649.1    PNF15647.1    PNF15648.1    CH963850    EDW74941.1    BC165582    AAI65582.1    BC091842    CR926887    GGFK01010429    MBW43750.1    GGFK01010539    MBW43860.1    ADMH02000758    ETN65142.1    KK852954    KDR13276.1    AXCP01007877    JYDP01000014    KRZ15897.1    JYDO01000004    KRZ79953.1    APCN01003537    AAAB01008848    EAA07056.3    JYDT01000020    KRY90586.1    JYDU01000204    JYDR01000106    JYDS01000090    KRX89249.1    KRY68687.1    KRZ26077.1    JYDL01000052    KRX20104.1    AHAT01015749    AHAT01015750    AHAT01015751    RJVU01072567    ROI33809.1    JYDN01000017    KRX65439.1    PYGN01002299    PSN30855.1    GFDL01010039    JAV25006.1    KQ414799    KOC60655.1    JYDK01000049    KRX79755.1    KRX79756.1    AMGL01108377    BC133378    JH880723    ELR59385.1    MKHE01000026    OWK01991.1    CAEY01000794    ACTA01075821    NOWV01000107    RDD40253.1    GL192740    EFB19021.1    CVRI01000043    CRK95956.1    JI173974    ADY46517.1    AANG04000169    DS985261    EDV20231.1    CP012524    ALC41194.1    CH940648    EDW61089.1    FM245125    CAR93051.1    AM293997    CAL25899.1    GGMR01018524    MBY31143.1    CM002911    KMY95698.1    AM293999    CAL25901.1    CH480824    EDW56717.1    RAZU01000095    RLQ73593.1    NDHI03003369    PNJ79019.1    GDIQ01036871    JAN57866.1    JH000025    EGV95942.1    GDIQ01230049    GDIQ01190024    GDIP01090106    LRGB01003389    JAK21676.1    JAM13609.1    KZS02859.1    GDIQ01230050    GDIQ01082159    JAN12578.1   
Pfam
PF01937   DUF89        + More
PF00076   RRM_1
PF00567   TUDOR
PF02159   Oest_recep
PF00105   zf-C4
PF00104   Hormone_recep
Interpro
IPR039763   ARMT1        + More
IPR036075   AF1104-like_sf       
IPR002791   DUF89       
IPR013087   Znf_C2H2_type       
IPR002999   Tudor       
IPR012677   Nucleotide-bd_a/b_plait_sf       
IPR000504   RRM_dom       
IPR035979   RBD_domain_sf       
IPR001292   Oestr_rcpt       
IPR035500   NHR-like_dom_sf       
IPR001723   Nuclear_hrmn_rcpt       
IPR013088   Znf_NHR/GATA       
IPR000536   Nucl_hrmn_rcpt_lig-bd       
IPR001628   Znf_hrmn_rcpt       
SUPFAM
SSF111321   SSF111321        + More
SSF54928   SSF54928       
SSF48508   SSF48508       
Gene 3D
PDB
5BY0     E-value=1.68722e-23,     Score=271

Ontologies

Topology

Subcellular location
Nucleus  
Length:
416
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.0152
Exp number, first 60 AAs:
0.00034
Total prob of N-in:
0.00595
outside
1  -  416
 
 

Population Genetic Test Statistics

Pi
251.46744
Theta
200.68686
Tajima's D
1.518747
CLR
0.090235
CSRT
0.791760411979401
Interpretation
Uncertain
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