Gene

KWMTBOMO14291

Pre Gene Modal

BGIBMGA013424

Annotation

PREDICTED:_rho_GTPase-activating_protein_190_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr24(+):1085846-1087236      View in EpiBrowser

Full name

Rho GTPase-activating protein 190      

Alternative Name

Rho GTPase-activating protein of 190 kDa

Location in the cell

Cytoplasmic   Reliability : 1.352 Mitochondrial   Reliability : 1.654

CDS

ATGGCGAGGAAAAGGAACTTGGTGAAGTGCATAGAGTTCATAGAGCGCGAAGGGCTGGGCTCTGAGGGACTCTACCGCGTGCCGGGGAACAGGGCTCACGTCGATATGCTCTTCACCAAGTTCTACGAAGATCCGAATATAGATTTAGATTCGCTAGACATACCCGTGAATGCTGTCGCCACTGCGCTCAAGGATTTCTTCTCGAAGAAATTACCGCCATTACTCGATGAGGCGAGCATGGCGCAGTTGGAAGATATCGCGAAAGTGCACGTTGTGGGTACAGCGATGCGCGGCTGCATGGCGGGCGGCGTGGAACTCAAGGACCGCAGCTGGCGGCTGCTGGCCCTGCGCGCGCTGCTGCACTCCGCGCTCACGCCGCTCGCGCGCGCCACGCTCGACTACCTGCTGCACCACTTCGCCAGAGTCGCCGACAACTCATACCTGAACCCGATGTTGCGGTAG

Protein

MARKRNLVKCIEFIEREGLGSEGLYRVPGNRAHVDMLFTKFYEDPNIDLDSLDIPVNAVATALKDFFSKKLPPLLDEASMAQLEDIAKVHVVGTAMRGCMAGGVELKDRSWRLLALRALLHSALTPLARATLDYLLHHFARVADNSYLNPMLR

Description

GTPase-activating protein (GAP) for RhoA/Rho1 that plays an essential role in the stability of dorsal branches of mushroom body (MB) neurons. The MB neurons are the center for olfactory learning and memory. Acts by converting RhoA/Rho1 to an inactive GDP-bound state, leading to repress the RhoA/Rho1-Drok-MRLC signaling pathway thereby maintaining axon branch stability.

Keywords

Alternative splicing   Coiled coil   Complete proteome   Developmental protein   GTPase activation   Phosphoprotein   Reference proteome   Repeat  

Feature

chain  Rho GTPase-activating protein 190
splice variant  In isoform 2.

Uniprot

H9JV61   A0A3S2TRZ6   A0A2A4JSL4   A0A2H1V6C9   A0A194PVW5   W8BQ35   + More
B4N201   A0A1B0FY42   A0A1Y1KVX8   A0A1W4XDQ3   B4R6L8   A0A0R1EBZ8   A0A0R1EBX3   A0A0Q5T3Z0   M9PJQ3   A0A0Q9WPF4   A0A0Q9WE01   A0A0Q9WPQ1   M9PHV3   B4IF32   B4MAZ2   B4Q2I7   Q9VX32-2   M9PHG0   A0A0R1EBJ3   A0A0Q9WQX0   A0A0Q5T3P9   B3NWW3   A0A0C5KMR0   Q9VX32   A0A0Q5T3R5   A0A0R1EI73   M9PHY4   A0A0R1EBR4   A0A0Q9WDF1   A0A0Q5T6H5   A0A0Q5TAE3   A0A0Q9WNN5   B4JNF5   A0A0M3QZ95   A0A1Y1KQ68   A0A1Y1KQ67   A0A0P8ZSL1   B3MY00   A0A0P8Y7S2   W8ARY8   W8AZE6   A0A1W4V836   A0A1W4V906   A0A1W4UVB7   A0A1W4V910   A0A1W4UVQ2   A0A1W4V842   W8BEI6   A0A139WPT7   A0A139WPM0   D6W848   A0A139WPL6   A0A139WPB3   A0A139WPB0   A0A2A3EBP9   A0A0R3P3J5   A0A0Q9XES7   A0A0Q9XE93   A0A0Q9XNN6   A0A0Q9XE78   A0A0Q9XPI0   A0A1Y1KSX7   A0A0R3NY69   A0A0R3NXX8   B4L5E1   A0A0Q9XE92   A0A0Q9XSK8   A0A0Q9XQR9   A0A0R3P485   B5DKM2   A0A0R3P3N5   A0A0R3P2Z7   A0A0R3NXW7   B4H9W9   A0A087ZTU0   A0A3B0J6L2   A0A3B0JWS2   A0A3B0J7L7   A0A3B0JBC8   A0A0L7RBB4   N6TE97   A0A1Y1KTM3   A0A034W094   A0A0K8VJ38   A0A034W1V2   A0A0K8VIK8   A0A0C9QV64   A0A0C9RH51   A0A0C9RL47   A0A3B0JCI9   E2A9N1   A0A151X3G2   A0A195ERU0  

Pubmed

19121390    26354079    24495485    17994087    28004739    17550304    + More
10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    18057021    11672527    12537569    17227793    18327897    18362917    19820115    15632085    23185243    23537049    25348373    20798317   

EMBL

BABH01026464    RSAL01000012    RVE53521.1    NWSH01000653    PCG75001.1    ODYU01000720    + More
SOQ35952.1    KQ459590    KPI97467.1    GAMC01014946    JAB91609.1    CH963925    EDW78390.2    AJVK01005168    GEZM01076912    JAV63556.1    CM000366    EDX18217.1    CM000162    KRK06857.1    KRK06858.1    KRK06861.1    KRK06862.1    CH954180    KQS29997.1    AE014298    AGB95501.1    CH940655    KRF82665.1    KRF82669.1    KRF82670.1    KRF82666.1    KRF82667.1    AGB95500.1    CH480832    EDW46286.1    EDW66401.2    EDX02628.1    KRK06860.1    AF387518    AY121666    AGB95498.1    KRK06863.1    KRK06864.1    KRF82672.1    KQS29995.1    KQS29999.1    KQS30003.1    EDV46510.1    KQS29996.1    BT150459    AJP62081.1    KQS29994.1    KQS30002.1    KRK06866.1    AGB95499.1    KRK06859.1    KRK06865.1    KRF82668.1    KQS30000.1    KQS29998.1    KQS30001.1    KRF82671.1    CH916371    EDV92248.1    CP012528    ALC49033.1    GEZM01076914    JAV63552.1    GEZM01076910    JAV63559.1    CH902630    KPU77485.1    EDV38615.2    KPU77486.1    GAMC01014945    JAB91610.1    GAMC01014943    JAB91612.1    GAMC01014944    JAB91611.1    KQ971307    KYB29835.1    KYB29836.1    EFA10998.2    KYB29837.1    KYB29838.1    KYB29839.1    KZ288291    PBC29203.1    CH379063    KRT05920.1    KRT05927.1    CH933811    KRG06893.1    KRG06895.1    KRG06900.1    KRG06896.1    KRG06894.1    GEZM01076915    JAV63551.1    KRT05924.1    KRT05921.1    EDW06400.2    KRG06892.1    KRG06899.1    KRG06897.1    KRT05926.1    EDY72072.1    KRT05923.1    KRT05925.1    KRT05922.1    CH479232    EDW36626.1    OUUW01000003    SPP77804.1    SPP77806.1    SPP77805.1    SPP77803.1    KQ414617    KOC68212.1    APGK01032712    KB740848    KB632411    ENN78679.1    ERL95234.1    GEZM01076909    JAV63560.1    GAKP01010838    JAC48114.1    GDHF01013437    GDHF01003775    JAI38877.1    JAI48539.1    GAKP01010837    JAC48115.1    GDHF01017657    GDHF01013929    JAI34657.1    JAI38385.1    GBYB01007639    JAG77406.1    GBYB01007640    JAG77407.1    GBYB01007641    JAG77408.1    SPP77802.1    GL437918    EFN69833.1    KQ982562    KYQ54932.1    KQ981993    KYN30896.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053268    UP000007798    UP000092462    + More
UP000192223    UP000000304    UP000002282    UP000008711    UP000000803    UP000008792    UP000001292    UP000001070    UP000092553    UP000007801    UP000192221    UP000007266    UP000242457    UP000001819    UP000009192    UP000008744    UP000005203    UP000268350    UP000053825    UP000019118    UP000030742    UP000000311    UP000075809    UP000078541   

PRIDE

H9JV61    M9PHV3    Q9VX32    M9PHG0    M9PHY4   

Pfam

PF00620   RhoGAP        + More
PF16512   RhoGAP-FF1
PF00071   Ras
PF00067   p450

Interpro

IPR008936   Rho_GTPase_activation_prot        + More
IPR000198   RhoGAP_dom       
IPR032835   RhoGAP-FF1       
IPR027417   P-loop_NTPase       
IPR039007   pG1       
IPR039006   RhoGAP_pG2       
IPR001806   Small_GTPase       
IPR002713   FF_domain       
IPR036517   FF_domain_sf       
IPR002401   Cyt_P450_E_grp-I       
IPR017972   Cyt_P450_CS       
IPR001128   Cyt_P450       
IPR036396   Cyt_P450_sf       

SUPFAM

SSF48350   SSF48350        + More
SSF52540   SSF52540       
SSF81698   SSF81698       
SSF48264   SSF48264       

Gene 3D

1.10.555.10     1.10.10.440     1.10.630.10    

ProteinModelPortal

H9JV61   A0A3S2TRZ6   A0A2A4JSL4   A0A2H1V6C9   A0A194PVW5   W8BQ35   + More
B4N201   A0A1B0FY42   A0A1Y1KVX8   A0A1W4XDQ3   B4R6L8   A0A0R1EBZ8   A0A0R1EBX3   A0A0Q5T3Z0   M9PJQ3   A0A0Q9WPF4   A0A0Q9WE01   A0A0Q9WPQ1   M9PHV3   B4IF32   B4MAZ2   B4Q2I7   Q9VX32-2   M9PHG0   A0A0R1EBJ3   A0A0Q9WQX0   A0A0Q5T3P9   B3NWW3   A0A0C5KMR0   Q9VX32   A0A0Q5T3R5   A0A0R1EI73   M9PHY4   A0A0R1EBR4   A0A0Q9WDF1   A0A0Q5T6H5   A0A0Q5TAE3   A0A0Q9WNN5   B4JNF5   A0A0M3QZ95   A0A1Y1KQ68   A0A1Y1KQ67   A0A0P8ZSL1   B3MY00   A0A0P8Y7S2   W8ARY8   W8AZE6   A0A1W4V836   A0A1W4V906   A0A1W4UVB7   A0A1W4V910   A0A1W4UVQ2   A0A1W4V842   W8BEI6   A0A139WPT7   A0A139WPM0   D6W848   A0A139WPL6   A0A139WPB3   A0A139WPB0   A0A2A3EBP9   A0A0R3P3J5   A0A0Q9XES7   A0A0Q9XE93   A0A0Q9XNN6   A0A0Q9XE78   A0A0Q9XPI0   A0A1Y1KSX7   A0A0R3NY69   A0A0R3NXX8   B4L5E1   A0A0Q9XE92   A0A0Q9XSK8   A0A0Q9XQR9   A0A0R3P485   B5DKM2   A0A0R3P3N5   A0A0R3P2Z7   A0A0R3NXW7   B4H9W9   A0A087ZTU0   A0A3B0J6L2   A0A3B0JWS2   A0A3B0J7L7   A0A3B0JBC8   A0A0L7RBB4   N6TE97   A0A1Y1KTM3   A0A034W094   A0A0K8VJ38   A0A034W1V2   A0A0K8VIK8   A0A0C9QV64   A0A0C9RH51   A0A0C9RL47   A0A3B0JCI9   E2A9N1   A0A151X3G2   A0A195ERU0  

PDB

2EE5     E-value=7.24534e-14,     Score=182

KEGG

101742582    K13709 Rho GTPase-activating protein 5 | (RefSeq) rho GTPase-activating protein 190

GO

GO:0007165   GO:0003924   GO:0005525   GO:0005829   GO:0050770   GO:0016319   GO:0007415   GO:0007266   GO:0005096   GO:0045792   GO:0030215   GO:0016021   GO:0020037   GO:0005506   GO:0016705   GO:0003676   GO:0005634   GO:0008270   GO:0005488   GO:0005507   GO:0004713   GO:0016491   GO:0015930  

Length:

153

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.99552

Exp number, first 60 AAs:

0

Total prob of N-in:

0.63265

inside

1  -  153

 

 

Pi

346.071863

Theta

132.034422

Tajima's D

5.075629

CLR

0.116471

CSRT

0.999950002499875

Interpretation

Uncertain