Gene

KWMTBOMO14280

Pre Gene Modal

BGIBMGA008171

Annotation

uncharacterized_protein_LOC692458_[Bombyx_mori]

Location

Bomo_Chr24(+):636616-644966      View in EpiBrowser

Full name

Acyl-CoA Delta(11) desaturase       + More
(11Z)-hexadec-11-enoyl-CoA conjugase      

Alternative Name

Acyl-CoA Delta-11 desaturase
SlsZ/E11
Acyl-CoA Z/E11 desaturase
Acyl-CoA Delta(11) desaturase
Acyl-CoA Z11/delta10,12 desaturase

Location in the cell

PlasmaMembrane   Reliability : 4.173

CDS

ATGTCTCCAAACATAGCGACCATTGTACCTTCACAAGAAACTGAAAATGAGTACGAAAAGCTTGAACCTCCTCAGGCATCGGAGAGAAAATACGAAATTATCTATTTTAATATCTTCACGTTTACTTTTGCACACTTATCTGCGCTGTACGGCGTGTACTTGTGCTTTACCAGTGCGAAACGGGAGAGCTTAATATTAGGTTACATAATAGGGGTGTTAGCAGGATTTGGAGTAACAGCCGGAGCACACCGCCTGTGGACCCACAGGACATACAAAGCCAAAATGCCACTGCAAATCCTACTCATGTTATTCTACAGTTTTGCCTACCAAAATTCAGCCGTTCATTGGATCAGAGATCATAGATTGCACCATAAGTACAGCGATACTGATGCCGACCCGCATAATGCCACGAGGGGCTTCTTCTACTCACATATGGGATGGTTATTGGTAAAGAAACACCCTGAAGTTAAGAGGAGAGGGAGATCCTTAGATATGTCGGATATTTACAGTAATCGGGTCTTGATGTTTCAGAAGAAATACGCAATACCGATCACGGGAACCATCTGCTTTGTTATCCCCACTCTCCTACCGATGTACCTATGGGGGGAGTCCTTCAAAAACGCTTGGCATATCACAATACTGAGATACATCATTACGCTCCACGTGGCGTTCTTAGTGAACAGCGCTGCGCACATCTGGGGGTACAAGCCTTACGACAAACGGATTCTGCCAACGCAAAATCTCTTCGTGTCATTCATGGCTTTCGGAGAAGGATTCCACAACTATCACCACGTGTTTCCTTGGGACTATAGGACGGCGGAGCTTGGGAACAATTACTTGAATCTGACGACCATGTTCATAGATTTTTTCGCTTGGTTAGGTTGGGCCTATGATCTGAAGTCAGTGCCTGTCAGTCTTGCCGAGAGCCGAGCTAGAAAGACGGGAGACGGAACTGGTTTGTGGGGCTGGGGAGATAAAGATATGAGCGAGGATCTCAAAAGACAAACTGTCGGGGAGAATTGA

Protein

MSPNIATIVPSQETENEYEKLEPPQASERKYEIIYFNIFTFTFAHLSALYGVYLCFTSAKRESLILGYIIGVLAGFGVTAGAHRLWTHRTYKAKMPLQILLMLFYSFAYQNSAVHWIRDHRLHHKYSDTDADPHNATRGFFYSHMGWLLVKKHPEVKRRGRSLDMSDIYSNRVLMFQKKYAIPITGTICFVIPTLLPMYLWGESFKNAWHITILRYIITLHVAFLVNSAAHIWGYKPYDKRILPTQNLFVSFMAFGEGFHNYHHVFPWDYRTAELGNNYLNLTTMFIDFFAWLGWAYDLKSVPVSLAESRARKTGDGTGLWGWGDKDMSEDLKRQTVGEN

Description

Catalyzes the formation of Delta(11) fatty acyl precursors in the pheromone gland.
Catalyzes the formation of delta(11) fatty acyl precursors in the pheromone gland, and has high activity towards palmitic acid and stearic acid.
Catalyzes the formation of Delta(11) fatty acyl precursors in the pheromone gland, with a preference for myristic acid.
Fatty acid desaturase that catalyzes 2 consecutive steps in the biosynthesis of bombykol, a sex pheromone produced by the moth. First acts as an acyl-CoA Delta(11) desaturase (1) by catalyzing the formation of Delta(11) fatty acyl precursors. Then acts as a (11Z)-hexadec-11-enoyl-CoA conjugase (2) by converting a single cis double bond at position 11 of (11Z)-hexadec-11-enoyl-CoA into conjugated 10 trans and 12 cis double bonds.

Catalytic Activity

2 [Fe(II)-cytochrome b5] + an 11,12-saturated fatty acyl-CoA + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an (11Z)-Delta(11)-fatty acyl-CoA + 2 H2O
(11Z)-hexadecenoyl-CoA + AH2 + O2 = (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O

Cofactor

Fe cation
Fe(2+)

Similarity

Belongs to the fatty acid desaturase type 1 family.

Keywords

Endoplasmic reticulum   Fatty acid biosynthesis   Fatty acid metabolism   Iron   Lipid biosynthesis   Lipid metabolism   Membrane   Metal-binding   Oxidoreductase   Transmembrane   Transmembrane helix   Complete proteome   Reference proteome  

Feature

chain  Acyl-CoA Delta(11) desaturase

Uniprot

H9JF74   T1RTE1   Q75PL5   A0A0K2GV16   A0A0N1PJV1   W5QM97   + More
A0A0K0N452   G8FQ76   M4PTD0   O44390   A0A076FRH6   G8FQ78   A0A2A4JG15   G8FQ77   A9YRX6   D2SNV3   Q6US81   T1RU40   Q2YHQ4   A0A068FKA4   A0A0U2F3F2   G8FQ79   Q9NB26   Q4A181   A0A1V0M868   A0A291P0P5   A0A0U2F3E1   Q8MZZ2   A0A212FJD3   Q6A4M5   U5KFQ4   E3UYX7   E3UYX8   B7SB74   Q8ISS3   A0A1L8D6M1   Q95VE7   Q95UJ3   A0A1L8D6B5   Q9GU82   Q75PL7   E3TMU8   A0A075BRA0   A0A194Q9S9   A0A0L7L2G4   S4WAY4   B6CBS5   A0A1L8D6C0   A8QVZ1   A0A1L8D6L2   Q2V0N6   Q8WPC0   Q7KEQ2   B8Q500   A0A0F7R1B4   D8L7A6   A0A0F7R6V7   A0A0F7R1B9   A0A0F7R6V4   Q95UU3   G8FQ83   G8FQ82   D8L626   A4KWE9   D8UUU1   A0A059TBF9   A4KWE7   A0A0F7R2Q5   G8FQ80   D8UUU2   C0STP4   A4KWG3   A0A0E3VMW5   G8FQ72   A0A0N0PDB8   B6CBS2   G8FQ74   A0A194QB86   B3P4B3   A0A059TBF7   A0A2J7Q458   Q7K4Y0   Q9U972   D8UUE4   B4QSA3   G8FQ73   Q94541   G8FQ75   A0A1L8DYT8   B4PPA5   Q8ITN6   T1PCA2   W6ACM3   A0A023EPC8   A6P6Z1   Q9NG28   A0A0A1XD14   D8UUT8   A0A1A9WBD6   Q9U967  

EC Number

1.14.19.5
1.14.19.15

Pubmed

19121390    24500170    26354079    24862548    22291612    9860961    + More
11483431    24817326    18405835    25796477    20074338    15544945    26417103    26385554    28986331    17517337    28349297    12524345    12770579    22118469    15527989    24053512    21331247    20403437    15455060    11805319    10767556    15173596    20691782    26227816    24569486    18831750    17921252    16360168    12237399    19257880    12213232    17360547    21444802    17994087    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    10920187    9501419    17550304    12421411    25315136    24945155    17916502    25830018   

EMBL

BABH01026838    BABH01026839    BABH01026840    JX531667    AGO45852.1    BABH01040457    + More
AB166853    BAD18124.1    KP890026    ALA65425.1    KQ460301    KPJ16138.1    JQ978772    AGD98720.1    KM378664    AKJ32408.1    JN022486    AER29851.1    KC422668    AGH12217.1    AF035375    AF297114    AF297113    KF960741    AII21943.1    JN022488    AER29853.1    NWSH01001511    PCG71017.1    JN022487    AER29852.1    EU285580    KM283200    ABX90049.1    AIU96339.1    EZ407237    ACX53794.1    AY362879    JX531654    AGO45839.1    AM158251    CAJ43430.2    KJ622051    AID66659.1    KP008124    MF687587    AKU76411.1    ATJ44513.1    JN022489    AER29854.1    AF272342    AAF81787.1    AM076339    CAJ27976.2    KU755471    ARD71181.1    MF687528    ATJ44454.1    KP008117    AKU76404.1    AF482908    AAM28483.2    AGBW02008279    OWR53845.1    AF518014    AAQ12891.1    JX989153    AGR49312.1    HM636633    ADP21587.1    HM636634    ADP21588.1    EU152400    FJ466458    ABX71809.1    ACS69071.1    AF545481    FJ999625    GEYN01000135    JAV01994.1    AF416738    AAL16642.1    AY049741    AAL11496.1    GEYN01000136    JAV01993.1    AF182405    AAG16901.1    AF157627    AB166851    BABH01015400    AAF80355.1    BAD18122.1    GU952763    ADO85596.1    JX679209    AGP26038.1    KQ459249    KPJ02273.1    JTDY01003403    KOB69615.1    JX964774    AGO96562.1    EU152335    ABX71630.1    GEYN01000123    JAV02006.1    EF150363    ABO43722.1    GEYN01000122    JAV02007.1    AB232855    BAE66602.1    AF441861    AAL32060.1    AF441221    AAL35331.1    EU350083    EU350084    GQ166860    ACA81687.1    ACA81688.1    ADE97413.1    LC020021    BAR72981.1    FJ999626    ADC53486.1    LC020024    BAR72989.1    LC020023    BAR72986.1    LC020022    BAR72984.1    AY017379    AAG54077.1    JN022493    AER29862.1    JN022491    JN022492    AER29861.1    FJ906800    ADB25212.1    EF113395    EF113396    ABO45228.1    ABO45229.1    GQ225753    ADE58526.1    KF022097    AHW98358.1    EF113393    EF113394    ABO45226.1    ABO45227.1    BAR72990.1    JN022490    AER29859.1    GQ225754    ADE58527.1    AB465511    BAH56286.1    BAR72983.1    EF113404    ABO45242.1    AB910048    BAR45527.1    JN022482    AER29856.1    KQ460253    KPJ16371.1    EU152332    ABX71627.1    JN022484    AER29858.1    KPJ02255.1    CH954181    EDV49358.1    KF022093    AHW98354.1    NEVH01018390    PNF23355.1    AE014297    AY051593    AAF54819.1    AAF54820.1    AAF54821.1    AAF54822.1    AAK93017.1    AAN13544.1    AJ245747    CAB52474.1    GQ166859    ADE97412.1    CM000364    EDX13199.1    JN022483    AER29857.1    U73160    AAB17283.1    JN022485    AER29855.1    GFDF01002622    JAV11462.1    CM000160    EDW97111.1    KRK03534.1    AF417841    AAN31393.1    KA646397    AFP61026.1    KF835695    AHI54575.1    GAPW01002266    JAC11332.1    AB300221    BAF69118.1    AF268275    JN022476    AAF73073.1    AER29845.1    GBXI01005435    JAD08857.1    GQ225750    ADE58523.1    AJ245748    CAB52475.1   

Proteomes

UP000005204    UP000053240    UP000218220    UP000007151    UP000053268    UP000037510    + More
UP000008711    UP000235965    UP000000803    UP000000304    UP000002282    UP000095301    UP000091820   

PRIDE

H9JF74    T1RTE1    Q75PL5    Q9GU82    Q75PL7    Q7K4Y0    + More
Q9U972    Q94541   

Pfam

PF00487   FA_desaturase

Interpro

IPR005804   FA_desaturase_dom        + More
IPR015876   Acyl-CoA_DS       
IPR001522   FADS-1_CS       
IPR009160   Acyl-CoA_deSatase_haem/ster-bd       

CDD

cd03505  Delta9-FADS-like

ProteinModelPortal

H9JF74   T1RTE1   Q75PL5   A0A0K2GV16   A0A0N1PJV1   W5QM97   + More
A0A0K0N452   G8FQ76   M4PTD0   O44390   A0A076FRH6   G8FQ78   A0A2A4JG15   G8FQ77   A9YRX6   D2SNV3   Q6US81   T1RU40   Q2YHQ4   A0A068FKA4   A0A0U2F3F2   G8FQ79   Q9NB26   Q4A181   A0A1V0M868   A0A291P0P5   A0A0U2F3E1   Q8MZZ2   A0A212FJD3   Q6A4M5   U5KFQ4   E3UYX7   E3UYX8   B7SB74   Q8ISS3   A0A1L8D6M1   Q95VE7   Q95UJ3   A0A1L8D6B5   Q9GU82   Q75PL7   E3TMU8   A0A075BRA0   A0A194Q9S9   A0A0L7L2G4   S4WAY4   B6CBS5   A0A1L8D6C0   A8QVZ1   A0A1L8D6L2   Q2V0N6   Q8WPC0   Q7KEQ2   B8Q500   A0A0F7R1B4   D8L7A6   A0A0F7R6V7   A0A0F7R1B9   A0A0F7R6V4   Q95UU3   G8FQ83   G8FQ82   D8L626   A4KWE9   D8UUU1   A0A059TBF9   A4KWE7   A0A0F7R2Q5   G8FQ80   D8UUU2   C0STP4   A4KWG3   A0A0E3VMW5   G8FQ72   A0A0N0PDB8   B6CBS2   G8FQ74   A0A194QB86   B3P4B3   A0A059TBF7   A0A2J7Q458   Q7K4Y0   Q9U972   D8UUE4   B4QSA3   G8FQ73   Q94541   G8FQ75   A0A1L8DYT8   B4PPA5   Q8ITN6   T1PCA2   W6ACM3   A0A023EPC8   A6P6Z1   Q9NG28   A0A0A1XD14   D8UUT8   A0A1A9WBD6   Q9U967  

PDB

4YMK     E-value=1.72251e-78,     Score=744

KEGG

101736834    K00507 stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1] | (RefSeq) BmorLPTQ; acyl-CoA Del

PATHWAY

01040    Biosynthesis of unsaturated fatty acids - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01212    Fatty acid metabolism - Bombyx mori (domestic silkworm)

GO

GO:0016717   GO:0016021   GO:0006633   GO:0017105   GO:0046872   GO:0005789   GO:0004768   GO:0042811   GO:0006631   GO:0055114   GO:0006636   GO:0031410   GO:0045793   GO:0006723   GO:0010506   GO:0042594   GO:0009744   GO:0045572   GO:0070328   GO:0060179   GO:0042593   GO:0040018   GO:0005783   GO:0019216   GO:0048047   GO:0006629   GO:0031461   GO:0016791   GO:0005488   GO:0005507   GO:0004713   GO:0016491   GO:0015930  

PANTHER

PTHR11351  

Subcellular location

Endoplasmic reticulum membrane  
Membrane  

Length:

340

Number of predicted TMHs:

5

Exp number of AAs in TMHs:

126.40321

Exp number, first 60 AAs:

22.50777

Total prob of N-in:

0.09830

POSSIBLE N-term signal

sequence

outside

1  -  33

TMhelix

34  -  56

inside

57  -  62

TMhelix

63  -  85

outside

86  -  94

TMhelix

95  -  117

inside

118  -  179

TMhelix

180  -  202

outside

203  -  211

TMhelix

212  -  234

inside

235  -  340

 

 

Pi

233.481278

Theta

2.986332

Tajima's D

0.905065

CLR

241.299031

CSRT

0.675166241687916

Interpretation

Uncertain