Gene

KWMTBOMO14253

Pre Gene Modal

BGIBMGA002160

Annotation

PREDICTED:_putative_fatty_acyl-CoA_reductase_CG5065_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr23(-):21451904-21458392      View in EpiBrowser

Full name

Fatty acyl-CoA reductase       + More
Putative fatty acyl-CoA reductase CG5065      

Location in the cell

Mitochondrial   Reliability : 1.463 Nuclear   Reliability : 1.073

CDS

ATGGCTGATATGTCAGAAGAGGCTCCGATCCTTCCAAGGTTCTACGCGGGGAGATCGGTCTTCATTACGGGAGGCACCGGCTTTATGGGAAAGGTGTTGGTGGAGCGTCTACTGTCCACGTGCGATGATATCCAGGAGGTGTTCCTCCTCGTGCGGGAGAAGAAGGACGTGCCGCCAGAGAAGAGGCTCGCTCAGTTCAAGCAGTGTCAGTACACGAGGGTAATATGTGTAATATTCGAGAAGGTTCGGGAGCGGTGTCCGTGGCAGCTCGACAAGCTGCGCGTGCTCCCCGGGAACCTGGAGCGACCCCTGCTGGGACTCGAACCGGTGACTATCGCTCGACTACACCAGCCTACAGAGCGCGTCCGGTGCCCGCAGGTGTCGGTGGTGTTCCACAACGCTGCGACCCTCAAGTTCGACGAGGCTCTACGCAAGGCGGTCGACCAGAACGTGCGGGGCCTCCTGTCCCTCGTCGACGTGTGCGACGCCCTGCCGAACCTCGAGGCGCTGGTGCACGTGTCCACTGCGTACAGCAACGCGGAGCTGTCGAGGGTGGAGGAGCGCGTGTACGCGGCGCCGGTGCCGCTGCAGCAGCTGCTGGCGCTGGCCGACGCGCTGCCGGACCAGCTCGCCGCCGACCTCACGCCCAGGTACATCCACCCGAAGCCGAACACTTACACGTTCACGAAGGCGATGGCGGAGTGCGTGCTGCAGGAGAGGACCAGCCGCCGCTACCCGGTCGCCATCTTCCGACCGACCATAGTGATATCAGCAGACCGGCACCCGGTCCCGGGGTGGATAGAGAACTTGAACGGGCCGAGCGGCGTCGTCGTGGGGGTCGGCAAGGGGCTGATGCACGTGTTCAGAGCGAAGCTCGCGCTGCGGGCCGACTTCATCCCGGTCGACGTCGTCGTGGACAACATGATCGCCGTTGCCTGGGAGACGGCCTCAGAACCGTGCGGCTCCTTGCGCGTGTACAACTGCGCGTCGGGCGAGCACGCGACGCGCTTATCGGACTTCAGAGCCACCGCAGTCCGCGTGCTCCGGAGCCTCCCGCTGGACTCAGGACTCTCCTATCCCTTTCTGATCGTGGTGCAGAACAGGTTCGTGTACCGGCTGCTGGAGTTCGTGCTGCAGACGGCGCCGCTGCACGTGGCCGAGTGCTTGCGGCAGACCGACGGGCAGAAGGCGAGGTTGAGTTTCACAACGGCAGGGCGGCGCATACGAGCGATGACGGAGGTGCTGCACTTCTTCGTGCTGCGCGAGTGGACGTTCCCGTGCGACAACATCCGGCGGCTGCGGCGGCGGCTCACGGCGCGCGACCGCCGCATCTACCACCTGGACGTCGCGGAGGTCCATTGGGACGAATTATATTTAAACTTCGTGAAAGGAACAAGAAAATATTTACTTCAGGAAAAGGAAGAAGATTTGAAAGAAGCGCAAAAAAGAATGAAGAGATTGCGTCTCGTCCACTACACCACCATCGTGTTCCTCGTCTTACTATCCTACAAACTAATTAAGTTTTTCCTAAATTTGTTTATGAACAACTAA

Protein

MADMSEEAPILPRFYAGRSVFITGGTGFMGKVLVERLLSTCDDIQEVFLLVREKKDVPPEKRLAQFKQCQYTRVICVIFEKVRERCPWQLDKLRVLPGNLERPLLGLEPVTIARLHQPTERVRCPQVSVVFHNAATLKFDEALRKAVDQNVRGLLSLVDVCDALPNLEALVHVSTAYSNAELSRVEERVYAAPVPLQQLLALADALPDQLAADLTPRYIHPKPNTYTFTKAMAECVLQERTSRRYPVAIFRPTIVISADRHPVPGWIENLNGPSGVVVGVGKGLMHVFRAKLALRADFIPVDVVVDNMIAVAWETASEPCGSLRVYNCASGEHATRLSDFRATAVRVLRSLPLDSGLSYPFLIVVQNRFVYRLLEFVLQTAPLHVAECLRQTDGQKARLSFTTAGRRIRAMTEVLHFFVLREWTFPCDNIRRLRRRLTARDRRIYHLDVAEVHWDELYLNFVKGTRKYLLQEKEEDLKEAQKRMKRLRLVHYTTIVFLVLLSYKLIKFFLNLFMNN

Description

Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Catalyzes the reduction of C16 or C18 fatty acyl-CoA to fatty alcohols.

Catalytic Activity

a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)

Similarity

Belongs to the fatty acyl-CoA reductase family.

Keywords

Complete proteome   Lipid biosynthesis   Lipid metabolism   Membrane   NADP   Oxidoreductase   Peroxisome   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Putative fatty acyl-CoA reductase CG5065

Uniprot

H9IY27   A0A212FG68   A0A068FJB7   A0A0F6Q104   A0A2W1BU43   A0A0F6Q4L1   + More
A0A2W1BD38   A0A0F6Q1K5   H9JNR0   A0A291P0Q0   D9D5H9   A0A386QW76   A0A194PTQ4   A0A0P0EA69   A0A2H1WNT2   A0A0P0EW34   A0A1V0M880   D7P5E4   U5KFU0   A0A3S2LSJ5   A0A2W1B0E2   A0A1L8D6B8   A0A291P0V6   A0A0F6Q1I7   A0A194RN00   A0A2A4JGI4   A0A3S2NBD7   A0A087TLH2   A0A023F1N4   E9GTL9   B4H764   Q28WN8   T1HPB8   A0A069DVI2   A0A1I8PNE0   A0A0N1IPU7   A0A3B0J1M1   B4KSN0   B4P5X9   B3NPG3   B3MDK3   B4LPA3   A0A1I8M522   T1PAL6   A0A0P5YBQ5   B4JWM8   A0A1W4UXP9   A0A0P5QJM8   A0A194PSL9   W8AXT4   A0A034VN48   A0A0K8U8F7   T1KB77   B4HT68   E0VSV6   A0A0J9RE92   E1JH83   A1ZAI5   A0A336LRW3   A0A0A1WIW0   A0A336MZZ9   B4MIU8   A0A212F418   A0A291P0J5   A0A1A9X2G9   A0A0M4EVU9   T1JSH5   A0A147BN16   A0A0P6ITJ7   A0A0L0BVZ6   A0A1B6EM21   A0A1B6G8A3   A0A1A9VQ82   A0A1B6GUZ4   A0A2J7PLY4   A0A0A9VYR3   A0A2L2YHA0   A0A1B6JB63   A0A1B0ARC3   A0A0A9VVQ7   A0A0C9QJE0   A0A131YLS0   A0A1B6KYT4   E9GMI7   A0A1J1IBH8   A0A0P0EM43   K7J1Z7   A0A069DV62   A7SBJ0   A0A3Q8FTW8   A0A1W4WEK2   A0A023GNB8   A0A023F1V0   A0A2J7PM67   E2B9J0   A0A132AJS7   E0VLJ7   A0A1E1X4I5   G3KIJ9  

EC Number

1.2.1.84

Pubmed

19121390    22118469    26385554    28756777    28986331    26354079    + More
26445454    28349297    20534481    24053512    25474469    21292972    17994087    15632085    26334808    17550304    18057021    25315136    24495485    25348373    20566863    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    25830018    29652888    26108605    25401762    26561354    26830274    20075255    17615350    20798317    26555130    28503490    21918929   

EMBL

BABH01029849    AGBW02008707    OWR52728.1    KJ622059    AID66647.1    KP237929    + More
AKD01782.1    KZ149962    PZC76300.1    KP237910    AKD01763.1    KZ150430    PZC70906.1    KP237936    MF687598    AKD01789.1    ATJ44524.1    BABH01035236    MF687540    ATJ44466.1    GU808255    ADI82779.1    MG585940    AYE54244.1    KQ459593    KPI96353.1    KT261705    ALJ30245.1    ODYU01009923    SOQ54667.1    KT261700    ALJ30240.1    KU755481    ARD71191.1    GQ907233    ADD62440.1    JX989157    AGR49316.1    RSAL01000287    RVE42944.1    KZ150513    PZC70632.1    GEYN01000138    JAV01991.1    MF687597    ATJ44523.1    KP237916    AKD01769.1    KQ460152    KPJ17376.1    NWSH01001610    PCG70694.1    RSAL01000280    RVE43065.1    KK115764    KFM65961.1    GBBI01003791    JAC14921.1    GL732564    EFX77189.1    CH479216    EDW33597.1    CM000071    EAL26629.1    ACPB03012985    GBGD01001172    JAC87717.1    KQ460036    KPJ18402.1    OUUW01000001    SPP72772.1    CH933808    EDW10529.2    CM000158    EDW91895.1    CH954179    EDV55730.1    CH902619    EDV37466.1    KPU76846.1    CH940648    EDW60212.2    KA645200    AFP59829.1    GDIP01061996    LRGB01000024    JAM41719.1    KZS21332.1    CH916375    EDV98366.1    GDIQ01123144    JAL28582.1    KPI96431.1    GAMC01012755    JAB93800.1    GAKP01015960    GAKP01015959    GAKP01015958    GAKP01015956    JAC42993.1    GDHF01029367    GDHF01008158    JAI22947.1    JAI44156.1    CAEY01001946    CH480816    EDW48169.1    DS235758    EEB16462.1    CM002911    KMY94302.1    AE013599    ACZ94440.1    AAF57974.1    UFQT01000095    SSX19701.1    GBXI01017222    GBXI01017048    GBXI01015288    GBXI01014990    GBXI01003875    JAC97069.1    JAC97243.1    JAC99003.1    JAC99301.1    JAD10417.1    UFQT01004920    SSX35816.1    CH963719    EDW72037.1    AGBW02010466    OWR48453.1    MF687541    ATJ44467.1    CP012524    ALC42075.1    CAEY01000461    GEGO01003258    JAR92146.1    GDIQ01005343    JAN89394.1    JRES01001254    KNC24212.1    GECZ01030782    JAS38987.1    GECZ01011099    JAS58670.1    GECZ01003528    JAS66241.1    NEVH01024421    PNF17348.1    GBHO01043288    GBRD01007683    JAG00316.1    JAG58138.1    IAAA01029277    IAAA01029278    LAA07536.1    GECU01011206    JAS96500.1    JXJN01002319    JXJN01002320    GBHO01043282    JAG00322.1    GBYB01014923    GBYB01014924    JAG84690.1    JAG84691.1    GEDV01009049    JAP79508.1    GEBQ01023412    JAT16565.1    GL732552    EFX79381.1    CVRI01000047    CRK97592.1    KT261695    ALJ30235.1    GBGD01001183    JAC87706.1    DS469616    EDO38930.1    MG573164    AWJ25026.1    GBBM01000775    JAC34643.1    GBBI01003721    JAC14991.1    PNF17417.1    GL446556    EFN87623.1    JXLN01016764    KPM11252.1    DS235271    EEB14253.1    GFAC01005008    JAT94180.1    JN243756    AEO89346.1   

Proteomes

UP000005204    UP000007151    UP000053268    UP000283053    UP000053240    UP000218220    + More
UP000054359    UP000000305    UP000008744    UP000001819    UP000015103    UP000095300    UP000268350    UP000009192    UP000002282    UP000008711    UP000007801    UP000008792    UP000095301    UP000076858    UP000001070    UP000192221    UP000015104    UP000001292    UP000009046    UP000000803    UP000007798    UP000091820    UP000092553    UP000037069    UP000078200    UP000235965    UP000092460    UP000183832    UP000002358    UP000001593    UP000192223    UP000008237   

PRIDE

H9IY27    H9JNR0    A1ZAI5   

Pfam

PF07993   NAD_binding_4        + More
PF03015   Sterile

Interpro

IPR026055   FAR        + More
IPR036291   NAD(P)-bd_dom_sf       
IPR013120   Male_sterile_NAD-bd       
IPR033640   FAR_C       

SUPFAM

SSF51735   SSF51735       

CDD

cd09071  FAR_C

ProteinModelPortal

H9IY27   A0A212FG68   A0A068FJB7   A0A0F6Q104   A0A2W1BU43   A0A0F6Q4L1   + More
A0A2W1BD38   A0A0F6Q1K5   H9JNR0   A0A291P0Q0   D9D5H9   A0A386QW76   A0A194PTQ4   A0A0P0EA69   A0A2H1WNT2   A0A0P0EW34   A0A1V0M880   D7P5E4   U5KFU0   A0A3S2LSJ5   A0A2W1B0E2   A0A1L8D6B8   A0A291P0V6   A0A0F6Q1I7   A0A194RN00   A0A2A4JGI4   A0A3S2NBD7   A0A087TLH2   A0A023F1N4   E9GTL9   B4H764   Q28WN8   T1HPB8   A0A069DVI2   A0A1I8PNE0   A0A0N1IPU7   A0A3B0J1M1   B4KSN0   B4P5X9   B3NPG3   B3MDK3   B4LPA3   A0A1I8M522   T1PAL6   A0A0P5YBQ5   B4JWM8   A0A1W4UXP9   A0A0P5QJM8   A0A194PSL9   W8AXT4   A0A034VN48   A0A0K8U8F7   T1KB77   B4HT68   E0VSV6   A0A0J9RE92   E1JH83   A1ZAI5   A0A336LRW3   A0A0A1WIW0   A0A336MZZ9   B4MIU8   A0A212F418   A0A291P0J5   A0A1A9X2G9   A0A0M4EVU9   T1JSH5   A0A147BN16   A0A0P6ITJ7   A0A0L0BVZ6   A0A1B6EM21   A0A1B6G8A3   A0A1A9VQ82   A0A1B6GUZ4   A0A2J7PLY4   A0A0A9VYR3   A0A2L2YHA0   A0A1B6JB63   A0A1B0ARC3   A0A0A9VVQ7   A0A0C9QJE0   A0A131YLS0   A0A1B6KYT4   E9GMI7   A0A1J1IBH8   A0A0P0EM43   K7J1Z7   A0A069DV62   A7SBJ0   A0A3Q8FTW8   A0A1W4WEK2   A0A023GNB8   A0A023F1V0   A0A2J7PM67   E2B9J0   A0A132AJS7   E0VLJ7   A0A1E1X4I5   G3KIJ9  

PDB

4U5Q     E-value=0.00250501,     Score=98

KEGG

101739999    K13356 alcohol-forming fatty acyl-CoA reductase [EC:1.2.1.84] | (RefSeq) putative fatty acyl-CoA red

PATHWAY

04146    Peroxisome - Bombyx mori (domestic silkworm)

GO

GO:0102965   GO:0016021   GO:0080019   GO:0006629   GO:0005777   GO:0035336   GO:0010025   GO:0016301   GO:0005778   GO:0008611   GO:0005779  

PANTHER

PTHR11011  

Subcellular location

Peroxisome membrane  

Length:

516

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

23.1481

Exp number, first 60 AAs:

0.64282

Total prob of N-in:

0.02616

outside

1  -  490

TMhelix

491  -  513

inside

514  -  516

 

 

Pi

12.926046

Theta

13.248354

Tajima's D

-0.272085

CLR

0.896463

CSRT

0.296185190740463

Interpretation

Uncertain