Gene

KWMTBOMO14250

Pre Gene Modal

BGIBMGA011164

Annotation

PREDICTED:_putative_fatty_acyl-CoA_reductase_CG5065_[Bombyx_mori]

Location

Bomo_Chr23(+):21383563-21406920      View in EpiBrowser

Full name

Fatty acyl-CoA reductase       + More
Putative fatty acyl-CoA reductase CG5065      

Location in the cell

PlasmaMembrane   Reliability : 2.392

CDS

ATGGTACCCCGTCCAGTGTCTCCGTATGCACGGGAGCCTCTCATTCCGCAGTTTTACGCTGGGAAAAGCATATTCATAACAGGAGCAACCGGTTTTATGGGAAAGGTACTGGTGGAGAGATTACTATGGACGTGTCCAGAGATCGAGCGCATCTTCCTCCTGATGAGAGAGAAGAAGGAAGTATCGCCAGAGAAGCGGCTCGCGCAGCTCAAGCAGTCACAGGTATTTGACGTGATCAGAGAGTATTGTCCGGGTCAGCTGGAGAAGCTGTACCTGATCCCGGGCGACACCACCGCCCCCAACCTCGGTCTCAGCGTGGAATCCATTGGTCTACTGAAAGAGGTGTCGGTGGTGTTCCACAGCGCGGCGACGCTCAAGTTCGACGAGGCCCTCAATAAGGCGGTGGACCAGAACGTGCGCTCCGTCTTGAGCCTCATGGACATATGCGACGGGATGCCCAACATCGAGGCGCTGGTGCACGTGTCCACTGCGTACAGCAACGCGGAGCTGTCGACAGTGGAGGAGCGCGTGTACGCGGCGCCGGTGCCGCTGCAGCAGCTGCTGGCGCTGGCCGACGCGCTGCCGGACCAGCTCGCCGCCGACCTCACGCCCAGGTTGATAAGTCCGAAACCCAACACGTACACGTTCACGAAGGCGCTCGCGGAGAACGCAGTGGCTGAGCGGACCAACAGGAAATACCCCGTGGCCATCTTCAGACCCACGATTGTAATATCTGCTCTTCGTCATCCCTTCCCTGGTTGGATCGAGAACCTAAATGGCCCCAGCGGCGTGCTGGTGGCAGCCGGGAAGGGCTTACTGCATTTCTTCTGCTGCAAGAGGTCAGCTAAGGCGGACATGATTCCAGTGGACATAGCTATTGACACGCTGATAGCGGCCGCCTGGGAGACCGCCGTGGATAAACTGGACGAGATTCGCGTGTACAACTGCAGCAGCGGGAGGAACTCGACCACGTGGGCGCAGTTTGAGATGGCGATCAAAAAGTTGCTGATTGAACATCCCCTGGACAAAACATATTGGTACCCGAGCGGAGCTGCCGTGGAGAACGAATATCTTCTTAATATATTGCAGTTAATAACACAGACGATCCCGTTACATATGGCGGAGTATTGTTCTCGAATGATCGGAATTAAATCAAGATTAAGTTTAATTACCATTAGCGAACGTCTCCAGGGAATGTGTAAGGTGCTAACGTTCTTTTCGATGCGCGAGTGGGATTTCAAGTCCGACAATGTCCGGAAATTGCAAGCCAGACTATCTCCACAGGACGCACTGATCTACAATCTGGACCCGAATACAATAGACTGGGACGCTCTGTACGTAGACTTCGTGAAAGGAACAAGGAAATATCTGCTGAAAGAAAAAGACCAGGACATTGACGAGGCCAAGCGACATTTGCGCAAGATGTTCTACGTCCACAACGGCTTCCTGGTGTTCGTGACGGCGCTGCTGCTGCGGCTATCGCTGCACGCGCCCCTGGTCCGCAGCCTCGTGCTGGGCACTCTCCGGCTGCTGTTCACGATCGTCAGCTCCACGTACTCGCGCGTCTCCTCGTAG

Protein

MVPRPVSPYAREPLIPQFYAGKSIFITGATGFMGKVLVERLLWTCPEIERIFLLMREKKEVSPEKRLAQLKQSQVFDVIREYCPGQLEKLYLIPGDTTAPNLGLSVESIGLLKEVSVVFHSAATLKFDEALNKAVDQNVRSVLSLMDICDGMPNIEALVHVSTAYSNAELSTVEERVYAAPVPLQQLLALADALPDQLAADLTPRLISPKPNTYTFTKALAENAVAERTNRKYPVAIFRPTIVISALRHPFPGWIENLNGPSGVLVAAGKGLLHFFCCKRSAKADMIPVDIAIDTLIAAAWETAVDKLDEIRVYNCSSGRNSTTWAQFEMAIKKLLIEHPLDKTYWYPSGAAVENEYLLNILQLITQTIPLHMAEYCSRMIGIKSRLSLITISERLQGMCKVLTFFSMREWDFKSDNVRKLQARLSPQDALIYNLDPNTIDWDALYVDFVKGTRKYLLKEKDQDIDEAKRHLRKMFYVHNGFLVFVTALLLRLSLHAPLVRSLVLGTLRLLFTIVSSTYSRVSS

Description

Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Catalyzes the reduction of C16 or C18 fatty acyl-CoA to fatty alcohols.

Catalytic Activity

a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)

Similarity

Belongs to the fatty acyl-CoA reductase family.

Keywords

Complete proteome   Lipid biosynthesis   Lipid metabolism   Membrane   NADP   Oxidoreductase   Peroxisome   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Putative fatty acyl-CoA reductase CG5065

Uniprot

H9JNR0   A0A2W1BD38   A0A0F6Q104   A0A068FJB7   A0A212FG68   A0A194PTQ4   + More
A0A0F6Q4L1   A0A2W1BU43   A0A0F6Q1K5   A0A386QW76   D9D5H9   A0A291P0Q0   D7P5E4   A0A1V0M880   A0A0P0EW34   U5KFU0   A0A0F6Q1I7   A0A291P0V6   A0A2A4JGI4   A0A194RN00   A0A0P0EA69   A0A2H1WNT2   A0A3S2LSJ5   A0A1L8D6B8   A0A2W1B0E2   A0A3S2NBD7   A0A023F1N4   A0A069DVI2   E2B9J0   E0VSV6   A0A1B6EM21   A0A0C9QJE0   A0A1B6G8A3   A0A0A9VYR3   A0A0A9VVQ7   E2AKA1   T1HPB8   A0A195D193   A0A0J7KV18   A0A151WGN3   A0A158NHJ4   A0A2J7PLY4   A0A2L2YHA0   A0A0M8ZN21   A0A026WZZ2   A0A1Z3FT38   A0A2J7PM67   A0A1B6CB27   A0A195ETJ3   A0A195E2A0   A0A3Q8FTW8   E9J0E5   K7J1Z7   H9IY27   D9MWM7   A0A2A3EL05   V9IAG7   G3KIJ9   A0A067R949   A0A087TLH2   B4KSN0   E0VLJ7   G3KIK0   A0A1A9X2G9   W8AXT4   B4H764   A0A0L7QWX8   B4LPA3   A0A291P0J5   A0A034VN48   A0A0K8U8F7   A0A0P5M2C1   Q28WN8   E9FTX3   A0A0A1WIW0   A0A0N1IPU7   A0A2S2R203   A0A224XJF5   A0A0J9RE92   B4HT68   A0A0P6HB46   E1JH83   A1ZAI5   A0A023F1V0   A0A0P5GW05   B4P5X9   A0A310SYR9   A0A069DV62   B3NPG3   A0A1I8PNE0   A0A1W4UXP9   B3MDK3   A0A194PSL9   A0A0P5ESY3   A0A1L8DYU2   A0A212F418   T1PAL6   A0A1I8M522   B4JWM8  

EC Number

1.2.1.84

Pubmed

19121390    28756777    26385554    22118469    26354079    28986331    + More
20534481    28349297    26445454    24053512    25474469    26334808    20798317    20566863    25401762    21347285    26561354    24508170    30249741    28608990    21282665    20075255    20542116    21918929    24845553    17994087    24495485    25348373    15632085    21292972    25830018    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    18057021    25315136   

EMBL

BABH01035236    KZ150430    PZC70906.1    KP237929    AKD01782.1    KJ622059    + More
AID66647.1    AGBW02008707    OWR52728.1    KQ459593    KPI96353.1    KP237910    AKD01763.1    KZ149962    PZC76300.1    KP237936    MF687598    AKD01789.1    ATJ44524.1    MG585940    AYE54244.1    GU808255    ADI82779.1    MF687540    ATJ44466.1    GQ907233    ADD62440.1    KU755481    ARD71191.1    KT261700    ALJ30240.1    JX989157    AGR49316.1    KP237916    AKD01769.1    MF687597    ATJ44523.1    NWSH01001610    PCG70694.1    KQ460152    KPJ17376.1    KT261705    ALJ30245.1    ODYU01009923    SOQ54667.1    RSAL01000287    RVE42944.1    GEYN01000138    JAV01991.1    KZ150513    PZC70632.1    RSAL01000280    RVE43065.1    GBBI01003791    JAC14921.1    GBGD01001172    JAC87717.1    GL446556    EFN87623.1    DS235758    EEB16462.1    GECZ01030782    JAS38987.1    GBYB01014923    GBYB01014924    JAG84690.1    JAG84691.1    GECZ01011099    JAS58670.1    GBHO01043288    GBRD01007683    JAG00316.1    JAG58138.1    GBHO01043282    JAG00322.1    GL440209    EFN66142.1    ACPB03012985    KQ976973    KYN06637.1    LBMM01002956    KMQ94136.1    KQ983167    KYQ46967.1    ADTU01015858    NEVH01024421    PNF17348.1    IAAA01029277    IAAA01029278    LAA07536.1    KQ436010    KOX67575.1    KK107069    QOIP01000002    EZA60709.1    RLU26126.1    KY274178    ASC44542.1    PNF17417.1    GEDC01026600    JAS10698.1    KQ981975    KYN31575.1    KQ979763    KYN19268.1    MG573164    AWJ25026.1    GL767462    EFZ13704.1    BABH01029849    HM483391    ADJ56408.1    KZ288220    PBC32174.1    JR038077    JR038078    AEY58108.1    AEY58109.1    JN243756    AEO89346.1    KK852807    KDR16086.1    KK115764    KFM65961.1    CH933808    EDW10529.2    DS235271    EEB14253.1    JN243757    AEO89347.1    GAMC01012755    JAB93800.1    CH479216    EDW33597.1    KQ414706    KOC63100.1    CH940648    EDW60212.2    MF687541    ATJ44467.1    GAKP01015960    GAKP01015959    GAKP01015958    GAKP01015956    JAC42993.1    GDHF01029367    GDHF01008158    JAI22947.1    JAI44156.1    GDIP01153633    GDIQ01163373    GDIQ01162077    LRGB01001937    JAJ69769.1    JAK89648.1    KZS09877.1    CM000071    EAL26629.1    GL732524    EFX89565.1    GBXI01017222    GBXI01017048    GBXI01015288    GBXI01014990    GBXI01003875    JAC97069.1    JAC97243.1    JAC99003.1    JAC99301.1    JAD10417.1    KQ460036    KPJ18402.1    GGMS01014761    MBY83964.1    GFTR01006468    JAW09958.1    CM002911    KMY94302.1    CH480816    EDW48169.1    GDIQ01022871    JAN71866.1    AE013599    ACZ94440.1    AAF57974.1    GBBI01003721    JAC14991.1    GDIQ01236900    JAK14825.1    CM000158    EDW91895.1    KQ759773    OAD62927.1    GBGD01001183    JAC87706.1    CH954179    EDV55730.1    CH902619    EDV37466.1    KPU76846.1    KPI96431.1    GDIQ01267958    JAJ83766.1    GFDF01002480    JAV11604.1    AGBW02010466    OWR48453.1    KA645200    AFP59829.1    CH916375    EDV98366.1   

Proteomes

UP000005204    UP000007151    UP000053268    UP000218220    UP000053240    UP000283053    + More
UP000008237    UP000009046    UP000000311    UP000015103    UP000078542    UP000036403    UP000075809    UP000005205    UP000235965    UP000053105    UP000053097    UP000279307    UP000078541    UP000078492    UP000002358    UP000005203    UP000242457    UP000027135    UP000054359    UP000009192    UP000091820    UP000008744    UP000053825    UP000008792    UP000076858    UP000001819    UP000000305    UP000001292    UP000000803    UP000002282    UP000008711    UP000095300    UP000192221    UP000007801    UP000095301    UP000001070   

PRIDE

H9JNR0    H9IY27    A1ZAI5   

Pfam

PF07993   NAD_binding_4        + More
PF03015   Sterile

Interpro

IPR036291   NAD(P)-bd_dom_sf        + More
IPR033640   FAR_C       
IPR026055   FAR       
IPR013120   Male_sterile_NAD-bd       

SUPFAM

SSF51735   SSF51735       

CDD

cd09071  FAR_C

ProteinModelPortal

H9JNR0   A0A2W1BD38   A0A0F6Q104   A0A068FJB7   A0A212FG68   A0A194PTQ4   + More
A0A0F6Q4L1   A0A2W1BU43   A0A0F6Q1K5   A0A386QW76   D9D5H9   A0A291P0Q0   D7P5E4   A0A1V0M880   A0A0P0EW34   U5KFU0   A0A0F6Q1I7   A0A291P0V6   A0A2A4JGI4   A0A194RN00   A0A0P0EA69   A0A2H1WNT2   A0A3S2LSJ5   A0A1L8D6B8   A0A2W1B0E2   A0A3S2NBD7   A0A023F1N4   A0A069DVI2   E2B9J0   E0VSV6   A0A1B6EM21   A0A0C9QJE0   A0A1B6G8A3   A0A0A9VYR3   A0A0A9VVQ7   E2AKA1   T1HPB8   A0A195D193   A0A0J7KV18   A0A151WGN3   A0A158NHJ4   A0A2J7PLY4   A0A2L2YHA0   A0A0M8ZN21   A0A026WZZ2   A0A1Z3FT38   A0A2J7PM67   A0A1B6CB27   A0A195ETJ3   A0A195E2A0   A0A3Q8FTW8   E9J0E5   K7J1Z7   H9IY27   D9MWM7   A0A2A3EL05   V9IAG7   G3KIJ9   A0A067R949   A0A087TLH2   B4KSN0   E0VLJ7   G3KIK0   A0A1A9X2G9   W8AXT4   B4H764   A0A0L7QWX8   B4LPA3   A0A291P0J5   A0A034VN48   A0A0K8U8F7   A0A0P5M2C1   Q28WN8   E9FTX3   A0A0A1WIW0   A0A0N1IPU7   A0A2S2R203   A0A224XJF5   A0A0J9RE92   B4HT68   A0A0P6HB46   E1JH83   A1ZAI5   A0A023F1V0   A0A0P5GW05   B4P5X9   A0A310SYR9   A0A069DV62   B3NPG3   A0A1I8PNE0   A0A1W4UXP9   B3MDK3   A0A194PSL9   A0A0P5ESY3   A0A1L8DYU2   A0A212F418   T1PAL6   A0A1I8M522   B4JWM8  

PDB

4U5Q     E-value=4.61714e-05,     Score=113

KEGG

105841608    K13356 alcohol-forming fatty acyl-CoA reductase [EC:1.2.1.84] | (RefSeq) putative fatty acyl-CoA red

PATHWAY

04146    Peroxisome - Bombyx mori (domestic silkworm)

GO

GO:0102965   GO:0006629   GO:0080019   GO:0016021   GO:0035336   GO:0005777   GO:0010025   GO:0005778   GO:0008611   GO:0005779  

PANTHER

PTHR11011  

Subcellular location

Peroxisome membrane  

Length:

524

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

27.59865

Exp number, first 60 AAs:

2.77328

Total prob of N-in:

0.09567

outside

1  -  524

 

 

Pi

17.654852

Theta

16.632506

Tajima's D

0.507112

CLR

1.283246

CSRT

0.525823708814559

Interpretation

Uncertain