Gene

KWMTBOMO14245

Pre Gene Modal

BGIBMGA011102

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_protein_son_of_sevenless_[Bombyx_mori]

Location

Bomo_Chr23(-):21321604-21332402      View in EpiBrowser

Full name

Protein son of sevenless      

Location in the cell

Cytoplasmic   Reliability : 2.134 Nuclear   Reliability : 1.489

CDS

ATGCTGCCCACAGTGGAGGAGATAAGGGGTTATGATTTTTTAGACCCCGAAAATGTAGATAAATGGAGAGGAATATTCGTAAACCCACTTAAAAAGGTTTTAGAACAAGTGCATCCATCATTGAGTGCTGAAGAGAGTGCCCTAGAGTATGTGGAATCATTATGCCTGAGATTACTCTCTACGCTGTGTGCAGCACCGACACCTAGAACTGTACAGGATGTGGAAGACCGTGTGGCTAGAACATTCCCGACACCTTTGGACAAATGGGCTCCAGCTGACGCTCGGGATGCAGCCACTAATAAGCGACGGAGACCATTGCTTCCACATGACAGATTACACAACATGTTGCATAAGGAAGTGTTCCAATACAAAATTGACAGTTCAGTGTCAGTGTTCATGACTGCCATATTAGAATATGTTAGTGTCGACATACTAAAGTTGGCCGGAAATTTTGTTAAGAAAATGTCACAGAAGTCTGGTTATGATACTATAACCTGCCAGGACATAAAGACAGCCATGTGTGCTGATAAGGTTTTAATGGATATGTTTTATCAAGAGACAGAATTGACAGTGGTGGAGAATTCCACTAGCACAGACAGGAGGGGCCGGAGGGGATCCCTCTCTTATGCAGAGCTGGTCCGAGACCTCATGACTGACGAGAAGCACTTCCTAAGGGACTTGCATCTCATAATAAGGGTCTTCAAAGAAGAGCTAGATAAAATACTGGATGGAGATACGAGGACTCTGTCCCTGATTTTTGGCAATATAGTGGACATCTACGAACTGACTGTCACTTTACTGGGAAATTTGGAGGACGCCATGGAGATGTCAGAGGACTCTCCTTCACCATATATTGGAAGTTGTTTTGAAGAATTAGCTGAAGTGGAAGAGTTTCGTGCGTACGTCCGATACGCCAACATCGTCACCAGGAAGGAGTCCAGGGAGGCCTTGCAGAACATCGTGGACGATCCGATCTTATCGGAAGGTCTCAAGACAGCCGGGCAGGGTTTCCTGCTGGCCACGAAGTACTACCTGCCCCGGTTGCTGCTGGCCCCCGTCGGACACGTGTTCCTGTACCACAAATACGTGCTCGCCCTGCTGCACGCCGCGCCCACGGTCGACGACCGGGAGAGCTTTAAACAGGTTCAGTGCAATTTAGATCCGATCAAGAAATTACTAGATAAAGCATTGGGGAACGGACCGAAAATGGACGGTACCCTGCGGATGGCGAGCAGGTCGCGCCGACAGCAAGCCATCGAGAAGTGCAACGAGCTGGCGCGGGTCGTGGACAACTGGGACAACCGGGACATCGGACAGTGCTGTAACGAATTCATCCGGGAAGACATACTGTCGAAGATAGGGCCCGGCAAGAAGGTGGCCGAGCGGAGGGCCTACCTGTTCGACGGGCTGCTGCTGCTGTGCAAGCCCGCCACCAGCCTGGTGACGGTGAACAGCGGGGGCGGCGCCGGCGGGGTGGGCGCCGTGCAGCTCAAGCTCAAGGAGAAGCTGCACATCCGGAAGCTGGAGATCGTGGACCGGCCCGACACGGACGAGGCGCGACACCTGCTGGAGCTGTCCCCGCGCGTGGGCGGCCCCGTGGTGCTGGCGTGCGCGTCGGCGCCCGACAAGCGGAACTGGATGTGCGACCTCGTCATGCTCAACACCAAGCCCATGCTGGACCGGTTCCTCGAGAGCATCCTGTCGGAGCTGGAGCGGCGGCACCCGCTGCGGCTGCCCCCGCCGCGCCTGTACCGGTTCGCGGAGGCCGACGCGCCGCACAACATCCTGCTGGAGCAGCCGCCCGTGCGCCGCCCCGCGCTCGTGCCGCTCGTCAAGGGCGCCACGCTGCTCAAGCTGGTGGAGCGCCTCACGTACCACGTGTACGCCGACCTGGCGCTCGTGCGCACCTTCCTCACCACCTACCGCTCCTTCTGCGAGCCCCGCGAGCTGCTGGCGCTGCTCATCGAGCGGTTCCGCATCCCCGAGCCCGCCGACGTCTACGACAAGCCGCCCCCAGCGGAGAGCATAGAGAGCGTGGCCAGCAGCGACGCCGAGAAGCTCAGCAAGAACACCGTGAGGGAAGACTGGAAGAGGTACAGGAAGGAGTTCCAGCAGCCCGTCAAGTTTAGGGTTATTAACGTTATTAGACACTGGGTGGATCAACACTTTTATGATTTCGAAAGAGATCCCGAGCTTTTGGACGAGCTCCGAGAGTTCCTGGAGTCCGTCGACGGGAAACCCATGAGGAAGTGGGTCCAGAGCGTGCTCAAGACCTTGCAGAGGAAGGTACGTCTGAACCTCTAG

Protein

MLPTVEEIRGYDFLDPENVDKWRGIFVNPLKKVLEQVHPSLSAEESALEYVESLCLRLLSTLCAAPTPRTVQDVEDRVARTFPTPLDKWAPADARDAATNKRRRPLLPHDRLHNMLHKEVFQYKIDSSVSVFMTAILEYVSVDILKLAGNFVKKMSQKSGYDTITCQDIKTAMCADKVLMDMFYQETELTVVENSTSTDRRGRRGSLSYAELVRDLMTDEKHFLRDLHLIIRVFKEELDKILDGDTRTLSLIFGNIVDIYELTVTLLGNLEDAMEMSEDSPSPYIGSCFEELAEVEEFRAYVRYANIVTRKESREALQNIVDDPILSEGLKTAGQGFLLATKYYLPRLLLAPVGHVFLYHKYVLALLHAAPTVDDRESFKQVQCNLDPIKKLLDKALGNGPKMDGTLRMASRSRRQQAIEKCNELARVVDNWDNRDIGQCCNEFIREDILSKIGPGKKVAERRAYLFDGLLLLCKPATSLVTVNSGGGAGGVGAVQLKLKEKLHIRKLEIVDRPDTDEARHLLELSPRVGGPVVLACASAPDKRNWMCDLVMLNTKPMLDRFLESILSELERRHPLRLPPPRLYRFAEADAPHNILLEQPPVRRPALVPLVKGATLLKLVERLTYHVYADLALVRTFLTTYRSFCEPRELLALLIERFRIPEPADVYDKPPPAESIESVASSDAEKLSKNTVREDWKRYRKEFQQPVKFRVINVIRHWVDQHFYDFERDPELLDELREFLESVDGKPMRKWVQSVLKTLQRKVRLNL

Description

Promotes the exchange of Ras-bound GDP by GTP. Functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development.

Cofactor

pyridoxal 5'-phosphate

Subunit

May form a complex with sevenless and DRK.

Keywords

3D-structure   Complete proteome   Developmental protein   Differentiation   Guanine-nucleotide releasing factor   Neurogenesis   Phosphoprotein   Reference proteome  

Feature

chain  Protein son of sevenless

Uniprot

H9JNJ8   A0A194PSE2   A0A212F5U9   E0VPV8   A0A310SXP7   A0A1L8DMM0   + More
A0A0L7RA02   A0A1B6GFE7   F4WM45   W4VRB9   A0A1B6I061   A0A1B6JBU9   A0A182Y9S9   A0A151XA05   A0A182XKX5   A0A182PFS1   A0A182IPD6   A0A182NF53   A0A182R6I6   A0A084VMX5   A0A182V7E9   A0A182QLU2   A0A1S4H138   A0A182WH71   A0A182I569   A0A195DCI2   Q7PVU9   A0A195BD76   A0A195FTS4   E2BCH5   A0A151IGI4   W8BEB8   A0A2M4B8P0   A0A2M4B992   A0A2M4CMM8   A0A1B0BT98   A0A2M3YZC6   A0A2M4A3S9   A0A2M3Z194   A0A1A9XT71   A0A2M4A2R9   W5JEJ6   A0A182GHH3   Q17M14   A0A1A9Z448   A0A1A9UYS0   A0A182GF78   A0A0P6K114   A0A1S4EY32   A0A0K8U4W1   A0A1Y1M9J7   A0A2M4A364   A0A182F0P6   A0A0A1XRC4   A0A0L0CK35   A0A146LL79   A0A034VX27   A0A1I8PMT3   A0A1A9WXD4   A0A088AD66   A0A336MR44   A0A1Q3G253   A0A1Q3G296   A0A2A3EKG0   A0A336MQ16   A0A182KUF6   A0A1Q3G284   A0A1B6MLN3   A0A1Q3G1W9   A0A1Q3G249   A0A1W4XP88   A0A1Q3G1Z5   A0A1Q3G1Y4   A0A026W5J5   D2A5R8   R4WDJ9   A0A0M4MAX7   A0A3L8DY59   A0A232F8B6   A0A069DXH5   A0A023FCF9   A0A224XGN1   T1I4F0   B4GX03   B5DK13   A0A1J1ITL9   A0A154PEK2   N6U5R5   U4UF62   B3NAD3   B4P3Q3   P26675   W8NR02   B3MN28   B4Q565   B4N0X6   A0A182M160   E9IY01   A0A1B0G692   B4JCX2  

Pubmed

19121390    26354079    22118469    20566863    21719571    25244985    + More
24438588    12364791    20798317    24495485    20920257    23761445    26483478    17510324    26999592    28004739    25830018    26108605    26823975    25348373    20966253    24508170    18362917    19820115    23691247    30249741    28648823    26334808    25474469    17994087    15632085    23537049    17550304    1736363    1934068    10471707    10731132    12537572    12537569    12618399    18327897    7773779    22936249    21282665   

EMBL

BABH01035229    BABH01035230    BABH01035231    BABH01035232    KQ459593    KPI96356.1    + More
AGBW02010130    OWR49103.1    DS235379    EEB15414.1    KQ759773    OAD62919.1    GFDF01006494    JAV07590.1    KQ414620    KOC67688.1    GECZ01008643    JAS61126.1    GL888217    EGI64689.1    GANO01003854    JAB56017.1    GECU01027406    JAS80300.1    GECU01011129    JAS96577.1    KQ982353    KYQ57212.1    AXCP01007772    ATLV01014632    KE524975    KFB39319.1    AXCN02000829    AAAB01008984    APCN01003792    APCN01003793    KQ980989    KYN10593.1    EAA15144.4    KQ976519    KYM82162.1    KQ981264    KYN44020.1    GL447283    EFN86601.1    KQ977726    KYN00322.1    GAMC01006920    JAB99635.1    GGFJ01000256    MBW49397.1    GGFJ01000257    MBW49398.1    GGFL01002273    MBW66451.1    JXJN01020064    GGFM01000871    MBW21622.1    GGFK01002142    MBW35463.1    GGFM01001500    MBW22251.1    GGFK01001711    MBW35032.1    ADMH02001466    ETN62476.1    JXUM01063728    JXUM01063729    JXUM01063730    JXUM01063731    JXUM01063732    CH477209    EAT47730.1    JXUM01059533    JXUM01059534    JXUM01059535    JXUM01059536    JXUM01059537    JXUM01059538    JXUM01059539    KQ562059    KXJ76787.1    GDUN01000352    JAN95567.1    GDHF01030706    JAI21608.1    GEZM01039717    JAV81270.1    GGFK01001935    MBW35256.1    GBXI01000716    JAD13576.1    JRES01000300    KNC32616.1    GDHC01011132    JAQ07497.1    GAKP01012315    JAC46637.1    UFQT01001740    SSX31599.1    GFDL01001137    JAV33908.1    GFDL01001122    JAV33923.1    KZ288220    PBC32180.1    SSX31601.1    GFDL01001164    JAV33881.1    GEBQ01003109    JAT36868.1    GFDL01001217    JAV33828.1    GFDL01001226    JAV33819.1    GFDL01001225    JAV33820.1    GFDL01001220    JAV33825.1    KK107399    EZA51345.1    KQ971345    EFA05036.1    AK417589    BAN20804.1    KR075867    ALE20586.1    QOIP01000002    RLU25400.1    NNAY01000744    OXU26718.1    GBGD01000136    JAC88753.1    GBBI01000259    JAC18453.1    GFTR01008684    JAW07742.1    ACPB03010950    CH479195    EDW27330.1    CH379061    EDY70639.1    CVRI01000057    CRL02446.1    KQ434889    KZC10273.1    APGK01038624    APGK01038625    APGK01038626    KB740963    ENN76955.1    KB632264    ERL90963.1    CH954177    EDV58635.1    CM000157    EDW88354.2    KRJ97715.1    M83931    M77501    AE014134    BT015294    AY058749    AF459566    AF459567    AF459568    AF459569    AF459570    AF459571    AF459572    AF459573    AF459574    AF459575    AF459576    AF459577    AF459578    AF459579    AF459580    AF459581    AF459582    AF459583    AF459584    AF459585    BT150434    AHL21638.1    CH902620    EDV32006.1    CM000361    CM002910    EDX04971.1    KMY90163.1    CH963920    EDW77739.1    AXCM01004062    AXCM01004063    GL766836    EFZ14555.1    CCAG010006778    CH916368    EDW03211.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000009046    UP000053825    UP000007755    + More
UP000076408    UP000075809    UP000076407    UP000075885    UP000075880    UP000075884    UP000075900    UP000030765    UP000075903    UP000075886    UP000075920    UP000075840    UP000078492    UP000007062    UP000078540    UP000078541    UP000008237    UP000078542    UP000092460    UP000092443    UP000000673    UP000069940    UP000008820    UP000092445    UP000078200    UP000249989    UP000069272    UP000037069    UP000095300    UP000091820    UP000005203    UP000242457    UP000075882    UP000192223    UP000053097    UP000007266    UP000279307    UP000215335    UP000015103    UP000008744    UP000001819    UP000183832    UP000076502    UP000019118    UP000030742    UP000008711    UP000002282    UP000000803    UP000007801    UP000000304    UP000007798    UP000075883    UP000092444    UP000001070   

PRIDE

H9JNJ8    P26675    W8NR02   

Pfam

PF00621   RhoGEF        + More
PF00617   RasGEF
PF00125   Histone
PF00618   RasGEF_N
PF00169   PH
PF00583   Acetyltransf_1
PF00282   Pyridoxal_deC

Interpro

IPR019804   Ras_G-nucl-exch_fac_CS        + More
IPR011993   PH-like_dom_sf       
IPR000651   Ras-like_Gua-exchang_fac_N       
IPR007125   Histone_H2A/H2B/H3       
IPR000219   DH-domain       
IPR009072   Histone-fold       
IPR036964   RASGEF_cat_dom_sf       
IPR008937   Ras-like_GEF       
IPR023578   Ras_GEF_dom_sf       
IPR035899   DBL_dom_sf       
IPR001895   RASGEF_cat_dom       
IPR001849   PH_domain       
IPR002119   Histone_H2A       
IPR013026   TPR-contain_dom       
IPR019734   TPR_repeat       
IPR011990   TPR-like_helical_dom_sf       
IPR000182   GNAT_dom       
IPR016181   Acyl_CoA_acyltransferase       
IPR015424   PyrdxlP-dep_Trfase       
IPR015421   PyrdxlP-dep_Trfase_major       
IPR002129   PyrdxlP-dep_de-COase       

SUPFAM

SSF48366   SSF48366        + More
SSF48065   SSF48065       
SSF47113   SSF47113       
SSF55729   SSF55729       
SSF48452   SSF48452       
SSF53383   SSF53383       

Gene 3D

1.10.20.10     1.10.840.10     1.20.900.10     2.30.29.30     1.25.40.10     3.40.640.10    

CDD

cd00155  RasGEF
cd00160  RhoGEF
cd06224  REM

ProteinModelPortal

H9JNJ8   A0A194PSE2   A0A212F5U9   E0VPV8   A0A310SXP7   A0A1L8DMM0   + More
A0A0L7RA02   A0A1B6GFE7   F4WM45   W4VRB9   A0A1B6I061   A0A1B6JBU9   A0A182Y9S9   A0A151XA05   A0A182XKX5   A0A182PFS1   A0A182IPD6   A0A182NF53   A0A182R6I6   A0A084VMX5   A0A182V7E9   A0A182QLU2   A0A1S4H138   A0A182WH71   A0A182I569   A0A195DCI2   Q7PVU9   A0A195BD76   A0A195FTS4   E2BCH5   A0A151IGI4   W8BEB8   A0A2M4B8P0   A0A2M4B992   A0A2M4CMM8   A0A1B0BT98   A0A2M3YZC6   A0A2M4A3S9   A0A2M3Z194   A0A1A9XT71   A0A2M4A2R9   W5JEJ6   A0A182GHH3   Q17M14   A0A1A9Z448   A0A1A9UYS0   A0A182GF78   A0A0P6K114   A0A1S4EY32   A0A0K8U4W1   A0A1Y1M9J7   A0A2M4A364   A0A182F0P6   A0A0A1XRC4   A0A0L0CK35   A0A146LL79   A0A034VX27   A0A1I8PMT3   A0A1A9WXD4   A0A088AD66   A0A336MR44   A0A1Q3G253   A0A1Q3G296   A0A2A3EKG0   A0A336MQ16   A0A182KUF6   A0A1Q3G284   A0A1B6MLN3   A0A1Q3G1W9   A0A1Q3G249   A0A1W4XP88   A0A1Q3G1Z5   A0A1Q3G1Y4   A0A026W5J5   D2A5R8   R4WDJ9   A0A0M4MAX7   A0A3L8DY59   A0A232F8B6   A0A069DXH5   A0A023FCF9   A0A224XGN1   T1I4F0   B4GX03   B5DK13   A0A1J1ITL9   A0A154PEK2   N6U5R5   U4UF62   B3NAD3   B4P3Q3   P26675   W8NR02   B3MN28   B4Q565   B4N0X6   A0A182M160   E9IY01   A0A1B0G692   B4JCX2  

PDB

3KSY     E-value=9.12343e-145,     Score=1319

KEGG

101736570    K03099 son of sevenless | (RefSeq) protein son of sevenless

PATHWAY

04013    MAPK signaling pathway - fly - Bombyx mori (domestic silkworm)
04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04320    Dorso-ventral axis formation - Bombyx mori (domestic silkworm)

GO

GO:0005089   GO:0046982   GO:0035023   GO:0003677   GO:0000786   GO:0007264   GO:0005634   GO:0005085   GO:0035022   GO:0030676   GO:0043703   GO:0051607   GO:0007427   GO:0048010   GO:0007480   GO:2000134   GO:0031234   GO:0008293   GO:0045793   GO:0007173   GO:0007426   GO:0008543   GO:0005829   GO:0035997   GO:0045500   GO:0016199   GO:0005088   GO:0046579   GO:0007465   GO:0016831   GO:0030170   GO:0019752   GO:0005488   GO:0005507   GO:0004713   GO:0016491   GO:0015930  

PANTHER

PTHR23113  

Length:

767

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.11641

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00331

outside

1  -  767

 

 

Pi

2.33181

Theta

4.378001

Tajima's D

0.17506

CLR

10.183002

CSRT

0.443977801109945

Interpretation

Uncertain