Pre Gene Modal
BGIBMGA011114
Annotation
PREDICTED:_protein_four-jointed?_partial_[Bombyx_mori]
Full name
Extracellular serine/threonine protein kinase four-jointed
Location in the cell
Nuclear Reliability : 2.366
Sequence
CDS
ATGGAGAATCTACAAACGAATGACCGAAAGCATGCGAGATTGGCCGCAGTAGAAGAATTAGCGGTGAAGGTCCTCGATGATTCGGACATCAAAGAAAAGTACAGGGCTTACTCCATATACTCTTACTGTTTATTGAGCGTGCTGATCAGTTTTGTGCTTGGTCTCTCCATTGGAGTCCTCATCACGAGGCCGGACCCTAAAAGACAGACGGACAGGATTACTAAAGCTAGACAAGGAAGGCGTTTGGATACAGCAAACGTCTCGTATACAGGAGTCGCATTCGTAAACAACCAACGCTCTGATTTCAATAGACAAATATACCCGAAACATTTGAACGACGATCTGCGGGACATATTGAAAGATAACAAAGGAACAAATGTGAATTTTCCACGGACGCCAAACGAGAACACCGTTTTGTATGATAACGTTTATTGGGGTCCCGAAATCGAGAACTCCATGCCGCAGGGCTATGGAGAGAACAGCGCGGAGCTCTGGGAGAGATACGTCGGCAGCAGCGAGGTAGTTAAGATGGAAATCGGCTGCGGCAGGATGCAAAATCGACTGGTAACATTCCGGGACGGCACCAGAGCCTGCGTTCGCTACAGACAAAACACCGATCAAATTCAAGGCGAAATATTCAGCTTCTACGTCGGCAGGTTGCTGAACCTGACTAATCTCGCCCCTTCGGTGGTCAAGATCGTCGATCTGAAAGACAAACTGTGGAGGAACGTGGTCAACGACATAGCGGCCGCTAAATGGAGCAGGAACCGCGCGATAGTACTGACACAGTACGTGCCTAGCTTGGAACCAGCTCACATACCGGACGTTTTCAAGTCCTCGACGCGCCACTTGAACAAAATCGACGTTTACAATATGTCGAACGAAGAGAACGAAACTAGCGACATCACGAAAGAGCTATTAATAGAGAAAATGAGGATTAAAGACGTGAGAAGTAAAGCGAAAAACATCGAAAAGTTTAGCAGAATCGATATGAGACTGAACGACAAAACAGTTAAGTCGTTCTTGGAGCTAGCTCAGTGGTCGGACTTGATTGTGTTTGATTATTTAACCGCCAATTTGGACAGGATAGTCAATAACTTGTTTAATTATCAATGGAACGAGAACATTATGAACGGGCCGGCCCATAATTTGGCCAAGAAGATGGACAGCGGTCTTTTGGTGTTCCTCGACAACGAGTCTGGTCTTCTGCACGGTTATAGGCTCCTGAAGAAATACAACGTATACCACAGCCTGCTGTTGGACAGTTTGTGTGTGTTCCGCAAAAGTACCATAGACGCTTTAAAGCGACTACATTATAAACAGGATGTTGGCGCGAAATTGAGTGATATGTTCCATTTGCGAAATAGCGCTGTAGTCAGGGATGTACTGCCCGCGTTGCCGGAGAAGAACTCGAAGGTTCTACACGAGAGAATAGGCAGGGTATTAAGTCAAGTGCAGAAATGTGAGGAGGCATTAAGATAG
Protein
MENLQTNDRKHARLAAVEELAVKVLDDSDIKEKYRAYSIYSYCLLSVLISFVLGLSIGVLITRPDPKRQTDRITKARQGRRLDTANVSYTGVAFVNNQRSDFNRQIYPKHLNDDLRDILKDNKGTNVNFPRTPNENTVLYDNVYWGPEIENSMPQGYGENSAELWERYVGSSEVVKMEIGCGRMQNRLVTFRDGTRACVRYRQNTDQIQGEIFSFYVGRLLNLTNLAPSVVKIVDLKDKLWRNVVNDIAAAKWSRNRAIVLTQYVPSLEPAHIPDVFKSSTRHLNKIDVYNMSNEENETSDITKELLIEKMRIKDVRSKAKNIEKFSRIDMRLNDKTVKSFLELAQWSDLIVFDYLTANLDRIVNNLFNYQWNENIMNGPAHNLAKKMDSGLLVFLDNESGLLHGYRLLKKYNVYHSLLLDSLCVFRKSTIDALKRLHYKQDVGAKLSDMFHLRNSAVVRDVLPALPEKNSKVLHERIGRVLSQVQKCEEALR
Summary
Description
Golgi serine/threonine protein kinase required for intermediate growth in the proximal-distal axis. Phosphorylates specific residues within extracellular cadherin domains of Fat (ft) and Dachsous (ds) as they transit through the Golgi (PubMed:18635802). Acts in ommatidial polarity determination as a secondary signal downstream of Notch, JAK/STAT and wingless. Also necessary for the initiation, up-regulation or maintenance of Notch ligand, Serrate (Ser) expression in legs, thereby participating in a feedback loop with N signaling. Sufficient for joint formation and growth in the leg (PubMed:10607560, PubMed:11566858, PubMed:14757640, PubMed:7555705, PubMed:8606003).
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Similarity
Belongs to the FJX1/FJ family.
Keywords
Complete proteome
Glycoprotein
Golgi apparatus
Kinase
Membrane
Notch signaling pathway
Reference proteome
Secreted
Signal-anchor
Transferase
Transmembrane
Transmembrane helix
Wnt signaling pathway
Feature
chain Extracellular serine/threonine protein kinase four-jointed
Uniprot
H9JNL0
A0A0L7LTD8
A0A2A4JNF8
A0A2W1BCE0
A0A2H1VU47
A0A212FG64
+ More
A0A194PTU3 A0A194RIR1 N6TTR6 U4USF7 A0A182PMN4 Q16S08 A0A182M4A6 A0A1W4WG50 A0A182WU55 A0A182RTC7 A0NF54 A0A182HUR8 B0W4F5 A0A1S4GY09 A0A182U0L4 A0A1S4J3Z7 A0A182V787 A0A182KD25 A0A182YRJ2 A0A182W756 B3NMN9 P54360 A0A084WGZ7 A0A182T3C6 A0A182NUB3 D2A589 A0A1B0CVS9 A0A1J1HP43 A0A182J8N4 A0A0K8UQE9 A0A0A1XT10 Q28YU1 W5JP76 B3MBD4 A0A182QDL5 B4GIQ0 B4J5R3 B4P4P3 A0A1B0CVV8 A0A1B0GN21 B4KM68 A0A1W4UZN2 B4LNM0 A0A0J9RH20 B4NN22 A0A3B0J2Y6 A0A336MGN0 A0A2J7Q326 A0A336L433 A0A067QWB1 B4HNK6 A0A2P8XVV7 A0A2R7WHE6 E9HEF3 T1I7H2 E9HEF6 A0A182L1J8 A0A0P5RI56 A0A423TG37 A0A1D2NG21 A0A0P6DVQ5 A0A0P5YW82 A0A0P5HC22 A0A0P6BSH0 A0A0P6HVQ1 K1PAI3 A0A0L8GZN1 A0A2C9K8S9 A0A3S0ZZJ9 A0A2T7P685 A0A443RHA8 A0A1S3J0J1 A0A443SIF1 B7PFE2 A0A210Q7J8 A0A2P6KP99 A0A1V9XYT8 A0A1V9XI36 R7URZ9 A0A2H5BFE1 A0A444TP72 I3KB47 A0A3B3R2W3 A0A3Q3C7A5 A0A3P8N8N5 A0A3P9CN94
A0A194PTU3 A0A194RIR1 N6TTR6 U4USF7 A0A182PMN4 Q16S08 A0A182M4A6 A0A1W4WG50 A0A182WU55 A0A182RTC7 A0NF54 A0A182HUR8 B0W4F5 A0A1S4GY09 A0A182U0L4 A0A1S4J3Z7 A0A182V787 A0A182KD25 A0A182YRJ2 A0A182W756 B3NMN9 P54360 A0A084WGZ7 A0A182T3C6 A0A182NUB3 D2A589 A0A1B0CVS9 A0A1J1HP43 A0A182J8N4 A0A0K8UQE9 A0A0A1XT10 Q28YU1 W5JP76 B3MBD4 A0A182QDL5 B4GIQ0 B4J5R3 B4P4P3 A0A1B0CVV8 A0A1B0GN21 B4KM68 A0A1W4UZN2 B4LNM0 A0A0J9RH20 B4NN22 A0A3B0J2Y6 A0A336MGN0 A0A2J7Q326 A0A336L433 A0A067QWB1 B4HNK6 A0A2P8XVV7 A0A2R7WHE6 E9HEF3 T1I7H2 E9HEF6 A0A182L1J8 A0A0P5RI56 A0A423TG37 A0A1D2NG21 A0A0P6DVQ5 A0A0P5YW82 A0A0P5HC22 A0A0P6BSH0 A0A0P6HVQ1 K1PAI3 A0A0L8GZN1 A0A2C9K8S9 A0A3S0ZZJ9 A0A2T7P685 A0A443RHA8 A0A1S3J0J1 A0A443SIF1 B7PFE2 A0A210Q7J8 A0A2P6KP99 A0A1V9XYT8 A0A1V9XI36 R7URZ9 A0A2H5BFE1 A0A444TP72 I3KB47 A0A3B3R2W3 A0A3Q3C7A5 A0A3P8N8N5 A0A3P9CN94
EC Number
2.7.11.1
Pubmed
19121390
26227816
28756777
22118469
26354079
23537049
+ More
17510324 12364791 25244985 17994087 7555705 8606003 10731132 12537572 12537569 10607560 11566858 14757640 18635802 24438588 18362917 19820115 25830018 15632085 20920257 23761445 17550304 22936249 24845553 29403074 21292972 20966253 27289101 22992520 15562597 28812685 28327890 23254933 29228898 25186727 29240929
17510324 12364791 25244985 17994087 7555705 8606003 10731132 12537572 12537569 10607560 11566858 14757640 18635802 24438588 18362917 19820115 25830018 15632085 20920257 23761445 17550304 22936249 24845553 29403074 21292972 20966253 27289101 22992520 15562597 28812685 28327890 23254933 29228898 25186727 29240929
EMBL
BABH01035185
JTDY01000119
KOB78738.1
NWSH01001039
PCG72973.1
KZ150223
+ More
PZC72081.1 ODYU01004450 SOQ44330.1 AGBW02008707 OWR52722.1 KQ459593 KPI96393.1 KQ460152 KPJ17334.1 APGK01019115 KB740092 ENN81443.1 KB632429 ERL95453.1 CH477690 EAT37243.1 AXCM01011840 AAAB01008964 EAU76350.2 APCN01002475 DS231837 EDS33538.1 CH954179 EDV55043.1 U28837 U44904 AE013599 AY071147 ATLV01023775 KE525346 KFB49491.1 KQ971345 EFA05328.1 AJWK01031154 CVRI01000014 CRK89723.1 GDHF01023402 JAI28912.1 GBXI01001027 GBXI01000130 JAD13265.1 JAD14162.1 CM000071 EAL25874.2 ADMH02000763 ETN65123.1 CH902619 EDV36059.2 AXCN02000769 CH479183 EDW36370.1 CH916367 EDW01839.1 CM000158 EDW91666.1 AJWK01031326 AJVK01012824 CH933808 EDW08732.1 CH940648 EDW62200.1 CM002911 KMY94794.1 CH964282 EDW85761.2 OUUW01000001 SPP75894.1 UFQS01001034 UFQT01001034 SSX08645.1 SSX28561.1 NEVH01019072 PNF22977.1 UFQS01001855 UFQT01001855 SSX12578.1 SSX32021.1 KK852881 KDR14416.1 CH480816 EDW48425.1 PYGN01001271 PYGN01000844 PSN36133.1 PSN40108.1 KK854673 PTY17805.1 GL732629 EFX69885.1 ACPB03012124 EFX69836.1 GDIQ01119623 JAL32103.1 QCYY01001774 ROT75416.1 LJIJ01000053 ODN04172.1 GDIQ01172007 GDIQ01168169 GDIQ01071595 GDIQ01068086 GDIQ01057492 LRGB01000005 JAN23142.1 KZS22021.1 GDIP01052421 JAM51294.1 GDIQ01229750 JAK21975.1 GDIP01010693 JAM93022.1 GDIQ01021425 JAN73312.1 JH818463 EKC20802.1 KQ419811 KOF82289.1 RQTK01000028 RUS90609.1 PZQS01000006 PVD28935.1 NCKU01000651 RWS14659.1 NCKV01002121 RWS27297.1 ABJB010418996 DS701983 EEC05314.1 NEDP02004694 OWF44704.1 MWRG01007609 PRD28151.1 MNPL01002145 OQR78518.1 MNPL01010596 OQR73038.1 AMQN01006438 KB298361 ELU09294.1 MG197698 AUG84448.1 SAUD01001302 RXG71812.1 AERX01005062
PZC72081.1 ODYU01004450 SOQ44330.1 AGBW02008707 OWR52722.1 KQ459593 KPI96393.1 KQ460152 KPJ17334.1 APGK01019115 KB740092 ENN81443.1 KB632429 ERL95453.1 CH477690 EAT37243.1 AXCM01011840 AAAB01008964 EAU76350.2 APCN01002475 DS231837 EDS33538.1 CH954179 EDV55043.1 U28837 U44904 AE013599 AY071147 ATLV01023775 KE525346 KFB49491.1 KQ971345 EFA05328.1 AJWK01031154 CVRI01000014 CRK89723.1 GDHF01023402 JAI28912.1 GBXI01001027 GBXI01000130 JAD13265.1 JAD14162.1 CM000071 EAL25874.2 ADMH02000763 ETN65123.1 CH902619 EDV36059.2 AXCN02000769 CH479183 EDW36370.1 CH916367 EDW01839.1 CM000158 EDW91666.1 AJWK01031326 AJVK01012824 CH933808 EDW08732.1 CH940648 EDW62200.1 CM002911 KMY94794.1 CH964282 EDW85761.2 OUUW01000001 SPP75894.1 UFQS01001034 UFQT01001034 SSX08645.1 SSX28561.1 NEVH01019072 PNF22977.1 UFQS01001855 UFQT01001855 SSX12578.1 SSX32021.1 KK852881 KDR14416.1 CH480816 EDW48425.1 PYGN01001271 PYGN01000844 PSN36133.1 PSN40108.1 KK854673 PTY17805.1 GL732629 EFX69885.1 ACPB03012124 EFX69836.1 GDIQ01119623 JAL32103.1 QCYY01001774 ROT75416.1 LJIJ01000053 ODN04172.1 GDIQ01172007 GDIQ01168169 GDIQ01071595 GDIQ01068086 GDIQ01057492 LRGB01000005 JAN23142.1 KZS22021.1 GDIP01052421 JAM51294.1 GDIQ01229750 JAK21975.1 GDIP01010693 JAM93022.1 GDIQ01021425 JAN73312.1 JH818463 EKC20802.1 KQ419811 KOF82289.1 RQTK01000028 RUS90609.1 PZQS01000006 PVD28935.1 NCKU01000651 RWS14659.1 NCKV01002121 RWS27297.1 ABJB010418996 DS701983 EEC05314.1 NEDP02004694 OWF44704.1 MWRG01007609 PRD28151.1 MNPL01002145 OQR78518.1 MNPL01010596 OQR73038.1 AMQN01006438 KB298361 ELU09294.1 MG197698 AUG84448.1 SAUD01001302 RXG71812.1 AERX01005062
Proteomes
UP000005204
UP000037510
UP000218220
UP000007151
UP000053268
UP000053240
+ More
UP000019118 UP000030742 UP000075885 UP000008820 UP000075883 UP000192223 UP000076407 UP000075900 UP000007062 UP000075840 UP000002320 UP000075902 UP000075903 UP000075881 UP000076408 UP000075920 UP000008711 UP000000803 UP000030765 UP000075901 UP000075884 UP000007266 UP000092461 UP000183832 UP000075880 UP000001819 UP000000673 UP000007801 UP000075886 UP000008744 UP000001070 UP000002282 UP000092462 UP000009192 UP000192221 UP000008792 UP000007798 UP000268350 UP000235965 UP000027135 UP000001292 UP000245037 UP000000305 UP000015103 UP000075882 UP000283509 UP000094527 UP000076858 UP000005408 UP000053454 UP000076420 UP000271974 UP000245119 UP000285301 UP000085678 UP000288716 UP000001555 UP000242188 UP000192247 UP000014760 UP000288706 UP000005207 UP000261540 UP000264840 UP000265100 UP000265160
UP000019118 UP000030742 UP000075885 UP000008820 UP000075883 UP000192223 UP000076407 UP000075900 UP000007062 UP000075840 UP000002320 UP000075902 UP000075903 UP000075881 UP000076408 UP000075920 UP000008711 UP000000803 UP000030765 UP000075901 UP000075884 UP000007266 UP000092461 UP000183832 UP000075880 UP000001819 UP000000673 UP000007801 UP000075886 UP000008744 UP000001070 UP000002282 UP000092462 UP000009192 UP000192221 UP000008792 UP000007798 UP000268350 UP000235965 UP000027135 UP000001292 UP000245037 UP000000305 UP000015103 UP000075882 UP000283509 UP000094527 UP000076858 UP000005408 UP000053454 UP000076420 UP000271974 UP000245119 UP000285301 UP000085678 UP000288716 UP000001555 UP000242188 UP000192247 UP000014760 UP000288706 UP000005207 UP000261540 UP000264840 UP000265100 UP000265160
Pfam
PF06702 Fam20C
ProteinModelPortal
H9JNL0
A0A0L7LTD8
A0A2A4JNF8
A0A2W1BCE0
A0A2H1VU47
A0A212FG64
+ More
A0A194PTU3 A0A194RIR1 N6TTR6 U4USF7 A0A182PMN4 Q16S08 A0A182M4A6 A0A1W4WG50 A0A182WU55 A0A182RTC7 A0NF54 A0A182HUR8 B0W4F5 A0A1S4GY09 A0A182U0L4 A0A1S4J3Z7 A0A182V787 A0A182KD25 A0A182YRJ2 A0A182W756 B3NMN9 P54360 A0A084WGZ7 A0A182T3C6 A0A182NUB3 D2A589 A0A1B0CVS9 A0A1J1HP43 A0A182J8N4 A0A0K8UQE9 A0A0A1XT10 Q28YU1 W5JP76 B3MBD4 A0A182QDL5 B4GIQ0 B4J5R3 B4P4P3 A0A1B0CVV8 A0A1B0GN21 B4KM68 A0A1W4UZN2 B4LNM0 A0A0J9RH20 B4NN22 A0A3B0J2Y6 A0A336MGN0 A0A2J7Q326 A0A336L433 A0A067QWB1 B4HNK6 A0A2P8XVV7 A0A2R7WHE6 E9HEF3 T1I7H2 E9HEF6 A0A182L1J8 A0A0P5RI56 A0A423TG37 A0A1D2NG21 A0A0P6DVQ5 A0A0P5YW82 A0A0P5HC22 A0A0P6BSH0 A0A0P6HVQ1 K1PAI3 A0A0L8GZN1 A0A2C9K8S9 A0A3S0ZZJ9 A0A2T7P685 A0A443RHA8 A0A1S3J0J1 A0A443SIF1 B7PFE2 A0A210Q7J8 A0A2P6KP99 A0A1V9XYT8 A0A1V9XI36 R7URZ9 A0A2H5BFE1 A0A444TP72 I3KB47 A0A3B3R2W3 A0A3Q3C7A5 A0A3P8N8N5 A0A3P9CN94
A0A194PTU3 A0A194RIR1 N6TTR6 U4USF7 A0A182PMN4 Q16S08 A0A182M4A6 A0A1W4WG50 A0A182WU55 A0A182RTC7 A0NF54 A0A182HUR8 B0W4F5 A0A1S4GY09 A0A182U0L4 A0A1S4J3Z7 A0A182V787 A0A182KD25 A0A182YRJ2 A0A182W756 B3NMN9 P54360 A0A084WGZ7 A0A182T3C6 A0A182NUB3 D2A589 A0A1B0CVS9 A0A1J1HP43 A0A182J8N4 A0A0K8UQE9 A0A0A1XT10 Q28YU1 W5JP76 B3MBD4 A0A182QDL5 B4GIQ0 B4J5R3 B4P4P3 A0A1B0CVV8 A0A1B0GN21 B4KM68 A0A1W4UZN2 B4LNM0 A0A0J9RH20 B4NN22 A0A3B0J2Y6 A0A336MGN0 A0A2J7Q326 A0A336L433 A0A067QWB1 B4HNK6 A0A2P8XVV7 A0A2R7WHE6 E9HEF3 T1I7H2 E9HEF6 A0A182L1J8 A0A0P5RI56 A0A423TG37 A0A1D2NG21 A0A0P6DVQ5 A0A0P5YW82 A0A0P5HC22 A0A0P6BSH0 A0A0P6HVQ1 K1PAI3 A0A0L8GZN1 A0A2C9K8S9 A0A3S0ZZJ9 A0A2T7P685 A0A443RHA8 A0A1S3J0J1 A0A443SIF1 B7PFE2 A0A210Q7J8 A0A2P6KP99 A0A1V9XYT8 A0A1V9XI36 R7URZ9 A0A2H5BFE1 A0A444TP72 I3KB47 A0A3B3R2W3 A0A3Q3C7A5 A0A3P8N8N5 A0A3P9CN94
Ontologies
GO
PANTHER
Topology
Subcellular location
Golgi apparatus membrane
Secreted
Secreted
Length:
493
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
22.72658
Exp number, first 60 AAs:
21.62132
Total prob of N-in:
0.99815
POSSIBLE N-term signal
sequence
inside
1 - 38
TMhelix
39 - 61
outside
62 - 493
Population Genetic Test Statistics
Pi
4.827183
Theta
17.151953
Tajima's D
0.20246
CLR
1.835852
CSRT
0.432978351082446
Interpretation
Uncertain
