Gene

KWMTBOMO14220

Pre Gene Modal

BGIBMGA011148

Annotation

fatty-acyl_CoA_reductase_3_[Ostrinia_nubilalis]

Location

Bomo_Chr23(+):20778792-20805193      View in EpiBrowser

Full name

Fatty acyl-CoA reductase      

Location in the cell

PlasmaMembrane   Reliability : 2.496

CDS

ATGTCTTCCGAAGGATATTCAGCGGAGGAGGTGGATTCGATGCCGGATCGCATAGCGGCCAGCTTCAGTAACATGACGGTCTTGATCACCGGAGGAACGGGTTTCATGGGAAAGGTCCTGGTGGAGAAATTGCTAAGGAAATGCGACGATGTGAAGAAGATAATACTCCTGGTCCGACCGAAGAAGTCGAAAAACCCGAAACAGAGACTAGAAGAAATGTTTAATGGAGAGCTCTTCGAACAAGTCCGGAATATGCGCGGAGGTGTTCAGGGACTCCTGAAGAAGGTCTGCTTGGTGAGCGGCGATGCCAGCGCTCCCGATCTGGCCATCAGTCCAGAAGACAGACAGAGCTTGGTTGAGAATGTGGATATTATAATTCACGCAGCTGCAACTATAAGGTTCGACGAAGAATTAAAAAAGGCAGTACTCCTGAACGTAAGAGGTACTAAGCTGATGGTGGAACTGGCGAAGGAGTGTAAGAAATTGCAGCTTTTCATCCATATCTCAACATCATACTGTCATCTCCATGAGAAACTTCTAGAGGAGAAGCCATATCCTCCGCCAGCGGACCCTCACCAGGTCATCCAAGCTGTGGAATGGATGGACGAGGAAACAATCGCTGCTATGACTCCCAAAATCCTCAACAAGTTGCCGAATTCGTATGCTTTCACGAAAGCACTCGGCGAAGCTCTGGCGGTCGAAGCCATGGATCACATTCCGGTGATGATTCTGAGACCATCAATTGTGATCCCAATCTGGCAGGAACCGATTCCAGGGTGGACCGACAACATCAATGGACCGACAGGATTATTAATAGGCGCCGGGAAGGGAGTCATTCGAAGCATGTATTGCAAGAGCAATAGCTACGCCGACTATTTACCTGTCGACGTATTTATAAACGGAATCATGATCGGAGTTTGGAACTATATTCACTACGGAGACAAAAAATCGAGCGTTATCAATTTCACTTCGTCGGCCGAGATCAAAGTTACGTGGTCGGAGATGATTGATGCTGGACGAGAGATCATCATGAACAGGGTCCCGCTGAACGGAGTCGTGTGGTACCCGGGCGGTTCAATGAAACACTCCAGGCTGTACCACAACATCTGCGTGTTCTTCTTCCACTGGATTCCGGCTGTTTTCATCGATATACTGCTCTTCTGTCTCGGCTATAAGCCAGTATTGATGCGCGTCCAGCGCCGCATAAACAAGGGATTCGAAGTTTTCGAATACTACACGAACAACCAGTGGGACTTCAAATCTGACATCGCGCAGACAGTCCGACAAAGGTTAAACACGAGAGAACGGAGGGACTACAAAGTGGACGCTGGCGGTCTTGACATCTCCAAATACTTTGAAGACTGCATAAGAGCTGCCCGCATTTATATCCTGAAAGAATACGACGATACATTGCCGGCTGCGAGGAGACATATGAAAGTGATGTGGTTCGTCGACCTGGTCACGCGGTGTCTCTTCTGGGGCTTCGTGTTTTACTGGCTCTACAGTTGGACGACGTCGTTCGGCTCAAGCGCGACCACCTCAAACGTCTTCCCGGCCGCGGTTGTGATGGAATCATAA

Protein

MSSEGYSAEEVDSMPDRIAASFSNMTVLITGGTGFMGKVLVEKLLRKCDDVKKIILLVRPKKSKNPKQRLEEMFNGELFEQVRNMRGGVQGLLKKVCLVSGDASAPDLAISPEDRQSLVENVDIIIHAAATIRFDEELKKAVLLNVRGTKLMVELAKECKKLQLFIHISTSYCHLHEKLLEEKPYPPPADPHQVIQAVEWMDEETIAAMTPKILNKLPNSYAFTKALGEALAVEAMDHIPVMILRPSIVIPIWQEPIPGWTDNINGPTGLLIGAGKGVIRSMYCKSNSYADYLPVDVFINGIMIGVWNYIHYGDKKSSVINFTSSAEIKVTWSEMIDAGREIIMNRVPLNGVVWYPGGSMKHSRLYHNICVFFFHWIPAVFIDILLFCLGYKPVLMRVQRRINKGFEVFEYYTNNQWDFKSDIAQTVRQRLNTRERRDYKVDAGGLDISKYFEDCIRAARIYILKEYDDTLPAARRHMKVMWFVDLVTRCLFWGFVFYWLYSWTTSFGSSATTSNVFPAAVVMES

Description

Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.

Catalytic Activity

a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)

Similarity

Belongs to the fatty acyl-CoA reductase family.

Uniprot

D9D5H6   A0A437AUP3   A0A0F6Q312   A0A291P0M5   A0A1V0M883   A0A0P0EUN8   + More
A0A0N1IQ27   H9JNP4   A0A068FJC2   I4DNB9   A0A0F6Q0Z4   A0A212F4P2   A0A2H1X3A1   A0A2H1W160   A0A2A4J8N1   A0A195ETK7   A0A158NHJ1   A0A195E2Y1   F4WVQ9   A0A151WGN1   A0A195D491   A0A0C9RPV7   A0A026WY93   A0A3L8DZ85   A0A182IU55   A0A1B0DPP4   A0A182WR01   A0A182FHG9   K7J201   A0A182Y0Y8   A0A182M294   A0A182PM35   A0A2M4BKQ8   E2AK99   A0A182X562   A0A1B6LLP7   A0A2M3Z6R0   A0A2M4AV78   A0A182S5D7   A0A182QF03   W5JSM1   A0A182HM10   A0A182VET2   A0A182UEA3   A0A182LJI9   Q7Q745   A0A3S7L466   A0A084VZ99   A0A088AD07   A0A182NZA8   D9MX51   Q16II8   A0A2S2NDI7   A0A2J7PM38   A0A023EW31   A0A1S3DCS2   A0A2A3EMA4   D2A4J7   J9K9Q7   A0A0M8ZS58   E2B9J3   A0A1Q3FZW2   A0A0L7QWV6   A0A2H8TS04   A0A1B6HAB1   A0A0A9WQG7   E0VLK1   A0A023F4U0   A0A1B6CHL9   A0A1Y1MBE1   A0A1I8PX66   A0A139WGU3   A0A336LR38   W8BZF0   A0A3B0JMM4   B3N6T8   A0A3B0J160   B4HMA0   B4QHT6   A0A0J7KNS5   B4NX15   B4MRJ0   Q7K3T3   B4KM36   A0A1W4V062   A0A0M4EEQ9   Q28Z01   A0A0L0BTQ4   B3MF32   B4GIF9   A0A182SRQ4   E9I868   A0A034VSY5   B4J5N2   A0A224XB38   A0A232EQW7   A0A1I8MXB8   T1PI92   A0A0K8UTQ0   B4LP42  

EC Number

1.2.1.84

Pubmed

28986331    28756777    28349297    26445454    26354079    19121390    + More
26385554    22651552    22118469    21347285    21719571    24508170    30249741    20075255    25244985    20798317    20920257    23761445    20966253    12364791    14747013    17210077    24438588    20542116    17510324    24945155    18362917    19820115    25401762    26823975    20566863    25474469    28004739    24495485    17994087    22936249    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    15632085    23185243    26108605    21282665    25348373    28648823    25315136    18057021   

EMBL

GU808252    ADI82776.1    RSAL01000406    RVE41881.1    KP237932    MF687594    + More
AKD01785.1    ATJ44520.1    MF687532    KZ150172    ATJ44458.1    PZC72602.1    KU755483    ARD71193.1    KT261702    ALJ30242.1    KQ460036    KPJ18433.1    BABH01035173    KJ622064    AID66652.1    AK402829    BAM19409.1    KP237919    AKD01772.1    AGBW02010333    OWR48706.1    ODYU01013061    SOQ59722.1    ODYU01005715    SOQ46835.1    NWSH01002428    PCG68321.1    KQ981975    KYN31573.1    ADTU01015840    ADTU01015841    ADTU01015842    ADTU01015843    KQ979763    KYN19267.1    GL888393    EGI61729.1    KQ983167    KYQ46968.1    KQ976870    KYN07720.1    GBYB01010525    JAG80292.1    KK107069    EZA60711.1    QOIP01000002    RLU25754.1    AJVK01008205    AJVK01008206    AJVK01008207    AJVK01008208    AXCM01001148    GGFJ01004515    MBW53656.1    GL440209    EFN66140.1    GEBQ01015391    JAT24586.1    GGFM01003433    MBW24184.1    GGFK01011350    MBW44671.1    AXCN02002330    AXCN02002331    ADMH02000483    ETN66303.1    APCN01004294    AAAB01008960    EAA11865.4    MG573168    AWJ25030.1    ATLV01018619    KE525239    KFB43293.1    HM536635    ADI87411.1    CH478074    EAT34078.1    GGMR01002644    GGMR01007453    MBY15263.1    MBY20072.1    NEVH01024421    PNF17396.1    GAPW01001044    JAC12554.1    KZ288220    PBC32171.1    KQ971344    EFA05233.2    ABLF02032266    ABLF02032273    ABLF02032275    KQ435878    KOX70025.1    GL446556    EFN87626.1    GFDL01001993    JAV33052.1    KQ414706    KOC63097.1    GFXV01005191    MBW16996.1    GECU01036103    JAS71603.1    GBHO01036524    GBRD01011335    GDHC01007874    GDHC01005144    JAG07080.1    JAG54489.1    JAQ10755.1    JAQ13485.1    DS235271    EEB14257.1    GBBI01002684    JAC16028.1    GEDC01024360    JAS12938.1    GEZM01035653    GEZM01035651    JAV83142.1    KYB27109.1    UFQT01000126    SSX20506.1    GAMC01007859    JAB98696.1    OUUW01000001    SPP74556.1    CH954177    EDV58187.1    SPP74557.1    CH480816    EDW47177.1    CM000362    CM002911    EDX06420.1    KMY92618.1    LBMM01004890    KMQ92013.1    CM000157    EDW89576.1    CH963850    EDW74729.1    AE013599    AY058365    AAF58875.1    AAL13594.1    CH933808    EDW08700.1    CP012524    ALC40560.1    CM000071    EAL25814.2    KRT02581.1    JRES01001351    KNC23465.1    CH902619    EDV37660.1    CH479183    EDW36279.1    GL761471    EFZ23234.1    GAKP01014007    JAC44945.1    CH916367    EDW01808.1    GFTR01006809    JAW09617.1    NNAY01002725    OXU20686.1    KA648399    AFP63028.1    GDHF01022240    GDHF01016501    JAI30074.1    JAI35813.1    CH940648    EDW62236.1    KRF80510.1   

Proteomes

UP000283053    UP000053240    UP000005204    UP000007151    UP000218220    UP000078541    + More
UP000005205    UP000078492    UP000007755    UP000075809    UP000078542    UP000053097    UP000279307    UP000075880    UP000092462    UP000075920    UP000069272    UP000002358    UP000076408    UP000075883    UP000075885    UP000000311    UP000076407    UP000075900    UP000075886    UP000000673    UP000075840    UP000075903    UP000075902    UP000075882    UP000007062    UP000030765    UP000005203    UP000075884    UP000008820    UP000235965    UP000079169    UP000242457    UP000007266    UP000007819    UP000053105    UP000008237    UP000053825    UP000009046    UP000095300    UP000268350    UP000008711    UP000001292    UP000000304    UP000036403    UP000002282    UP000007798    UP000000803    UP000009192    UP000192221    UP000092553    UP000001819    UP000037069    UP000007801    UP000008744    UP000075901    UP000001070    UP000215335    UP000095301    UP000008792   

PRIDE

H9JNP4    Q7K3T3   

Pfam

PF03015   Sterile        + More
PF07993   NAD_binding_4

Interpro

IPR026055   FAR        + More
IPR036291   NAD(P)-bd_dom_sf       
IPR013120   Male_sterile_NAD-bd       
IPR033640   FAR_C       

SUPFAM

SSF51735   SSF51735       

CDD

cd09071  FAR_C

ProteinModelPortal

D9D5H6   A0A437AUP3   A0A0F6Q312   A0A291P0M5   A0A1V0M883   A0A0P0EUN8   + More
A0A0N1IQ27   H9JNP4   A0A068FJC2   I4DNB9   A0A0F6Q0Z4   A0A212F4P2   A0A2H1X3A1   A0A2H1W160   A0A2A4J8N1   A0A195ETK7   A0A158NHJ1   A0A195E2Y1   F4WVQ9   A0A151WGN1   A0A195D491   A0A0C9RPV7   A0A026WY93   A0A3L8DZ85   A0A182IU55   A0A1B0DPP4   A0A182WR01   A0A182FHG9   K7J201   A0A182Y0Y8   A0A182M294   A0A182PM35   A0A2M4BKQ8   E2AK99   A0A182X562   A0A1B6LLP7   A0A2M3Z6R0   A0A2M4AV78   A0A182S5D7   A0A182QF03   W5JSM1   A0A182HM10   A0A182VET2   A0A182UEA3   A0A182LJI9   Q7Q745   A0A3S7L466   A0A084VZ99   A0A088AD07   A0A182NZA8   D9MX51   Q16II8   A0A2S2NDI7   A0A2J7PM38   A0A023EW31   A0A1S3DCS2   A0A2A3EMA4   D2A4J7   J9K9Q7   A0A0M8ZS58   E2B9J3   A0A1Q3FZW2   A0A0L7QWV6   A0A2H8TS04   A0A1B6HAB1   A0A0A9WQG7   E0VLK1   A0A023F4U0   A0A1B6CHL9   A0A1Y1MBE1   A0A1I8PX66   A0A139WGU3   A0A336LR38   W8BZF0   A0A3B0JMM4   B3N6T8   A0A3B0J160   B4HMA0   B4QHT6   A0A0J7KNS5   B4NX15   B4MRJ0   Q7K3T3   B4KM36   A0A1W4V062   A0A0M4EEQ9   Q28Z01   A0A0L0BTQ4   B3MF32   B4GIF9   A0A182SRQ4   E9I868   A0A034VSY5   B4J5N2   A0A224XB38   A0A232EQW7   A0A1I8MXB8   T1PI92   A0A0K8UTQ0   B4LP42  

PDB

4U5Q     E-value=5.97726e-15,     Score=198

KEGG

101744120    K13356 alcohol-forming fatty acyl-CoA reductase [EC:1.2.1.84] | (RefSeq) putative fatty acyl-CoA red

PATHWAY

04146    Peroxisome - Bombyx mori (domestic silkworm)

GO

GO:0102965   GO:0016021   GO:0080019   GO:0006629   GO:0010025   GO:0005777   GO:0035336  

PANTHER

PTHR11011  

Length:

525

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

79.3994

Exp number, first 60 AAs:

17.3042

Total prob of N-in:

0.08069

POSSIBLE N-term signal

sequence

outside

1  -  368

TMhelix

369  -  391

inside

392  -  479

TMhelix

480  -  502

outside

503  -  525

 

 

Pi

22.413637

Theta

19.135767

Tajima's D

0.222493

CLR

1.880476

CSRT

0.432328383580821

Interpretation

Uncertain