Gene

KWMTBOMO14216  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011145

Annotation

putative_fatty_acyl_reductase_FAR1_[Spodoptera_litura]

Location

Bomo_Chr23(+):20692883-20710006      View in EpiBrowser

Full name

Fatty acyl-CoA reductase      

Location in the cell

Cytoplasmic   Reliability : 1.243 PlasmaMembrane   Reliability : 1.611

CDS

ATGGTTGCGGATATCCAAAAATATTCACCGAAGATGAAGCCAGTTGGTGAGGTGACTGGGTTCGACGCGATGGATAAGCTGGAGGCGTTGGGAGAGTCACAGATCGGGAAGATGTTCGCTGGGACCACGGTGCTACTGACCGGGGGCACAGGGTTCCTGGGGAAGCTGATGGTCGACAAACTTTTGAGATGCTGTCCGGATTTAAAAAAGCTGTTCCTACTGGCGAGACCAAAGAAAAATAAAGATATCGCGAAAAGGCTGCAGGAACAGTTTGATGACGTGCTATACGACAAGCTAAGGAAGGAGAGACCGAATTTTATAGAGAAAATATGTATAGTCGAGGGAGATGTAGGTGCTATCAACCTTGGACTCAGTCAAGAGGATCGAACGAAAATCGCTAATGAGGTTGAATTTATCTTCCACGGAGCCGCCACCGTGAGGTTCGACGAGGCTCTGAAGACAGCCGTGGAGATAAACGTGCGGGGCACCAGAGAGATGTGTATTTTGGCCAGATCCTGTGGGAAGCTGAAGGCTCTAGTTCACATTTCGACCGCATACAGTAACTGCACCGTAATGGAGATCGAAGAGAGATTCTACGAGAGCTCCCTCCCTGGTGACAAACTCATCGACCTGGTGGAAACTATGGACGAGAAGGTTATAAACAGCATCACTCCCGGTTTACTGGGGGATTTCCCGAATACGTATGCGTATACGAAATCTGTGGCCGAAGACGTGGTGCAGAAATACTCGAAGGGTCTTCCGGTGGCTTTGTTCAGGCCGTCCATAGTAATTGGAACAGCCAAAGAACCAGTCGCGGGGTGGATAGACAACGTATATGGACCTACAGGGGTTGTGGTAGGAGCCGCAGTGGGTCTACTTCACGCTCTGATCTGCAAACCCAACGCGGTAGCTGACTTGGTCCCCGGAGATATGGTTGTAAACGCTTGCATTGCAACCGCCTGGAAGACAGCCAAAGACTATCCGGGCAACCACGAGGACGCTCCACCCCCGGACCTGACGCCACCAGTTTACAACTTTGTTTCCTCAACACAGAAGCCCCTGACTTGGAGTAAATTCATGAAATACAATGAGATATATGGCCTCGAAGTGCCCACGGTGCAAGCGATTTATTACTACGTGTTTATGTTGACGTCTTCTCGTTTCGCCTACACCCTGTACTGTTTCTTCCTGCACTGGATCCCGGCCTACATCATCGATGGAGTGGCTGTGCTGATAGGCAAAAAGCCAATGCTAAGGAAAGCGTATACGAAGATAAGCAAATTCTCCGAAGTCATATCGTATTTCGCGACGCGCGAGTGGAAATTCCACAGCGGCAACACGGAGGGTCTGGTGCGGGAGCTGTGCCCGGCAGACCGGCAGACGTTCGACTTTGATTTGTCGCGGCTCGACTGGAGCGAATACTTCTACAACTACGTCAGGGGCGTCCGGGTGTACCTGCTCAAGGATCCGGTGGAAACAGTACCGGCCGGCCTCAGGAGGCATAACATACTGAAGTACTCGCACTATATCTTCTGTGCTGTATTAACGTTTGTGCTGGTCAGACTGTTGTGGGCCGCGTGGAGTCTTTTAGACCTTTAA

Protein

MVADIQKYSPKMKPVGEVTGFDAMDKLEALGESQIGKMFAGTTVLLTGGTGFLGKLMVDKLLRCCPDLKKLFLLARPKKNKDIAKRLQEQFDDVLYDKLRKERPNFIEKICIVEGDVGAINLGLSQEDRTKIANEVEFIFHGAATVRFDEALKTAVEINVRGTREMCILARSCGKLKALVHISTAYSNCTVMEIEERFYESSLPGDKLIDLVETMDEKVINSITPGLLGDFPNTYAYTKSVAEDVVQKYSKGLPVALFRPSIVIGTAKEPVAGWIDNVYGPTGVVVGAAVGLLHALICKPNAVADLVPGDMVVNACIATAWKTAKDYPGNHEDAPPPDLTPPVYNFVSSTQKPLTWSKFMKYNEIYGLEVPTVQAIYYYVFMLTSSRFAYTLYCFFLHWIPAYIIDGVAVLIGKKPMLRKAYTKISKFSEVISYFATREWKFHSGNTEGLVRELCPADRQTFDFDLSRLDWSEYFYNYVRGVRVYLLKDPVETVPAGLRRHNILKYSHYIFCAVLTFVLVRLLWAAWSLLDL

Description

Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.

Catalytic Activity

a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)

Similarity

Belongs to the fatty acyl-CoA reductase family.

Feature

chain  Fatty acyl-CoA reductase

Uniprot

H9JNP1   A0A0P0EM43   A0A1V0M874   A0A437BK99   A0A2W1BH51   A0A0F6Q2N3   + More
A0A068FK94   A0A0F6Q1J7   A0A194PTV2   A0A0N1I9W9   A0A212F0D5   A0A158NHD8   A0A151XFK4   K7J7I5   F4WU72   A0A195D4N2   K7J7I4   A0A1B6I9B4   A0A1B6IV08   A0A067QQS7   A0A1B6EVR8   A0A195EE25   A0A232EN92   A0A1B6KC16   N6TBL5   A0A1Y1ML19   A0A0M9ABB1   X1WJK9   A0A232EN78   A0A195EZP6   A0A195BRC5   A0A2S2QSR0   K7J7I3   A0A026X284   A0A195C2N5   A0A1Y1LHX9   A0A151X2I2   E9I8G2   A0A2S2QPP2   E2AWD8   A0A2S2PN15   A0A2J7QR94   A0A2J7QWL4   A0A3Q8FLY7   F4W5T8   A0A195DFI7   K7J6N1   E2BHA7   A0A0L7R054   A0A1B0CRM9   J9JN47   D2A5T7   A0A1W4W338   A0A3Q8G169   A0A2J7RNA3   J9K0H2   A0A336LZ97   A0A232F2D0   A0A1B6EEG7   E2AWD9   A0A336MV31   A0A336LCJ1   A0A2H8TQE5   A0A0T6BDN9   A0A067QUF0   A0A1B6EX35   E2AKQ3   D6WUH3   A0A1B6J450   A0A1B6HWN6   K7IT37   A0A0C9RAR7   J9JQW1   A0A2H8U048   A0A232FLM2   A0A310SC03   A0A195FYB7   A0A1B6KTN1   A0A0A9WBX3   K7J6N4   A0A1B6LVG8   A0A3Q8FT79   A0A3Q8FRZ7   A0A2J7RNB9   A0A1B6CR01   A0A1B6DLK7   D9MX52   A0A232EYC4   A0A2A3E309   V9IIS7   A0A0L7RAS9   A0A310S4M5   A0A1J1IJD8   A0A0C9PMV0   J9K312   A0A182YL41   A0A0A1X8B9  

EC Number

1.2.1.84

Pubmed

19121390    26445454    28349297    28756777    28986331    26385554    + More
26354079    22118469    21347285    20075255    21719571    24845553    28648823    23537049    28004739    24508170    30249741    21282665    20798317    18362917    19820115    25401762    26823975    20542116    25244985    25830018   

EMBL

BABH01035163    BABH01035164    KT261695    ALJ30235.1    KU755476    ARD71186.1    + More
RSAL01000044    RVE50678.1    KZ150217    PZC72130.1    KP237913    MF687534    AKD01766.1    ATJ44460.1    KJ622061    AID66649.1    KP237926    MF687596    AKD01779.1    ATJ44522.1    KQ459593    KPI96403.1    KQ460036    KPJ18430.1    AGBW02011118    OWR47192.1    ADTU01015701    ADTU01015702    KQ982194    KYQ59115.1    GL888353    EGI62240.1    KQ976870    KYN07801.1    GECU01024246    JAS83460.1    GECU01016929    JAS90777.1    KK853504    KDR07123.1    GECZ01027740    JAS42029.1    KQ979039    KYN23453.1    NNAY01003198    OXU19820.1    GEBQ01030984    JAT08993.1    APGK01044237    APGK01044238    KB741021    ENN75098.1    GEZM01028194    GEZM01028193    JAV86394.1    KQ435694    KOX80980.1    ABLF02017919    ABLF02017920    OXU19819.1    KQ981905    KYN33349.1    KQ976417    KYM89582.1    GGMS01011572    MBY80775.1    KK107031    QOIP01000008    EZA62096.1    RLU19323.1    KQ978379    KYM94471.1    GEZM01061226    JAV70627.1    KQ982576    KYQ54647.1    GL761538    EFZ23139.1    GGMS01010440    MBY79643.1    GL443286    EFN62238.1    GGMR01018223    MBY30842.1    NEVH01011924    PNF31087.1    NEVH01009426    PNF32977.1    MG573160    AWJ25022.1    GL887695    EGI70414.1    KQ980903    KYN11612.1    GL448287    EFN84876.1    KQ414672    KOC64230.1    AJWK01024997    AJWK01024998    AJWK01024999    ABLF02012968    KQ971345    EFA05024.1    MG573162    AWJ25024.1    NEVH01002545    PNF42320.1    ABLF02017921    UFQS01000315    UFQT01000315    SSX02758.1    SSX23130.1    NNAY01001243    OXU24628.1    GEDC01000976    JAS36322.1    EFN62239.1    UFQS01002712    UFQT01002712    SSX14582.1    SSX33980.1    SSX14581.1    SSX33979.1    GFXV01003673    MBW15478.1    LJIG01001484    KRT85456.1    KK853249    KDR09345.1    GECZ01027241    JAS42528.1    GL440368    EFN65993.1    KQ971357    EFA08474.2    GECU01013749    JAS93957.1    GECU01028612    JAS79094.1    AAZX01006711    GBYB01003931    JAG73698.1    ABLF02026798    GFXV01007576    MBW19381.1    NNAY01000061    OXU31410.1    KQ764772    OAD54398.1    KQ981208    KYN44829.1    GEBQ01025216    JAT14761.1    GBHO01038325    GBHO01038321    GBRD01012464    GDHC01011251    JAG05279.1    JAG05283.1    JAG53360.1    JAQ07378.1    GEBQ01012294    JAT27683.1    MG573171    AWJ25033.1    MG573167    AWJ25029.1    PNF42309.1    GEDC01021312    JAS15986.1    GEDC01010770    JAS26528.1    HM536636    ADI87412.1    NNAY01001641    OXU23345.1    KZ288460    PBC25481.1    JR049440    AEY60965.1    KQ414617    KOC68027.1    KQ776822    OAD52165.1    CVRI01000054    CRL00357.1    GBYB01002483    JAG72250.1    ABLF02017029    GBXI01015281    GBXI01013342    GBXI01011681    GBXI01007379    GBXI01001263    JAC99010.1    JAD00950.1    JAD02611.1    JAD06913.1    JAD13029.1   

Proteomes

UP000005204    UP000283053    UP000053268    UP000053240    UP000007151    UP000005205    + More
UP000075809    UP000002358    UP000007755    UP000078542    UP000027135    UP000078492    UP000215335    UP000019118    UP000053105    UP000007819    UP000078541    UP000078540    UP000053097    UP000279307    UP000000311    UP000235965    UP000008237    UP000053825    UP000092461    UP000007266    UP000192223    UP000005203    UP000242457    UP000183832    UP000076408   

PRIDE

H9JNP1   

Pfam

PF07993   NAD_binding_4        + More
PF03015   Sterile

Interpro

IPR026055   FAR        + More
IPR013120   Male_sterile_NAD-bd       
IPR036291   NAD(P)-bd_dom_sf       
IPR033640   FAR_C       

SUPFAM

SSF51735   SSF51735       

CDD

cd09071  FAR_C

ProteinModelPortal

H9JNP1   A0A0P0EM43   A0A1V0M874   A0A437BK99   A0A2W1BH51   A0A0F6Q2N3   + More
A0A068FK94   A0A0F6Q1J7   A0A194PTV2   A0A0N1I9W9   A0A212F0D5   A0A158NHD8   A0A151XFK4   K7J7I5   F4WU72   A0A195D4N2   K7J7I4   A0A1B6I9B4   A0A1B6IV08   A0A067QQS7   A0A1B6EVR8   A0A195EE25   A0A232EN92   A0A1B6KC16   N6TBL5   A0A1Y1ML19   A0A0M9ABB1   X1WJK9   A0A232EN78   A0A195EZP6   A0A195BRC5   A0A2S2QSR0   K7J7I3   A0A026X284   A0A195C2N5   A0A1Y1LHX9   A0A151X2I2   E9I8G2   A0A2S2QPP2   E2AWD8   A0A2S2PN15   A0A2J7QR94   A0A2J7QWL4   A0A3Q8FLY7   F4W5T8   A0A195DFI7   K7J6N1   E2BHA7   A0A0L7R054   A0A1B0CRM9   J9JN47   D2A5T7   A0A1W4W338   A0A3Q8G169   A0A2J7RNA3   J9K0H2   A0A336LZ97   A0A232F2D0   A0A1B6EEG7   E2AWD9   A0A336MV31   A0A336LCJ1   A0A2H8TQE5   A0A0T6BDN9   A0A067QUF0   A0A1B6EX35   E2AKQ3   D6WUH3   A0A1B6J450   A0A1B6HWN6   K7IT37   A0A0C9RAR7   J9JQW1   A0A2H8U048   A0A232FLM2   A0A310SC03   A0A195FYB7   A0A1B6KTN1   A0A0A9WBX3   K7J6N4   A0A1B6LVG8   A0A3Q8FT79   A0A3Q8FRZ7   A0A2J7RNB9   A0A1B6CR01   A0A1B6DLK7   D9MX52   A0A232EYC4   A0A2A3E309   V9IIS7   A0A0L7RAS9   A0A310S4M5   A0A1J1IJD8   A0A0C9PMV0   J9K312   A0A182YL41   A0A0A1X8B9  

PDB

4W4T     E-value=3.84834e-09,     Score=148

KEGG

101735916    K13356 alcohol-forming fatty acyl-CoA reductase [EC:1.2.1.84] | (RefSeq) putative fatty acyl-CoA red

PATHWAY

04146    Peroxisome - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0080019   GO:0102965   GO:0006629   GO:0035336   GO:0005777   GO:0010025  

PANTHER

PTHR11011  

Length:

532

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

59.4463800000001

Exp number, first 60 AAs:

2.93125

Total prob of N-in:

0.16884

outside

1  -  388

TMhelix

389  -  411

inside

412  -  507

TMhelix

508  -  530

outside

531  -  532

 

 

Pi

6.349821

Theta

13.952805

Tajima's D

-1.211505

CLR

3.539518

CSRT

0.0981950902454877

Interpretation

Uncertain