Gene

KWMTBOMO14212

Pre Gene Modal

BGIBMGA011121

Annotation

PREDICTED:_fatty_acyl-CoA_reductase_1-like_isoform_X2_[Papilio_polytes]

Location

Bomo_Chr23(-):20565884-20566992      View in EpiBrowser

Full name

Fatty acyl-CoA reductase       + More
Fatty acyl-CoA reductase wat      

Alternative Name

Protein waterproof

Location in the cell

Cytoplasmic   Reliability : 1.755

CDS

ATGGTAAACACAGAGGTCCACGAAGAATTCTATCCTTGCACATGGACTCCTGAAGCTATGCTGGCGATAGCAGAGAAACTAGATGCGGAACAACTCAACGCCATCACTCCAAGTATCATAAAAGGATGGCCGAACACTTACACGTTCGAAAAAGCTTTGGCTGAAGCTTTAGTGAAGAATGCTTCGGATCTGCCCATCTGTATAGTGAGGCCCGCAGTTGTGATTGGCGCTTATTACGAACCGATGCCTGGCTGGTTGGATAAGACTTGTTTATTCGGCGCAAATGCGGTATGA

Protein

MVNTEVHEEFYPCTWTPEAMLAIAEKLDAEQLNAITPSIIKGWPNTYTFEKALAEALVKNASDLPICIVRPAVVIGAYYEPMPGWLDKTCLFGANAV

Description

Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Catalyzes the reduction of saturated fatty acyl-CoA to fatty alcohols. The preferred substrates are C24:0 and C26:0. Necessary for the final stages of tracheal maturation, to facilitate the transition from water-filled to gas-filled tubes. May help to maintain the integrity of the outer hydrophobic envelope of the trachea.

Catalytic Activity

a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)

Similarity

Belongs to the fatty acyl-CoA reductase family.

Keywords

Cell membrane   Complete proteome   Lipid biosynthesis   Lipid metabolism   Membrane   NADP   Oxidoreductase   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Fatty acyl-CoA reductase wat

Uniprot

H9JNL7   A0A2H1VAJ7   A0A2H1WRU0   A0A2W1BRZ8   D2SNS9   A0A2H1VWV0   + More
A0A2A4K1F7   A0A2W1BAL1   A0A0P0ELA9   A0A2A4JIF6   A0A2H1WIY5   A0A2H1WRX8   A0A2A4K1U6   A0A2H1W006   A0A291P0Q6   A0A2W1BEZ6   A0A2A4JY42   A0A2H1VVN7   A0A2W1BUR6   A0A194PUH6   A0A0N1PK47   A0A2W1B8Q0   A0A2H1WT26   A0A2A4J5Y0   A0A2A4JYT4   A0A194PV95   A0A212ER01   A0A2A4K2D3   A0A2A4JY41   A0A2H1V3I1   A0A2W1BH40   D6WUG9   A0A3B0KQF0   B3LXP4   A0A3M7QWY4   B4LXG9   B3P5N1   B4QZE6   B4N9K4   B4JRF4   A0A1W4VH99   A0A2S2R203   Q8MS59   B4PQM4   Q298Y9   B4G4W3   A0A147BN16   A0A1B6LNP5   A0A2S2PD11   D6X3Q1   B4HZ37   A0A1B6J484   T2M8I6   A0A0L0BW16   W8BGY4   A0A1I8MLW5   J9KT21   A0A1B6G8A3   A0A1B6EM21   A0A0Q9WGB4   B4M063   A0A0A9VVQ7   A0A0A9VYR3   A0A2H1VZY4   A0A0M8ZN21   A0A194PT03   E2AKA1   A0A067R2Y2   A0A2S2PW93   B4KDT7   A0A194QZH1   B5DVJ3   A0A0Q9XA67   E2BCH8   A0A194R4R4   B4LPA6   A0A1W4UAR6   A0A1W4UPL0   A0A3B0JDM3   A0A0J7KV18   E0VSV6   Q29B58   A0A0M4F301   A0A3R7QBQ9   A0A1L8DYA8   A0A1Z3FT38   D2A5A7   B4PMY1   A0A0K8W8A8   A0A2R7WZM3   B4NBE6   A0A0K8U220   A0A034W8C5   A0A2A3EL05   V9IAG7   D9MWM7   A0A195EP06   A0A069DV62   B4JTC0   A0A182G8H4  

EC Number

1.2.1.84

Pubmed

19121390    28756777    20074338    26445454    28986331    26354079    + More
22118469    18362917    19820115    17994087    30375419    10731132    12537572    12537569    24183938    17550304    15632085    29652888    24065732    26108605    24495485    25315136    25401762    20798317    24845553    20566863    28608990    25348373    20542116    26334808    26483478   

EMBL

BABH01035147    BABH01035148    BABH01035149    ODYU01001262    SOQ37234.1    ODYU01010569    + More
SOQ55773.1    KZ149959    PZC76395.1    EZ407212    ACX53770.1    ODYU01004617    SOQ44684.1    NWSH01000263    PCG77899.1    KZ150217    PZC72128.1    KT261699    ALJ30239.1    NWSH01001446    PCG71213.1    ODYU01008973    SOQ53018.1    ODYU01010591    SOQ55811.1    PCG77898.1    ODYU01005466    SOQ46353.1    MF687542    ATJ44468.1    KZ150147    PZC72871.1    NWSH01000368    PCG76935.1    ODYU01004416    SOQ44264.1    PZC76396.1    KQ459593    KPI96404.1    KQ460036    KPJ18429.1    PZC72129.1    ODYU01010853    SOQ56210.1    NWSH01003107    PCG66934.1    PCG76936.1    KPI96679.1    AGBW02013183    OWR43905.1    NWSH01000230    PCG78176.1    PCG76937.1    ODYU01000509    SOQ35403.1    PZC72126.1    KQ971357    EFA08470.2    OUUW01000013    SPP88066.1    CH902617    EDV43938.1    REGN01004851    RNA15897.1    CH940650    EDW67847.2    CH954182    EDV53281.1    CM000364    EDX14784.1    CH964232    EDW81680.1    CH916373    EDV94344.1    GGMS01014761    MBY83964.1    AE014297    AY119078    AAM50938.1    CM000160    EDW98363.1    CM000070    EAL27815.1    CH479179    EDW24629.1    GEGO01003258    JAR92146.1    GEBQ01014616    JAT25361.1    GGMR01014701    MBY27320.1    KQ971377    EEZ97452.1    CH480819    EDW53294.1    GECU01013738    JAS93968.1    HAAD01002192    CDG68424.1    JRES01001250    KNC24227.1    GAMC01006030    JAC00526.1    ABLF02009079    ABLF02025536    ABLF02025541    ABLF02025542    ABLF02025547    ABLF02032807    GECZ01011099    JAS58670.1    GECZ01030782    JAS38987.1    KRF83772.1    EDW68313.2    GBHO01043282    JAG00322.1    GBHO01043288    GBRD01007683    JAG00316.1    JAG58138.1    ODYU01005462    SOQ46347.1    KQ436010    KOX67575.1    KPI96442.1    GL440209    EFN66142.1    KK852740    KDR17399.1    GGMS01000518    MBY69721.1    CH933806    EDW14934.1    KQ460890    KPJ10852.1    EDY67660.1    KRG01287.1    GL447283    EFN86604.1    KPJ10851.1    CH940648    EDW60215.1    OUUW01000005    SPP80484.1    LBMM01002956    KMQ94136.1    DS235758    EEB16462.1    EAL27142.2    CP012526    ALC45532.1    QCYY01001969    ROT73914.1    GFDF01002656    JAV11428.1    KY274178    ASC44542.1    KQ971345    EFA05103.1    EDW96993.1    GDHF01004943    JAI47371.1    KK855841    PTY24075.1    EDW81110.1    GDHF01031934    JAI20380.1    GAKP01008396    GAKP01008395    JAC50557.1    KZ288220    PBC32174.1    JR038077    JR038078    AEY58108.1    AEY58109.1    HM483391    ADJ56408.1    KQ978625    KYN29624.1    GBGD01001183    JAC87706.1    EDV95010.1    JXUM01047959    KQ561540    KXJ78212.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000007266    + More
UP000268350    UP000007801    UP000276133    UP000008792    UP000008711    UP000000304    UP000007798    UP000001070    UP000192221    UP000000803    UP000002282    UP000001819    UP000008744    UP000001292    UP000037069    UP000095301    UP000007819    UP000053105    UP000000311    UP000027135    UP000009192    UP000008237    UP000036403    UP000009046    UP000092553    UP000283509    UP000242457    UP000005203    UP000078492    UP000069940    UP000249989   

PRIDE

H9JNL7    Q8MS59   

Pfam

PF07993   NAD_binding_4        + More
PF03015   Sterile
PF03184   DDE_1
PF03221   HTH_Tnp_Tc5

Interpro

IPR026055   FAR        + More
IPR013120   Male_sterile_NAD-bd       
IPR033640   FAR_C       
IPR036291   NAD(P)-bd_dom_sf       
IPR004875   DDE_SF_endonuclease_dom       
IPR009057   Homeobox-like_sf       
IPR006600   HTH_CenpB_DNA-bd_dom       

SUPFAM

SSF51735   SSF51735        + More
SSF46689   SSF46689       

CDD

cd09071  FAR_C

ProteinModelPortal

H9JNL7   A0A2H1VAJ7   A0A2H1WRU0   A0A2W1BRZ8   D2SNS9   A0A2H1VWV0   + More
A0A2A4K1F7   A0A2W1BAL1   A0A0P0ELA9   A0A2A4JIF6   A0A2H1WIY5   A0A2H1WRX8   A0A2A4K1U6   A0A2H1W006   A0A291P0Q6   A0A2W1BEZ6   A0A2A4JY42   A0A2H1VVN7   A0A2W1BUR6   A0A194PUH6   A0A0N1PK47   A0A2W1B8Q0   A0A2H1WT26   A0A2A4J5Y0   A0A2A4JYT4   A0A194PV95   A0A212ER01   A0A2A4K2D3   A0A2A4JY41   A0A2H1V3I1   A0A2W1BH40   D6WUG9   A0A3B0KQF0   B3LXP4   A0A3M7QWY4   B4LXG9   B3P5N1   B4QZE6   B4N9K4   B4JRF4   A0A1W4VH99   A0A2S2R203   Q8MS59   B4PQM4   Q298Y9   B4G4W3   A0A147BN16   A0A1B6LNP5   A0A2S2PD11   D6X3Q1   B4HZ37   A0A1B6J484   T2M8I6   A0A0L0BW16   W8BGY4   A0A1I8MLW5   J9KT21   A0A1B6G8A3   A0A1B6EM21   A0A0Q9WGB4   B4M063   A0A0A9VVQ7   A0A0A9VYR3   A0A2H1VZY4   A0A0M8ZN21   A0A194PT03   E2AKA1   A0A067R2Y2   A0A2S2PW93   B4KDT7   A0A194QZH1   B5DVJ3   A0A0Q9XA67   E2BCH8   A0A194R4R4   B4LPA6   A0A1W4UAR6   A0A1W4UPL0   A0A3B0JDM3   A0A0J7KV18   E0VSV6   Q29B58   A0A0M4F301   A0A3R7QBQ9   A0A1L8DYA8   A0A1Z3FT38   D2A5A7   B4PMY1   A0A0K8W8A8   A0A2R7WZM3   B4NBE6   A0A0K8U220   A0A034W8C5   A0A2A3EL05   V9IAG7   D9MWM7   A0A195EP06   A0A069DV62   B4JTC0   A0A182G8H4  

KEGG

101743396    K13356 alcohol-forming fatty acyl-CoA reductase [EC:1.2.1.84] | (RefSeq) putative fatty acyl-CoA red

PATHWAY

04146    Peroxisome - Bombyx mori (domestic silkworm)

GO

GO:0006629   GO:0102965   GO:0080019   GO:0016021   GO:0003677   GO:0010025   GO:0035336   GO:0005777   GO:0035149   GO:0045177   GO:0005737   GO:0050062   GO:0035002   GO:0016324   GO:0055114  

PANTHER

PTHR11011  

Subcellular location

Apical cell membrane  

Length:

97

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.10147

Exp number, first 60 AAs:

0.0067

Total prob of N-in:

0.20237

outside

1  -  97

 

 

Pi

21.42643

Theta

16.629205

Tajima's D

0.838395

CLR

1.009546

CSRT

0.621618919054047

Interpretation

Uncertain