Gene

KWMTBOMO14201

Pre Gene Modal

BGIBMGA011140

Annotation

PREDICTED:_fatty_acyl-CoA_reductase_1-like_[Bombyx_mori]

Location

Bomo_Chr23(+):20367043-20380049      View in EpiBrowser

Full name

Fatty acyl-CoA reductase      

Location in the cell

PlasmaMembrane   Reliability : 3.212

CDS

ATGGACAGCGCTTTGGCTTTGGAAATCGAGCAGGTCTCGCGTCAGAAGGCGCTGGAGGAGGAAGCGCTTCGCGGCGAGTCGGCTGTGCGGCAGTTCTACGCGGGAACCACAGCGCTGATCACTGGAGGCACGGGCTTCATCGGGAAACAACTCATAGAGAAACTTCTAAGATCGTGCGATGTTAAGCGGATTTACATATTGATACGATCGAAAAAGGGACTGTCTATGGAAGAAAGACTCCAGTTACAATTTAAAGATCCTGTATACGACAATTTACGGTCTCAACAACCAGATTTTGCTCGGAAAGTGATACCGGTCGAAGGCGACATCTCAGAACTAGGCGTCGGCCTGAACGATGAAGACAGGATGAAGCTTGCGCAAGAGGCGAATGTGATATTCCACGTGGCCGCCACGACCAGGTTCGAAGAGCCACTAAAGAAGGCCACATTCATTAACGTCAGAGGAACCAGGGAGATCATGGAATTGGCCAAATGCTGCAAAAATCTAAGATCCTTCGTACACGTGTCAACTGCGTTCTTCAATGCAACTAAGAGCAGAATAAATCACACCATCGAGGAGAAATTCTATGAAAGCCCTGTCCCTCCGGAAGTCATGATACAACTCGCGGAGACAGTTGAAGAATGCAGACTCAACGCGATCACTGCTGATTTGATAAGGGACTGGCCCAACACGTACTGCTTCACGAAGGCCATAGCGGAGGATGTCGTGCGTACAATGGGCAAGGCTTTACCTGTGGCCATATTTAACACCGGACCTCTATGTGCCGATCGAAGCAATCCATTATATTTTCCGTTTTCAGTTGCCTGCACGCTCAATGAACCCACACCTGGATGGCTGGATATGAGCTCGGTGATCGGTCCCAGCGGGATTCTTTTAACCGCAGGCCTTGGCGTGACGCATGTGGTTTTAATAGGTGACATAACGATAGCGCTAGCTCCTGTGGACTACGTCAACAACACTGTATTGGCGACAGCGTGGGAAACCGACAAACGTTTTAAAACTAATGAAAAAGAGTCTAAGATTTACAATATAAGCAACTCCAGATGCACACTTGAGAAAAATCTTTTGTGCGATGTCCTGCATCATCCTAACACAAAACAGTACGCTACGCCGAAAGCCGTTTGGTACTGTTATGGTTTTGAGACCGGAAGCGATGTTGTATTCTGGTTGTCAACGTGGCTGCTGCATTACATACCTGCGTATGTAGCCGACTTCGTGTTTAATGTGACCTCCATGAAGCGACCTGAAGGCATAAAGTCATTCGTTAAAATGTATGAAAAGATATACAAAATGTCTTTGTTGTACGGCTATTTCCTGAGGAACCAGTGGAATTTTGTCGATGACAACACCGTGGCCATGTTGAACCAAATGTCAAAAACTGACAGGATATTGTTCAATTTTGACATTTCGAAGATCGATTGGCCGCGCTATATGCTGATCTGGTGCATCGGCTTGAGAAAGTTCATCGTGAAAGACGGACTCAAAGACAGCGAGTATGGAATGAAGAAACAGAGATGGCTGAAGATAGCTCACATTAGTTTTTATACGCTGTTCTTTGGAGTCGTATTTTCTTTGTTATATCTCGCCTGTAGAATTTTTATGTCTGTAATTTGA

Protein

MDSALALEIEQVSRQKALEEEALRGESAVRQFYAGTTALITGGTGFIGKQLIEKLLRSCDVKRIYILIRSKKGLSMEERLQLQFKDPVYDNLRSQQPDFARKVIPVEGDISELGVGLNDEDRMKLAQEANVIFHVAATTRFEEPLKKATFINVRGTREIMELAKCCKNLRSFVHVSTAFFNATKSRINHTIEEKFYESPVPPEVMIQLAETVEECRLNAITADLIRDWPNTYCFTKAIAEDVVRTMGKALPVAIFNTGPLCADRSNPLYFPFSVACTLNEPTPGWLDMSSVIGPSGILLTAGLGVTHVVLIGDITIALAPVDYVNNTVLATAWETDKRFKTNEKESKIYNISNSRCTLEKNLLCDVLHHPNTKQYATPKAVWYCYGFETGSDVVFWLSTWLLHYIPAYVADFVFNVTSMKRPEGIKSFVKMYEKIYKMSLLYGYFLRNQWNFVDDNTVAMLNQMSKTDRILFNFDISKIDWPRYMLIWCIGLRKFIVKDGLKDSEYGMKKQRWLKIAHISFYTLFFGVVFSLLYLACRIFMSVI

Description

Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.

Catalytic Activity

a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)

Similarity

Belongs to the fatty acyl-CoA reductase family.

Feature

chain  Fatty acyl-CoA reductase

Uniprot

H9JWY2   H9JNM2   A0A2A4JYT4   A0A291P0Q6   A0A2W1BEZ6   A0A2A4K1F7   + More
A0A2W1BUR6   A0A2W1BFX3   A0A2H1VWV0   A0A2W1BRZ8   A0A2W1B8Q0   A0A0P0ELA9   A0A2A4JY41   A0A2A4J5Y0   A0A2W1BH40   A0A212ER01   A0A0N1PK47   A0A2H1WT26   A0A194PSN1   A0A194PZ57   A0A194R4R4   A0A194PV95   A0A2W1BAL1   A0A2A4K1U6   A0A2A4JY42   A0A2A4K2D3   A0A2A4JG81   A0A0P0EM43   A0A1V0M874   H9JNP1   A0A2W1BH51   A0A0F6Q2N3   A0A0F6Q1J7   A0A068FK94   A0A212F0D5   A0A194PT03   A0A194PTV2   A0A067R2Y2   K7J6N4   A0A0A9XGI9   U4UBB5   N6TBL5   A0A2J7RNB9   A0A1B6CR01   A0A1B6DLK7   A0A232EYC4   A0A146LDG8   A0A068FRD3   D9D5H5   A0A1J1J054   A0A0N1I9W9   A0A0C9PMV0   A0A1B0CRM9   A0A0M9ABB1   A0A1B6KC16   A0A1B6I9B4   A0A336L0D6   A0A3Q8FRZ7   A0A2J7QR94   A0A3Q8FLY7   A0A2S2QSR0   A0A1B6IV08   A0A195BRC5   A0A1V0M882   A0A0A9WBX3   A0A1B6EVR8   A0A1B6KTN1   A0A194RHP3   A0A2H8TIW3   A0A2S2QPP2   A0A0P0EGI7   J9K0H2   A0A2A4K2M9   A0A2H8U048   A0A2W1BMW7   A0A1Y1LHX9   D6WUH3   T1HHV9   A0A1B6EEG7   A0A310S4M5   A0A0F6Q2Q6   A0A2S2PN15   A0A195D4N2   A0A193CHN6   A0A3M7QWY4   J9JSM4   A0A1J1IJD8   A0A151XFK4   J9JN47   A0A158NHD8   A0A2H8TPT6   A0A0L0BW16  

EC Number

1.2.1.84

Pubmed

19121390    28986331    28756777    26445454    22118469    26354079    + More
28349297    26385554    24845553    20075255    25401762    23537049    28648823    26823975    28004739    18362917    19820115    27271970    30375419    21347285    26108605   

EMBL

BABH01042202    BABH01042203    BABH01042204    BABH01035129    BABH01035130    BABH01035131    + More
BABH01035132    NWSH01000368    PCG76936.1    MF687542    ATJ44468.1    KZ150147    PZC72871.1    NWSH01000263    PCG77899.1    KZ149959    PZC76396.1    KZ150217    PZC72127.1    ODYU01004617    SOQ44684.1    PZC76395.1    PZC72129.1    KT261699    ALJ30239.1    PCG76937.1    NWSH01003107    PCG66934.1    PZC72126.1    AGBW02013183    OWR43905.1    KQ460036    KPJ18429.1    ODYU01010853    SOQ56210.1    KQ459593    KPI96441.1    KPI96440.1    KQ460890    KPJ10851.1    KPI96679.1    PZC72128.1    PCG77898.1    PCG76935.1    NWSH01000230    PCG78176.1    NWSH01001490    PCG71095.1    KT261695    ALJ30235.1    KU755476    ARD71186.1    BABH01035163    BABH01035164    PZC72130.1    KP237913    MF687534    AKD01766.1    ATJ44460.1    KP237926    MF687596    AKD01779.1    ATJ44522.1    KJ622061    AID66649.1    AGBW02011118    OWR47192.1    KPI96442.1    KPI96403.1    KK852740    KDR17399.1    GBHO01025676    JAG17928.1    KB632003    ERL87876.1    APGK01044237    APGK01044238    KB741021    ENN75098.1    NEVH01002545    PNF42309.1    GEDC01021312    JAS15986.1    GEDC01010770    JAS26528.1    NNAY01001641    OXU23345.1    GDHC01012276    JAQ06353.1    KJ622062    AID66650.1    GU808251    ADI82775.1    CVRI01000065    CRL05837.1    KPJ18430.1    GBYB01002483    JAG72250.1    AJWK01024997    AJWK01024998    AJWK01024999    KQ435694    KOX80980.1    GEBQ01030984    JAT08993.1    GECU01024246    JAS83460.1    UFQS01001285    UFQT01001285    SSX10116.1    SSX29838.1    MG573167    AWJ25029.1    NEVH01011924    PNF31087.1    MG573160    AWJ25022.1    GGMS01011572    MBY80775.1    GECU01016929    JAS90777.1    KQ976417    KYM89582.1    KU755485    ARD71195.1    GBHO01038325    GBHO01038321    GBRD01012464    GDHC01011251    JAG05279.1    JAG05283.1    JAG53360.1    JAQ07378.1    GECZ01027740    JAS42029.1    GEBQ01025216    JAT14761.1    KQ460152    KPJ17348.1    GFXV01002241    MBW14046.1    GGMS01010440    MBY79643.1    KT261704    ALJ30244.1    ABLF02017921    PCG77902.1    GFXV01007576    MBW19381.1    PZC76399.1    GEZM01061226    JAV70627.1    KQ971357    EFA08474.2    ACPB03001017    GEDC01000976    JAS36322.1    KQ776822    OAD52165.1    KP237938    MF687591    AKD01791.1    ATJ44517.1    GGMR01018223    MBY30842.1    KQ976870    KYN07801.1    KU963289    ANN23959.1    REGN01004851    RNA15897.1    ABLF02017029    CVRI01000054    CRL00357.1    KQ982194    KYQ59115.1    ABLF02012968    ADTU01015701    ADTU01015702    GFXV01004402    MBW16207.1    JRES01001250    KNC24227.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000053268    UP000027135    + More
UP000002358    UP000030742    UP000019118    UP000235965    UP000215335    UP000183832    UP000092461    UP000053105    UP000078540    UP000007819    UP000007266    UP000015103    UP000078542    UP000276133    UP000075809    UP000005205    UP000037069   

PRIDE

H9JWY2    H9JNM2    H9JNP1   

Pfam

PF03015   Sterile        + More
PF07993   NAD_binding_4

Interpro

IPR036291   NAD(P)-bd_dom_sf        + More
IPR013120   Male_sterile_NAD-bd       
IPR033640   FAR_C       
IPR026055   FAR       

SUPFAM

SSF51735   SSF51735       

CDD

cd09071  FAR_C

ProteinModelPortal

H9JWY2   H9JNM2   A0A2A4JYT4   A0A291P0Q6   A0A2W1BEZ6   A0A2A4K1F7   + More
A0A2W1BUR6   A0A2W1BFX3   A0A2H1VWV0   A0A2W1BRZ8   A0A2W1B8Q0   A0A0P0ELA9   A0A2A4JY41   A0A2A4J5Y0   A0A2W1BH40   A0A212ER01   A0A0N1PK47   A0A2H1WT26   A0A194PSN1   A0A194PZ57   A0A194R4R4   A0A194PV95   A0A2W1BAL1   A0A2A4K1U6   A0A2A4JY42   A0A2A4K2D3   A0A2A4JG81   A0A0P0EM43   A0A1V0M874   H9JNP1   A0A2W1BH51   A0A0F6Q2N3   A0A0F6Q1J7   A0A068FK94   A0A212F0D5   A0A194PT03   A0A194PTV2   A0A067R2Y2   K7J6N4   A0A0A9XGI9   U4UBB5   N6TBL5   A0A2J7RNB9   A0A1B6CR01   A0A1B6DLK7   A0A232EYC4   A0A146LDG8   A0A068FRD3   D9D5H5   A0A1J1J054   A0A0N1I9W9   A0A0C9PMV0   A0A1B0CRM9   A0A0M9ABB1   A0A1B6KC16   A0A1B6I9B4   A0A336L0D6   A0A3Q8FRZ7   A0A2J7QR94   A0A3Q8FLY7   A0A2S2QSR0   A0A1B6IV08   A0A195BRC5   A0A1V0M882   A0A0A9WBX3   A0A1B6EVR8   A0A1B6KTN1   A0A194RHP3   A0A2H8TIW3   A0A2S2QPP2   A0A0P0EGI7   J9K0H2   A0A2A4K2M9   A0A2H8U048   A0A2W1BMW7   A0A1Y1LHX9   D6WUH3   T1HHV9   A0A1B6EEG7   A0A310S4M5   A0A0F6Q2Q6   A0A2S2PN15   A0A195D4N2   A0A193CHN6   A0A3M7QWY4   J9JSM4   A0A1J1IJD8   A0A151XFK4   J9JN47   A0A158NHD8   A0A2H8TPT6   A0A0L0BW16  

PDB

4W4T     E-value=2.6968e-09,     Score=150

KEGG

101735674    K13356 alcohol-forming fatty acyl-CoA reductase [EC:1.2.1.84] | (RefSeq) fatty acyl-CoA reductase 1-

PATHWAY

04146    Peroxisome - Bombyx mori (domestic silkworm)

GO

GO:0102965   GO:0080019   GO:0006629   GO:0016021   GO:0035336   GO:0005777   GO:0010025  

PANTHER

PTHR11011  

Length:

544

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

44.5435

Exp number, first 60 AAs:

1.01303

Total prob of N-in:

0.09358

outside

1  -  517

TMhelix

518  -  540

inside

541  -  544

 

 

Pi

10.049372

Theta

14.026036

Tajima's D

-1.600398

CLR

0.974017

CSRT

0.0474976251187441

Interpretation

Uncertain