Gene

KWMTBOMO14199

Pre Gene Modal

BGIBMGA011140

Annotation

PREDICTED:_fatty_acyl-CoA_reductase_1-like_[Bombyx_mori]

Location

Bomo_Chr23(+):20311312-20323212      View in EpiBrowser

Full name

Fatty acyl-CoA reductase      

Location in the cell

PlasmaMembrane   Reliability : 3.037

CDS

ATGGACAGCGCTTTAGCGTTGGAGATCGAGCAGGTCTCGCGTCAGAAGGCGCTGGAGGAGGAAGCGCTCCGCGGCGAGTCGGCTGTGCGGCAGTTCTACGCGGGAACCACAGCGCTGATCACTGGAGGCACGGGCTTCATCGGGAAACAACTCATAGAGAAGCTTCTAAGATCGTGCGATGTTAAGCGGATTTACATATTGATACGATCGAAAAAGGGACTGTCTATGGAAGAAAGGCTCCAGTTACAATTTAAAGATCCTGTATACGACAATTTACGGTCTCAACAACCAGATTTCGCTCGGAAAGTGATACCGGTCGAAGGCGACATCTCAGAACTAGGCGTCGGCCTGAACAACGAAGACAGAATGAAGCTTGCGCAAGAGGCGAATGTGATATTCCACGTGGCCGCCACGACCAAGTTCGAAGAGCCACTAAAGAAGGCCACATTCATTAACGTCAGAGGAACCAGGGAGATCCTTGAATTGGCCAAATGCTGCAAAAATCTAAGATCCTTCGTACACGTGTCAACTGCGTTCTTCAATGCAACAAAGAGCAGAATAAATCACACCATCGAGGAGAAATTCTATGAAAGCCCTGTCCCTCCGGAAGTCATGATACAACTCGCGGAGACAGTTGAAGAATGCAGACTCAACGCGATCACTGCTGATTTGATAAGGGACTGGCCCAACACGTACTGCTTCACGAAGGCCATAGCGGAGGATGTCGTGCGTACAATGGGCAAGGCTTTACCTGTGGCCATAGTGAGGCCACCCGTAGTTGTCTGCACGCTCAATGAACCCACACCTGGATGGGTGGATATGAGCTCGGTGATTGGTCCCAGCGGGATTATTTTAGGCGTAGGCCTTGGCGTGACGCATGTGGTTTTAATAGGTGAAATAATGATAGCGATAGCTCCTGTGGACTACGTCAACAACACTGTATTGGCGACAGCGTGGGAAACCGACAAACGTTTTAAAAATAATGAAAAAGAGTCTAAGATTTACAATATAAGCAACTCCAGATGCACACTTGAGAAAAATCTTTTGTGCGATGTCCTGAAAAATCCTAACACAAAACAGTACGCTACGCCGAAAGCCGTTTGGTACTGTTATGGTTTTGAGACCGGAAGCGATGTTGTATTCTGGTTGTTAACATGGCTGCTGCATTACATACCTGCGTATGTAGCCGACTTCGTGTTTAATGTGACCTCCATGAAGCGTCCTGAGGGCATAAAGTCATTCGTTAAAATGTATGAAAAGATATACAAAATGTCTTTGTTGTACGGCTATTTCCTGAGGAACCAGTGGAATTTTGTCGATGACAACACCGTGGCCATGTTGAACCAAATGTCAAAAACTGACAGGATATTGTTCAATTTTGACATTTCGAAGATCGATTGGCCGCACTATATGCTGATCTGGTGCATCGGCTTGAGAAAGTTCATCGTGAAAGACGGACTCAAAGACAGCGACTATGGAATGAAGAAACAGAGATGGCTGAAGATAGCGCACATTAGTTTTTATACGCTGTTCTTTGGAGTCGTGTTTTCTTTGTTATATCTCGCCTGTAGAATTTTTATGTCTGTAATTTGA

Protein

MDSALALEIEQVSRQKALEEEALRGESAVRQFYAGTTALITGGTGFIGKQLIEKLLRSCDVKRIYILIRSKKGLSMEERLQLQFKDPVYDNLRSQQPDFARKVIPVEGDISELGVGLNNEDRMKLAQEANVIFHVAATTKFEEPLKKATFINVRGTREILELAKCCKNLRSFVHVSTAFFNATKSRINHTIEEKFYESPVPPEVMIQLAETVEECRLNAITADLIRDWPNTYCFTKAIAEDVVRTMGKALPVAIVRPPVVVCTLNEPTPGWVDMSSVIGPSGIILGVGLGVTHVVLIGEIMIAIAPVDYVNNTVLATAWETDKRFKNNEKESKIYNISNSRCTLEKNLLCDVLKNPNTKQYATPKAVWYCYGFETGSDVVFWLLTWLLHYIPAYVADFVFNVTSMKRPEGIKSFVKMYEKIYKMSLLYGYFLRNQWNFVDDNTVAMLNQMSKTDRILFNFDISKIDWPHYMLIWCIGLRKFIVKDGLKDSDYGMKKQRWLKIAHISFYTLFFGVVFSLLYLACRIFMSVI

Description

Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.

Catalytic Activity

a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)

Similarity

Belongs to the fatty acyl-CoA reductase family.

Feature

chain  Fatty acyl-CoA reductase

Uniprot

H9JWY2   H9JNM2   A0A2A4JYT4   A0A2A4K1F7   A0A291P0Q6   A0A2W1BEZ6   + More
A0A2W1BUR6   A0A2H1VWV0   A0A2W1BFX3   A0A2W1B8Q0   A0A2W1BRZ8   A0A0P0ELA9   A0A0N1PK47   A0A2A4JY41   A0A2A4J5Y0   A0A2W1BH40   A0A212ER01   A0A2H1WT26   A0A194PSN1   A0A194PZ57   A0A194R4R4   A0A2W1BAL1   A0A2A4K1U6   A0A2A4JY42   A0A2A4K2D3   A0A2A4JG81   A0A0P0EM43   A0A1V0M874   A0A212F0D5   H9JNP1   A0A2W1BH51   A0A0F6Q2N3   A0A0F6Q1J7   A0A068FK94   A0A194PTV2   A0A194PT03   U4UBB5   N6TBL5   D9D5H5   A0A068FRD3   A0A0A9XGI9   A0A146LDG8   A0A1B6CR01   A0A1B6DLK7   A0A1V0M882   A0A0N1I9W9   A0A2S2QSR0   A0A2H8U048   A0A0M9ABB1   A0A2J7QR94   A0A1B0CRM9   A0A2S2PN15   A0A195BRC5   A0A0P0EGI7   J9K0H2   A0A151XFK4   A0A2W1BMW7   A0A2S2QPP2   A0A1Y1ML19   A0A194RHP3   A0A2A4K2M9   A0A310S4M5   A0A2H8TIW3   A0A3Q8FLY7   A0A0F6Q2Q6   A0A158NHD8   A0A195D4N2   A0A336L0D6   A0A1Y1K3T9   A0A1L8D6B1   A0A195DFI7   A0A1B6KC16   A0A1B6KTN1   A0A3Q8FRZ7   A0A3M7QWY4   A0A1J1IJD8   F4W5T8   K7J7I5   A0A151X2I2   A0A195EZP6   A0A1B6I9B4   A0A1Y1LHX9   A0A194PST9   E0VCP2   A0A2H8TPT6   A0A1I8P794   E2AWD8   A0A2J7QWL4   E2AWD9   A0A195C2N5   A0A1B6IV08   J9JSM4   X1WJK9   A0A1B6EVR8  

EC Number

1.2.1.84

Pubmed

19121390    28986331    28756777    26445454    26354079    22118469    + More
28349297    26385554    23537049    25401762    26823975    28004739    21347285    30375419    21719571    20075255    20566863    20798317   

EMBL

BABH01042202    BABH01042203    BABH01042204    BABH01035129    BABH01035130    BABH01035131    + More
BABH01035132    NWSH01000368    PCG76936.1    NWSH01000263    PCG77899.1    MF687542    ATJ44468.1    KZ150147    PZC72871.1    KZ149959    PZC76396.1    ODYU01004617    SOQ44684.1    KZ150217    PZC72127.1    PZC72129.1    PZC76395.1    KT261699    ALJ30239.1    KQ460036    KPJ18429.1    PCG76937.1    NWSH01003107    PCG66934.1    PZC72126.1    AGBW02013183    OWR43905.1    ODYU01010853    SOQ56210.1    KQ459593    KPI96441.1    KPI96440.1    KQ460890    KPJ10851.1    PZC72128.1    PCG77898.1    PCG76935.1    NWSH01000230    PCG78176.1    NWSH01001490    PCG71095.1    KT261695    ALJ30235.1    KU755476    ARD71186.1    AGBW02011118    OWR47192.1    BABH01035163    BABH01035164    PZC72130.1    KP237913    MF687534    AKD01766.1    ATJ44460.1    KP237926    MF687596    AKD01779.1    ATJ44522.1    KJ622061    AID66649.1    KPI96403.1    KPI96442.1    KB632003    ERL87876.1    APGK01044237    APGK01044238    KB741021    ENN75098.1    GU808251    ADI82775.1    KJ622062    AID66650.1    GBHO01025676    JAG17928.1    GDHC01012276    JAQ06353.1    GEDC01021312    JAS15986.1    GEDC01010770    JAS26528.1    KU755485    ARD71195.1    KPJ18430.1    GGMS01011572    MBY80775.1    GFXV01007576    MBW19381.1    KQ435694    KOX80980.1    NEVH01011924    PNF31087.1    AJWK01024997    AJWK01024998    AJWK01024999    GGMR01018223    MBY30842.1    KQ976417    KYM89582.1    KT261704    ALJ30244.1    ABLF02017921    KQ982194    KYQ59115.1    PZC76399.1    GGMS01010440    MBY79643.1    GEZM01028194    GEZM01028193    JAV86394.1    KQ460152    KPJ17348.1    PCG77902.1    KQ776822    OAD52165.1    GFXV01002241    MBW14046.1    MG573160    AWJ25022.1    KP237938    MF687591    AKD01791.1    ATJ44517.1    ADTU01015701    ADTU01015702    KQ976870    KYN07801.1    UFQS01001285    UFQT01001285    SSX10116.1    SSX29838.1    GEZM01093770    JAV56139.1    GEYN01000141    JAV01988.1    KQ980903    KYN11612.1    GEBQ01030984    JAT08993.1    GEBQ01025216    JAT14761.1    MG573167    AWJ25029.1    REGN01004851    RNA15897.1    CVRI01000054    CRL00357.1    GL887695    EGI70414.1    KQ982576    KYQ54647.1    KQ981905    KYN33349.1    GECU01024246    JAS83460.1    GEZM01061226    JAV70627.1    KPI96377.1    DS235060    EEB11148.1    GFXV01004402    MBW16207.1    GL443286    EFN62238.1    NEVH01009426    PNF32977.1    EFN62239.1    KQ978379    KYM94471.1    GECU01016929    JAS90777.1    ABLF02017029    ABLF02017919    ABLF02017920    GECZ01027740    JAS42029.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000007151    UP000053268    UP000030742    + More
UP000019118    UP000053105    UP000235965    UP000092461    UP000078540    UP000007819    UP000075809    UP000005205    UP000078542    UP000078492    UP000276133    UP000183832    UP000007755    UP000002358    UP000078541    UP000009046    UP000095300    UP000000311   

PRIDE

H9JWY2    H9JNM2    H9JNP1   

Pfam

PF03015   Sterile        + More
PF07993   NAD_binding_4
PF02535   Zip

Interpro

IPR036291   NAD(P)-bd_dom_sf        + More
IPR013120   Male_sterile_NAD-bd       
IPR033640   FAR_C       
IPR026055   FAR       
IPR003689   ZIP       

SUPFAM

SSF51735   SSF51735       

CDD

cd09071  FAR_C

ProteinModelPortal

H9JWY2   H9JNM2   A0A2A4JYT4   A0A2A4K1F7   A0A291P0Q6   A0A2W1BEZ6   + More
A0A2W1BUR6   A0A2H1VWV0   A0A2W1BFX3   A0A2W1B8Q0   A0A2W1BRZ8   A0A0P0ELA9   A0A0N1PK47   A0A2A4JY41   A0A2A4J5Y0   A0A2W1BH40   A0A212ER01   A0A2H1WT26   A0A194PSN1   A0A194PZ57   A0A194R4R4   A0A2W1BAL1   A0A2A4K1U6   A0A2A4JY42   A0A2A4K2D3   A0A2A4JG81   A0A0P0EM43   A0A1V0M874   A0A212F0D5   H9JNP1   A0A2W1BH51   A0A0F6Q2N3   A0A0F6Q1J7   A0A068FK94   A0A194PTV2   A0A194PT03   U4UBB5   N6TBL5   D9D5H5   A0A068FRD3   A0A0A9XGI9   A0A146LDG8   A0A1B6CR01   A0A1B6DLK7   A0A1V0M882   A0A0N1I9W9   A0A2S2QSR0   A0A2H8U048   A0A0M9ABB1   A0A2J7QR94   A0A1B0CRM9   A0A2S2PN15   A0A195BRC5   A0A0P0EGI7   J9K0H2   A0A151XFK4   A0A2W1BMW7   A0A2S2QPP2   A0A1Y1ML19   A0A194RHP3   A0A2A4K2M9   A0A310S4M5   A0A2H8TIW3   A0A3Q8FLY7   A0A0F6Q2Q6   A0A158NHD8   A0A195D4N2   A0A336L0D6   A0A1Y1K3T9   A0A1L8D6B1   A0A195DFI7   A0A1B6KC16   A0A1B6KTN1   A0A3Q8FRZ7   A0A3M7QWY4   A0A1J1IJD8   F4W5T8   K7J7I5   A0A151X2I2   A0A195EZP6   A0A1B6I9B4   A0A1Y1LHX9   A0A194PST9   E0VCP2   A0A2H8TPT6   A0A1I8P794   E2AWD8   A0A2J7QWL4   E2AWD9   A0A195C2N5   A0A1B6IV08   J9JSM4   X1WJK9   A0A1B6EVR8  

PDB

4W4T     E-value=2.69697e-10,     Score=158

KEGG

101742447    K13356 alcohol-forming fatty acyl-CoA reductase [EC:1.2.1.84] | (RefSeq) fatty acyl-CoA reductase 1-

GO

GO:0102965   GO:0080019   GO:0006629   GO:0016021   GO:0046873  

PANTHER

PTHR11011  

Length:

530

Number of predicted TMHs:

3

Exp number of AAs in TMHs:

70.19104

Exp number, first 60 AAs:

3.96231

Total prob of N-in:

0.37615

inside

1  -  282

TMhelix

283  -  305

outside

306  -  379

TMhelix

380  -  402

inside

403  -  503

TMhelix

504  -  526

outside

527  -  530

 

 

Pi

2.132505

Theta

2.310419

Tajima's D

-1.300549

CLR

1.747697

CSRT

0.0787460626968652

Interpretation

Uncertain