Gene

KWMTBOMO14192  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011129

Annotation

putative_fatty_acyl_reductase_FAR10_[Spodoptera_litura]

Location

Bomo_Chr23(-):20185165-20195281      View in EpiBrowser

Full name

Fatty acyl-CoA reductase       + More
Fatty acyl-CoA reductase wat      

Alternative Name

Protein waterproof

Location in the cell

PlasmaMembrane   Reliability : 3.582

CDS

ATGACGCTTCCTGGGCTGGGCATAAGCGACGAGGACAGGAAGACCCTGGTCAGCAAGGTGACAATTATAATTAATGCGGCTGCCACCGTCAAATTTGACGAGAAGCTGAGCATCGCGACCGCGATCAACGTTAAAGGAACCAAGGAAGTCCTGAAACTCGCCAAGGAGTGCAGGAACTTGAAGGCGGTTACCCATGTCTCGACCGCCTTCTCGAATACGCAAGTCAAACACATCGAAGAGAAGTTCTACGACTCTCCGATGTCGGTGGAGACTTTGGAGGCTGTTTCGGAGCTAGACGATGAACTGATCAATAGCATACTGCCTACTCTCCTCGGCAAAAGACCAAACACATACTGCTTCACGAAGGCAGTCGCTGAAGAGGCGGTGAGGAGATACGGAGAAGGACTGCCTATTTGCATTTTAAGACCATCTATAGTTGTGTCTACGTATGAGGAGCCGGTGCGCGGCTGGACGGACAGCGTGTACGGTCCGACGGGGCTCGTCGTGGGCATCGGCACTGGGGTTCTACGCACTATGTACATGGATTTAGAGAAAGTTGCCGACATGGTGCCCGTGGACTACACCGTGAACGCCATACTGGTTTCGGCGTGGCACACCGCTAAGAACTTCAAAGAGAATCAAACATCGCACATACCGATCTATAATTATGTGTCCGGAGCCCAGAATCCTATCAAATGGGGCGAATTCATAGATTTGAATCGAAAATACGGTATCGACAAACCCACTACGAAGGCTGTGTGGTACTACGGATTGAATCCGACCAACAATTACTACATGTTCCTGTTTTACAATTTCTTCTTGCACTATCTACCAGCGCTTTTTGTCGACATTTACTTCGTTCTGGCGGGCAAGAAGGCTACGATGGTGAAGATCTACAAAAAGGTGATGAAGCTGACCAACATCCTGTTCTACTTCTCGACCCAGGACTGGCAGTTCAGCGACAACGGAGTCCGGGACATGTGGGGCTCGCTGCCGGACGACGACAAAGTCATATTCCCGTTTAACATAGCCGATATGTCCTGGGACTATATGTGCGAGACCTTCCTAGTCGGACTTCGTGTGTATCTACTTAAGGACGACCTGTCCTCTCTGCCCGAAGCCAGAAAAAAATGGACAAGATTATTCATCCTGCATCAAATTGTGAAGCTCGTCACTCTTAGTTTTGTTTTGTATTTAGCCTATGTAATACTAAAACCGATCGTATCTTTGTTTGTGGCTTGA

Protein

MTLPGLGISDEDRKTLVSKVTIIINAAATVKFDEKLSIATAINVKGTKEVLKLAKECRNLKAVTHVSTAFSNTQVKHIEEKFYDSPMSVETLEAVSELDDELINSILPTLLGKRPNTYCFTKAVAEEAVRRYGEGLPICILRPSIVVSTYEEPVRGWTDSVYGPTGLVVGIGTGVLRTMYMDLEKVADMVPVDYTVNAILVSAWHTAKNFKENQTSHIPIYNYVSGAQNPIKWGEFIDLNRKYGIDKPTTKAVWYYGLNPTNNYYMFLFYNFFLHYLPALFVDIYFVLAGKKATMVKIYKKVMKLTNILFYFSTQDWQFSDNGVRDMWGSLPDDDKVIFPFNIADMSWDYMCETFLVGLRVYLLKDDLSSLPEARKKWTRLFILHQIVKLVTLSFVLYLAYVILKPIVSLFVA

Description

Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Catalyzes the reduction of saturated fatty acyl-CoA to fatty alcohols. The preferred substrates are C24:0 and C26:0. Necessary for the final stages of tracheal maturation, to facilitate the transition from water-filled to gas-filled tubes. May help to maintain the integrity of the outer hydrophobic envelope of the trachea.

Catalytic Activity

a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)

Similarity

Belongs to the fatty acyl-CoA reductase family.

Keywords

Cell membrane   Complete proteome   Lipid biosynthesis   Lipid metabolism   Membrane   NADP   Oxidoreductase   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Fatty acyl-CoA reductase

Uniprot

H9JNM5   A0A0P0EGI7   A0A1V0M882   A0A2A4K2M9   D9D5H5   A0A0F6Q2Q6   + More
A0A2W1BMW7   A0A291P0H9   A0A068FRD3   A0A1L8D6B1   A0A194PST9   A0A194RHP3   A0A2H1WQP9   A0A1B0CRM9   A0A336LZ97   A0A336MV31   A0A336LCJ1   J9K312   A0A3Q8FRZ7   E2BHA7   E0VCP2   A0A1J1IJD8   A0A1B6CR01   A0A1B6DLK7   J9JWZ1   A0A1B6KTN1   J9JSM4   A0A069DU52   A0A0A9WBX7   A0A0A9WBX3   K7J6N1   A0A067R2Y2   A0A0C9PMV0   A0A195C2N5   F4W5T8   A0A2H8TGZ2   A0A232F2D0   A0A195EZP6   T1HHV9   E2AKQ3   D2A5E7   A0A195DFI7   B4G4W3   Q298Y9   A0A3B0KQF0   A0A1W4VH99   E9I8G2   A0A151X2I2   A0A1B6KC16   B3LXP4   A0A067QQS7   Q8MS59   B3P5N1   A0A2S2R0X5   B4PQM4   A0A1B6EX35   A0A1B6I9B4   A0A1B6IV08   A0A1B6J450   A0A1B6HWN6   B4QZE6   A0A1A9Z6W1   A0A1B6EVR8   A0A2J7QWL4   B4HZ37   A0A0A1X8B9   A0A195BRC5   A0A0M9ABB1   A0A1B6IWP7   A0A232EXZ4   A0A1A9US74   B4KXR1   A0A1W4W338   A0A2S2NVM3   A0A2J7RNB9   A0A1I8P794   A0A2J7RNA3   A0A1I8MLW5   A0A1B0B844   K7J6N2   A0A1A9XQ99   A0A034VW62   B4N9K4   A0A1B6DWS1   A0A151XFK4   A0A0L0BW16   A0A212F4X1   A0A0T6BDN9   A0A0K8TZJ6   A0A1B6LVG8   A0A212F0D5   A0A1Y1LHX9   A0A1A9X1V1   A0A1B0GE94   A0A1B6I6Q5   A0A195D4N2  

EC Number

1.2.1.84

Pubmed

19121390    26445454    28349297    28986331    28756777    26385554    + More
26354079    20798317    20566863    26334808    25401762    26823975    20075255    24845553    21719571    28648823    18362917    19820115    17994087    15632085    21282665    10731132    12537572    12537569    24183938    17550304    25830018    25315136    25348373    26108605    22118469    28004739   

EMBL

BABH01035103    KT261704    ALJ30244.1    KU755485    ARD71195.1    NWSH01000263    + More
PCG77902.1    GU808251    ADI82775.1    KP237938    MF687591    AKD01791.1    ATJ44517.1    KZ149959    PZC76399.1    MF687535    ATJ44461.1    KJ622062    AID66650.1    GEYN01000141    JAV01988.1    KQ459593    KPI96377.1    KQ460152    KPJ17348.1    ODYU01009985    SOQ54764.1    AJWK01024997    AJWK01024998    AJWK01024999    UFQS01000315    UFQT01000315    SSX02758.1    SSX23130.1    UFQS01002712    UFQT01002712    SSX14582.1    SSX33980.1    SSX14581.1    SSX33979.1    ABLF02017029    MG573167    AWJ25029.1    GL448287    EFN84876.1    DS235060    EEB11148.1    CVRI01000054    CRL00357.1    GEDC01021312    JAS15986.1    GEDC01010770    JAS26528.1    ABLF02020034    ABLF02020036    GEBQ01025216    JAT14761.1    GBGD01001246    JAC87643.1    GBHO01038324    GBHO01038320    JAG05280.1    JAG05284.1    GBHO01038325    GBHO01038321    GBRD01012464    GDHC01011251    JAG05279.1    JAG05283.1    JAG53360.1    JAQ07378.1    KK852740    KDR17399.1    GBYB01002483    JAG72250.1    KQ978379    KYM94471.1    GL887695    EGI70414.1    GFXV01001581    MBW13386.1    NNAY01001243    OXU24628.1    KQ981905    KYN33349.1    ACPB03001017    GL440368    EFN65993.1    KQ971345    EFA05090.1    KQ980903    KYN11612.1    CH479179    EDW24629.1    CM000070    EAL27815.1    OUUW01000013    SPP88066.1    GL761538    EFZ23139.1    KQ982576    KYQ54647.1    GEBQ01030984    JAT08993.1    CH902617    EDV43938.1    KK853504    KDR07123.1    AE014297    AY119078    AAM50938.1    CH954182    EDV53281.1    GGMS01014433    MBY83636.1    CM000160    EDW98363.1    GECZ01027241    JAS42528.1    GECU01024246    JAS83460.1    GECU01016929    JAS90777.1    GECU01013749    JAS93957.1    GECU01028612    JAS79094.1    CM000364    EDX14784.1    GECZ01027740    JAS42029.1    NEVH01009426    PNF32977.1    CH480819    EDW53294.1    GBXI01015281    GBXI01013342    GBXI01011681    GBXI01007379    GBXI01001263    JAC99010.1    JAD00950.1    JAD02611.1    JAD06913.1    JAD13029.1    KQ976417    KYM89582.1    KQ435694    KOX80980.1    GECU01016349    JAS91357.1    NNAY01001641    OXU23344.1    CH933809    EDW19768.2    GGMR01008565    MBY21184.1    NEVH01002545    PNF42309.1    PNF42320.1    JXJN01009826    GAKP01013214    GAKP01013207    JAC45738.1    CH964232    EDW81680.1    GEDC01007188    JAS30110.1    KQ982194    KYQ59115.1    JRES01001250    KNC24227.1    AGBW02010301    OWR48770.1    LJIG01001484    KRT85456.1    GDHF01032442    GDHF01031317    GDHF01019601    JAI19872.1    JAI20997.1    JAI32713.1    GEBQ01012294    JAT27683.1    AGBW02011118    OWR47192.1    GEZM01061226    JAV70627.1    CCAG010012178    GECU01025131    JAS82575.1    KQ976870    KYN07801.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000092461    UP000007819    + More
UP000008237    UP000009046    UP000183832    UP000002358    UP000027135    UP000078542    UP000007755    UP000215335    UP000078541    UP000015103    UP000000311    UP000007266    UP000078492    UP000008744    UP000001819    UP000268350    UP000192221    UP000075809    UP000007801    UP000000803    UP000008711    UP000002282    UP000000304    UP000092445    UP000235965    UP000001292    UP000078540    UP000053105    UP000078200    UP000009192    UP000192223    UP000095300    UP000095301    UP000092460    UP000092443    UP000007798    UP000037069    UP000007151    UP000091820    UP000092444   

PRIDE

H9JNM5    Q8MS59   

Pfam

PF03015   Sterile        + More
PF07993   NAD_binding_4
PF02535   Zip

Interpro

IPR013120   Male_sterile_NAD-bd        + More
IPR036291   NAD(P)-bd_dom_sf       
IPR033640   FAR_C       
IPR026055   FAR       
IPR003689   ZIP       

SUPFAM

SSF51735   SSF51735       

CDD

cd09071  FAR_C

ProteinModelPortal

H9JNM5   A0A0P0EGI7   A0A1V0M882   A0A2A4K2M9   D9D5H5   A0A0F6Q2Q6   + More
A0A2W1BMW7   A0A291P0H9   A0A068FRD3   A0A1L8D6B1   A0A194PST9   A0A194RHP3   A0A2H1WQP9   A0A1B0CRM9   A0A336LZ97   A0A336MV31   A0A336LCJ1   J9K312   A0A3Q8FRZ7   E2BHA7   E0VCP2   A0A1J1IJD8   A0A1B6CR01   A0A1B6DLK7   J9JWZ1   A0A1B6KTN1   J9JSM4   A0A069DU52   A0A0A9WBX7   A0A0A9WBX3   K7J6N1   A0A067R2Y2   A0A0C9PMV0   A0A195C2N5   F4W5T8   A0A2H8TGZ2   A0A232F2D0   A0A195EZP6   T1HHV9   E2AKQ3   D2A5E7   A0A195DFI7   B4G4W3   Q298Y9   A0A3B0KQF0   A0A1W4VH99   E9I8G2   A0A151X2I2   A0A1B6KC16   B3LXP4   A0A067QQS7   Q8MS59   B3P5N1   A0A2S2R0X5   B4PQM4   A0A1B6EX35   A0A1B6I9B4   A0A1B6IV08   A0A1B6J450   A0A1B6HWN6   B4QZE6   A0A1A9Z6W1   A0A1B6EVR8   A0A2J7QWL4   B4HZ37   A0A0A1X8B9   A0A195BRC5   A0A0M9ABB1   A0A1B6IWP7   A0A232EXZ4   A0A1A9US74   B4KXR1   A0A1W4W338   A0A2S2NVM3   A0A2J7RNB9   A0A1I8P794   A0A2J7RNA3   A0A1I8MLW5   A0A1B0B844   K7J6N2   A0A1A9XQ99   A0A034VW62   B4N9K4   A0A1B6DWS1   A0A151XFK4   A0A0L0BW16   A0A212F4X1   A0A0T6BDN9   A0A0K8TZJ6   A0A1B6LVG8   A0A212F0D5   A0A1Y1LHX9   A0A1A9X1V1   A0A1B0GE94   A0A1B6I6Q5   A0A195D4N2  

PDB

4W4T     E-value=0.000212193,     Score=106

KEGG

101741864    K13356 alcohol-forming fatty acyl-CoA reductase [EC:1.2.1.84] | (RefSeq) fatty acyl-CoA reductase 1-

GO

GO:0080019   GO:0016021   GO:0102965   GO:0006629   GO:0046873   GO:0010025   GO:0005777   GO:0035336   GO:0035002   GO:0005737   GO:0045177   GO:0035149   GO:0050062   GO:0016324   GO:0055114  

PANTHER

PTHR11011  

Subcellular location

Apical cell membrane  

Length:

413

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

46.28743

Exp number, first 60 AAs:

0.03519

Total prob of N-in:

0.03632

outside

1  -  266

TMhelix

267  -  289

inside

290  -  381

TMhelix

382  -  404

outside

405  -  413

 

 

Pi

14.189647

Theta

13.85439

Tajima's D

-0.818817

CLR

11.262334

CSRT

0.174091295435228

Interpretation

Uncertain